LOCUS       NM_011459               3075 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus serine (or cysteine) peptidase inhibitor, clade B,
            member 8 (Serpinb8), transcript variant 1, mRNA.
ACCESSION   NM_011459
VERSION     NM_011459.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3075)
  AUTHORS   Heit,C., Jackson,B.C., McAndrews,M., Wright,M.W., Thompson,D.C.,
            Silverman,G.A., Nebert,D.W. and Vasiliou,V.
  TITLE     Update of the human and mouse SERPIN gene superfamily
  JOURNAL   Hum Genomics 7 (1), 22 (2013)
   PUBMED   24172014
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3075)
  AUTHORS   Askew,D.J., Askew,Y.S., Kato,Y., Turner,R.F., Dewar,K., Lehoczky,J.
            and Silverman,G.A.
  TITLE     Comparative genomic analysis of the clade B serpin cluster at human
            chromosome 18q21: amplification within the mouse squamous cell
            carcinoma antigen gene locus
  JOURNAL   Genomics 84 (1), 176-184 (2004)
   PUBMED   15203215
REFERENCE   3  (bases 1 to 3075)
  AUTHORS   Kaiserman,D., Knaggs,S., Scarff,K.L., Gillard,A., Mirza,G.,
            Cadman,M., McKeone,R., Denny,P., Cooley,J., Benarafa,C.,
            Remold-O'Donnell,E., Ragoussis,J. and Bird,P.I.
  TITLE     Comparison of human chromosome 6p25 with mouse chromosome 13
            reveals a greatly expanded ov-serpin gene repertoire in the mouse
  JOURNAL   Genomics 79 (3), 349-362 (2002)
   PUBMED   11863365
REFERENCE   4  (bases 1 to 3075)
  AUTHORS   Sun,J., Ooms,L., Bird,C.H., Sutton,V.R., Trapani,J.A. and Bird,P.I.
  TITLE     A new family of 10 murine ovalbumin serpins includes two homologs
            of proteinase inhibitor 8 and two homologs of the granzyme B
            inhibitor (proteinase inhibitor 9)
  JOURNAL   J Biol Chem 272 (24), 15434-15441 (1997)
   PUBMED   9182575
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK032659.1, AK036811.1 and AC015658.11.
            
            On May 1, 2009 this sequence version replaced NM_011459.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK148413.1, AK032659.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                AK032659.1         2-66
            66-2529             AK036811.1         2-2465
            2530-3075           AC015658.11        121259-121804
FEATURES             Location/Qualifiers
     source          1..3075
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 50.34 cM"
     gene            1..3075
                     /gene="Serpinb8"
                     /gene_synonym="CAP-2; CAP2; NK10; ovalbumin; Spi8"
                     /note="serine (or cysteine) peptidase inhibitor, clade B,
                     member 8"
                     /db_xref="GeneID:20725"
                     /db_xref="MGI:MGI:894657"
     exon            1..282
                     /gene="Serpinb8"
                     /gene_synonym="CAP-2; CAP2; NK10; ovalbumin; Spi8"
                     /inference="alignment:Splign:2.1.0"
     exon            283..465
                     /gene="Serpinb8"
                     /gene_synonym="CAP-2; CAP2; NK10; ovalbumin; Spi8"
                     /inference="alignment:Splign:2.1.0"
     CDS             298..1422
                     /gene="Serpinb8"
                     /gene_synonym="CAP-2; CAP2; NK10; ovalbumin; Spi8"
                     /note="isoform 1 is encoded by transcript variant 1;
                     serine (or cysteine) proteinase inhibitor, clade B, member
                     8; serpin B8; serine protease inhibitor 8; serine (or
                     cysteine) peptdiase inhibitor, clade B, member 8"
                     /codon_start=1
                     /product="serpin B8 isoform 1"
                     /protein_id="NP_035589.1"
                     /db_xref="CCDS:CCDS15220.1"
                     /db_xref="GeneID:20725"
                     /db_xref="MGI:MGI:894657"
                     /translation="MDDLSEANGSFAISLLKILSEKDKSRNLFFCPMSVSSALAMVYL
                     GAKGNTATQMSEVLGLSGNGDVHQSFQTLLAEINKTDTQYLLKSACRLFGEESCDFLS
                     TFKESCHKFYQAGLEELSFAKDTEGCRKHINDWVSEKTEGKISEVLSPGTVCPLTKLV
                     LVNAMYFKGKWKAQFDRKYTRGMPFKTNQEKKTVQMMFKHAKFKMGHVDEVNMQVLAL
                     PYAEEELSMVILLPDESTDLAVVEKALTYEKLRAWTNPETLTESQVQVFLPRLKLEES
                     YDLETVLQNLGMTDAFEETRADFSGMTTKKNVPVSKVAHKCFVEVNEEGTEAAAATAV
                     IRNARCCRTEPRFCADHPFLFFIWHHKTSSILFCGRFSSP"
     exon            466..603
                     /gene="Serpinb8"
                     /gene_synonym="CAP-2; CAP2; NK10; ovalbumin; Spi8"
                     /inference="alignment:Splign:2.1.0"
     exon            604..721
                     /gene="Serpinb8"
                     /gene_synonym="CAP-2; CAP2; NK10; ovalbumin; Spi8"
                     /inference="alignment:Splign:2.1.0"
     exon            722..864
                     /gene="Serpinb8"
                     /gene_synonym="CAP-2; CAP2; NK10; ovalbumin; Spi8"
                     /inference="alignment:Splign:2.1.0"
     exon            865..1017
                     /gene="Serpinb8"
                     /gene_synonym="CAP-2; CAP2; NK10; ovalbumin; Spi8"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..3075
                     /gene="Serpinb8"
                     /gene_synonym="CAP-2; CAP2; NK10; ovalbumin; Spi8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1689..1694
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Serpinb8"
                     /gene_synonym="CAP-2; CAP2; NK10; ovalbumin; Spi8"
                     /note="hexamer: ATTAAA"
     polyA_site      1710
                     /gene="Serpinb8"
                     /gene_synonym="CAP-2; CAP2; NK10; ovalbumin; Spi8"
                     /note="major polyA site"
     regulatory      2991..2996
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Serpinb8"
                     /gene_synonym="CAP-2; CAP2; NK10; ovalbumin; Spi8"
                     /note="hexamer: ATTAAA"
     polyA_site      3012
                     /gene="Serpinb8"
                     /gene_synonym="CAP-2; CAP2; NK10; ovalbumin; Spi8"
ORIGIN      
        1 gtgcattatg ttctgagtca cccgacaggc gccttgcccc gatcaggagg atcaggacag
       61 actttaagta tccacaaagc aagaatagca gcaggatcag ccacagcagc aggtatcttc
      121 aaggtgaagc tgtgggagag gctctcaaac ctctcagacc ccgggggcct aggatagata
      181 ctggcactga agaacctgga cagaagccaa gaaggagaaa ggccaggatc tcaccaaagt
      241 taaagagccc aggagttagc agaggactcc agtgacagag agtctagacc ctctcaaatg
      301 gatgacctca gtgaagccaa tgggtctttt gccatcagtc tattaaaaat actgagtgaa
      361 aaagacaagt cacgaaacct gttcttctgc cccatgagtg tctcctcagc cctggccatg
      421 gtctaccttg gagccaaagg aaacactgct acccagatgt ctgaggtact tggtttgagt
      481 ggaaatggag atgttcatca aagtttccag acacttctcg ctgaaattaa caaaactgac
      541 actcagtact tgttaaaaag tgcctgccga ctctttggag aagaatcgtg tgatttcctt
      601 tcgaccttca aggaatcctg ccacaaattc tatcaggctg gactagaaga gctgtccttt
      661 gctaaagaca cagaagggtg caggaaacac atcaatgact gggtgtcgga aaaaactgaa
      721 ggtaaaattt ctgaagttct gagtcctgga acagtctgcc cactgactaa gctggttctt
      781 gtgaatgcca tgtatttcaa agggaagtgg aaggctcagt ttgaccgaaa gtacacgaga
      841 ggcatgccct ttaaaactaa tcaggagaaa aaaacagtgc agatgatgtt caagcatgct
      901 aaatttaaga tggggcatgt ggacgaggtg aacatgcagg ttctggctct gccctatgcc
      961 gaggaagagc tgagcatggt cattctcctt cctgatgaaa gcactgatct cgccgtggtg
     1021 gaaaaagcac ttacatatga gaagcttaga gcctggacaa acccagaaac cctgacagaa
     1081 agtcaagtgc aagtcttttt acccagatta aagctggagg agagttacga cctggaaact
     1141 gtacttcaga atttgggaat gacagatgcc tttgaggaaa caagggctga cttctctggc
     1201 atgacaacta agaagaatgt gcccgtgtcc aaggttgccc acaagtgctt tgtggaggtc
     1261 aatgaggaag gcaccgaagc agctgcggcc actgcagtga ttaggaacgc ccggtgctgt
     1321 agaacagaac caaggttctg tgctgaccac ccattccttt tctttatctg gcaccacaaa
     1381 accagtagca tcttgttctg tggcaggttc tcttctccat aagggtcttc tggggcttag
     1441 aattggtgaa gtgtttgcat ttgcataaca agcacaagac cgtgggcaca gccctaagaa
     1501 ccctataaaa atagacatga tggtgccaac ctgccgatcc aagcatttgg gaggtgcagg
     1561 ctaggtaggt cacacattca agatcatcca aaatgataca ggggactctg cctcaaacaa
     1621 cagcaacaac caaagtcaag aaaggtgaat gtgattgatt tatataccat tctttgctga
     1681 atgacataat taaaattcca tgctaccaaa tttgccaagg tgatttcaat gtaaaagtaa
     1741 agagagtatg cttagtagtt ggtgactatt gttgctgact gtcccaatgc ggtgtatggc
     1801 tgtatggcag ttttgagctg acaagaaggc catacttgat ttgggatgtc tgaggtgaat
     1861 ctcttcacca gcgatactaa caacccagac cctaaagtgc tgctacgccc tgttaacatc
     1921 tctaagctgt gcacccccac cactgacaga cttaccaggg aatgccagtg gaggtccccc
     1981 attcacaaag ctaagggtaa gagttacaga ataactgccg tgtgattccc gaggagctga
     2041 gagagtatct ccttccatca gtgctaccca gtactcctgt aggagtcagg gttcaggcaa
     2101 ctctttccat aaagttcaag tgcaagttca aggactcagt gagaaccttc aggatggagc
     2161 tgagagataa ggctctgaag tgtttcctca tccccccccc ccaacttctt tctaaagctc
     2221 caagtgtttt tcttatctcc tcctactctt tctaatggaa acatcacatg gaatgattct
     2281 tacaaaccat aattaaccac atgctcagac atgattcaaa tgtactccca atgccctaaa
     2341 tgcatatgca tgccagcatt gtacatagac tcagtgggtt gtatttatac gtctctctgt
     2401 gtgtgtttgt gtgtatgtgt gtgtgtgtgc ctctgtgtgt gtgtgtgcct gtgtgtgtgt
     2461 gcctctgtgt gtgtgtgtgt gcgccgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg
     2521 tgtgtgtgtg taaaacaaag aagtcatgaa tatgagaggg agttacaggg ccacaggagg
     2581 ggacaggtga ggagtgaggg atgggaatat aaatagacta cttatatatg aagttctaaa
     2641 ataaattaaa aattaaataa aaaagactga attatatttt ctgactgcat atcatttgta
     2701 ttatggtaga aagtggaaaa ttataggaaa acattcaaag aaaatttaag ctttttgaaa
     2761 gtccccttct cagaaatcac cactaatgtg aacatgtatt atctctgtta taggtataca
     2821 aatatacatt catactattt tgccacagga taatgatcat ttttgtagct tatttttact
     2881 gtaagtcttg ctcacaacaa ttatcattca gtggcaacat cttgctgtgc attgaatttc
     2941 aggatggggc aaagttttct gtaattgaac ctactttgac aatttggaaa attaaaaatg
     3001 tattgcagac tactgtgctg aatatcttca atagtttatt acactcttaa tttctcaata
     3061 aatattactg aaatg
//
