LOCUS       NM_011452               1959 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus serine (or cysteine) peptidase inhibitor, clade B,
            member 9b (Serpinb9b), mRNA.
ACCESSION   NM_011452
VERSION     NM_011452.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1959)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1959)
  AUTHORS   Spring,J., Khan,A.A., Lara,S., O'Grady,K., Wilks,J., Gurbuxani,S.,
            Erickson,S., Fischbach,M., Jacobson,A., Chervonsky,A. and
            Golovkina,T.
  TITLE     Gut commensal bacteria enhance pathogenesis of a tumorigenic murine
            retrovirus
  JOURNAL   Cell Rep 40 (11), 111341 (2022)
   PUBMED   36103821
REFERENCE   3  (bases 1 to 1959)
  AUTHORS   Heit,C., Jackson,B.C., McAndrews,M., Wright,M.W., Thompson,D.C.,
            Silverman,G.A., Nebert,D.W. and Vasiliou,V.
  TITLE     Update of the human and mouse SERPIN gene superfamily
  JOURNAL   Hum Genomics 7 (1), 22 (2013)
   PUBMED   24172014
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1959)
  AUTHORS   Abdallah,B.M., Ditzel,N., Mahmood,A., Isa,A., Traustadottir,G.A.,
            Schilling,A.F., Ruiz-Hidalgo,M.J., Laborda,J., Amling,M. and
            Kassem,M.
  TITLE     DLK1 is a novel regulator of bone mass that mediates estrogen
            deficiency-induced bone loss in mice
  JOURNAL   J Bone Miner Res 26 (7), 1457-1471 (2011)
   PUBMED   21308776
REFERENCE   5  (bases 1 to 1959)
  AUTHORS   Lee,M.P. and Yutzey,K.E.
  TITLE     Twist1 directly regulates genes that promote cell proliferation and
            migration in developing heart valves
  JOURNAL   PLoS One 6 (12), e29758 (2011)
   PUBMED   22242143
REFERENCE   6  (bases 1 to 1959)
  AUTHORS   Bots,M., Kolfschoten,I.G., Bres,S.A., Rademaker,M.T., de Roo,G.M.,
            Kruse,M., Franken,K.L., Hahne,M., Froelich,C.J., Melief,C.J.,
            Offringa,R. and Medema,J.P.
  TITLE     SPI-CI and SPI-6 cooperate in the protection from effector
            cell-mediated cytotoxicity
  JOURNAL   Blood 105 (3), 1153-1161 (2005)
   PUBMED   15454490
  REMARK    GeneRIF: evidence that colon carcinoma cell lines resist
            membranolysis dependent on SPI-6 but also requires expression of
            SPI-CI
REFERENCE   7  (bases 1 to 1959)
  AUTHORS   Kaiserman,D., Knaggs,S., Scarff,K.L., Gillard,A., Mirza,G.,
            Cadman,M., McKeone,R., Denny,P., Cooley,J., Benarafa,C.,
            Remold-O'Donnell,E., Ragoussis,J. and Bird,P.I.
  TITLE     Comparison of human chromosome 6p25 with mouse chromosome 13
            reveals a greatly expanded ov-serpin gene repertoire in the mouse
  JOURNAL   Genomics 79 (3), 349-362 (2002)
   PUBMED   11863365
REFERENCE   8  (bases 1 to 1959)
  AUTHORS   Sun,J., Ooms,L., Bird,C.H., Sutton,V.R., Trapani,J.A. and Bird,P.I.
  TITLE     A new family of 10 murine ovalbumin serpins includes two homologs
            of proteinase inhibitor 8 and two homologs of the granzyme B
            inhibitor (proteinase inhibitor 9)
  JOURNAL   J Biol Chem 272 (24), 15434-15441 (1997)
   PUBMED   9182575
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            U96705.2 and BG089710.1.
            
            On Feb 7, 2019 this sequence version replaced NM_011452.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U96705.2, AK005491.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1930              U96705.2           2-1931
            1931-1959           BG089710.1         13-41               c
FEATURES             Location/Qualifiers
     source          1..1959
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 13.79 cM"
     gene            1..1959
                     /gene="Serpinb9b"
                     /gene_synonym="1600019A21Rik; ovalbumin; R86; SPI-CI;
                     Spi10"
                     /note="serine (or cysteine) peptidase inhibitor, clade B,
                     member 9b"
                     /db_xref="GeneID:20706"
                     /db_xref="MGI:MGI:894668"
     exon            1..187
                     /gene="Serpinb9b"
                     /gene_synonym="1600019A21Rik; ovalbumin; R86; SPI-CI;
                     Spi10"
                     /inference="alignment:Splign:2.1.0"
     exon            188..365
                     /gene="Serpinb9b"
                     /gene_synonym="1600019A21Rik; ovalbumin; R86; SPI-CI;
                     Spi10"
                     /inference="alignment:Splign:2.1.0"
     CDS             198..1331
                     /gene="Serpinb9b"
                     /gene_synonym="1600019A21Rik; ovalbumin; R86; SPI-CI;
                     Spi10"
                     /note="serine proteinase inhibitor R86; serine protease
                     inhibitor 10"
                     /codon_start=1
                     /product="serine (or cysteine) proteinase inhibitor, clade
                     B, member 9b"
                     /protein_id="NP_035582.1"
                     /db_xref="CCDS:CCDS26432.1"
                     /db_xref="GeneID:20706"
                     /db_xref="MGI:MGI:894668"
                     /translation="MSTLSEANGTFAIHLLKMLCQSNPSKNVCFSPVSISSALAMVLL
                     GAKEQTAVQISQALGLKKEKGIHQGFLKLLRKLNKPDRKYSLIVANRLFADKTCEVLQ
                     TFKESCFRFYDSEMEQVNFFKAAVESRQCINTWVSKQTEGKIPELLADDSVNFQTRLV
                     LVNALYFKGMWACQFCKESTREMPFYINKDEKRPVQMMCQTDTFMFAFVDELPARLLI
                     MPYEGMELSLMVLLPEKGVDLSKVENDLTFEKLIAWTKPDIMWSTEVKVFLPKFKLQE
                     DYEMKSVLQCLGIVDVFEKEKADLSAMSPERNLCLSKFIHKSVVEVNEEGTEAAAASS
                     AEGIIPLCLGGGPSWFCADHPFLFFIRHNQTNSILFCGRFSSP"
     exon            366..503
                     /gene="Serpinb9b"
                     /gene_synonym="1600019A21Rik; ovalbumin; R86; SPI-CI;
                     Spi10"
                     /inference="alignment:Splign:2.1.0"
     exon            504..621
                     /gene="Serpinb9b"
                     /gene_synonym="1600019A21Rik; ovalbumin; R86; SPI-CI;
                     Spi10"
                     /inference="alignment:Splign:2.1.0"
     exon            622..764
                     /gene="Serpinb9b"
                     /gene_synonym="1600019A21Rik; ovalbumin; R86; SPI-CI;
                     Spi10"
                     /inference="alignment:Splign:2.1.0"
     exon            765..920
                     /gene="Serpinb9b"
                     /gene_synonym="1600019A21Rik; ovalbumin; R86; SPI-CI;
                     Spi10"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1959
                     /gene="Serpinb9b"
                     /gene_synonym="1600019A21Rik; ovalbumin; R86; SPI-CI;
                     Spi10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1930..1935
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Serpinb9b"
                     /gene_synonym="1600019A21Rik; ovalbumin; R86; SPI-CI;
                     Spi10"
                     /note="hexamer: AATAAA"
     polyA_site      1952
                     /gene="Serpinb9b"
                     /gene_synonym="1600019A21Rik; ovalbumin; R86; SPI-CI;
                     Spi10"
                     /note="major polyA site"
ORIGIN      
        1 agtcctcttc ttgcaaagga tagagctgga ggcagcctat ctctctgtag gtggccagag
       61 gcactaaaca ggaagtccct gccctgaagt gaatgaataa aaggctcagc tgaatctgga
      121 aggctgctgt gttaagctat aggggacatc caggctgaaa aagctacatt gagcagcagc
      181 tactcagact ctgcatcatg agtactctgt ctgaagcaaa tggcaccttt gccatccatc
      241 tattgaagat gttatgtcaa agcaaccctt ccaaaaatgt atgtttttct cctgtgagca
      301 tctcctctgc tctagctatg gtcctcctgg gtgcaaagga gcagaccgca gtccagatat
      361 ctcaggcact tggtttgaag aaagagaaag gcatccatca gggattcctg aagcttctca
      421 ggaagctgaa caagccagac agaaaatact cccttatagt ggccaacagg ctctttgcag
      481 acaaaacttg tgaagtcctc caaaccttta aggagtcctg ttttcgcttc tatgattcag
      541 agatggagca ggtcaacttt ttcaaagctg cagtggagtc caggcaatgc ataaacacgt
      601 gggtctccaa acagactgaa ggcaaaatcc cagagttgtt ggcagatgac tcagttaatt
      661 tccagaccag gctggttctc gtcaatgcct tatatttcaa agggatgtgg gcttgccagt
      721 tttgcaaaga atccaccagg gaaatgccat tttacataaa caaggatgag aaaaggccag
      781 tgcagatgat gtgtcagaca gacacattta tgtttgcctt tgtggatgag ttgccagcta
      841 gattgctgat aatgccctat gaaggcatgg agctgagctt gatggtcctg ctcccagaga
      901 agggtgtgga cctcagcaag gtggaaaatg atctcacttt tgaaaagtta atagcctgga
      961 ccaaaccaga cattatgtgg tccactgagg ttaaggtttt ccttccaaaa tttaaactgc
     1021 aagaggatta tgagatgaaa tctgtgcttc agtgcttggg aattgtggat gtcttcgaaa
     1081 aagaaaaggc tgacttatca gcaatgtctc cagagagaaa cctatgtctg tccaagttta
     1141 ttcacaagag tgtagtggag gtcaatgagg aaggcacaga ggctgcagca gcatcctccg
     1201 ctgagggcat cattcctctc tgcttaggtg gtggcccatc atggttctgt gcggaccacc
     1261 ccttcctttt cttcatcagg cacaaccaaa ccaacagcat cctgttctgt ggcaggttct
     1321 catctccata aaggcacatt actatgtggg gtgagttcac actccagcat ctccaccact
     1381 cctacagctc cgtgagaatg ggcaaacaga gggaatccat gttctaagat gaaggcactt
     1441 tctccctgtc agcctgatct tatgatgcct gctttcacct ttccctgtcc tgaatgcacc
     1501 tgtgccctct gcacagttat gtctaaccat gccatatacc ctctgctatg ccactgatac
     1561 ccataactta aagtcaatta tgtagaacca gttagaagtg atttcaccgt acaagtcttg
     1621 ttactcttgc agaggaccaa ggaatatttc ccaccactca cctgactgct cacaagccct
     1681 gaaattctag tttcccatct attacttgat tttttatttt attttatttt tttttgcttc
     1741 tactggctct tgtatgcata tgtgcactta tccagactga ggattttaca aagcagtaaa
     1801 tttaaattta caaacaagta aattttaaaa atataaagga aattttaaga gtgctatggg
     1861 ttttactaat ggttgaataa ttttgactat gtgatttttt tggatttaat gcaacttatc
     1921 ttgtaacaaa ataaaaaatt tatgtgtagg tatcagtga
//
