LOCUS       NM_080844               1710 bp    mRNA    linear   ROD 09-JUN-2024
DEFINITION  Mus musculus serine (or cysteine) peptidase inhibitor, clade C
            (antithrombin), member 1 (Serpinc1), transcript variant 1, mRNA.
ACCESSION   NM_080844
VERSION     NM_080844.5
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1710)
  AUTHORS   Iwako,H., Tashiro,H., Okimoto,S., Yamaguchi,M., Abe,T., Kuroda,S.,
            Kobayashi,T. and Ohdan,H.
  TITLE     Antithrombin Insufficiency Promotes Susceptibility to Liver
            Tumorigenesis
  JOURNAL   J Surg Res 236, 198-208 (2019)
   PUBMED   30694755
  REMARK    GeneRIF: Tumor size and the number of diethylnitrosamine and carbon
            tetrachloride-induced liver tumors significantly increased in
            antithrombin (AT)-insufficient mice compared with the wild-type
            mice. AT insufficiency led to increased susceptibility to liver
            tumorigenesis by increasing hepatic inflammation.
REFERENCE   2  (bases 1 to 1710)
  AUTHORS   Gould,T.W., Dominguez,B., de Winter,F., Yeo,G.W., Liu,P.,
            Sundararaman,B., Stark,T., Vu,A., Degen,J.L., Lin,W. and Lee,K.F.
  TITLE     Glial cells maintain synapses by inhibiting an activity-dependent
            retrograde protease signal
  JOURNAL   PLoS Genet 15 (3), e1007948 (2019)
   PUBMED   30870413
  REMARK    GeneRIF: Trancriptomic analysis shows that expression of the
            antithrombins serpin C1 and D1 is significantly reduced in Schwann
            cell-deficient mice. In the absence of peripheral neuromuscular
            activity, neurodegeneration is completely blocked, and expression
            of prothrombin in muscle is markedly reduced.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1710)
  AUTHORS   Heit,C., Jackson,B.C., McAndrews,M., Wright,M.W., Thompson,D.C.,
            Silverman,G.A., Nebert,D.W. and Vasiliou,V.
  TITLE     Update of the human and mouse SERPIN gene superfamily
  JOURNAL   Hum Genomics 7 (1), 22 (2013)
   PUBMED   24172014
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1710)
  AUTHORS   Safdar,H., Cheung,K.L., Salvatori,D., Versteeg,H.H., Laghmani
            el,H., Wagenaar,G.T., Reitsma,P.H. and van Vlijmen,B.J.
  TITLE     Acute and severe coagulopathy in adult mice following silencing of
            hepatic antithrombin and protein C production
  JOURNAL   Blood 121 (21), 4413-4416 (2013)
   PUBMED   23550037
  REMARK    GeneRIF: RNA interference of Serpinc1 and/or Proc allows for
            evaluation of the function of these genes in vivo and provides a
            novel, controlled mouse model for spontaneous venous thrombosis.
REFERENCE   5  (bases 1 to 1710)
  AUTHORS   Naba,A., Clauser,K.R., Hoersch,S., Liu,H., Carr,S.A. and Hynes,R.O.
  TITLE     The matrisome: in silico definition and in vivo characterization by
            proteomics of normal and tumor extracellular matrices
  JOURNAL   Mol Cell Proteomics 11 (4), M111.014647 (2012)
   PUBMED   22159717
REFERENCE   6  (bases 1 to 1710)
  AUTHORS   Wu,J.K., Sheffield,W.P. and Blajchman,M.A.
  TITLE     Molecular cloning and cell-free expression of mouse antithrombin
            III
  JOURNAL   Thromb Haemost 68 (3), 291-296 (1992)
   PUBMED   1440494
REFERENCE   7  (bases 1 to 1710)
  AUTHORS   Serikawa,T., Montagutelli,X., Simon-Chazottes,D. and Guenet,J.L.
  TITLE     Polymorphisms revealed by PCR with single, short-sized, arbitrary
            primers are reliable markers for mouse and rat gene mapping
  JOURNAL   Mamm Genome 3 (2), 65-72 (1992)
   PUBMED   1617216
REFERENCE   8  (bases 1 to 1710)
  AUTHORS   Singh,G., Kaur,S., Stock,J.L., Jenkins,N.A., Gilbert,D.J.,
            Copeland,N.G. and Potter,S.S.
  TITLE     Identification of 10 murine homeobox genes
  JOURNAL   Proc Natl Acad Sci U S A 88 (23), 10706-10710 (1991)
   PUBMED   1683707
REFERENCE   9  (bases 1 to 1710)
  AUTHORS   Siracusa,L.D., Rosner,M.H., Vigano,M.A., Gilbert,D.J., Staudt,L.M.,
            Copeland,N.G. and Jenkins,N.A.
  TITLE     Chromosomal location of the octamer transcription factors, Otf-1,
            Otf-2, and Otf-3, defines multiple Otf-3-related sequences
            dispersed in the mouse genome
  JOURNAL   Genomics 10 (2), 313-326 (1991)
   PUBMED   1676977
REFERENCE   10 (bases 1 to 1710)
  AUTHORS   Allen,J.D., Lints,T., Jenkins,N.A., Copeland,N.G., Strasser,A.,
            Harvey,R.P. and Adams,J.M.
  TITLE     Novel murine homeo box gene on chromosome 1 expressed in specific
            hematopoietic lineages and during embryogenesis
  JOURNAL   Genes Dev 5 (4), 509-520 (1991)
   PUBMED   1672660
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC119204.7 and AC163327.2.
            
            On Mar 30, 2020 this sequence version replaced NM_080844.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC019447.1, SRR5189685.122319.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-133               AC119204.7         14956-15088         c
            134-276             AC119204.7         6088-6230           c
            277-646             AC119204.7         3923-4292           c
            647-862             AC119204.7         60-275              c
            863-1000            AC163327.2         77539-77676
            1001-1391           AC163327.2         79571-79961
            1392-1456           AC163327.2         82210-82274
            1457-1710           AC163327.2         84508-84761
FEATURES             Location/Qualifiers
     source          1..1710
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 69.75 cM"
     gene            1..1710
                     /gene="Serpinc1"
                     /gene_synonym="At-3; At3; ATIII"
                     /note="serine (or cysteine) peptidase inhibitor, clade C
                     (antithrombin), member 1"
                     /db_xref="GeneID:11905"
                     /db_xref="MGI:MGI:88095"
     exon            1..133
                     /gene="Serpinc1"
                     /gene_synonym="At-3; At3; ATIII"
                     /inference="alignment:Splign:2.1.0"
     exon            134..276
                     /gene="Serpinc1"
                     /gene_synonym="At-3; At3; ATIII"
                     /inference="alignment:Splign:2.1.0"
     CDS             236..1633
                     /gene="Serpinc1"
                     /gene_synonym="At-3; At3; ATIII"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; serpin peptidase inhibitor, clade C, member 1;
                     antithrombin-III; serpin C1; serine (or cysteine)
                     proteinase inhibitor, clade C (antithrombin), member 1;
                     anti-thrombin 3"
                     /codon_start=1
                     /product="antithrombin-III isoform 1 precursor"
                     /protein_id="NP_543120.1"
                     /db_xref="CCDS:CCDS15411.1"
                     /db_xref="GeneID:11905"
                     /db_xref="MGI:MGI:88095"
                     /translation="MYSPGAGSGAAGERKLCLLSLLLIGALGCAICHGNPVDDICIAK
                     PRDIPVNPLCIYRSPGKKATEEDGSEQKVPEATNRRVWELSKANSRFATNFYQHLADS
                     KNDNDNIFLSPLSISTAFAMTKLGACNDTLKQLMEVFKFDTISEKTSDQIHFFFAKLN
                     CRLYRKANKSSDLVSANRLFGDKSLTFNESYQDVSEVVYGAKLQPLDFKENPEQSRVT
                     INNWVANKTEGRIKDVIPQGAINELTALVLVNTIYFKGLWKSKFSPENTRKEPFYKVD
                     GQSCPVPMMYQEGKFKYRRVAEGTQVLELPFKGDDITMVLILPKPEKSLAKVEQELTP
                     ELLQEWLDELSETMLVVHMPRFRTEDGFSLKEQLQDMGLIDLFSPEKSQLPGIVAGGR
                     DDLYVSDAFHKAFLEVNEEGSEAAASTSVVITGRSLNPNRVTFKANRPFLVLIREVAL
                     NTIIFMGRVANPCVN"
     exon            277..646
                     /gene="Serpinc1"
                     /gene_synonym="At-3; At3; ATIII"
                     /inference="alignment:Splign:2.1.0"
     exon            647..862
                     /gene="Serpinc1"
                     /gene_synonym="At-3; At3; ATIII"
                     /inference="alignment:Splign:2.1.0"
     exon            863..1000
                     /gene="Serpinc1"
                     /gene_synonym="At-3; At3; ATIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1391
                     /gene="Serpinc1"
                     /gene_synonym="At-3; At3; ATIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1456
                     /gene="Serpinc1"
                     /gene_synonym="At-3; At3; ATIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1710
                     /gene="Serpinc1"
                     /gene_synonym="At-3; At3; ATIII"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1689..1694
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Serpinc1"
                     /gene_synonym="At-3; At3; ATIII"
                     /note="hexamer: AATAAA"
     polyA_site      1710
                     /gene="Serpinc1"
                     /gene_synonym="At-3; At3; ATIII"
                     /note="major polyA site"
ORIGIN      
        1 acacttgcgt aagactcgcc ataataggta attttagaaa tagatctgat ttgtatctga
       61 gacattttag tgaagtggtg agatataaga cataatcaga agacatatct acctgaagac
      121 tttaagggga gagctccctc ccccacctgg cctctggacc tctcagattt aggggaaaga
      181 accagttttc ggagtgatcg tctcagtcag caccatctct gtaggagcat cggccatgta
      241 ttcccctggg gcaggaagtg gggctgctgg tgagaggaag ctttgtctcc tctctctgct
      301 cctcatcggt gccttgggct gtgctatctg tcacggaaac cctgtggacg acatctgcat
      361 agcgaagccc cgagacatcc ccgtgaatcc cttgtgcatt taccgctccc ctgggaagaa
      421 ggccaccgag gaggatggct cagagcagaa ggttccagaa gccaccaacc ggcgggtctg
      481 ggaactgtcc aaggccaatt cgcgatttgc cactaacttc taccagcacc tggcagactc
      541 caagaatgac aacgacaaca ttttcctgtc acccttgagc atctccactg cttttgctat
      601 gaccaagctg ggtgcctgta acgacactct caagcagctg atggaggttt ttaaatttga
      661 taccatctcc gagaagacat ccgaccagat ccacttcttc tttgccaaac tgaactgccg
      721 actctatcga aaagccaaca agtcctctga cttggtatca gccaaccgcc tttttggaga
      781 caaatccctc accttcaacg agagctatca agatgttagt gaggttgtct atggagccaa
      841 gctccagccc ctggacttca aggagaatcc ggagcaatcc agagtgacca tcaacaactg
      901 ggtagctaat aagactgaag gccgcatcaa agatgtcatc ccacagggcg ccattaacga
      961 gctcactgcc ctggttctgg ttaacaccat ttacttcaag ggcctgtgga agtcaaagtt
     1021 cagccctgag aacacaagga aggaaccgtt ctataaggtc gatgggcagt catgcccagt
     1081 gcctatgatg taccaggaag gcaaattcaa ataccggcgc gtggcagagg gcacccaggt
     1141 gctagagctg cccttcaagg gggatgacat caccatggtg ctcatcctgc ccaagcctga
     1201 gaagagcctg gccaaggtgg agcaggagct caccccagag ctgctgcagg agtggctgga
     1261 tgagctgtca gagactatgc ttgtggtcca catgccccgc ttccgcaccg aggatggctt
     1321 cagtctgaag gagcagctgc aagacatggg cctcattgat ctcttcagcc ctgaaaagtc
     1381 ccaactccca gggatcgttg ctggaggcag ggacgacctc tatgtctccg acgcattcca
     1441 caaagcattt cttgaggtaa atgaggaagg cagtgaagca gcagcgagta cttctgtcgt
     1501 gattactggc cggtcactga accccaatag ggtgaccttc aaggccaaca ggcccttcct
     1561 ggttcttata agggaagttg cactgaacac tattatattc atggggagag tggctaatcc
     1621 ttgtgtgaac taaaatattc ttaatctttg caccttttcc tactttggtg tttgtgaata
     1681 gaagtaaaaa taaatacgac tgccacctca
//
