LOCUS       NM_009126               1629 bp    mRNA    linear   ROD 28-NOV-2023
DEFINITION  Mus musculus serine (or cysteine) peptidase inhibitor, clade B
            (ovalbumin), member 3A (Serpinb3a), mRNA.
ACCESSION   NM_009126 XM_484905
VERSION     NM_009126.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1629)
  AUTHORS   Qiu T, Huteckova B, Seppala M, Cobourne MT, Chen Z, Hovorakova M,
            Buchtova M and Tucker AS.
  TITLE     Molecular profiling of the vestibular lamina highlights a key role
            for Hedgehog signalling
  JOURNAL   Development 150 (7) (2023)
   PUBMED   36971701
REFERENCE   2  (bases 1 to 1629)
  AUTHORS   Novo E, Cappon A, Villano G, Quarta S, Cannito S, Bocca C, Turato
            C, Guido M, Maggiora M, Protopapa F, Sutti S, Provera A, Ruvoletto
            M, Biasiolo A, Foglia B, Albano E, Pontisso P and Parola M.
  TITLE     SerpinB3 as a Pro-Inflammatory Mediator in the Progression of
            Experimental Non-Alcoholic Fatty Liver Disease
  JOURNAL   Front Immunol 13, 910526 (2022)
   PUBMED   35874657
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1629)
  AUTHORS   Luke CJ, Markovina S, Good M, Wight IE, Thomas BJ, Linneman JM,
            Lanik WE, Koroleva O, Coffman MR, Miedel MT, Gong Q, Andress A,
            Campos Guerrero M, Wang S, Chen L, Beatty WL, Hausmann KN, White
            FV, Fitzpatrick JAJ, Orvedahl A, Pak SC and Silverman GA.
  TITLE     Lysoptosis is an evolutionarily conserved cell death pathway
            moderated by intracellular serpins
  JOURNAL   Commun Biol 5 (1), 47 (2022)
   PUBMED   35022507
  REMARK    GeneRIF: Lysoptosis is an evolutionarily conserved cell death
            pathway moderated by intracellular serpins.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1629)
  AUTHORS   Zieman AG, Poll BG, Ma J and Coulombe PA.
  TITLE     Altered keratinocyte differentiation is an early driver of keratin
            mutation-based palmoplantar keratoderma
  JOURNAL   Hum Mol Genet 28 (13), 2255-2270 (2019)
   PUBMED   31220272
REFERENCE   5  (bases 1 to 1629)
  AUTHORS   Sivaprasad U, Kinker KG, Ericksen MB, Lindsey M, Gibson AM, Bass
            SA, Hershey NS, Deng J, Medvedovic M and Khurana Hershey GK.
  TITLE     SERPINB3/B4 contributes to early inflammation and barrier
            dysfunction in an experimental murine model of atopic dermatitis
  JOURNAL   J Invest Dermatol 135 (1), 160-169 (2015)
   PUBMED   25111616
  REMARK    GeneRIF: Serpinb3a deficiency attenuates barrier dysfunction and
            the early inflammatory response following cutaneous allergen
            exposure, supporting a role for Serpinb3a (mice) and SERPINB3/B4
            (humans) early in atopic dermatitis.
REFERENCE   6  (bases 1 to 1629)
  AUTHORS   Sakata Y, Arima K, Takeshita K, Takai T, Aoki S, Ogawa H, Sugihara
            H, Fujimoto K and Izuhara K.
  TITLE     Characterization of novel squamous cell carcinoma antigen-related
            molecules in mice
  JOURNAL   Biochem Biophys Res Commun 324 (4), 1340-1345 (2004)
   PUBMED   15504361
  REMARK    GeneRIF: Characerization of the functional properties of Serpinb3c.
REFERENCE   7  (bases 1 to 1629)
  AUTHORS   Askew DJ, Askew YS, Kato Y, Turner RF, Dewar K, Lehoczky J and
            Silverman GA.
  TITLE     Comparative genomic analysis of the clade B serpin cluster at human
            chromosome 18q21: amplification within the mouse squamous cell
            carcinoma antigen gene locus
  JOURNAL   Genomics 84 (1), 176-184 (2004)
   PUBMED   15203215
REFERENCE   8  (bases 1 to 1629)
  AUTHORS   Gariboldi M, Peissel B, Fabbri A, Saran A, Zaffaroni D, Falvella
            FS, Spinola M, Tanuma J, Pazzaglia S, Mancuso MT, Maurichi A,
            Bartoli C, Cataltepe S, Silverman GA, Pilotti S, Hayashizaki Y,
            Okazaki Y and Dragani TA.
  TITLE     SCCA2-like serpins mediate genetic predisposition to skin tumors
  JOURNAL   Cancer Res 63 (8), 1871-1875 (2003)
   PUBMED   12702576
  REMARK    GeneRIF: SCCA2-like serpins mediate genetic predisposition to skin
            cancer in a mouse model and in humans.
REFERENCE   9  (bases 1 to 1629)
  AUTHORS   Al-Khunaizi M, Luke CJ, Askew YS, Pak SC, Askew DJ, Cataltepe S,
            Miller D, Mills DR, Tsu C, Bromme D, Irving JA, Whisstock JC and
            Silverman GA.
  TITLE     The serpin SQN-5 is a dual mechanistic-class inhibitor of serine
            and cysteine proteinases
  JOURNAL   Biochemistry 41 (9), 3189-3199 (2002)
   PUBMED   11863458
  REMARK    GeneRIF: SQN-5 employed different reactive centers to neutralize
            the serine and cysteine proteinases.
REFERENCE   10 (bases 1 to 1629)
  AUTHORS   Bartuski AJ, Kamachi Y, Schick C, Massa H, Trask BJ and Silverman
            GA.
  TITLE     A murine ortholog of the human serpin SCCA2 maps to chromosome 1
            and inhibits chymotrypsin-like serine proteinases
  JOURNAL   Genomics 54 (2), 297-306 (1998)
   PUBMED   9828132
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC063756.1, AC125111.3 and BB699605.1.
            
            On Apr 18, 2009 this sequence version replaced NM_009126.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC063756.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849387 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-546               BC063756.1         1-546
            547-547             AC125111.3         155525-155525       c
            548-935             BC063756.1         548-935
            936-936             AC125111.3         154240-154240       c
            937-1250            BC063756.1         937-1250
            1251-1629           BB699605.1         138-516
FEATURES             Location/Qualifiers
     source          1..1629
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 50.34 cM"
     gene            1..1629
                     /gene="Serpinb3a"
                     /gene_synonym="1110001H02Rik; 1110013A16Rik; Scca2;
                     Serpinb4; Sqn5"
                     /note="serine (or cysteine) peptidase inhibitor, clade B
                     (ovalbumin), member 3A"
                     /db_xref="GeneID:20248"
                     /db_xref="MGI:MGI:3573933"
     exon            1..11
                     /gene="Serpinb3a"
                     /gene_synonym="1110001H02Rik; 1110013A16Rik; Scca2;
                     Serpinb4; Sqn5"
                     /inference="alignment:Splign:2.1.0"
     exon            12..198
                     /gene="Serpinb3a"
                     /gene_synonym="1110001H02Rik; 1110013A16Rik; Scca2;
                     Serpinb4; Sqn5"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..1200
                     /gene="Serpinb3a"
                     /gene_synonym="1110001H02Rik; 1110013A16Rik; Scca2;
                     Serpinb4; Sqn5"
                     /note="serine (or cysteine) proteinase inhibitor, clade B
                     (ovalbumin), member 3A; squamous cell carcinoma antigen 2"
                     /codon_start=1
                     /product="serine peptidase inhibitor, clade B, member 3A"
                     /protein_id="NP_033152.3"
                     /db_xref="CCDS:CCDS15214.1"
                     /db_xref="GeneID:20248"
                     /db_xref="MGI:MGI:3573933"
                     /translation="MHLFAEATTKFTLELYRQLRESDNNIFYSPISMMTALAMLQLGA
                     KGNTEKQIEKVLQFNETTKKTTEKSAHCHDEENVHEQFQKLMTQLNKSNDAYDLKAAN
                     SIYGAKGFPFVQTFLEDIKEYYQANVESLDFEHAAEESEKKINSWVESQTNGKIKDLF
                     PNGSLNRSTIMVLVNAVYFKGQWNHKFDEKHTTEEKFWLNKNTSKPVQMMKQNIEFNF
                     MFLEDVQAKIVEIPYKGKELSMIVLLPVEINGLKQLEEQLTADKLLEWTRAENMHMTE
                     LYLSLPRFKVDEKYDLPIPLEHMGMVDAFDPQKADFSGMSSTQGLVVSKVLHKSFVEV
                     NEEGTEAAAATGVEVSLTSAQIAEDFCCDHPFLFFIIHRKTNSILFFGRISSP"
     exon            199..255
                     /gene="Serpinb3a"
                     /gene_synonym="1110001H02Rik; 1110013A16Rik; Scca2;
                     Serpinb4; Sqn5"
                     /inference="alignment:Splign:2.1.0"
     exon            256..378
                     /gene="Serpinb3a"
                     /gene_synonym="1110001H02Rik; 1110013A16Rik; Scca2;
                     Serpinb4; Sqn5"
                     /inference="alignment:Splign:2.1.0"
     exon            379..496
                     /gene="Serpinb3a"
                     /gene_synonym="1110001H02Rik; 1110013A16Rik; Scca2;
                     Serpinb4; Sqn5"
                     /inference="alignment:Splign:2.1.0"
     exon            497..639
                     /gene="Serpinb3a"
                     /gene_synonym="1110001H02Rik; 1110013A16Rik; Scca2;
                     Serpinb4; Sqn5"
                     /inference="alignment:Splign:2.1.0"
     exon            640..795
                     /gene="Serpinb3a"
                     /gene_synonym="1110001H02Rik; 1110013A16Rik; Scca2;
                     Serpinb4; Sqn5"
                     /inference="alignment:Splign:2.1.0"
     exon            796..1629
                     /gene="Serpinb3a"
                     /gene_synonym="1110001H02Rik; 1110013A16Rik; Scca2;
                     Serpinb4; Sqn5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagaaacaca agacttcaag ttcccactaa gccaccatgc atttgtttgc tgaagccact
       61 actaaattca cacttgagct gtacaggcag ctcagagaat cagataacaa cattttctat
      121 tccccgatca gcatgatgac agcattagca atgctccagc ttggagccaa aggaaacact
      181 gaaaaacaaa ttgagaaggt tcttcaattc aatgaaacca ccaagaagac aacagaaaaa
      241 tctgcacact gccatgatga agaaaatgtt catgaacaat ttcaaaagct tatgactcag
      301 ttaaacaaat ccaatgatgc ttatgatcta aaggctgcca acagtatcta tggagcaaag
      361 ggtttcccat ttgtccagac atttttggaa gacattaagg aatattatca agctaacgtg
      421 gaatcactgg atttcgaaca tgcagcagaa gagagtgaaa agaagattaa ttcctgggta
      481 gaaagccaaa caaatggaaa aatcaaggac ttatttccta atgggagcct gaacaggagc
      541 actataatgg ttctggtgaa tgcagtgtat ttcaaaggac aatggaacca caaatttgat
      601 gaaaagcata ccacagaaga aaagttttgg ctgaacaaga acacaagtaa acctgtccag
      661 atgatgaaac aaaacatcga atttaacttc atgtttctgg aggatgtgca ggccaagatt
      721 gtggaaatac catacaaagg caaagagcta agtatgattg tcctgttgcc agtggaaatc
      781 aatggtctga agcagcttga agaacaactc actgctgaca agttactgga gtggacaaga
      841 gcagaaaaca tgcatatgac cgagttgtat ttatctttgc ctcggttcaa agtggatgag
      901 aagtatgacc tcccaattcc attggaacac atgggaatgg tcgatgcctt tgatccacag
      961 aaggctgact tctctggtat gagcagcact caaggtcttg tggtgtctaa agttttacac
     1021 aagtcctttg tggaggtgaa tgaagaggga acagaagctg ctgctgcaac aggtgtggaa
     1081 gtcagtttaa catcagcaca gatagcagaa gatttctgtt gtgatcatcc attcctattc
     1141 ttcatcattc acagaaaaac caacagcatc ctcttctttg gcagaatctc ctccccttag
     1201 atgtggtgtc tcttccatgt gtccagaaaa gttaacaagg ttgctgcagc taattgaggc
     1261 ctggaaacat gtttctcttc ctgcattctt tttctcatat ccaagtccct gctaagaatg
     1321 cactacttgg gccaggatag ctctattatc tctatttttc ctcatttcct tatttttttc
     1381 tatatatcca tacattctct gggggaaaat gttcaacaaa aggatgaagg gatattttat
     1441 tatagtttct tctaatctag catatatctg tgccctgtgt gaagtgagct agagaaaatc
     1501 agaccttcct tttaaacgga ttaatataag catctacatt gctttacaag atatctagat
     1561 acttcataag ttataaatgt tgtgatttta caaaatacat tttcaataaa ataatgatcc
     1621 tttcaattt
//
