LOCUS       NM_173051               1599 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus serine (or cysteine) peptidase inhibitor, clade B,
            member 1c (Serpinb1c), transcript variant 1, mRNA.
ACCESSION   NM_173051 XM_354746
VERSION     NM_173051.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1599)
  AUTHORS   Kolanowski,T.J., Wargocka-Matuszewska,W., Zimna,A., Cheda,L.,
            Zyprych-Walczak,J., Rugowska,A., Drabik,M., Fiedorowicz,M.,
            Krajewski,S., Steczek,L., Kozanecki,C., Rogulski,Z., Rozwadowska,N.
            and Kurpisz,M.
  TITLE     Multiparametric Evaluation of Post-MI Small Animal Models Using
            Metabolic ([18F]FDG) and Perfusion-Based (SYN1) Heart Viability
            Tracers
  JOURNAL   Int J Mol Sci 22 (22), 12591 (2021)
   PUBMED   34830471
  REMARK    GeneRIF: Multiparametric Evaluation of Post-MI Small Animal Models
            Using Metabolic ([(18)F]FDG) and Perfusion-Based (SYN1) Heart
            Viability Tracers.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1599)
  AUTHORS   Choi,Y.J., Kim,S., Choi,Y., Nielsen,T.B., Yan,J., Lu,A., Ruan,J.,
            Lee,H.R., Wu,H., Spellberg,B. and Jung,J.U.
  TITLE     SERPINB1-mediated checkpoint of inflammatory caspase activation
  JOURNAL   Nat Immunol 20 (3), 276-287 (2019)
   PUBMED   30692621
  REMARK    Erratum:[Nat Immunol. 2019 May;20(5):664. doi:
            10.1038/s41590-019-0361-x.. PMID: 30846880]
REFERENCE   3  (bases 1 to 1599)
  AUTHORS   Heit,C., Jackson,B.C., McAndrews,M., Wright,M.W., Thompson,D.C.,
            Silverman,G.A., Nebert,D.W. and Vasiliou,V.
  TITLE     Update of the human and mouse SERPIN gene superfamily
  JOURNAL   Hum Genomics 7 (1), 22 (2013)
   PUBMED   24172014
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1599)
  AUTHORS   Rutitzky,L.I., Hernandez,H.J., Yim,Y.S., Ricklan,D.E., Finger,E.,
            Mohan,C., Peter,I., Wakeland,E.K. and Stadecker,M.J.
  TITLE     Enhanced egg-induced immunopathology correlates with high IFN-gamma
            in murine schistosomiasis: identification of two epistatic genetic
            intervals
  JOURNAL   J Immunol 174 (1), 435-440 (2005)
   PUBMED   15611268
REFERENCE   5  (bases 1 to 1599)
  AUTHORS   Benarafa,C., Cooley,J., Zeng,W., Bird,P.I. and Remold-O'Donnell,E.
  TITLE     Characterization of four murine homologs of the human ov-serpin
            monocyte neutrophil elastase inhibitor MNEI (SERPINB1)
  JOURNAL   J Biol Chem 277 (44), 42028-42033 (2002)
   PUBMED   12189154
  REMARK    GeneRIF: cDNA cloning, gene structure and biological
            characterization homologous to human MNEI
REFERENCE   6  (bases 1 to 1599)
  AUTHORS   Kaiserman,D., Knaggs,S., Scarff,K.L., Gillard,A., Mirza,G.,
            Cadman,M., McKeone,R., Denny,P., Cooley,J., Benarafa,C.,
            Remold-O'Donnell,E., Ragoussis,J. and Bird,P.I.
  TITLE     Comparison of human chromosome 6p25 with mouse chromosome 13
            reveals a greatly expanded ov-serpin gene repertoire in the mouse
  JOURNAL   Genomics 79 (3), 349-362 (2002)
   PUBMED   11863365
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL606533.4, BC104332.2, AL645693.8 and CJ203237.1.
            
            On May 28, 2009 this sequence version replaced NM_173051.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            CDS exon combination :: BC104332.2 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                AL606533.4         16206-16224         c
            20-1357             BC104332.2         3-1340
            1358-1459           AL645693.8         11398-11499         c
            1460-1599           CJ203237.1         256-395
FEATURES             Location/Qualifiers
     source          1..1599
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 13.76 cM"
     gene            1..1599
                     /gene="Serpinb1c"
                     /gene_synonym="EIC; ovalbumin"
                     /note="serine (or cysteine) peptidase inhibitor, clade B,
                     member 1c"
                     /db_xref="GeneID:380839"
                     /db_xref="MGI:MGI:2445363"
     exon            1..27
                     /gene="Serpinb1c"
                     /gene_synonym="EIC; ovalbumin"
                     /inference="alignment:Splign:2.1.0"
     exon            28..203
                     /gene="Serpinb1c"
                     /gene_synonym="EIC; ovalbumin"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..1163
                     /gene="Serpinb1c"
                     /gene_synonym="EIC; ovalbumin"
                     /note="isoform 1 is encoded by transcript variant 1;
                     leukocyte elastase inhibitor C; serpin B1c; serine
                     protease inhibitor EIC; serine (or cysteine) proteinase
                     inhibitor, clade B, member 1c; serine (or cysteine)
                     proteinase inhibitor, clade B (ovalbumin), member 1c"
                     /codon_start=1
                     /product="leukocyte elastase inhibitor C isoform 1"
                     /protein_id="NP_766639.2"
                     /db_xref="CCDS:CCDS26429.1"
                     /db_xref="GeneID:380839"
                     /db_xref="MGI:MGI:2445363"
                     /translation="MGQLSSANNLFALELFHTLNESNPTGNTIFSPVSISSALAMVYL
                     GARGSTAAQLSKTLHFDSAEDIHSQFQSLTAEVSKRGASHTLKLANRLYGEKTYNFLP
                     EYLASIQKTYSADLALVDFQHASEDARKEINQWVKGQTEEKIQELFAVGVVDSMTKLV
                     LVNATYFKGMWQKKFMARDTTDAPFRLSKKVTKTVKMMYLKNNLPFGYIPDLKCKVLE
                     MPYQGGELSMVILLPEDIEDETTGLEEIEKQLTLEKLQECENLQNIDVCVKLPKFKME
                     ESYILNSNLGQLGVQDLFSSSKADLSGMSGSRDLFISKIVHKSYVEVNEEGTETDAAM
                     PGTVVGCCLMPMEFTVDHPFLFFIRHNPTAHVLFLGRVCSP"
     exon            204..341
                     /gene="Serpinb1c"
                     /gene_synonym="EIC; ovalbumin"
                     /inference="alignment:Splign:2.1.0"
     exon            342..459
                     /gene="Serpinb1c"
                     /gene_synonym="EIC; ovalbumin"
                     /inference="alignment:Splign:2.1.0"
     exon            460..602
                     /gene="Serpinb1c"
                     /gene_synonym="EIC; ovalbumin"
                     /inference="alignment:Splign:2.1.0"
     exon            603..770
                     /gene="Serpinb1c"
                     /gene_synonym="EIC; ovalbumin"
                     /inference="alignment:Splign:2.1.0"
     exon            771..1599
                     /gene="Serpinb1c"
                     /gene_synonym="EIC; ovalbumin"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtggagcca gacctgctaa gcaagagcct tcaccatggg gcagctgagt tcagccaaca
       61 acctctttgc tttggagctg ttccacaccc tgaatgagag caaccccaca ggaaatacca
      121 tcttctctcc cgtcagcatt tcttctgcct tggccatggt ctatctgggg gccagaggca
      181 gcactgcagc ccaactctct aagactctgc attttgactc tgctgaggac atccattcac
      241 agtttcaaag cctgactgct gaagtgagca agcgtggagc atctcacact ctgaaacttg
      301 ctaacagact gtatggagag aaaacctaca acttccttcc tgagtacttg gcttcaatcc
      361 agaaaacgta cagtgctgac ttggcccttg tggattttca gcatgcttct gaggatgcaa
      421 ggaaggagat aaaccagtgg gtcaaaggtc aaacagaaga gaaaattcag gaactgtttg
      481 ctgtgggtgt ggtggacagt atgactaaac ttgtactagt gaatgccacc tatttcaagg
      541 gaatgtggca gaaaaaattc atggcacggg acacaaccga tgctccattc cgactgagta
      601 agaaagtcac aaaaacagtg aagatgatgt atctaaagaa taatcttcca tttggctaca
      661 ttccagacct gaagtgcaag gtgctggaga tgccttacca gggtggagaa cttagcatgg
      721 tcattctgct gcctgaagac attgaggacg agaccacagg tcttgaggag attgagaaac
      781 aattaacttt ggaaaaactg caagaatgtg agaacttaca aaacattgat gtctgtgtca
      841 aattgcccaa attcaagatg gaagagagct acatcctcaa ctctaacctg ggccaactgg
      901 gagtgcagga tctctttagc agcagcaaag ctgatctctc tggcatgtcg ggatccagag
      961 atcttttcat atcaaaaatt gttcacaagt cctatgtgga agtgaatgag gagggaacag
     1021 agacagatgc tgccatgcca ggcactgttg ttggatgctg cctgatgccc atggaattca
     1081 cggtggacca tccattcctt ttcttcattc ggcacaatcc cacggctcat gtgctcttcc
     1141 ttggcagggt ttgttcccca tagaagaagg agactttaga gatacaaggc agagcttaga
     1201 gtttcattac ctgagatttt aatagtgatt attttcactt gcccttgacc ataaaacctc
     1261 tatcagaatc aaacttgact ttattttgta agaaagagca caactccatt ggctttttat
     1321 atccatgtct tttggcatgg gtgtgtctat tttgttttta cactgaaaaa aaaatgctgt
     1381 tgtcactgtc aacaatgtca tgtttaaagt ccaaaggaca aaatagatat agttttctga
     1441 ccataaggta acctgtacaa ttgacctaca gtactgacag gcatgaaaat atgtagcttt
     1501 tcctaaatca gttttttctc agtctaaaac tagagtaaga caagaagaaa gaaggagaga
     1561 gagagagaga gagagagaga gagagagaga gagagaaag
//
