LOCUS       NM_198028               3490 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus serine (or cysteine) peptidase inhibitor, clade B
            (ovalbumin), member 10 (Serpinb10), transcript variant 1, mRNA.
ACCESSION   NM_198028
VERSION     NM_198028.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3490)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3490)
  AUTHORS   Mo,Y., Ye,L., Cai,H., Zhu,G., Wang,J., Zhu,M., Song,X., Yang,C. and
            Jin,M.
  TITLE     SERPINB10 contributes to asthma by inhibiting the apoptosis of
            allergenic Th2 cells
  JOURNAL   Respir Res 22 (1), 178 (2021)
   PUBMED   34126986
  REMARK    GeneRIF: SERPINB10 contributes to asthma by inhibiting the
            apoptosis of allergenic Th2 cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3490)
  AUTHORS   Mo,Y., Zhang,K., Feng,Y., Yi,L., Liang,Y., Wu,W., Zhao,J.,
            Zhang,Z., Xu,Y., Hu,Q., He,J. and Zhen,G.
  TITLE     Epithelial SERPINB10, a novel marker of airway eosinophilia in
            asthma, contributes to allergic airway inflammation
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 316 (1), L245-L254 (2019)
   PUBMED   30382768
  REMARK    GeneRIF: Epithelial SERPINB10 contributes to allergic airway
            eosinophilic inflammation, at least in part, by regulating the
            expression of periostin and CCL26.
REFERENCE   4  (bases 1 to 3490)
  AUTHORS   Heit,C., Jackson,B.C., McAndrews,M., Wright,M.W., Thompson,D.C.,
            Silverman,G.A., Nebert,D.W. and Vasiliou,V.
  TITLE     Update of the human and mouse SERPIN gene superfamily
  JOURNAL   Hum Genomics 7 (1), 22 (2013)
   PUBMED   24172014
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3490)
  AUTHORS   Askew,D.J., Askew,Y.S., Kato,Y., Turner,R.F., Dewar,K., Lehoczky,J.
            and Silverman,G.A.
  TITLE     Comparative genomic analysis of the clade B serpin cluster at human
            chromosome 18q21: amplification within the mouse squamous cell
            carcinoma antigen gene locus
  JOURNAL   Genomics 84 (1), 176-184 (2004)
   PUBMED   15203215
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK052580.1, AK036537.1 and AC148982.4.
            
            On May 19, 2009 this sequence version replaced NM_198028.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK036537.1, BC069938.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                AK052580.1         2-25
            25-2808             AK036537.1         3-2786
            2809-3172           AC148982.4         20498-20861         c
            3173-3490           AK036537.1         3151-3468
FEATURES             Location/Qualifiers
     source          1..3490
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 50.34 cM"
     gene            1..3490
                     /gene="Serpinb10"
                     /gene_synonym="9830131G07; Serpinb10-ps"
                     /note="serine (or cysteine) peptidase inhibitor, clade B
                     (ovalbumin), member 10"
                     /db_xref="GeneID:241197"
                     /db_xref="MGI:MGI:2138648"
     exon            1..89
                     /gene="Serpinb10"
                     /gene_synonym="9830131G07; Serpinb10-ps"
                     /inference="alignment:Splign:2.1.0"
     exon            90..265
                     /gene="Serpinb10"
                     /gene_synonym="9830131G07; Serpinb10-ps"
                     /inference="alignment:Splign:2.1.0"
     CDS             218..1291
                     /gene="Serpinb10"
                     /gene_synonym="9830131G07; Serpinb10-ps"
                     /note="isoform 1 is encoded by transcript variant 1;
                     serine (or cysteine) proteinase inhibitor, clade B
                     (ovalbumin), member 10; serpin B10; serine (or cysteine)
                     peptidase inhibitor, clade B (ovalbumin), member 10,
                     pseudogene"
                     /codon_start=1
                     /product="serpin B10 isoform 1"
                     /protein_id="NP_932145.3"
                     /db_xref="GeneID:241197"
                     /db_xref="MGI:MGI:2138648"
                     /translation="MVYLGTKGTTADQMAQVLQFSSVEDFKSCPDSEKKRKMEFNSGK
                     FEEIQSDFQTLAAEILKPGNSYVLKTANRIYGEKTYPFHNKYLEDMKTYFGAEPQSVN
                     FVEASGQIRKEINSWVGSQTGGKIPNLLPDDSVDTKTKMVLVNALYFKGTWEHQFSVK
                     STTERPFRVNKTTSKPVQMMSMKQSLQVFHIEELQTIGLQLHYQNRDLSLLLLLPEAI
                     DGLEQLERAITYEKLDKWTSADMMDTYEVQLYLPKFKMEESYDLKSALRGMGMTDVFS
                     QSKADFSNMTSERNLFLSNVFHKTFLEINEEGTEAAAGTGSEISVRIKAPSIELNVDH
                     PFLFFIRHNKTKSILFCGRFCSP"
     exon            266..331
                     /gene="Serpinb10"
                     /gene_synonym="9830131G07; Serpinb10-ps"
                     /inference="alignment:Splign:2.1.0"
     exon            332..469
                     /gene="Serpinb10"
                     /gene_synonym="9830131G07; Serpinb10-ps"
                     /inference="alignment:Splign:2.1.0"
     exon            470..587
                     /gene="Serpinb10"
                     /gene_synonym="9830131G07; Serpinb10-ps"
                     /inference="alignment:Splign:2.1.0"
     exon            588..730
                     /gene="Serpinb10"
                     /gene_synonym="9830131G07; Serpinb10-ps"
                     /inference="alignment:Splign:2.1.0"
     exon            731..886
                     /gene="Serpinb10"
                     /gene_synonym="9830131G07; Serpinb10-ps"
                     /inference="alignment:Splign:2.1.0"
     exon            887..3490
                     /gene="Serpinb10"
                     /gene_synonym="9830131G07; Serpinb10-ps"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1431..1436
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Serpinb10"
                     /gene_synonym="9830131G07; Serpinb10-ps"
                     /note="hexamer: AATGAA"
     polyA_site      1447
                     /gene="Serpinb10"
                     /gene_synonym="9830131G07; Serpinb10-ps"
                     /note="major polyA site"
ORIGIN      
        1 ttcttcagtt aaaagttacc taacttttca gccacagtct tttcctaaaa gcacaatttg
       61 tcaagtttgc tccaggagag gaaaataagg ttgcccaatg gcctcactag cagtatctat
      121 caaccagttt gctctggagt ttagcaaaaa gctagcttag tctgctgagg gtagaaacat
      181 cttcttttcc ccctggggca tctcaactgc tttggctatg gtatatttgg gtaccaaagg
      241 gactactgca gaccagatgg cccaggtact tcaatttagc agtgttgaag acttcaaatc
      301 ttgtcctgat agtgaaaaga aaaggaaaat ggaatttaac tcaggcaaat ttgaagaaat
      361 acagtccgac ttccagaccc ttgctgctga aatcctcaaa cctggaaatt cttacgttct
      421 taaaacagct aacaggatat atggagagaa aacatatcca tttcataata aatatttgga
      481 ggacatgaaa acgtactttg gggcagaacc acaatctgtt aactttgttg aagcttctgg
      541 acagatcagg aaggagatca actcctgggt tggaagccag actggaggta aaattccaaa
      601 tctcctccca gatgactcag tcgacaccaa gactaaaatg gttctggtga atgcccttta
      661 ttttaaagga acctgggagc atcagttctc agtgaaaagc accaccgaaa ggcctttcag
      721 agtaaacaag accacaagca aaccagtgca aatgatgtca atgaaacaga gtcttcaagt
      781 cttccacatt gaggagctgc aaaccatagg ccttcaactc cactatcaga accgtgacct
      841 cagcctgctt ctactgcttc cagaagcaat agatggcctg gaacagctgg agagagccat
      901 tacctatgag aaactagata agtggaccag tgcagacatg atggacacat acgaagtgca
      961 gctgtacctc cccaagttca agatggagga gagttatgac ctcaagtcag ccctgagagg
     1021 tatgggaatg accgacgttt tcagccagag taaagctgat ttctcaaaca tgacttcaga
     1081 gagaaatcta tttttgtcca atgttttcca taagactttt ctggaaataa atgaagaagg
     1141 tacagaagct gcagctggca ctggaagtga aatcagtgtt cgaattaagg caccttccat
     1201 tgaattaaat gtagatcatc catttctatt tttcatcagg cacaacaaaa ccaaaagcat
     1261 tcttttttgt ggaagattct gctcccccta aactctgcat ctctcattta atgaaaacat
     1321 tttatagtat aaaacaaaca aacacacaaa aacccatatt atgagacgga aaatcagaca
     1381 tcacaaaatc agcccatagc ctatacacat ttcatgcttg tatattaata aatgaacctt
     1441 cagagaatgt gttcttgtga tcctctcaag tatatctgtt tgtttgttta catatttatt
     1501 tatttattac catcgtgcat accattttgt tttagggtga attttattta tgttgcaaaa
     1561 gtgatgtttg taaataccag agcttactta ctgacccagg atctccagat gtggttgatg
     1621 acaatgaaaa ccaggccatg ttggaggtgt ctcagcaaga ctgaggtgga agcaaattta
     1681 tcaaaagcaa tcacactttt tatatcctta tcagaaaatg aatacaatag tgatttccag
     1741 taagaataca attgtagttg tctggataca ataattttta caagctatgt gggtatacca
     1801 gattaatgtc taagactaat tgttcttcca aacttctata tactttgatg atttttgggg
     1861 aatgcagaga tatatgaggt tggggaggtg ggtttggaat gtttcactgc ccgagggagt
     1921 gcctcagttc tcaggaactg aaaggtatat agtgcccctg agaaacctgt gacacatacc
     1981 tcttaaggct gctggaccag gccatcttca tgactccttg cagtccccta gtttttgttt
     2041 gtttatttgt ttgtttttta attttaaggc atgaaagtca ttcttcaaaa caaatatgga
     2101 gtaggaaaac aacctcaata gtcaatctca aggcaataat ggctcccaat acaatcaaca
     2161 acaaaattcc cagagacact cctagtgact acaatttaga agtccaaaaa ataaagacca
     2221 aaaccctttg gtagactttt cataggatta gaggaggata attcatttaa ctttgaattt
     2281 atattttatc catatgtata aatgtaaata aatttatttg tatttatatc attctatttt
     2341 tttattcaag gcctgaacag caatactcaa attgtcatgt gaccagcttt gcctggaaaa
     2401 cagtatgttc tgcattgggg gcacccaaga atttagaata gttaacataa atagtaaagt
     2461 tattcttttc ccagctaaca aagtaaaatg caggaagacc aggaacataa acccaacacg
     2521 tctcagcagt cacagacaca ttcaccagag acaatatatc aaggaacaga aattctacag
     2581 ccacacgttt tttttgagat ttcaccaact ttgacccttc catcactagt ttctttgagt
     2641 cattgttggg atgcagactc tattcttggc tctaagactc tgacgccata ttattttctt
     2701 tttcttctgg tgaagccttt gaagaccctt tggaagctct ttgtccatct taacgatgat
     2761 tctcaggttg gatcagtcct ttttctttct caggtctgct cagtccttcg tgtatccaca
     2821 accaattctc agtaccttga ggataaaact caaacataac cttagctcca gtgaattact
     2881 agatcatgac cattccactg gccagacatc tctctatgac cttgaattgc tttggagggt
     2941 gccccctcca aaatattggg tatcaggaag gccatcctta cccaaatttt aacattttga
     3001 aatataacta gaaggtaaat tattgtgagg aattgccata cctgtctccc ttactttatg
     3061 tttgaataat atttaggttg cagattagct cttttcacaa aagattgcct gtgagggttc
     3121 tgttgttaca acaaatgtta cattttgttg gcaaaattct tgaaagcctt ggcagtatat
     3181 gtagttgaat gccagttttt aatacttaac agggggttaa catagtaaaa gccttgagtc
     3241 aaaaagtgat agcaccttta tctgtctttc ctgacagggg aacagcaaaa atgagcaatg
     3301 agtgggtgtc cacagtgaca caaatatatt gtaacttcct aaaactggtg acattagtaa
     3361 cattcatgtg gcaatacaat ttggaaataa tccttgggga gttacagttt aaaagggaaa
     3421 agaaatgata ttgattttta tgcatgaatg gcattcctta attaccaaat aaacctgctc
     3481 ctttgttagt
//
