LOCUS       NM_011111               2007 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Mus musculus serine (or cysteine) peptidase inhibitor, clade B,
            member 2 (Serpinb2), transcript variant 1, mRNA.
ACCESSION   NM_011111
VERSION     NM_011111.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2007)
  AUTHORS   Piao,Y.J., Kim,H.S., Kim,H., Shen,J. and Moon,W.K.
  TITLE     SerpinB2 deficiency is associated with delayed mammary tumor
            development and decreased pro-tumorigenic macrophage polarization
  JOURNAL   BMC Cancer 24 (1), 792 (2024)
   PUBMED   38956496
  REMARK    GeneRIF: SerpinB2 deficiency is associated with delayed mammary
            tumor development and decreased pro-tumorigenic macrophage
            polarization.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2007)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2007)
  AUTHORS   Teske,N.C., Engelen-Lee,J.Y., Dyckhoff-Shen,S., Pfister,H.W.,
            Klein,M., van de Beek,D., Kirschning,C.K., Koedel,U. and
            Brouwer,M.C.
  TITLE     The role of plasminogen activator inhibitor-2 in pneumococcal
            meningitis
  JOURNAL   Acta Neuropathol Commun 10 (1), 155 (2022)
   PUBMED   36309755
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2007)
  AUTHORS   Piao,Y.J., Kim,H.S., Han,W. and Moon,W.K.
  TITLE     Transcriptome analysis of SerpinB2-deficient breast tumors provides
            insight into deciphering SerpinB2-mediated roles in breast cancer
            progression
  JOURNAL   BMC Genomics 23 (1), 479 (2022)
   PUBMED   35768767
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2007)
  AUTHORS   Kidger,A.M., Saville,M.K., Rushworth,L.K., Davidson,J.,
            Stellzig,J., Ono,M., Kuebelsbeck,L.A., Janssen,K.P., Holzmann,B.,
            Morton,J.P., Sansom,O.J., Caunt,C.J. and Keyse,S.M.
  TITLE     Suppression of mutant Kirsten-RAS (KRASG12D)-driven pancreatic
            carcinogenesis by dual-specificity MAP kinase phosphatases 5 and 6
  JOURNAL   Oncogene 41 (20), 2811-2823 (2022)
   PUBMED   35418690
REFERENCE   6  (bases 1 to 2007)
  AUTHORS   Kawata,Y., Mimuro,J., Kaneko,M., Shimada,K. and Sakata,Y.
  TITLE     Expression of plasminogen activator inhibitor 2 in the adult and
            embryonic mouse tissues
  JOURNAL   Thromb Haemost 76 (4), 569-576 (1996)
   PUBMED   8902998
REFERENCE   7  (bases 1 to 2007)
  AUTHORS   Teesalu,T., Blasi,F. and Talarico,D.
  TITLE     Embryo implantation in mouse: fetomaternal coordination in the
            pattern of expression of uPA, uPAR, PAI-1 and alpha 2MR/LRP genes
  JOURNAL   Mech Dev 56 (1-2), 103-116 (1996)
   PUBMED   8798151
REFERENCE   8  (bases 1 to 2007)
  AUTHORS   Larsen,N.J., Womack,J.E. and Kirkpatrick,B.W.
  TITLE     Seven genes from human chromosome 18 map to chromosome 24 in the
            bovine
  JOURNAL   Cytogenet Cell Genet 73 (3), 184-186 (1996)
   PUBMED   8697804
REFERENCE   9  (bases 1 to 2007)
  AUTHORS   Harvey,M.B., Leco,K.J., Arcellana-Panlilio,M.Y., Zhang,X.,
            Edwards,D.R. and Schultz,G.A.
  TITLE     Proteinase expression in early mouse embryos is regulated by
            leukaemia inhibitory factor and epidermal growth factor
  JOURNAL   Development 121 (4), 1005-1014 (1995)
   PUBMED   7743917
REFERENCE   10 (bases 1 to 2007)
  AUTHORS   Belin,D., Wohlwend,A., Schleuning,W.D., Kruithof,E.K. and
            Vassalli,J.D.
  TITLE     Facultative polypeptide translocation allows a single mRNA to
            encode the secreted and cytosolic forms of plasminogen activators
            inhibitor 2
  JOURNAL   EMBO J 8 (11), 3287-3294 (1989)
   PUBMED   2583099
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY195599.1, AK090049.1 and AI847983.1.
            
            On Apr 1, 2010 this sequence version replaced NM_011111.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK090049.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                BY195599.1         15-49
            36-1983             AK090049.1         5-1952
            1984-2007           AI847983.1         1-24                c
FEATURES             Location/Qualifiers
     source          1..2007
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 50.34 cM"
     gene            1..2007
                     /gene="Serpinb2"
                     /gene_synonym="ovalbumin; PAI-2; Planh2"
                     /note="serine (or cysteine) peptidase inhibitor, clade B,
                     member 2"
                     /db_xref="GeneID:18788"
                     /db_xref="MGI:MGI:97609"
     exon            1..75
                     /gene="Serpinb2"
                     /gene_synonym="ovalbumin; PAI-2; Planh2"
                     /inference="alignment:Splign:2.1.0"
     exon            76..252
                     /gene="Serpinb2"
                     /gene_synonym="ovalbumin; PAI-2; Planh2"
                     /inference="alignment:Splign:2.1.0"
     exon            253..372
                     /gene="Serpinb2"
                     /gene_synonym="ovalbumin; PAI-2; Planh2"
                     /inference="alignment:Splign:2.1.0"
     exon            373..501
                     /gene="Serpinb2"
                     /gene_synonym="ovalbumin; PAI-2; Planh2"
                     /inference="alignment:Splign:2.1.0"
     exon            502..619
                     /gene="Serpinb2"
                     /gene_synonym="ovalbumin; PAI-2; Planh2"
                     /inference="alignment:Splign:2.1.0"
     exon            620..762
                     /gene="Serpinb2"
                     /gene_synonym="ovalbumin; PAI-2; Planh2"
                     /inference="alignment:Splign:2.1.0"
     exon            763..927
                     /gene="Serpinb2"
                     /gene_synonym="ovalbumin; PAI-2; Planh2"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1991
                     /gene="Serpinb2"
                     /gene_synonym="ovalbumin; PAI-2; Planh2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1966..1971
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Serpinb2"
                     /gene_synonym="ovalbumin; PAI-2; Planh2"
                     /note="hexamer: AATAAA"
     polyA_site      1991
                     /gene="Serpinb2"
                     /gene_synonym="ovalbumin; PAI-2; Planh2"
                     /note="major polyA site"
ORIGIN      
        1 atctctagtg aatccagggc gtctttcttc tctcctcctt catagcaata gttactatat
       61 tgagctgtgt agaggattga aacaatggaa gaactttcca tggcaaacac catgtttgcc
      121 ctcaatctcc ttaagcagat agaaaaatca aactctaccc agaacatctt tatctctcca
      181 tggagcatct catcaacatt ggccatagtt ctcctcggtg ctgggggtaa cactgaacag
      241 cagatggcca aagtgctgca gtttaatgaa attggcagtt atggtatcac cacaagaaac
      301 ccagagaact tcagtggctg tgatttcgca caacagatac agaaggaaaa ttatcctagt
      361 gctattttac aggcacaagc aggagataaa atccattcag ccttctcctc tctcagctca
      421 acaatcaaca caccacaggg ggattatttg ttagaaagtg caaacaagct gtttggagag
      481 aagtctgcaa gattcaaaga agaatacatc caactctcta agaaatatta ctcaacagaa
      541 ccagaagcag tggacttcct tgaatgtgct gaagaagcta gggaaaagat taattcttgg
      601 gtcaagactc aaaccaaagg tgaaatccca aacctgctac ccgaaggttc tgtagatgaa
      661 gacaccaaga tggtgctggt gaatgctgtc tacttcaaag gaaagtggaa aactccattt
      721 gagaagaaac ttaatgggct ttatcctttc cgtgtgaact cgcatgagag catacctgtc
      781 cagatgatgt tcctccatgc aaagctgaac attggataca taaaggacct gaagactcag
      841 atcctagaac ttccgcatac tggaaacatc agcatgctcc tgttgcttcc cgatgagatt
      901 gaggacgcat ccactggctt ggaattgctg gaaagtgaaa taaactttgc caacttcaac
      961 aagtggatca gcaaagacac actggatgaa gatgatgttg tggtctacat tcccaagttc
     1021 aaactggcac aaagctacga actcaagtcc attcttcaaa gcatgggcat ggaggatgcc
     1081 ttcaacaagg gcaaggccaa cttctcagga atgtctgaga ggaatgacct ttttctttct
     1141 gaggtgttcc atcaagccag cgtggatgtc accgaggagg gcactgtggc agctggtggg
     1201 actggggcag ttatgacagg aagaactggc catggtggcc cacagtttgt ggccgatcat
     1261 ccctttcttt tctttatcat ggacaaaatt acccacacga tactatttgt tggtagattc
     1321 tcctcaccct aaaaggggaa gacctatttc cacatgaggt tttgtagcat gaactataag
     1381 cctcagaatt gcatcttcaa gtgccaaaag tttaaatact ttcttacaca tttttatact
     1441 tctgctatac actaaatata acctaaaagc aattgtatag cagtcttcag tgcttacagt
     1501 ataactctat taatgatttt gtttcctaaa gtcagatgat gtctatttag ttcatcctta
     1561 ttactgcttt gtctttataa ctttagtttt tacagtgtta tttattgttt atataatggt
     1621 tgttttacaa attgttgtcc tctgtttaat gaaactgtaa cactacagaa gcagaaaatt
     1681 agataatttt ctatttaaag aaaatcagcc atttaattta ataatgaagg aaaaatatga
     1741 gtcttccata ctttcccatg atattcaccc agaaaaaatg tacttaacaa aagacatgtt
     1801 atatctctat cattatatat catatgtacg tatctgcaac tcatctataa ttaggactac
     1861 atcataagta agcatgctta cttacacact gctatctgtt gtataaaact tagcaatcct
     1921 tatttgttag ttatctttct atcactgtaa caaaatacct gagataataa agttcaaaga
     1981 tttattttgg aaaaaaaaaa aaaaaaa
//
