LOCUS       NM_001164524            1932 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus serine (or cysteine) peptidase inhibitor, clade B,
            member 9c (Serpinb9c), transcript variant 1, mRNA.
ACCESSION   NM_001164524
VERSION     NM_001164524.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1932)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1932)
  AUTHORS   Heit,C., Jackson,B.C., McAndrews,M., Wright,M.W., Thompson,D.C.,
            Silverman,G.A., Nebert,D.W. and Vasiliou,V.
  TITLE     Update of the human and mouse SERPIN gene superfamily
  JOURNAL   Hum Genomics 7 (1), 22 (2013)
   PUBMED   24172014
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1932)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
REFERENCE   4  (bases 1 to 1932)
  AUTHORS   Kaiserman,D., Knaggs,S., Scarff,K.L., Gillard,A., Mirza,G.,
            Cadman,M., McKeone,R., Denny,P., Cooley,J., Benarafa,C.,
            Remold-O'Donnell,E., Ragoussis,J. and Bird,P.I.
  TITLE     Comparison of human chromosome 6p25 with mouse chromosome 13
            reveals a greatly expanded ov-serpin gene repertoire in the mouse
  JOURNAL   Genomics 79 (3), 349-362 (2002)
   PUBMED   11863365
REFERENCE   5  (bases 1 to 1932)
  AUTHORS   Sun,J., Ooms,L., Bird,C.H., Sutton,V.R., Trapani,J.A. and Bird,P.I.
  TITLE     A new family of 10 murine ovalbumin serpins includes two homologs
            of proteinase inhibitor 8 and two homologs of the granzyme B
            inhibitor (proteinase inhibitor 9)
  JOURNAL   J Biol Chem 272 (24), 15434-15441 (1997)
   PUBMED   9182575
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN704519.1, AK014448.1 and BU757932.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK014448.1, AK017139.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                CN704519.1         1-73
            74-1913             AK014448.1         49-1888
            1914-1932           BU757932.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..1932
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 13.82 cM"
     gene            1..1932
                     /gene="Serpinb9c"
                     /gene_synonym="3830421J05Rik; Nk9; Spi11"
                     /note="serine (or cysteine) peptidase inhibitor, clade B,
                     member 9c"
                     /db_xref="GeneID:20707"
                     /db_xref="MGI:MGI:894669"
     exon            1..70
                     /gene="Serpinb9c"
                     /gene_synonym="3830421J05Rik; Nk9; Spi11"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..1211
                     /gene="Serpinb9c"
                     /gene_synonym="3830421J05Rik; Nk9; Spi11"
                     /note="isoform 1 is encoded by transcript variant 1;
                     serine (or cysteine) proteinase inhibitor, clade B, member
                     9c; ovalbumin; serine protease inhibitor 11"
                     /codon_start=1
                     /product="serine (or cysteine) proteinase inhibitor, clade
                     B, member 9c isoform 1"
                     /protein_id="NP_001157996.1"
                     /db_xref="CCDS:CCDS49226.1"
                     /db_xref="GeneID:20707"
                     /db_xref="MGI:MGI:894669"
                     /translation="MGGHKVGRPPFLNIVYEANGTFAVNLLRMLCNNNPSKNVCYSPI
                     NISSALAMFLLGVKGNTEIQISEAIGLNTAIDIHQSFLWILNILKKPTRKYTFRMANR
                     LFAENTCEFLPTFKEPCLQFYHWEMEHLPFTKAPEEARNHINTWVCKNTKGKIPELLS
                     SGSVDSETRLVLVNALYFKGRWHHQFDIKSTRKMPFKINKDEERPVQMMFQEDMFKLA
                     YVNEVQVQVLVLPYKGKELSLVVLLPDDGVELSKVEGNLTFEKLSAWTKPDYLKTTKV
                     LVFLPKFKLEDYYDMESIFQDLGVGDIFQGGKADLSEMSPERGLCVSKFIQKCVVEVN
                     EEGTEATAATADDTVCSAETHDGQTFCADHPFLFFIRHNKTNSILFCGRFSFP"
     exon            71..248
                     /gene="Serpinb9c"
                     /gene_synonym="3830421J05Rik; Nk9; Spi11"
                     /inference="alignment:Splign:2.1.0"
     exon            249..386
                     /gene="Serpinb9c"
                     /gene_synonym="3830421J05Rik; Nk9; Spi11"
                     /inference="alignment:Splign:2.1.0"
     exon            387..504
                     /gene="Serpinb9c"
                     /gene_synonym="3830421J05Rik; Nk9; Spi11"
                     /inference="alignment:Splign:2.1.0"
     exon            505..647
                     /gene="Serpinb9c"
                     /gene_synonym="3830421J05Rik; Nk9; Spi11"
                     /inference="alignment:Splign:2.1.0"
     exon            648..803
                     /gene="Serpinb9c"
                     /gene_synonym="3830421J05Rik; Nk9; Spi11"
                     /inference="alignment:Splign:2.1.0"
     exon            804..1914
                     /gene="Serpinb9c"
                     /gene_synonym="3830421J05Rik; Nk9; Spi11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1581..1586
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Serpinb9c"
                     /gene_synonym="3830421J05Rik; Nk9; Spi11"
                     /note="hexamer: AGTAAA"
     polyA_site      1604
                     /gene="Serpinb9c"
                     /gene_synonym="3830421J05Rik; Nk9; Spi11"
                     /note="major polyA site"
     regulatory      1891..1896
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Serpinb9c"
                     /gene_synonym="3830421J05Rik; Nk9; Spi11"
                     /note="hexamer: AATATA"
     polyA_site      1914
                     /gene="Serpinb9c"
                     /gene_synonym="3830421J05Rik; Nk9; Spi11"
                     /note="major polyA site"
ORIGIN      
        1 gggtaggcag ttaagctgca ctccagtagc atcaagactc gaatacaatg ggaggccaca
       61 aagttggaag accacccttc ctgaatattg tgtatgaagc aaatggcacc tttgccgtca
      121 atcttttaag gatgttatgt aataacaacc cttccaaaaa tgtatgctat tctcccatca
      181 acatctcctc tgctctagct atgttccttt tgggagtgaa aggaaacacc gaaatccaga
      241 tatctgaggc aattggctta aacacagcaa tagacattca tcagagcttc ctgtggattc
      301 tcaatatcct gaagaagcca accagaaagt acaccttcag aatggccaat aggctctttg
      361 cagagaacac ttgtgaattc ctcccaacat ttaaggagcc ctgtcttcag ttctatcact
      421 gggagatgga gcacctcccc ttcaccaagg ctccagagga ggccaggaat cacataaaca
      481 catgggtctg caaaaataca aaagggaaaa ttccagaatt gttgtcaagt ggctcggttg
      541 attcagagac caggcttgta cttgtcaatg ccttatattt caaaggaaga tggcatcacc
      601 agtttgacat aaagtccacc aggaaaatgc cctttaaaat aaacaaggat gaggaaagac
      661 cagtgcagat gatgtttcag gaagacatgt ttaagctcgc ctatgtgaat gaggtgcagg
      721 ttcaagtgct ggtgctgccc tataagggca aggagctgag cttggtggtc ctgctcccgg
      781 atgatggtgt ggaactcagc aaggtggaag gcaatctcac ttttgagaag ttatcagctt
      841 ggaccaaacc agactatttg aagaccacta aagttttggt tttccttcca aaatttaaac
      901 tggaagatta ttatgacatg gagtccatct ttcaggactt gggagtgggg gatattttcc
      961 aagggggcaa ggctgactta tcagaaatgt ctccagagag aggcctgtgt gtgtccaagt
     1021 tcattcaaaa gtgtgttgtg gaagttaatg aagaaggcac agaagctaca gcagccacag
     1081 ctgatgatac tgtatgttca gctgaaactc atgatggcca gactttctgt gctgaccacc
     1141 ctttcctttt ctttatcagg cacaacaaaa ccaacagcat cctgttctgt ggcaggttct
     1201 catttccata aagacacttt tactatgtga aggagagatc tctcttcagc atcttaatac
     1261 tcctatagct ctgtgagaat ggacaagtag gggcaaagca ccttccacaa taagggcact
     1321 ttcttgtttg gagcctggtc tattgacacc cacatttatc tgtccctacc ctgacactca
     1381 tctgtgccct ttggcaagcc agagttgctt ggtttcctgt tgtgtttaga atccaaagat
     1441 attctacgag atagcctaca aggttctcta aggtaatcct gaataaatgt cagactcact
     1501 gcacaaacta tgccaactat atacactgct ttcctggcat atgaatcttg ccatatcttg
     1561 ccttaccttg attacatcct agtaaatgct tccgtgaaca atgactgcta ctgaagtttt
     1621 cttgataact agtctctaat gtaaattttc catttatatt ctttgctgtt cactacccat
     1681 caggtatgtg cctaacactg tgtcaggctt gcaaacaggt agagacagta tgaacttcta
     1741 acaactgatc tttactatct cctttcaact tatccagctg ttatgaaaac tagtttggac
     1801 taccatgttc tccatgcttt tgttgagtat ttgatttctc taccatgaaa tgtaattgtt
     1861 aaattgtata gtcttcaaat ttcatttcaa aatatatttt gttttctcac tgtcaaaaaa
     1921 aaaaaaaaaa aa
//
