LOCUS       NM_027971               1689 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus serine (or cysteine) peptidase inhibitor, clade B
            (ovalbumin), member 12 (Serpinb12), transcript variant 1, mRNA.
ACCESSION   NM_027971 XM_910796
VERSION     NM_027971.4
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1689)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1689)
  AUTHORS   Kumar,V., Bouameur,J.E., Bar,J., Rice,R.H., Hornig-Do,H.T.,
            Roop,D.R., Schwarz,N., Brodesser,S., Thiering,S., Leube,R.E.,
            Wiesner,R.J., Vijayaraj,P., Brazel,C.B., Heller,S., Binder,H.,
            Loffler-Wirth,H., Seibel,P. and Magin,T.M.
  TITLE     A keratin scaffold regulates epidermal barrier formation,
            mitochondrial lipid composition, and activity
  JOURNAL   J Cell Biol 211 (5), 1057-1075 (2015)
   PUBMED   26644517
  REMARK    Erratum:[J Cell Biol. 2016 Mar 28;212(7):877. doi:
            10.1083/jcb.20140414703042016c.. PMID: 27002167]
REFERENCE   3  (bases 1 to 1689)
  AUTHORS   Niehaus,J.Z., Good,M., Jackson,L.E., Ozolek,J.A., Silverman,G.A.
            and Luke,C.J.
  TITLE     Human SERPINB12 Is an Abundant Intracellular Serpin Expressed in
            Most Surface and Glandular Epithelia
  JOURNAL   J Histochem Cytochem 63 (11), 854-865 (2015)
   PUBMED   26220980
  REMARK    GeneRIF: data suggest that SERPINB12, like some other intracellular
            serpins, may play a vital role in barrier function by providing
            protection of epithelial cells.
REFERENCE   4  (bases 1 to 1689)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 1689)
  AUTHORS   Heit,C., Jackson,B.C., McAndrews,M., Wright,M.W., Thompson,D.C.,
            Silverman,G.A., Nebert,D.W. and Vasiliou,V.
  TITLE     Update of the human and mouse SERPIN gene superfamily
  JOURNAL   Hum Genomics 7 (1), 22 (2013)
   PUBMED   24172014
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1689)
  AUTHORS   Nagamachi,A., Matsui,H., Asou,H., Ozaki,Y., Aki,D., Kanai,A.,
            Takubo,K., Suda,T., Nakamura,T., Wolff,L., Honda,H. and Inaba,T.
  TITLE     Haploinsufficiency of SAMD9L, an endosome fusion facilitator,
            causes myeloid malignancies in mice mimicking human diseases with
            monosomy 7
  JOURNAL   Cancer Cell 24 (3), 305-317 (2013)
   PUBMED   24029230
REFERENCE   7  (bases 1 to 1689)
  AUTHORS   Askew,D.J., Askew,Y.S., Kato,Y., Turner,R.F., Dewar,K., Lehoczky,J.
            and Silverman,G.A.
  TITLE     Comparative genomic analysis of the clade B serpin cluster at human
            chromosome 18q21: amplification within the mouse squamous cell
            carcinoma antigen gene locus
  JOURNAL   Genomics 84 (1), 176-184 (2004)
   PUBMED   15203215
REFERENCE   8  (bases 1 to 1689)
  AUTHORS   Silverman,G.A., Whisstock,J.C., Askew,D.J., Pak,S.C., Luke,C.J.,
            Cataltepe,S., Irving,J.A. and Bird,P.I.
  TITLE     Human clade B serpins (ov-serpins) belong to a cohort of
            evolutionarily dispersed intracellular proteinase inhibitor clades
            that protect cells from promiscuous proteolysis
  JOURNAL   Cell Mol Life Sci 61 (3), 301-325 (2004)
   PUBMED   14770295
  REMARK    Review article
REFERENCE   9  (bases 1 to 1689)
  AUTHORS   Askew,Y.S., Pak,S.C., Luke,C.J., Askew,D.J., Cataltepe,S.,
            Mills,D.R., Kato,H., Lehoczky,J., Dewar,K., Birren,B. and
            Silverman,G.A.
  TITLE     SERPINB12 is a novel member of the human ov-serpin family that is
            widely expressed and inhibits trypsin-like serine proteinases
  JOURNAL   J Biol Chem 276 (52), 49320-49330 (2001)
   PUBMED   11604408
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163626.5.
            
            On Mar 27, 2023 this sequence version replaced NM_027971.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK009018.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-116               AC163626.5         128043-128158
            117-302             AC163626.5         140123-140308
            303-434             AC163626.5         142718-142849
            435-572             AC163626.5         143156-143293
            573-690             AC163626.5         144296-144413
            691-833             AC163626.5         147285-147427
            834-1001            AC163626.5         148916-149083
            1002-1689           AC163626.5         149987-150674
FEATURES             Location/Qualifiers
     source          1..1689
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 50.34 cM"
     gene            1..1689
                     /gene="Serpinb12"
                     /gene_synonym="2300003F07Rik; 4833409F13Rik"
                     /note="serine (or cysteine) peptidase inhibitor, clade B
                     (ovalbumin), member 12"
                     /db_xref="GeneID:71869"
                     /db_xref="MGI:MGI:1919119"
     exon            1..116
                     /gene="Serpinb12"
                     /gene_synonym="2300003F07Rik; 4833409F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            117..302
                     /gene="Serpinb12"
                     /gene_synonym="2300003F07Rik; 4833409F13Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..1406
                     /gene="Serpinb12"
                     /gene_synonym="2300003F07Rik; 4833409F13Rik"
                     /note="serine (or cysteine) proteinase inhibitor, clade B
                     (ovalbumin), member 12"
                     /codon_start=1
                     /product="serpin B12"
                     /protein_id="NP_082247.1"
                     /db_xref="CCDS:CCDS15212.1"
                     /db_xref="GeneID:71869"
                     /db_xref="MGI:MGI:1919119"
                     /translation="MDSLTAANNKFCFDFFREISKDDAHKNIFVCPLSLSAAFGMVRL
                     GARGDSAHQIDEALHFNELSKDEHKEPNDPSPQSESKASDSSLEGQKQTSASQDQQGE
                     STNDHQLLGCHFGKLLSRIDRDKSYYTLSMANRLYGEQEFPICSEYSDDVTEFFHTTV
                     ESVDFQKDSEKSRQEINFWVESQSQGKIKELFGKEAIDNSTVLVLVNAVYFKAKWERE
                     FNSENTVDASFCLNENEKKTVKMMNQKGKFRIGFIDELQAQILEMKYAMGKLSMLVLL
                     PSCSEDNVNSLQELEKKINHEKLLAWSSSENLSEKPVAISFPQFNLEDSYDLKSILQD
                     MGIKDVFDETKADLTGISKSPNLYLSKIVHKTFVEVDEMGTQAAAASGVVAAEKALPS
                     WVEFNANHPFLFFIRHNPTQSLLFCGRVYCP"
     exon            303..434
                     /gene="Serpinb12"
                     /gene_synonym="2300003F07Rik; 4833409F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            435..572
                     /gene="Serpinb12"
                     /gene_synonym="2300003F07Rik; 4833409F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            573..690
                     /gene="Serpinb12"
                     /gene_synonym="2300003F07Rik; 4833409F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            691..833
                     /gene="Serpinb12"
                     /gene_synonym="2300003F07Rik; 4833409F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            834..1001
                     /gene="Serpinb12"
                     /gene_synonym="2300003F07Rik; 4833409F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1689
                     /gene="Serpinb12"
                     /gene_synonym="2300003F07Rik; 4833409F13Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acctctcctt accagtctct gcaggctgta gaacttggct gttcttacct tgaggtattg
       61 aattgacttc atcagagctt ggacttcagt tggagacggg cctcactagg ttgcagacag
      121 taaccagttt tacaatggac tctcttactg cagcaaataa taaattttgc ttcgattttt
      181 tccgagagat tagcaaagat gatgctcata aaaatatctt cgtctgccct ctgagtctct
      241 cagctgcctt tggcatggtc cgcctgggag ctcgagggga cagtgcacat cagattgatg
      301 aggcattaca tttcaatgaa ctttctaagg atgaacacaa agaacccaat gatccctctc
      361 cacaaagtga aagcaaagct tctgacagct ctctggaagg gcagaaacaa acatcagctt
      421 ctcaggatca gcagggtgaa tctacaaatg accatcaatt gcttggctgc cactttggga
      481 aacttctctc cagaatagac agagacaaat cttattacac tttaagtatg gccaacagac
      541 tctatggaga gcaggaattt ccaatctgct cagaatactc tgatgacgta acggaatttt
      601 tccacacaac agtcgaaagt gtagatttcc agaaggattc tgagaaatca agacaagaga
      661 ttaacttctg ggttgaaagt caaagccaag gtaaaatcaa ggaactgttt ggcaaggagg
      721 ctattgataa ctcaactgtg ctggtgctgg tgaatgctgt ttacttcaag gccaagtggg
      781 agagagaatt caactctgaa aacaccgttg atgcatcttt ctgtctcaat gagaacgaga
      841 agaagactgt aaagatgatg aatcagaagg gtaagtttag aattggcttt atcgacgagc
      901 tgcaggcaca gatcctggaa atgaagtatg ccatggggaa gctcagcatg ctggtcctgc
      961 ttccatcttg ctcagaagac aatgtgaata gcctgcaaga gcttgaaaag aaaataaatc
     1021 atgaaaaact actggcctgg agtagctcag aaaatttgtc agaaaaacct gtagctattt
     1081 cctttcccca gttcaacctg gaagatagct atgatctcaa gtcgattcta caggacatgg
     1141 gcatcaagga tgtctttgat gaaacgaagg ctgaccttac tggaatctct aagagtccca
     1201 atctgtattt gtccaaaatt gtccacaaga cctttgtgga ggtggatgag atgggtaccc
     1261 aggcagctgc agccagtggg gttgtggctg cagagaaggc ccttccatct tgggtggagt
     1321 ttaatgccaa ccaccctttc ctctttttta tccgtcacaa tccaacccag agtttacttt
     1381 tctgtggcag agtctattgc ccttgaatct actctggctt ttgaggggtt tagaagaatg
     1441 gcaatatggt tttctcctta caaaacatgg gcatttgtgt ttggctgagt gcctgaagct
     1501 gaccacctgc tgctacagtt gttcacggaa tcccacaagc ctcccttgag tttggttctg
     1561 ataacctctg tcaccagaag ccagatctca ctacctatca atgaagcagc cttgctttct
     1621 ccctaatctt tattgctcta aactttcaag catataaatt caccttctat gatttgaagg
     1681 tcaacacaa
//
