LOCUS       NM_027548               1888 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus serine (or cysteine) peptidase inhibitor, clade B,
            member 7 (Serpinb7), mRNA.
ACCESSION   NM_027548
VERSION     NM_027548.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1888)
  AUTHORS   Wang,Z., Zheng,H., Zhou,H., Huang,N., Wei,X., Liu,X., Teng,X.,
            Hu,Z., Zhang,J., Zhou,X., Li,W. and Li,J.
  TITLE     Systematic screening and identification of novel psoriasis-specific
            genes from the transcriptome of psoriasis-like keratinocytes
  JOURNAL   Mol Med Rep 19 (3), 1529-1542 (2019)
   PUBMED   30592269
  REMARK    GeneRIF: in systemic inflammatory response syndrome (SIRS),
            SERPINB7 showed no difference in expression in immuneactivated
            tissues from systemic inflammatory response syndrome and control
            mice.
REFERENCE   2  (bases 1 to 1888)
  AUTHORS   Heit,C., Jackson,B.C., McAndrews,M., Wright,M.W., Thompson,D.C.,
            Silverman,G.A., Nebert,D.W. and Vasiliou,V.
  TITLE     Update of the human and mouse SERPIN gene superfamily
  JOURNAL   Hum Genomics 7 (1), 22 (2013)
   PUBMED   24172014
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1888)
  AUTHORS   Liu,M., Zhang,Y., Chi,Y., Zhai,S., Wang,B., Shi,Y. and Li,Y.
  TITLE     Delivery of megsin siRNA plasmid reveals therapeutic potential
            against diabetic nephropathy by down-regulating p27(kip1) level
  JOURNAL   J Nephrol 25 (3), 418-425 (2012)
   PUBMED   21928229
  REMARK    GeneRIF: Suggest that the down-regulation of megsin might exert
            beneficial effects on the diabetic kidney partly through
            down-regulation of p27(kip1).
REFERENCE   4  (bases 1 to 1888)
  AUTHORS   Inagi,R., Yamamoto,Y., Nangaku,M., Usuda,N., Okamato,H.,
            Kurokawa,K., van Ypersele de Strihou,C., Yamamoto,H. and Miyata,T.
  TITLE     A severe diabetic nephropathy model with early development of
            nodule-like lesions induced by megsin overexpression in RAGE/iNOS
            transgenic mice
  JOURNAL   Diabetes 55 (2), 356-366 (2006)
   PUBMED   16443768
  REMARK    GeneRIF: diabetic nephropathy model in triple transgenic mice
            overexpressing RAGE, iNOS & megsin; triple-hit damage develops
            severe diabetic nephropathy at early age with mesangial expansion,
            nodule-like lesion & tubulointerstitial damage with oxidative
            stress
REFERENCE   5  (bases 1 to 1888)
  AUTHORS   Askew,D.J., Askew,Y.S., Kato,Y., Turner,R.F., Dewar,K., Lehoczky,J.
            and Silverman,G.A.
  TITLE     Comparative genomic analysis of the clade B serpin cluster at human
            chromosome 18q21: amplification within the mouse squamous cell
            carcinoma antigen gene locus
  JOURNAL   Genomics 84 (1), 176-184 (2004)
   PUBMED   15203215
REFERENCE   6  (bases 1 to 1888)
  AUTHORS   Miyata,T., Inagi,R., Nangaku,M., Imasawa,T., Sato,M., Izuhara,Y.,
            Suzuki,D., Yoshino,A., Onogi,H., Kimura,M., Sugiyama,S. and
            Kurokawa,K.
  TITLE     Overexpression of the serpin megsin induces progressive mesangial
            cell proliferation and expansion
  JOURNAL   J Clin Invest 109 (5), 585-593 (2002)
   PUBMED   11877466
REFERENCE   7  (bases 1 to 1888)
  AUTHORS   Kaiserman,D., Knaggs,S., Scarff,K.L., Gillard,A., Mirza,G.,
            Cadman,M., McKeone,R., Denny,P., Cooley,J., Benarafa,C.,
            Remold-O'Donnell,E., Ragoussis,J. and Bird,P.I.
  TITLE     Comparison of human chromosome 6p25 with mouse chromosome 13
            reveals a greatly expanded ov-serpin gene repertoire in the mouse
  JOURNAL   Genomics 79 (3), 349-362 (2002)
   PUBMED   11863365
REFERENCE   8  (bases 1 to 1888)
  AUTHORS   Nangaku,M., Miyata,T., Suzuki,D., Umezono,T., Hashimoto,T.,
            Wada,T., Yagi,M., Nagano,N., Inagi,R. and Kurokawa,K.
  TITLE     Cloning of rodent megsin revealed its up-regulation in
            mesangioproliferative nephritis
  JOURNAL   Kidney Int 60 (2), 641-652 (2001)
   PUBMED   11473647
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC129295.4 and AC148982.4.
            
            On Oct 12, 2022 this sequence version replaced NM_027548.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC064004.1, AK014524.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                AC129295.4         118302-118346
            46-231              AC148982.4         141035-141220       c
            232-282             AC148982.4         134665-134715       c
            283-399             AC148982.4         134008-134124       c
            400-517             AC148982.4         123342-123459       c
            518-660             AC148982.4         121201-121343       c
            661-807             AC148982.4         119129-119275       c
            808-1888            AC148982.4         116762-117842       c
FEATURES             Location/Qualifiers
     source          1..1888
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 50.34 cM"
     gene            1..1888
                     /gene="Serpinb7"
                     /gene_synonym="4631416M05Rik; megsin; ovalbumin"
                     /note="serine (or cysteine) peptidase inhibitor, clade B,
                     member 7"
                     /db_xref="GeneID:116872"
                     /db_xref="MGI:MGI:2151053"
     exon            1..45
                     /gene="Serpinb7"
                     /gene_synonym="4631416M05Rik; megsin; ovalbumin"
                     /inference="alignment:Splign:2.1.0"
     exon            46..231
                     /gene="Serpinb7"
                     /gene_synonym="4631416M05Rik; megsin; ovalbumin"
                     /inference="alignment:Splign:2.1.0"
     exon            232..282
                     /gene="Serpinb7"
                     /gene_synonym="4631416M05Rik; megsin; ovalbumin"
                     /inference="alignment:Splign:2.1.0"
     exon            283..399
                     /gene="Serpinb7"
                     /gene_synonym="4631416M05Rik; megsin; ovalbumin"
                     /inference="alignment:Splign:2.1.0"
     exon            400..517
                     /gene="Serpinb7"
                     /gene_synonym="4631416M05Rik; megsin; ovalbumin"
                     /inference="alignment:Splign:2.1.0"
     exon            518..660
                     /gene="Serpinb7"
                     /gene_synonym="4631416M05Rik; megsin; ovalbumin"
                     /inference="alignment:Splign:2.1.0"
     exon            661..807
                     /gene="Serpinb7"
                     /gene_synonym="4631416M05Rik; megsin; ovalbumin"
                     /inference="alignment:Splign:2.1.0"
     exon            808..1888
                     /gene="Serpinb7"
                     /gene_synonym="4631416M05Rik; megsin; ovalbumin"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1277..1282
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Serpinb7"
                     /gene_synonym="4631416M05Rik; megsin; ovalbumin"
                     /note="hexamer: AATACA"
     polyA_site      1296
                     /gene="Serpinb7"
                     /gene_synonym="4631416M05Rik; megsin; ovalbumin"
                     /note="major polyA site"
     regulatory      1866..1871
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Serpinb7"
                     /gene_synonym="4631416M05Rik; megsin; ovalbumin"
                     /note="hexamer: AATAAA"
     polyA_site      1888
                     /gene="Serpinb7"
                     /gene_synonym="4631416M05Rik; megsin; ovalbumin"
                     /note="major polyA site"
ORIGIN      
        1 cagactcacc caaccagctg caacttcctc tatgaagaga gtaaggcaat acttggtttc
       61 aaaatggcct cccttgctgc agcaaatgca gaatttggct tcgacttatt cagagagatg
      121 gatagtagcc aaggaaatgg aaatgtattc ttctcttccc tgagcatctt cactgccctg
      181 accctaatcc gtctgggtgc tcgaggtgac tgtgcacgtc agattgacaa ggcactgcac
      241 tttaacatac catcaagaca aggaaactca tctaataatc agccaggact tcagtatcaa
      301 ttgaaaagag ttcttgctga cataaactca tctcataagg attatgaact cagcattgcc
      361 actggagttt ttgcagaaaa agtctatgac tttcataaga actacattga gtgtgctgaa
      421 aacttataca atgctaaagt ggaaagagtt gacttcacaa atgatgtaca agataccaga
      481 tttaaaatta ataaatggat tgaaaatgag acacatggaa agatcaagaa ggtgttgggc
      541 gacagcagcc tcagctcgtc ggctgtcatg gtgctggtga acgctgttta cttcaaaggc
      601 aaatggaaat cggccttcac caagactgat accctcagtt gccgttttag gtctcccacg
      661 tgtcctggaa aagtagttaa tatgatgcat caagaacggc ggttcaattt gtctaccatt
      721 cagcagccac caatgcaggt tcttgagctc caatatcatg gtggcataag catgtacatt
      781 atgctgcctg aggatggcct atgtgaaatt gaaagcaagc tgagtttcca gaatctgatg
      841 gactggacca ataggaggaa aatgaaatct cagtatgtga acgtgtttct cccccagttc
      901 aagatagaga agaattatga aatgacgcac cacttgaaat ccttaggctt gaaagatatc
      961 tttgatgagt ccagtgcaga tctctctgga attgcctctg gaggtcgtct ctacgtatca
     1021 aagctaatgc acaagtcatt catagaggtc tcagaggagg gcactgaagc cactgctgcc
     1081 acagaaaata acattgttga aaagcagctt cctgagtcca cagtgttcag agccgaccgc
     1141 ccctttctgt ttgtcatcaa gaagaatgac atcatcttat ttactggcaa agtctcttgt
     1201 ccttgaaatt cgatttggtt tcctatacag taacaggcat caagaagcat cataagtgaa
     1261 tagaattgta attggaaata catgggtttg ctttgatttg tttcagtgca ttgatggtca
     1321 gcaaatgata ctggtgactt aactcttttc gatacctggt tgatagtcta aatgcctgct
     1381 ctcatcattt ctactccatt tacttccctt tgtctaatac tattgaccca tctggggttt
     1441 gatccactca caaagagaat gcaggggctg cctgtagaaa cttttacatt taaattcctg
     1501 agttttcaga gacattcctg attcatgata caacaatcta aaaagtaagc ccatttgttt
     1561 ctcagaaacc agaatgaagg ctaactcatt cttgagaaac aagatgatgc tagtatttcc
     1621 ttcagtatgc ttgacttcac aatcactgta aaaatcaggg actcaaaaat acagaattaa
     1681 gattggtaag caaccaaagt atttcattaa taacttcaaa tttatagcct ttggcattcc
     1741 tgggtaagac ctaatatgta cataattttc aaatattaag tattttttaa atgttggcag
     1801 ttgttatttg cagaatatta tttcgtattc ttttgagatc ctgagtattt tctcatgttt
     1861 ctcataataa agatgtataa cacctgca
//
