LOCUS       NM_007618               1618 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus serine (or cysteine) peptidase inhibitor, clade A,
            member 6 (Serpina6), mRNA.
ACCESSION   NM_007618
VERSION     NM_007618.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1618)
  AUTHORS   Monica Shih,M.C., Huang,C.C., Chu,H.P., Hsu,N.C. and Chung,B.C.
  TITLE     Embryonic Steroids Control Developmental Programming of Energy
            Balance
  JOURNAL   Endocrinology 162 (12) (2021)
   PUBMED   34599818
REFERENCE   2  (bases 1 to 1618)
  AUTHORS   Gulfo,J., Perez de San Roman,J., Ledda,A., Junyent,F.,
            Ramirez,M.J., Gil-Bea,F.J., Esteve,M. and Grasa,M.
  TITLE     Corticosteroid-binding-globulin (CBG)-deficient mice show high
            pY216-GSK3beta and phosphorylated-Tau levels in the hippocampus
  JOURNAL   PLoS One 16 (2), e0246930 (2021)
   PUBMED   33592009
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1618)
  AUTHORS   Gulfo,J., Castel,R., Ledda,A., Romero,M.D.M., Esteve,M. and
            Grasa,M.
  TITLE     Corticosteroid-Binding Globulin is expressed in the adrenal gland
            and its absence impairs corticosterone synthesis and secretion in a
            sex-dependent manner
  JOURNAL   Sci Rep 9 (1), 14018 (2019)
   PUBMED   31570737
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1618)
  AUTHORS   Gulfo,J., Ledda,A., Gea-Sorli,S., Bonjoch,L., Closa,D., Grasa,M.
            and Esteve,M.
  TITLE     New Roles for Corticosteroid Binding Globulin and Opposite
            Expression Profiles in Lung and Liver
  JOURNAL   PLoS One 11 (1), e0146497 (2016)
   PUBMED   26741814
  REMARK    GeneRIF: CBG is involved in the gender differences observed in
            corticosteroids circulating levels and plays a role in the local
            regulation of corticosteroids availability in organs like lung.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1618)
  AUTHORS   Sivukhina,E.V. and Jirikowski,G.F.
  TITLE     Adrenal steroids in the brain: role of the intrinsic expression of
            corticosteroid-binding globulin (CBG) in the stress response
  JOURNAL   Steroids 81, 70-73 (2014)
   PUBMED   24246737
  REMARK    GeneRIF: the same gene encodes brain and liver
            corticosteroid-binding globulin
REFERENCE   6  (bases 1 to 1618)
  AUTHORS   Brinkmeier,M.L. and Camper,S.A.
  TITLE     Localization of somatostatin receptor genes on mouse chromosomes 2,
            11, 12, 15, and 17: correlation with growth QTLs
  JOURNAL   Genomics 43 (1), 9-14 (1997)
   PUBMED   9226367
REFERENCE   7  (bases 1 to 1618)
  AUTHORS   Yehiely,F., Bamborough,P., Da Costa,M., Perry,B.J., Thinakaran,G.,
            Cohen,F.E., Carlson,G.A. and Prusiner,S.B.
  TITLE     Identification of candidate proteins binding to prion protein
  JOURNAL   Neurobiol Dis 3 (4), 339-355 (1997)
   PUBMED   9173930
  REMARK    Erratum:[Neurobiol Dis 2002 Jun;10(1):67-8]
REFERENCE   8  (bases 1 to 1618)
  AUTHORS   Semenza,G.L., Rue,E.A., Iyer,N.V., Pang,M.G. and Kearns,W.G.
  TITLE     Assignment of the hypoxia-inducible factor 1alpha gene to a region
            of conserved synteny on mouse chromosome 12 and human chromosome
            14q
  JOURNAL   Genomics 34 (3), 437-439 (1996)
   PUBMED   8786149
REFERENCE   9  (bases 1 to 1618)
  AUTHORS   Orava,M., Zhao,X.F., Leiter,E. and Hammond,G.L.
  TITLE     Structure and chromosomal location of the gene encoding mouse
            corticosteroid-binding globulin: strain differences in coding
            sequence and steroid-binding activity
  JOURNAL   Gene 144 (2), 259-264 (1994)
   PUBMED   8039711
REFERENCE   10 (bases 1 to 1618)
  AUTHORS   Scrocchi,L.A., Orava,M., Smith,C.L., Han,V.K. and Hammond,G.L.
  TITLE     Spatial and temporal distribution of corticosteroid-binding
            globulin and its messenger ribonucleic acid in embryonic and fetal
            mice
  JOURNAL   Endocrinology 132 (2), 903-909 (1993)
   PUBMED   7916682
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC125360.4, BY090546.1,
            AK145842.1 and AA230586.1.
            
            On Sep 15, 2015 this sequence version replaced NM_007618.2.
            
            Summary: This gene encodes a protein that belongs to the serpin
            (serine protease inhibitor) family. The encoded protein is an
            alpha-globulin with corticosteroid-binding properties. This is the
            major transport protein for glucorticoids and progestins in the
            blood of most vertebrates. The gene localizes to a chromosomal
            region containing several closely related serine protease
            inhibitors. [provided by RefSeq, Sep 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC013632.1, X70533.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-89                AC125360.4         157282-157370       c
            90-116              BY090546.1         2-28
            117-669             AK145842.1         2-554
            670-670             AC125360.4         154172-154172       c
            671-1576            AK145842.1         556-1461
            1577-1618           AA230586.1         476-517
FEATURES             Location/Qualifiers
     source          1..1618
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 52.98 cM"
     gene            1..1618
                     /gene="Serpina6"
                     /gene_synonym="Cbg"
                     /note="serine (or cysteine) peptidase inhibitor, clade A,
                     member 6"
                     /db_xref="GeneID:12401"
                     /db_xref="MGI:MGI:88278"
     exon            1..182
                     /gene="Serpina6"
                     /gene_synonym="Cbg"
                     /inference="alignment:Splign:2.1.0"
     exon            183..793
                     /gene="Serpina6"
                     /gene_synonym="Cbg"
                     /inference="alignment:Splign:2.1.0"
     CDS             202..1395
                     /gene="Serpina6"
                     /gene_synonym="Cbg"
                     /note="serine (or cysteine) proteinase inhibitor, clade A,
                     member 6; corticosteroid-binding globulin; serpin A6;
                     transcortin"
                     /codon_start=1
                     /product="corticosteroid-binding globulin precursor"
                     /protein_id="NP_031644.1"
                     /db_xref="CCDS:CCDS26135.1"
                     /db_xref="GeneID:12401"
                     /db_xref="MGI:MGI:88278"
                     /translation="MSLALYTCLFWLCTSGLWTTQAVTDEDSSSHRDLAPTNVDFAFN
                     LYKRLVALNSDKNTLISPVSISMALAMLSLSTRGSTQYLENLGFNMSKMSEAEIHQGF
                     QYLNSLLQQSDTGLEMNMGNVMFLLQNLKLKDSFLADTKHYYESEALTIPSKDWTKAG
                     EQINNHVKNKTQGKIEHVVSDLDSSATLILINYIFLKGIWKLPFSPENTREEDFYVNE
                     TSTVKVPMMVQSGNISYFRDSAIPCQMVQMNYVGNGTTFIILPDQGQMDTVVAALNRD
                     TIDRWGKLMIPRQMNLYIPKFSMSDTYDLQDVLADVGIKDLFTNQSDFADTTKDTPLT
                     LTVLHKAMLQLDEGNVLPAATNGPPVHLPSESFTLKYNRPFIFLAFDKYTWSSLMMSQ
                     VMNPA"
     exon            794..1064
                     /gene="Serpina6"
                     /gene_synonym="Cbg"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1209
                     /gene="Serpina6"
                     /gene_synonym="Cbg"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1611
                     /gene="Serpina6"
                     /gene_synonym="Cbg"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1591..1596
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Serpina6"
                     /gene_synonym="Cbg"
                     /note="hexamer: ATTAAA"
     polyA_site      1611
                     /gene="Serpina6"
                     /gene_synonym="Cbg"
                     /note="major polyA site"
ORIGIN      
        1 atgcttgggg ggtgggggcc accaaatggt gaaggccact gcccccctcc tctaaccatt
       61 aaccagcaag acaccagcaa acaagattta gtggggagtc tccccgaagc cttactgtac
      121 gtgtgctagg attccagaca gcaaagcaga gccagaagga acagctggag cccacagcag
      181 acgacctggt caaccaaaac aatgtcgctc gccctgtata cctgtctctt ctggctctgc
      241 accagtggcc tctggaccac ccaggctgtc actgatgagg attcaagttc tcaccgagac
      301 ctggctccca ccaatgttga ctttgccttc aacttgtaca aacgcctagt ggccctgaat
      361 tctgacaaga ataccttaat ctccccagtg agcatctcca tggccctggc catgctgtcc
      421 ctaagcacca ggggctccac ccagtatctc gagaacctgg gcttcaacat gtcaaagatg
      481 tctgaagctg agatccacca gggtttccag tacctcaatt cccttctcca gcagtctgac
      541 actggcttgg agatgaacat gggcaatgtc atgttcctcc tccagaacct aaagctgaaa
      601 gactcattct tagcagacac caaacactat tatgagtcag aggccttgac catcccttcc
      661 aaggactgga ctaaagccgg cgaacagatc aacaatcatg tgaagaataa gacacagggg
      721 aaaattgagc atgtggtctc agacctggat agttcagcca ccctcatcct gatcaactac
      781 atcttcctca aaggaatatg gaaacttccc ttcagcccag aaaatactag agaggaggac
      841 ttctatgtga atgagacaag cacagtgaag gtgcccatga tggtccagtc aggcaacatt
      901 agttactttc gtgattcggc gatcccctgc cagatggtac agatgaatta tgtgggaaat
      961 ggaactacct tcatcattct tccagaccag ggccagatgg acactgtcgt cgctgcactt
     1021 aatcgggaca caattgatag gtggggcaag cttatgattc caaggcagat gaacctgtac
     1081 atccccaaat tctccatgtc tgatacctat gaccttcaag atgtgctggc agatgtgggc
     1141 attaaggatt tgttcaccaa ccaatctgat ttcgcagaca ccaccaaaga cactcccttg
     1201 acattaacgg tactccacaa ggccatgctg caactggatg aagggaatgt gctgcctgct
     1261 gccaccaatg gccctcctgt acacctgccc tccgaatcat tcaccctcaa gtacaacagg
     1321 cccttcatct tcctggcctt tgacaagtac acatggagca gcctgatgat gagccaagtc
     1381 atgaatccag cctaaaagct tgtcccggaa aaccatggtg ccatctgact ttgagagcat
     1441 agaagtcttt ccccagtctt cttcagggtc tccccccaac ccaacccaac cagatgctcc
     1501 cacttttaga catcttgtaa tgaataggcc ttgttgctac tctcaaaaca aatcaatcgg
     1561 gaggggacca ctgagaaaga ggtaacagtt attaaaggat gtttttgcaa aaaaaaaa
//
