LOCUS       NM_198680               1632 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus serine (or cysteine) peptidase inhibitor, clade B
            (ovalbumin), member 3B (Serpinb3b), mRNA.
ACCESSION   NM_198680 XM_357118
VERSION     NM_198680.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1632)
  AUTHORS   Gerber H, Mosser S, Boury-Jamot B, Stumpe M, Piersigilli A,
            Goepfert C, Dengjel J, Albrecht U, Magara F and Fraering PC.
  TITLE     The APMAP interactome reveals new modulators of APP processing and
            beta-amyloid production that are altered in Alzheimer's disease
  JOURNAL   Acta Neuropathol Commun 7 (1), 13 (2019)
   PUBMED   30704515
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1632)
  AUTHORS   Turato C, Kent P, Sebastiani G, Cannito S, Morello E, Terrin L,
            Biasiolo A, Simonato D, Parola M, Pantopoulos K and Pontisso P.
  TITLE     Serpinb3 is overexpressed in the liver in presence of iron overload
  JOURNAL   J Investig Med 66 (1), 32-38 (2018)
   PUBMED   28935635
  REMARK    GeneRIF: iron overload and was previously found capable of
            up-regulating SerpinB3 at the transcriptional level.
REFERENCE   3  (bases 1 to 1632)
  AUTHORS   Sivaprasad U, Kinker KG, Ericksen MB, Lindsey M, Gibson AM, Bass
            SA, Hershey NS, Deng J, Medvedovic M and Khurana Hershey GK.
  TITLE     SERPINB3/B4 contributes to early inflammation and barrier
            dysfunction in an experimental murine model of atopic dermatitis
  JOURNAL   J Invest Dermatol 135 (1), 160-169 (2015)
   PUBMED   25111616
  REMARK    GeneRIF: Serpinb3a deficiency attenuates barrier dysfunction and
            the early inflammatory response following cutaneous allergen
            exposure.
REFERENCE   4  (bases 1 to 1632)
  AUTHORS   Heit C, Jackson BC, McAndrews M, Wright MW, Thompson DC, Silverman
            GA, Nebert DW and Vasiliou V.
  TITLE     Update of the human and mouse SERPIN gene superfamily
  JOURNAL   Hum Genomics 7 (1), 22 (2013)
   PUBMED   24172014
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1632)
  AUTHORS   Villano G, Lunardi F, Turato C, Schiff S, Tono N, Campagna F, Gatta
            A, Amodio P, Calabrese F and Pontisso P.
  TITLE     Increased Th1 immune response in SERPINB3 transgenic mice during
            acute liver failure
  JOURNAL   Exp Biol Med (Maywood) 237 (12), 1474-1482 (2012)
   PUBMED   23354406
  REMARK    GeneRIF: in acute liver failure SERPINB3 determines an enhanced
            inflammatory background, mainly mediated by higher levels of Th1
            proinflammatory cytokines.
REFERENCE   6  (bases 1 to 1632)
  AUTHORS   Ullman E, Pan JA and Zong WX.
  TITLE     Squamous cell carcinoma antigen 1 promotes caspase-8-mediated
            apoptosis in response to endoplasmic reticulum stress while
            inhibiting necrosis induced by lysosomal injury
  JOURNAL   Mol Cell Biol 31 (14), 2902-2919 (2011)
   PUBMED   21576355
  REMARK    GeneRIF: Data suggest that SCCA1 inhibits cell death induced by
            lysosomal injury while, on the other hand, it sensitizes cells to
            ER stress by activating caspase-8 independently of the death
            receptor apoptotic pathway.
REFERENCE   7  (bases 1 to 1632)
  AUTHORS   Sakata Y, Arima K, Takeshita K, Takai T, Aoki S, Ogawa H, Sugihara
            H, Fujimoto K and Izuhara K.
  TITLE     Characterization of novel squamous cell carcinoma antigen-related
            molecules in mice
  JOURNAL   Biochem Biophys Res Commun 324 (4), 1340-1345 (2004)
   PUBMED   15504361
  REMARK    GeneRIF: Characerization of the functional properties of Serpinb3b.
REFERENCE   8  (bases 1 to 1632)
  AUTHORS   Askew DJ, Askew YS, Kato Y, Turner RF, Dewar K, Lehoczky J and
            Silverman GA.
  TITLE     Comparative genomic analysis of the clade B serpin cluster at human
            chromosome 18q21: amplification within the mouse squamous cell
            carcinoma antigen gene locus
  JOURNAL   Genomics 84 (1), 176-184 (2004)
   PUBMED   15203215
REFERENCE   9  (bases 1 to 1632)
  AUTHORS   Askew DJ, Askew YS, Kato Y, Luke CJ, Pak SC, Bromme D and Silverman
            GA.
  TITLE     The amplified mouse squamous cell carcinoma antigen gene locus
            contains a serpin (Serpinb3b) that inhibits both papain-like
            cysteine and trypsin-like serine proteinases
  JOURNAL   Genomics 84 (1), 166-175 (2004)
   PUBMED   15203214
REFERENCE   10 (bases 1 to 1632)
  AUTHORS   Gariboldi M, Peissel B, Fabbri A, Saran A, Zaffaroni D, Falvella
            FS, Spinola M, Tanuma J, Pazzaglia S, Mancuso MT, Maurichi A,
            Bartoli C, Cataltepe S, Silverman GA, Pilotti S, Hayashizaki Y,
            Okazaki Y and Dragani TA.
  TITLE     SCCA2-like serpins mediate genetic predisposition to skin tumors
  JOURNAL   Cancer Res 63 (8), 1871-1875 (2003)
   PUBMED   12702576
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK003220.1.
            
            On Apr 6, 2007 this sequence version replaced NM_198680.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK003220.1, BC099584.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1632              AK003220.1         2-1633
FEATURES             Location/Qualifiers
     source          1..1632
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 50.34 cM"
     gene            1..1632
                     /gene="Serpinb3b"
                     /gene_synonym="Scca2-rs; Scca2-rs1"
                     /note="serine (or cysteine) peptidase inhibitor, clade B
                     (ovalbumin), member 3B"
                     /db_xref="GeneID:383548"
                     /db_xref="MGI:MGI:2683293"
     exon            1..35
                     /gene="Serpinb3b"
                     /gene_synonym="Scca2-rs; Scca2-rs1"
                     /inference="alignment:Splign:2.1.0"
     exon            36..222
                     /gene="Serpinb3b"
                     /gene_synonym="Scca2-rs; Scca2-rs1"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..1224
                     /gene="Serpinb3b"
                     /gene_synonym="Scca2-rs; Scca2-rs1"
                     /note="squamous cell carcinoma antigen 2 related protein
                     1; serine (or cysteine) proteinase inhibitor, clade B
                     (ovalbumin), member 3B"
                     /codon_start=1
                     /product="serine (or cysteine) proteinase inhibitor, clade
                     b, member 3b"
                     /protein_id="NP_941373.1"
                     /db_xref="CCDS:CCDS15216.1"
                     /db_xref="GeneID:383548"
                     /db_xref="MGI:MGI:2683293"
                     /translation="MIRFHAADVKFAVEMYRQLRESDKNIFYSPISMMTALAMLQLGA
                     KGNTEIQIEKVLQFIETTKKTTEKSEHCDDEENVHEQFQKLITQLNKSNDDYDLKAAN
                     SIYGAKGFPFLQTFLEDIKEYYQAKVESLDFEHATEESEKKINSWVESKTNGKIKDLF
                     PSGSLSSSTILVLVNAVYFKGQWNRKFNENHTREEKFWLNKNTSKPVQMMKQRNKFNF
                     SFLGDVHAQIVEIPYKGKDLSMFVLLPMEIDGLKQLEEQLTTDKLLEWIKAENMHLTE
                     LYLSLPRFKVEEKYDLQVPLEHMGMVDAFDPQKADFSGMSSIPGLVVSKVLHKSFVEV
                     NEEGTEAAAATGVEVSVRSAQIAEDFCCDHPFLFFIIHRMTNSILFFGRICSP"
     exon            223..279
                     /gene="Serpinb3b"
                     /gene_synonym="Scca2-rs; Scca2-rs1"
                     /inference="alignment:Splign:2.1.0"
     exon            280..402
                     /gene="Serpinb3b"
                     /gene_synonym="Scca2-rs; Scca2-rs1"
                     /inference="alignment:Splign:2.1.0"
     exon            403..520
                     /gene="Serpinb3b"
                     /gene_synonym="Scca2-rs; Scca2-rs1"
                     /inference="alignment:Splign:2.1.0"
     exon            521..663
                     /gene="Serpinb3b"
                     /gene_synonym="Scca2-rs; Scca2-rs1"
                     /inference="alignment:Splign:2.1.0"
     exon            664..819
                     /gene="Serpinb3b"
                     /gene_synonym="Scca2-rs; Scca2-rs1"
                     /inference="alignment:Splign:2.1.0"
     exon            820..1632
                     /gene="Serpinb3b"
                     /gene_synonym="Scca2-rs; Scca2-rs1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atccttcctg ctaacttctg ccttcagaaa cacaagactt caagttccca gtaagccacc
       61 atgattcgtt ttcatgcagc tgatgttaaa ttcgcagttg aaatgtacag gcagctcaga
      121 gaatcagaca agaacatttt ctattccccg atcagcatga tgacagcatt agcaatgctc
      181 cagcttggag ccaaaggaaa cactgaaata caaattgaga aggttcttca attcattgaa
      241 accaccaaga agacaacaga aaaatctgaa cactgcgatg atgaagaaaa tgtccatgaa
      301 caatttcaaa agcttataac tcagttaaac aaatccaatg atgattatga cctgaaggct
      361 gccaacagta tctatggagc aaagggtttc ccatttctcc agacattttt ggaagacatt
      421 aaggaatatt atcaagctaa ggtggaatca ctggatttcg aacatgcaac agaagagagc
      481 gaaaagaaga ttaattcctg ggtggaaagc aaaacaaatg gaaaaatcaa agacttattt
      541 cctagtggga gcctaagcag tagcactata ctggttctgg tgaatgcagt gtatttcaaa
      601 gggcaatgga atcgcaaatt taatgaaaac catacaagag aagaaaagtt ttggctgaac
      661 aagaacacaa gtaaacctgt ccagatgatg aaacaacgaa acaaatttaa cttcagcttt
      721 ctgggggatg tgcacgccca gattgtggaa ataccataca aaggcaaaga tctaagtatg
      781 tttgtcctgc tgccaatgga aattgatggt ctgaagcagc ttgaagaaca actcactact
      841 gacaaattac tagagtggat aaaagcagaa aacatgcatt tgactgagtt gtatttatct
      901 ttgcctcggt tcaaagtgga agagaagtat gacctccaag ttccattgga acacatgggg
      961 atggtcgacg cctttgatcc acagaaggct gacttctctg gcatgagcag cattccaggt
     1021 cttgtggtgt ctaaagtttt acacaagtcc tttgtggagg tgaatgaaga gggaacagaa
     1081 gctgctgctg ccacaggagt ggaagtcagt gtaagatcag cacagatagc agaagatttc
     1141 tgttgtgatc atccattcct attcttcatc attcacagaa tgaccaacag catcctcttc
     1201 tttggcagaa tctgctcccc ttaagtgtgg tgtctcttcc atgtgtccag aaagttaaca
     1261 aggttgctgc agctaattga ggcctggaaa catgtttctc ttccttcatt ctttttctca
     1321 tatccaagtc cctgctaaga atgcattagt tgggccagga tagctctatc aactctattt
     1381 ttcttcattc ccttattttt tctatatatc catacattct ctgggggaaa acgttcaaca
     1441 aaaggatgaa ggaatatttt aatataattt cttctaattt agcatgcatc tgtgccctgt
     1501 gtgaagcaag ctagagaaaa tcagaccttc cttttaaact gattaatata agcatctata
     1561 ttgttttacg aaatatctgg aaatttcata agcttataca tgttgtgatt ttacaaaata
     1621 cattttcaat at
//
