LOCUS       NM_173052               1729 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Mus musculus serine (or cysteine) peptidase inhibitor, clade B,
            member 1b (Serpinb1b), mRNA.
ACCESSION   NM_173052
VERSION     NM_173052.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1729)
  AUTHORS   Choi,Y.J., Kim,S., Choi,Y., Nielsen,T.B., Yan,J., Lu,A., Ruan,J.,
            Lee,H.R., Wu,H., Spellberg,B. and Jung,J.U.
  TITLE     SERPINB1-mediated checkpoint of inflammatory caspase activation
  JOURNAL   Nat Immunol 20 (3), 276-287 (2019)
   PUBMED   30692621
  REMARK    Erratum:[Nat Immunol. 2019 May;20(5):664. doi:
            10.1038/s41590-019-0361-x. PMID: 30846880]
REFERENCE   2  (bases 1 to 1729)
  AUTHORS   Heit,C., Jackson,B.C., McAndrews,M., Wright,M.W., Thompson,D.C.,
            Silverman,G.A., Nebert,D.W. and Vasiliou,V.
  TITLE     Update of the human and mouse SERPIN gene superfamily
  JOURNAL   Hum Genomics 7 (1), 22 (2013)
   PUBMED   24172014
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1729)
  AUTHORS   Benarafa,C., Cooley,J., Zeng,W., Bird,P.I. and Remold-O'Donnell,E.
  TITLE     Characterization of four murine homologs of the human ov-serpin
            monocyte neutrophil elastase inhibitor MNEI (SERPINB1)
  JOURNAL   J Biol Chem 277 (44), 42028-42033 (2002)
   PUBMED   12189154
  REMARK    GeneRIF: cDNA cloning, gene structure and biological
            characterization homologous to human MNEI
REFERENCE   4  (bases 1 to 1729)
  AUTHORS   Kaiserman,D., Knaggs,S., Scarff,K.L., Gillard,A., Mirza,G.,
            Cadman,M., McKeone,R., Denny,P., Cooley,J., Benarafa,C.,
            Remold-O'Donnell,E., Ragoussis,J. and Bird,P.I.
  TITLE     Comparison of human chromosome 6p25 with mouse chromosome 13
            reveals a greatly expanded ov-serpin gene repertoire in the mouse
  JOURNAL   Genomics 79 (3), 349-362 (2002)
   PUBMED   11863365
REFERENCE   5  (bases 1 to 1729)
  AUTHORS   Bleul,C.C. and Boehm,T.
  TITLE     Laser capture microdissection-based expression profiling identifies
            PD1-ligand as a target of the nude locus gene product
  JOURNAL   Eur J Immunol 31 (8), 2497-2503 (2001)
   PUBMED   11500834
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY109795.1, BC030354.1 and BE980791.1.
            
            On Aug 25, 2009 this sequence version replaced NM_173052.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC030354.1, SRR7345562.3316589.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                BY109795.1         1-67
            68-1650             BC030354.1         13-1595
            1651-1729           BE980791.1         1-79                c
FEATURES             Location/Qualifiers
     source          1..1729
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 13.81 cM"
     gene            1..1729
                     /gene="Serpinb1b"
                     /gene_synonym="6330533H24Rik; EIB; ovalbumin; Serpin1b1"
                     /note="serine (or cysteine) peptidase inhibitor, clade B,
                     member 1b"
                     /db_xref="GeneID:282663"
                     /db_xref="MGI:MGI:2445361"
     exon            1..115
                     /gene="Serpinb1b"
                     /gene_synonym="6330533H24Rik; EIB; ovalbumin; Serpin1b1"
                     /inference="alignment:Splign:2.1.0"
     exon            116..291
                     /gene="Serpinb1b"
                     /gene_synonym="6330533H24Rik; EIB; ovalbumin; Serpin1b1"
                     /inference="alignment:Splign:2.1.0"
     exon            292..429
                     /gene="Serpinb1b"
                     /gene_synonym="6330533H24Rik; EIB; ovalbumin; Serpin1b1"
                     /inference="alignment:Splign:2.1.0"
     exon            430..547
                     /gene="Serpinb1b"
                     /gene_synonym="6330533H24Rik; EIB; ovalbumin; Serpin1b1"
                     /inference="alignment:Splign:2.1.0"
     exon            548..690
                     /gene="Serpinb1b"
                     /gene_synonym="6330533H24Rik; EIB; ovalbumin; Serpin1b1"
                     /inference="alignment:Splign:2.1.0"
     exon            691..858
                     /gene="Serpinb1b"
                     /gene_synonym="6330533H24Rik; EIB; ovalbumin; Serpin1b1"
                     /inference="alignment:Splign:2.1.0"
     exon            859..1718
                     /gene="Serpinb1b"
                     /gene_synonym="6330533H24Rik; EIB; ovalbumin; Serpin1b1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1356..1361
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Serpinb1b"
                     /gene_synonym="6330533H24Rik; EIB; ovalbumin; Serpin1b1"
                     /note="hexamer: AATAAA"
     polyA_site      1380
                     /gene="Serpinb1b"
                     /gene_synonym="6330533H24Rik; EIB; ovalbumin; Serpin1b1"
                     /note="major polyA site"
     regulatory      1695..1700
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Serpinb1b"
                     /gene_synonym="6330533H24Rik; EIB; ovalbumin; Serpin1b1"
                     /note="hexamer: AATAAA"
     polyA_site      1718
                     /gene="Serpinb1b"
                     /gene_synonym="6330533H24Rik; EIB; ovalbumin; Serpin1b1"
ORIGIN      
        1 ttcccagctt gtgcttgcca gtaagacact ctcctttcag agtcaaggct gcagctggcc
       61 ttgggagctt cttcctaggt ctctagcaag tggagccaga gctgctacag aggagccttc
      121 accatggagc agctgagttc agcgaacacc ctcttcacct tggagctgtt ccacacactg
      181 aaggaaagca gccccacagg aaacatcttc ttctctccat ttagtatttc ttcttccttg
      241 gccatggtct ttctgggagc caaaggcagc actgcagccc agctctctaa gactcttcat
      301 tttgactctg ttgaggacat ccattcatgc tttcaaagcc tgactgctga agtgagcaag
      361 ctgggagcat ctcacactct gaaacttgct aacagactgt atggagagaa aacctacaat
      421 ttccttcctg agttcttggc ttccacccag aaaatgtaca gtgctgactt ggccgctgtg
      481 gattttcagc atgcctctga ggatgcaagg aaggagataa accaatgggt caaaggtcaa
      541 acagaaggta aaatcccaga actgctggct aagggtgtgg tagacagcat gaccaaactt
      601 gtgctagtga atgccattta cttcaaagga atatgggagg agcaattcat gacaagagaa
      661 acaatcaatg ctccattcag actgaataag aaagacacaa aaacagtgaa gatgatgtat
      721 caaaagaaaa aatttccatt cggttacatt tcggacctga agtgcaaggt gctggagatg
      781 ccttaccagg gtggagaact tagcatggtc attctgctgc ctgaagacat tgaggatgag
      841 tccacgggtc ttaagaagat tgaggagcaa ttaactttgg gaaaacttca tgaatggacc
      901 aaacatgaga acttgagaaa cattgatgtc catgtcaaat tgcccaggtt caagatggaa
      961 gagagctaca tactcaactc taacctgtgc tgcctgggag tgcaggatct ctttagtagt
     1021 ggcaaggctg atctctctgg catgtcagga tccagagatc ttttcgtatc aaaaattgtc
     1081 cacaagtcat ttgtggatgt taatgagcag ggaacagagg cagctgctgc cacaggaggc
     1141 attattcagg tgctctgcga gaagatgcct actccacagg aagtattcac tgtggatcac
     1201 ccattccttt tctttattcg gcacaacccc acagctaata tgatcttctt tggcagggtt
     1261 tgttccccat agaagaagga gactttagag atagaaggca gagcttagca tttcattccc
     1321 tgagattaat gatgattatt ccattagtcc ttgtcaataa aacctctata caaaacacaa
     1381 tcattctttc ttttgtatgt gtgtatgttt tgtatgtttc ttttgtatgt tggcttttta
     1441 tatccattgg catgggtatg tatatattgt ttttcccctg aaaaatctaa tttccactgt
     1501 caacagaatc acgtctaaaa gctaaagaat taaatagatg tatagattca tgactgtgag
     1561 gtaacctgtg caattgtaat aggctcctga taggcatgaa aatgtatggc ttttcccatt
     1621 caattgtttt ccaatttaga attagagtaa gaaaaaaaaa accaggacat aaaactgaca
     1681 attcataaag ccctaataaa attaatggtt gcaaaataaa aaaaaaaaa
//
