LOCUS       NM_011454               2141 bp    mRNA    linear   ROD 16-OCT-2021
DEFINITION  Mus musculus serine (or cysteine) peptidase inhibitor, clade B,
            member 6b (Serpinb6b), mRNA.
ACCESSION   NM_011454
VERSION     NM_011454.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2141)
  AUTHORS   Yu HF, Zheng LW, Yang ZQ, Wang YS, Huang JC, Liu S, Yue ZP and Guo
            B.
  TITLE     Bmp2 regulates Serpinb6b expression via cAMP/PKA/Wnt4 pathway
            during uterine decidualization
  JOURNAL   J Cell Mol Med 24 (12), 7023-7033 (2020)
   PUBMED   32391984
  REMARK    GeneRIF: Bmp2 regulates Serpinb6b expression via cAMP/PKA/Wnt4
            pathway during uterine decidualization.
REFERENCE   2  (bases 1 to 2141)
  AUTHORS   Kaiserman D, Stewart SE, Plasman K, Gevaert K, Van Damme P and Bird
            PI.
  TITLE     Identification of Serpinb6b as a species-specific mouse granzyme A
            inhibitor suggests functional divergence between human and mouse
            granzyme A
  JOURNAL   J Biol Chem 289 (13), 9408-9417 (2014)
   PUBMED   24505135
REFERENCE   3  (bases 1 to 2141)
  AUTHORS   Heit C, Jackson BC, McAndrews M, Wright MW, Thompson DC, Silverman
            GA, Nebert DW and Vasiliou V.
  TITLE     Update of the human and mouse SERPIN gene superfamily
  JOURNAL   Hum Genomics 7, 22 (2013)
   PUBMED   24172014
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2141)
  AUTHORS   Klattig J, Sierig R, Kruspe D, Makki MS and Englert C.
  TITLE     WT1-mediated gene regulation in early urogenital ridge development
  JOURNAL   Sex Dev 1 (4), 238-254 (2007)
   PUBMED   18391535
REFERENCE   5  (bases 1 to 2141)
  AUTHORS   Charron Y, Madani R, Nef S, Combepine C, Govin J, Khochbin S and
            Vassalli JD.
  TITLE     Expression of serpinb6 serpins in germ and somatic cells of mouse
            gonads
  JOURNAL   Mol Reprod Dev 73 (1), 9-19 (2006)
   PUBMED   16175637
REFERENCE   6  (bases 1 to 2141)
  AUTHORS   Rutitzky LI, Hernandez HJ, Yim YS, Ricklan DE, Finger E, Mohan C,
            Peter I, Wakeland EK and Stadecker MJ.
  TITLE     Enhanced egg-induced immunopathology correlates with high IFN-gamma
            in murine schistosomiasis: identification of two epistatic genetic
            intervals
  JOURNAL   J Immunol 174 (1), 435-440 (2005)
   PUBMED   15611268
REFERENCE   7  (bases 1 to 2141)
  AUTHORS   Kaiserman D, Knaggs S, Scarff KL, Gillard A, Mirza G, Cadman M,
            McKeone R, Denny P, Cooley J, Benarafa C, Remold-O'Donnell E,
            Ragoussis J and Bird PI.
  TITLE     Comparison of human chromosome 6p25 with mouse chromosome 13
            reveals a greatly expanded ov-serpin gene repertoire in the mouse
  JOURNAL   Genomics 79 (3), 349-362 (2002)
   PUBMED   11863365
REFERENCE   8  (bases 1 to 2141)
  AUTHORS   Sun J, Ooms L, Bird CH, Sutton VR, Trapani JA and Bird PI.
  TITLE     A new family of 10 murine ovalbumin serpins includes two homologs
            of proteinase inhibitor 8 and two homologs of the granzyme B
            inhibitor (proteinase inhibitor 9)
  JOURNAL   J Biol Chem 272 (24), 15434-15441 (1997)
   PUBMED   9182575
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DV058071.1, U96707.2, BB065179.2 and AI448094.1.
            
            On Feb 7, 2019 this sequence version replaced NM_011454.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.3005990.1,
                                           SRR5189679.77395.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-835               DV058071.1         44-878
            836-2111            U96707.2           584-1859
            2112-2136           BB065179.2         640-664
            2137-2141           AI448094.1         26-30               c
FEATURES             Location/Qualifiers
     source          1..2141
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 13.78 cM"
     gene            1..2141
                     /gene="Serpinb6b"
                     /gene_synonym="NK13; ovalbumin; Spi12"
                     /note="serine (or cysteine) peptidase inhibitor, clade B,
                     member 6b"
                     /db_xref="GeneID:20708"
                     /db_xref="MGI:MGI:894688"
     exon            1..283
                     /gene="Serpinb6b"
                     /gene_synonym="NK13; ovalbumin; Spi12"
                     /inference="alignment:Splign:2.1.0"
     exon            284..458
                     /gene="Serpinb6b"
                     /gene_synonym="NK13; ovalbumin; Spi12"
                     /inference="alignment:Splign:2.1.0"
     exon            459..611
                     /gene="Serpinb6b"
                     /gene_synonym="NK13; ovalbumin; Spi12"
                     /inference="alignment:Splign:2.1.0"
     exon            612..729
                     /gene="Serpinb6b"
                     /gene_synonym="NK13; ovalbumin; Spi12"
                     /inference="alignment:Splign:2.1.0"
     exon            730..872
                     /gene="Serpinb6b"
                     /gene_synonym="NK13; ovalbumin; Spi12"
                     /inference="alignment:Splign:2.1.0"
     exon            873..1028
                     /gene="Serpinb6b"
                     /gene_synonym="NK13; ovalbumin; Spi12"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..2141
                     /gene="Serpinb6b"
                     /gene_synonym="NK13; ovalbumin; Spi12"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcatagca aacaaacagt gctagcgagg attcctgatt taactagacc agtctgcagc
       61 tagctgctga acccgactgc aggcaatggt caaagtgcag cgatcctgct tttccgtttc
      121 ttttcctttt cacccggaca gcccacagcc cctctgacac ctcccctggg acttcctgac
      181 tctgggacct ccccacgctg cgccctgcag ctatttgagg ccagagcaca ggctcttcct
      241 tctctagatt ctgcttgctg acagcctgaa cctggggttc caggcttacc atcatggatc
      301 cactgctgga agcaaatgcc acttttgcct taaacctttt gaaaacactg ggtgaagaca
      361 gctccagaaa tgtacttttc tcacctataa gcgtctcctc agccctggcc atggtcttca
      421 tgggggcaaa aggaactact gcaagccaga tggctcaggc actgtctttg gataaatgca
      481 gtggcaaagg aggtagagat gtccaccagg gattccaatc acttctcaca gaaacgaaca
      541 agactggcac acagtatgtg ctcagaacag ccaacaggct cttcggggaa aagactttcg
      601 atatcctagc ttcttttaaa gattcctgcc gcaagttcta tgaagcagag atggaagagc
      661 tggactttaa gggtgctaca gagcagtccc gacagcacat caacgcctgg gtagccaaaa
      721 agacagaaga taaaattaca gagttgctat cttcgggttc agtaaattca aacactccac
      781 tggtccttgt gaatgccatc tacttcaaag gaaactggga gaagcagttt aacaaagagg
      841 acactcaaga aatgcctttc aatgtcacca aggatgtggt gaaacctgtg caaatgatgt
      901 ttcagaagtc tacctttaag atgacctatg tggaagagat atccaccaac attctgttgc
      961 ttccctatgt tggcaatgag ctaaacatga tcatcatgct tccagatgaa cacattgaac
     1021 taagtatggt ggaaaaggag ataacttata agaaattcat agagtggacg aggctggaca
     1081 agatggaaga agaagaggtg gaggttttcc tcccaaagtt taagctggag gagaactacg
     1141 acatgaaaga tgtcctgtgc aggctgggca tgactgatgc ctttgaggag ggcatggcag
     1201 acttttcagg aatagcatct aaagaaggct tgtttctgtc caaggtcatt cacaagtcct
     1261 ttgtggaggt caatgaggag ggcacagagg ctgcagctgc cactgcagcc aatataggtt
     1321 ttaggtgtat ggtcccctac ttctgtgcca accacccttt ccttttcttc atccaacaca
     1381 gcaggaccag tgggattgtg ttctgtggtc ggttctcctc cccatgagaa aggatgctgt
     1441 ggtgtcaggc cactgccttt gcccattctt tttctcatga tttgtctgca tcagtaaatg
     1501 ttgtgacaat tctgcacttg gtagcacaca cctgaaaagc taacatttag cagatgaagg
     1561 tgagagaatc agagatcatg cagggctagc ctcaactgca tagcaagttc aaagcaagcc
     1621 tgggctacac tagaccatta aacacaaaac caaatcaaat taaaacaata caaaaagaaa
     1681 agaatatacc catgtctgga tgctttataa aatagtattt tgtttacagt tctggaagct
     1741 gcagaacata gttggggctt ctgtacagtt ccagggaaaa tggtttcaca aaaacaggat
     1801 catgcaagag tgttgagcag tatataagtt tcagattcct tatgaatgag tcattcttac
     1861 agggtttaat gtaacccctt gatcccaaca ttaacctttt cctagactgt aaccttcaat
     1921 actgaagtaa ctttaccaca ctgtgaacca tcatgagata aactttatcc aagtgagcac
     1981 ccttcatcct ctctgcagca atactgggat ctcaattttt tggttactta gtaatttatt
     2041 ttacaatact gaagatttac tatgtatttt tacagtactg aagatttaca tgcaaggcaa
     2101 tgtactatac aataaattat atctacaatt tccttcaaaa a
//
