LOCUS       NM_025429               1931 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus serine (or cysteine) peptidase inhibitor, clade B,
            member 1a (Serpinb1a), mRNA.
ACCESSION   NM_025429
VERSION     NM_025429.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1931)
  AUTHORS   Dani,N., Herbst,R.H., McCabe,C., Green,G.S., Kaiser,K., Head,J.P.,
            Cui,J., Shipley,F.B., Jang,A., Dionne,D., Nguyen,L., Rodman,C.,
            Riesenfeld,S.J., Prochazka,J., Prochazkova,M., Sedlacek,R.,
            Zhang,F., Bryja,V., Rozenblatt-Rosen,O., Habib,N., Regev,A. and
            Lehtinen,M.K.
  TITLE     A cellular and spatial map of the choroid plexus across brain
            ventricles and ages
  JOURNAL   Cell 184 (11), 3056-3074 (2021)
   PUBMED   33932339
REFERENCE   2  (bases 1 to 1931)
  AUTHORS   Leborgne,N.G.F., Taddeo,A., Freigang,S. and Benarafa,C.
  TITLE     Serpinb1a Is Dispensable for the Development and Cytokine Response
            of Invariant Natural Killer T Cell Subsets
  JOURNAL   Front Immunol 11, 562587 (2020)
   PUBMED   33262755
  REMARK    GeneRIF: Serpinb1a Is Dispensable for the Development and Cytokine
            Response of Invariant Natural Killer T Cell Subsets.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1931)
  AUTHORS   Hou,L., Rao,D.A., Yuki,K., Cooley,J., Henderson,L.A., Jonsson,A.H.,
            Kaiserman,D., Gorman,M.P., Nigrovic,P.A., Bird,P.I., Becher,B. and
            Remold-O'Donnell,E.
  TITLE     SerpinB1 controls encephalitogenic T helper cells in
            neuroinflammation
  JOURNAL   Proc Natl Acad Sci U S A 116 (41), 20635-20643 (2019)
   PUBMED   31548399
REFERENCE   4  (bases 1 to 1931)
  AUTHORS   Burgener,S.S., Leborgne,N.G.F., Snipas,S.J., Salvesen,G.S.,
            Bird,P.I. and Benarafa,C.
  TITLE     Cathepsin G Inhibition by Serpinb1 and Serpinb6 Prevents Programmed
            Necrosis in Neutrophils and Monocytes and Reduces GSDMD-Driven
            Inflammation
  JOURNAL   Cell Rep 27 (12), 3646-3656 (2019)
   PUBMED   31216481
REFERENCE   5  (bases 1 to 1931)
  AUTHORS   Choi,Y.J., Kim,S., Choi,Y., Nielsen,T.B., Yan,J., Lu,A., Ruan,J.,
            Lee,H.R., Wu,H., Spellberg,B. and Jung,J.U.
  TITLE     SERPINB1-mediated checkpoint of inflammatory caspase activation
  JOURNAL   Nat Immunol 20 (3), 276-287 (2019)
   PUBMED   30692621
  REMARK    Erratum:[Nat Immunol. 2019 May;20(5):664. doi:
            10.1038/s41590-019-0361-x.. PMID: 30846880]
REFERENCE   6  (bases 1 to 1931)
  AUTHORS   Benarafa,C., Cooley,J., Zeng,W., Bird,P.I. and Remold-O'Donnell,E.
  TITLE     Characterization of four murine homologs of the human ov-serpin
            monocyte neutrophil elastase inhibitor MNEI (SERPINB1)
  JOURNAL   J Biol Chem 277 (44), 42028-42033 (2002)
   PUBMED   12189154
REFERENCE   7  (bases 1 to 1931)
  AUTHORS   Kaiserman,D., Knaggs,S., Scarff,K.L., Gillard,A., Mirza,G.,
            Cadman,M., McKeone,R., Denny,P., Cooley,J., Benarafa,C.,
            Remold-O'Donnell,E., Ragoussis,J. and Bird,P.I.
  TITLE     Comparison of human chromosome 6p25 with mouse chromosome 13
            reveals a greatly expanded ov-serpin gene repertoire in the mouse
  JOURNAL   Genomics 79 (3), 349-362 (2002)
   PUBMED   11863365
REFERENCE   8  (bases 1 to 1931)
  AUTHORS   Bleul,C.C. and Boehm,T.
  TITLE     Laser capture microdissection-based expression profiling identifies
            PD1-ligand as a target of the nude locus gene product
  JOURNAL   Eur J Immunol 31 (8), 2497-2503 (2001)
   PUBMED   11500834
REFERENCE   9  (bases 1 to 1931)
  AUTHORS   Shimada,H., Ichikawa,H., Nakamura,S., Katsu,R., Iwasa,M.,
            Kitabayashi,I. and Ohki,M.
  TITLE     Analysis of genes under the downstream control of the t(8;21)
            fusion protein AML1-MTG8: overexpression of the TIS11b (ERF-1,
            cMG1) gene induces myeloid cell proliferation in response to G-CSF
  JOURNAL   Blood 96 (2), 655-663 (2000)
   PUBMED   10887131
REFERENCE   10 (bases 1 to 1931)
  AUTHORS   Hara,T., Harada,N., Mitsui,H., Miura,T., Ishizaka,T. and
            Miyajima,A.
  TITLE     Characterization of cell phenotype by a novel cDNA library
            subtraction system: expression of CD8 alpha in a mast cell-derived
            interleukin-4-dependent cell line
  JOURNAL   Blood 84 (1), 189-199 (1994)
   PUBMED   8018917
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY266933.1, AK160167.1 and AI325983.1.
            
            On Sep 8, 2006 this sequence version replaced NM_025429.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK160167.1, AK004500.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 BY266933.1         1-5
            6-1915              AK160167.1         2-1911
            1916-1931           AI325983.1         1-16                c
FEATURES             Location/Qualifiers
     source          1..1931
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 13.75 cM"
     gene            1..1931
                     /gene="Serpinb1a"
                     /gene_synonym="1190005M04Rik; EI; EIA; ELANH2; LEI; M/NEI;
                     MNEI; PI2"
                     /note="serine (or cysteine) peptidase inhibitor, clade B,
                     member 1a"
                     /db_xref="GeneID:66222"
                     /db_xref="MGI:MGI:1913472"
     exon            1..44
                     /gene="Serpinb1a"
                     /gene_synonym="1190005M04Rik; EI; EIA; ELANH2; LEI; M/NEI;
                     MNEI; PI2"
                     /inference="alignment:Splign:2.1.0"
     exon            45..220
                     /gene="Serpinb1a"
                     /gene_synonym="1190005M04Rik; EI; EIA; ELANH2; LEI; M/NEI;
                     MNEI; PI2"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..1192
                     /gene="Serpinb1a"
                     /gene_synonym="1190005M04Rik; EI; EIA; ELANH2; LEI; M/NEI;
                     MNEI; PI2"
                     /note="serine (or cysteine) proteinase inhibitor, clade B
                     (ovalbumin), member 1a; serine (or cysteine) proteinase
                     inhibitor, clade B, member 1a; serpin B1a; serine protease
                     inhibitor EIA"
                     /codon_start=1
                     /product="leukocyte elastase inhibitor A"
                     /protein_id="NP_079705.2"
                     /db_xref="CCDS:CCDS26428.1"
                     /db_xref="GeneID:66222"
                     /db_xref="MGI:MGI:1913472"
                     /translation="MEQLSSANTLFALELFQTLNESSPTGNIFFSPFSISSALAMVIL
                     GAKGSTAAQLSKTFHFDSVEDIHSRFQSLNAEVSKRGASHTLKLANRLYGEKTYNFLP
                     EYLASTQKMYGADLAPVDFLHASEDARKEINQWVKGQTEGKIPELLSVGVVDSMTKLV
                     LVNAIYFKGMWEEKFMTEDTTDAPFRLSKKDTKTVKMMYQKKKFPFGYISDLKCKVLE
                     MPYQGGELSMVILLPKDIEDESTGLKKIEKQITLEKLLEWTKRENLEFIDVHVKLPRF
                     KIEESYTLNSNLGRLGVQDLFSSSKADLSGMSGSRDLFISKIVHKSFVEVNEEGTEAA
                     AATGGIATFCMLLPEEEFTVDHPFIFFIRHNPTSNVLFLGRVCSP"
     exon            221..358
                     /gene="Serpinb1a"
                     /gene_synonym="1190005M04Rik; EI; EIA; ELANH2; LEI; M/NEI;
                     MNEI; PI2"
                     /inference="alignment:Splign:2.1.0"
     exon            359..476
                     /gene="Serpinb1a"
                     /gene_synonym="1190005M04Rik; EI; EIA; ELANH2; LEI; M/NEI;
                     MNEI; PI2"
                     /inference="alignment:Splign:2.1.0"
     exon            477..619
                     /gene="Serpinb1a"
                     /gene_synonym="1190005M04Rik; EI; EIA; ELANH2; LEI; M/NEI;
                     MNEI; PI2"
                     /inference="alignment:Splign:2.1.0"
     exon            620..787
                     /gene="Serpinb1a"
                     /gene_synonym="1190005M04Rik; EI; EIA; ELANH2; LEI; M/NEI;
                     MNEI; PI2"
                     /inference="alignment:Splign:2.1.0"
     exon            788..1918
                     /gene="Serpinb1a"
                     /gene_synonym="1190005M04Rik; EI; EIA; ELANH2; LEI; M/NEI;
                     MNEI; PI2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1279..1284
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Serpinb1a"
                     /gene_synonym="1190005M04Rik; EI; EIA; ELANH2; LEI; M/NEI;
                     MNEI; PI2"
                     /note="hexamer: AATAAA"
     polyA_site      1299
                     /gene="Serpinb1a"
                     /gene_synonym="1190005M04Rik; EI; EIA; ELANH2; LEI; M/NEI;
                     MNEI; PI2"
                     /note="major polyA site"
     regulatory      1860..1865
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Serpinb1a"
                     /gene_synonym="1190005M04Rik; EI; EIA; ELANH2; LEI; M/NEI;
                     MNEI; PI2"
                     /note="hexamer: AATAAA"
     polyA_site      1887
                     /gene="Serpinb1a"
                     /gene_synonym="1190005M04Rik; EI; EIA; ELANH2; LEI; M/NEI;
                     MNEI; PI2"
     regulatory      1889..1894
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Serpinb1a"
                     /gene_synonym="1190005M04Rik; EI; EIA; ELANH2; LEI; M/NEI;
                     MNEI; PI2"
                     /note="hexamer: AATAAA"
     polyA_site      1918
                     /gene="Serpinb1a"
                     /gene_synonym="1190005M04Rik; EI; EIA; ELANH2; LEI; M/NEI;
                     MNEI; PI2"
ORIGIN      
        1 acttcatcct agctgtaagt ggagccagac ctgctaagca agagacttca ccatggagca
       61 gctgagttca gccaacaccc tcttcgcctt ggagctgttc caaaccctga atgaaagcag
      121 ccccacagga aacatcttct tctctccctt cagcatttct tctgccttgg ccatggtcat
      181 tctgggggcc aaaggcagca ctgcagctca gctttctaag acttttcatt ttgactctgt
      241 tgaggacatc cattcacgct tccaaagcct gaatgctgaa gtgagcaaac gtggagcatc
      301 tcacactctg aaacttgcta acagactgta tggagagaaa acctacaact tccttcctga
      361 atacttggct tcaacccaga aaatgtatgg tgctgacttg gcccctgtgg attttctgca
      421 tgcctctgag gatgcaagga aggagataaa ccagtgggtc aaaggtcaaa cagaagggaa
      481 aatcccagaa ctgttgtctg tgggtgtggt ggacagtatg accaaacttg tgctggtgaa
      541 tgccatctac tttaagggaa tgtgggagga gaaattcatg acagaggaca caacggatgc
      601 tccattccga ctgagtaaga aagacacaaa aacagtgaag atgatgtatc aaaagaaaaa
      661 atttccattt ggttacattt cggacctgaa gtgcaaggtg ctggagatgc cttaccaggg
      721 tggagaactt agcatggtca ttctgctgcc taaagacatt gaggacgagt ccacgggtct
      781 taagaagatt gaaaagcaaa taactttgga aaaactgctt gaatggacca aacgtgagaa
      841 cttggaattc attgatgtcc acgtcaaact gccccggttc aagatagaag agagctatac
      901 cctcaactct aacctgggcc gcctgggagt gcaggatctc tttagcagta gcaaggctga
      961 tctctctggc atgtcaggat ccagagatct tttcatatca aaaattgtcc acaagtcctt
     1021 tgtggaagtg aatgaggaag gaacagaggc agccgctgct acaggaggca ttgctacatt
     1081 ctgtatgttg ttgcctgagg aagaattcac agtggaccat ccgttcattt tcttcattcg
     1141 gcacaatccc acatctaatg tgctcttcct tggcagggtt tgttccccat agaagaagga
     1201 gactttacag atacaaggca gagcttagag tttcattccc tgagatttta atagtgatta
     1261 ttttcatttg tacttgacaa taaaaactct aaccagaaac caatctttct tttgtatgtt
     1321 caaccctgtt agctctttat atccatgact tttggcatgg gtatgtctat tttgattgta
     1381 caatgaaagc aggactcctg ttttcctcct cggcttttgc atgacctcca gagtacatca
     1441 aaggttcata gctaggctga aaattctgga cgactccatc ctcaaacttt atggactgta
     1501 ggtgggtgcc tgcagatgct aactgaagtc atatccatct ggggtagcgt ggataccctt
     1561 aagcctcaaa tcattattac aatctgcttt tcaagtacaa catccagagt ataatcaaag
     1621 ataactgttt gggtgggcag ccatggcaac agagatacaa agcagcacaa acaaaagaga
     1681 aggacaacag tggaaggctc taaatgctgc tgccgcccat acaaaccaga gaacaacagt
     1741 ctgtgaagat aatattgacg aaatccaagg tcagatactt tagcaggcta ttgcaaactt
     1801 acaaacaaca tttcatgtct ggatgaaaag gaactagaaa ccccagagct taaacataca
     1861 ataaattatt tccattgaaa acttaaataa taaagaattt gtggattttt aagtctgaaa
     1921 aaaaaaaaaa a
//
