LOCUS       NM_172852               1607 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus serine (or cysteine) peptidase inhibitor, clade B
            (ovalbumin), member 13 (Serpinb13), mRNA.
ACCESSION   NM_172852
VERSION     NM_172852.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1607)
  AUTHORS   Lo,C.W., Kryvalap,Y., Sheu,T.J., Chang,C.H. and Czyzyk,J.
  TITLE     Cellular proliferation in mouse and human pancreatic islets is
            regulated by serpin B13 inhibition and downstream targeting of
            E-cadherin by cathepsin L
  JOURNAL   Diabetologia 62 (5), 822-834 (2019)
   PUBMED   30824970
  REMARK    GeneRIF: serpin B13 inhibition and downstream targeting of
            E-cadherin by cathepsin L regulates cell proliferation in mouse and
            human pancreatic islets
REFERENCE   2  (bases 1 to 1607)
  AUTHORS   Heit,C., Jackson,B.C., McAndrews,M., Wright,M.W., Thompson,D.C.,
            Silverman,G.A., Nebert,D.W. and Vasiliou,V.
  TITLE     Update of the human and mouse SERPIN gene superfamily
  JOURNAL   Hum Genomics 7 (1), 22 (2013)
   PUBMED   24172014
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1607)
  AUTHORS   Czyzyk,J., Henegariu,O., Preston-Hurlburt,P., Baldzizhar,R.,
            Fedorchuk,C., Esplugues,E., Bottomly,K., Gorus,F.K., Herold,K. and
            Flavell,R.A.
  TITLE     Enhanced anti-serpin antibody activity inhibits autoimmune
            inflammation in type 1 diabetes
  JOURNAL   J Immunol 188 (12), 6319-6327 (2012)
   PUBMED   22593614
  REMARK    GeneRIF: clade B serpins help to maintain homeostasis by inducing
            protective humoral immunity
REFERENCE   4  (bases 1 to 1607)
  AUTHORS   Walz,M., Kellermann,S., Bylaite,M., Andree,B., Ruther,U., Paus,R.,
            Kloepper,J.E., Reifenberger,J. and Ruzicka,T.
  TITLE     Expression of the human Cathepsin L inhibitor hurpin in mice: skin
            alterations and increased carcinogenesis
  JOURNAL   Exp Dermatol 16 (9), 715-723 (2007)
   PUBMED   17697143
  REMARK    GeneRIF: results suggest an important role of Cat L regulation by
            hurpin which might be of clinical relevance in human skin diseases
REFERENCE   5  (bases 1 to 1607)
  AUTHORS   Askew,D.J., Askew,Y.S., Kato,Y., Turner,R.F., Dewar,K., Lehoczky,J.
            and Silverman,G.A.
  TITLE     Comparative genomic analysis of the clade B serpin cluster at human
            chromosome 18q21: amplification within the mouse squamous cell
            carcinoma antigen gene locus
  JOURNAL   Genomics 84 (1), 176-184 (2004)
   PUBMED   15203215
REFERENCE   6  (bases 1 to 1607)
  AUTHORS   Silverman,G.A., Whisstock,J.C., Askew,D.J., Pak,S.C., Luke,C.J.,
            Cataltepe,S., Irving,J.A. and Bird,P.I.
  TITLE     Human clade B serpins (ov-serpins) belong to a cohort of
            evolutionarily dispersed intracellular proteinase inhibitor clades
            that protect cells from promiscuous proteolysis
  JOURNAL   Cell Mol Life Sci 61 (3), 301-325 (2004)
   PUBMED   14770295
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK030670.1 and BC117990.1.
            
            On May 9, 2009 this sequence version replaced NM_172852.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK030670.1, BC117990.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN00849375
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-946               AK030670.1         3-948
            947-1310            BC117990.1         937-1300
            1311-1607           AK030670.1         1313-1609
FEATURES             Location/Qualifiers
     source          1..1607
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 50.34 cM"
     gene            1..1607
                     /gene="Serpinb13"
                     /gene_synonym="5430417G24; headpin; HUR7; HURPIN; PI13"
                     /note="serine (or cysteine) peptidase inhibitor, clade B
                     (ovalbumin), member 13"
                     /db_xref="GeneID:241196"
                     /db_xref="MGI:MGI:3042250"
     exon            1..46
                     /gene="Serpinb13"
                     /gene_synonym="5430417G24; headpin; HUR7; HURPIN; PI13"
                     /inference="alignment:Splign:2.1.0"
     exon            47..228
                     /gene="Serpinb13"
                     /gene_synonym="5430417G24; headpin; HUR7; HURPIN; PI13"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..1233
                     /gene="Serpinb13"
                     /gene_synonym="5430417G24; headpin; HUR7; HURPIN; PI13"
                     /note="serine (or cysteine) proteinase inhibitor, clade B
                     (ovalbumin), member 13"
                     /codon_start=1
                     /product="serpin B13"
                     /protein_id="NP_766440.2"
                     /db_xref="CCDS:CCDS15213.1"
                     /db_xref="GeneID:241196"
                     /db_xref="MGI:MGI:3042250"
                     /translation="MDSLGTAATQFLFDLFKELNKTNDGNVFFSPVGISTAIGMIILG
                     TRGATASELQKVLYTEQGTESSRIKSEEEEIEKREEIHHQLQMLLTEISKFSNDYDLI
                     ISNRLFGEKTYLFLQKYIDYVEKYYHASLEPVDFVNAADESRKKINSWVESQTNVKVK
                     DLFPEGSLNSSTKLVLINTVYFKGLWDREFKKEHTKEEDFWLNKNLSKPVQMMALCSS
                     FNFTFLEDLQAKIVGIPYKNNDISMFVLLPNDIDGLEKIMDKMSPEKLVEWTSPGHLE
                     QRRVDLRLPRLQVEETYDLEPVLEAVGIHSAFSEHADYSGMSARSGLHAQNFLHRSFL
                     VVTEEGVEATAGTGVGLKVSSAASCELVHCNHPFLFFIRHRESDSILFFGKFSSP"
     exon            229..285
                     /gene="Serpinb13"
                     /gene_synonym="5430417G24; headpin; HUR7; HURPIN; PI13"
                     /inference="alignment:Splign:2.1.0"
     exon            286..414
                     /gene="Serpinb13"
                     /gene_synonym="5430417G24; headpin; HUR7; HURPIN; PI13"
                     /inference="alignment:Splign:2.1.0"
     exon            415..532
                     /gene="Serpinb13"
                     /gene_synonym="5430417G24; headpin; HUR7; HURPIN; PI13"
                     /inference="alignment:Splign:2.1.0"
     exon            533..675
                     /gene="Serpinb13"
                     /gene_synonym="5430417G24; headpin; HUR7; HURPIN; PI13"
                     /inference="alignment:Splign:2.1.0"
     exon            676..831
                     /gene="Serpinb13"
                     /gene_synonym="5430417G24; headpin; HUR7; HURPIN; PI13"
                     /inference="alignment:Splign:2.1.0"
     exon            832..1607
                     /gene="Serpinb13"
                     /gene_synonym="5430417G24; headpin; HUR7; HURPIN; PI13"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tagattccta gtctctgtcc agccactgct gtctcttcag agccagatta cttggaaaca
       61 atcatggact cactaggcac agcagccaca cagttcctgt ttgatctttt caaagaactg
      121 aataaaacaa atgatggcaa cgtcttcttt tcccctgtgg gcatctcaac agccattggc
      181 atgatcatcc tggggacccg aggagccact gcttctgagt tacagaaggt actttacact
      241 gaacaaggca cagaaagctc gagaattaag tctgaagaag aagagatcga gaagagagaa
      301 gaaatacatc atcaactcca aatgctgttg actgaaataa gcaaattttc taacgattat
      361 gacctgatca taagcaacag gctgttcgga gaaaaaacat acctcttcct tcaaaaatac
      421 atagattatg ttgaaaaata ttaccatgca tctctggagc ctgttgattt tgtaaatgct
      481 gcagacgaaa gtcgaaagaa gattaattcc tgggttgaaa gccaaacaaa tgtaaaagtc
      541 aaggacctgt ttccagaagg ctctttgaac agctccacca agctggtgct aataaataca
      601 gtttatttta aaggcctgtg ggacagagaa tttaagaaag aacacaccaa ggaggaggac
      661 ttctggctga ataagaacct aagtaaacct gtgcagatga tggctctgtg cagctccttc
      721 aacttcacct tcttagagga cctgcaggcg aaaattgtgg ggattccata taaaaacaac
      781 gatatcagca tgtttgtgct tctgcccaat gacatagatg gtctggagaa gataatggat
      841 aaaatgtctc ctgagaagtt ggtggagtgg accagccccg gacacctgga gcaaaggagg
      901 gtggacctgc gcctgccccg cttgcaggtg gaggagacct atgatctgga acccgtgctg
      961 gaagctgtgg gcattcacag tgccttcagc gagcatgcgg actactcagg aatgtcggcg
     1021 cgctctgggc tgcatgccca gaatttcctg cacagatcgt tcctggtggt gacagaggaa
     1081 ggcgttgagg ccactgcagg cactggagtg ggcctcaagg tctcgtcagc tgcaagctgt
     1141 gagcttgtgc actgtaacca tccattcttg ttcttcatca gacacagaga gtctgacagc
     1201 attctctttt tcggcaagtt ttcttctccc taagatagtc aaactgaaac attagagcac
     1261 taagtagcac tcaagagttg acagaccatg gggttcatat ttgtgcttca aagtcctttg
     1321 cacaatggta gcaatagcac gttttcttaa tctgtttaaa agttaatctc aatcatgtgt
     1381 gcactactca ggaggccagg cagcttaaga tcagttctta tcttgttttc cttcaaaagt
     1441 tgtcatgccc tgagggagga ggtttttttg ttttgttttt tgttttttgt ttttgttttt
     1501 gattttgttt ttaaaatgaa gagttatgga agactttagg attcattcac ttctattatc
     1561 ttggcattct gtaaggcata gtaaaataaa acaaccattt actagct
//
