LOCUS       NP_031644                397 aa            linear   ROD 03-JUN-2024
DEFINITION  corticosteroid-binding globulin precursor [Mus musculus].
ACCESSION   NP_031644
VERSION     NP_031644.1
DBSOURCE    REFSEQ: accession NM_007618.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 397)
  AUTHORS   Monica Shih,M.C., Huang,C.C., Chu,H.P., Hsu,N.C. and Chung,B.C.
  TITLE     Embryonic Steroids Control Developmental Programming of Energy
            Balance
  JOURNAL   Endocrinology 162 (12) (2021)
   PUBMED   34599818
REFERENCE   2  (residues 1 to 397)
  AUTHORS   Gulfo,J., Perez de San Roman,J., Ledda,A., Junyent,F.,
            Ramirez,M.J., Gil-Bea,F.J., Esteve,M. and Grasa,M.
  TITLE     Corticosteroid-binding-globulin (CBG)-deficient mice show high
            pY216-GSK3beta and phosphorylated-Tau levels in the hippocampus
  JOURNAL   PLoS One 16 (2), e0246930 (2021)
   PUBMED   33592009
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 397)
  AUTHORS   Gulfo,J., Castel,R., Ledda,A., Romero,M.D.M., Esteve,M. and
            Grasa,M.
  TITLE     Corticosteroid-Binding Globulin is expressed in the adrenal gland
            and its absence impairs corticosterone synthesis and secretion in a
            sex-dependent manner
  JOURNAL   Sci Rep 9 (1), 14018 (2019)
   PUBMED   31570737
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 397)
  AUTHORS   Gulfo,J., Ledda,A., Gea-Sorli,S., Bonjoch,L., Closa,D., Grasa,M.
            and Esteve,M.
  TITLE     New Roles for Corticosteroid Binding Globulin and Opposite
            Expression Profiles in Lung and Liver
  JOURNAL   PLoS One 11 (1), e0146497 (2016)
   PUBMED   26741814
  REMARK    GeneRIF: CBG is involved in the gender differences observed in
            corticosteroids circulating levels and plays a role in the local
            regulation of corticosteroids availability in organs like lung.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 397)
  AUTHORS   Sivukhina,E.V. and Jirikowski,G.F.
  TITLE     Adrenal steroids in the brain: role of the intrinsic expression of
            corticosteroid-binding globulin (CBG) in the stress response
  JOURNAL   Steroids 81, 70-73 (2014)
   PUBMED   24246737
  REMARK    GeneRIF: the same gene encodes brain and liver
            corticosteroid-binding globulin
REFERENCE   6  (residues 1 to 397)
  AUTHORS   Brinkmeier,M.L. and Camper,S.A.
  TITLE     Localization of somatostatin receptor genes on mouse chromosomes 2,
            11, 12, 15, and 17: correlation with growth QTLs
  JOURNAL   Genomics 43 (1), 9-14 (1997)
   PUBMED   9226367
REFERENCE   7  (residues 1 to 397)
  AUTHORS   Yehiely,F., Bamborough,P., Da Costa,M., Perry,B.J., Thinakaran,G.,
            Cohen,F.E., Carlson,G.A. and Prusiner,S.B.
  TITLE     Identification of candidate proteins binding to prion protein
  JOURNAL   Neurobiol Dis 3 (4), 339-355 (1997)
   PUBMED   9173930
  REMARK    Erratum:[Neurobiol Dis 2002 Jun;10(1):67-8]
REFERENCE   8  (residues 1 to 397)
  AUTHORS   Semenza,G.L., Rue,E.A., Iyer,N.V., Pang,M.G. and Kearns,W.G.
  TITLE     Assignment of the hypoxia-inducible factor 1alpha gene to a region
            of conserved synteny on mouse chromosome 12 and human chromosome
            14q
  JOURNAL   Genomics 34 (3), 437-439 (1996)
   PUBMED   8786149
REFERENCE   9  (residues 1 to 397)
  AUTHORS   Orava,M., Zhao,X.F., Leiter,E. and Hammond,G.L.
  TITLE     Structure and chromosomal location of the gene encoding mouse
            corticosteroid-binding globulin: strain differences in coding
            sequence and steroid-binding activity
  JOURNAL   Gene 144 (2), 259-264 (1994)
   PUBMED   8039711
REFERENCE   10 (residues 1 to 397)
  AUTHORS   Scrocchi,L.A., Orava,M., Smith,C.L., Han,V.K. and Hammond,G.L.
  TITLE     Spatial and temporal distribution of corticosteroid-binding
            globulin and its messenger ribonucleic acid in embryonic and fetal
            mice
  JOURNAL   Endocrinology 132 (2), 903-909 (1993)
   PUBMED   7916682
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC125360.4, BY090546.1,
            AK145842.1 and AA230586.1.
            
            Summary: This gene encodes a protein that belongs to the serpin
            (serine protease inhibitor) family. The encoded protein is an
            alpha-globulin with corticosteroid-binding properties. This is the
            major transport protein for glucorticoids and progestins in the
            blood of most vertebrates. The gene localizes to a chromosomal
            region containing several closely related serine protease
            inhibitors. [provided by RefSeq, Sep 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC013632.1, X70533.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..397
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 52.98 cM"
     Protein         1..397
                     /product="corticosteroid-binding globulin precursor"
                     /note="serine (or cysteine) proteinase inhibitor, clade A,
                     member 6; corticosteroid-binding globulin; serpin A6;
                     transcortin"
                     /calculated_mol_wt=42277
     sig_peptide     1..22
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2510
     mat_peptide     23..397
                     /product="Corticosteroid-binding globulin.
                     /id=PRO_0000032431"
                     /note="propagated from UniProtKB/Swiss-Prot (Q06770.1)"
                     /calculated_mol_wt=42277
     Region          28..397
                     /region_name="serpinA6_CBG"
                     /note="serpin family A member 6, corticosteroid-binding
                     globulin; cd19554"
                     /db_xref="CDD:381022"
     Site            order(35..36,39,247,255,257,275,278..279,282,380,382,385)
                     /site_type="other"
                     /note="cortisol binding site [polypeptide binding]"
                     /db_xref="CDD:381022"
     Site            89
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:16944957,
                     ECO:0000269|PubMed:17330941; propagated from
                     UniProtKB/Swiss-Prot (Q06770.1)"
     Site            169
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q06770.1)"
     Site            217
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:16944957; propagated from
                     UniProtKB/Swiss-Prot (Q06770.1)"
     Site            232
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:16944957; propagated from
                     UniProtKB/Swiss-Prot (Q06770.1)"
     Site            243
                     /site_type="other"
                     /note="Conserved cysteine within steroid binding domain;
                     propagated from UniProtKB/Swiss-Prot (Q06770.1)"
     Site            253
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q06770.1)"
     Site            320
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q06770.1)"
     Site            order(349..366,368..374)
                     /site_type="other"
                     /note="reactive center loop (RCL)"
                     /db_xref="CDD:381022"
     CDS             1..397
                     /gene="Serpina6"
                     /gene_synonym="Cbg"
                     /coded_by="NM_007618.3:202..1395"
                     /db_xref="CCDS:CCDS26135.1"
                     /db_xref="GeneID:12401"
                     /db_xref="MGI:MGI:88278"
ORIGIN      
        1 mslalytclf wlctsglwtt qavtdedsss hrdlaptnvd fafnlykrlv alnsdkntli
       61 spvsismala mlslstrgst qylenlgfnm skmseaeihq gfqylnsllq qsdtglemnm
      121 gnvmfllqnl klkdsfladt khyyesealt ipskdwtkag eqinnhvknk tqgkiehvvs
      181 dldssatlil inyiflkgiw klpfspentr eedfyvnets tvkvpmmvqs gnisyfrdsa
      241 ipcqmvqmny vgngttfiil pdqgqmdtvv aalnrdtidr wgklmiprqm nlyipkfsms
      301 dtydlqdvla dvgikdlftn qsdfadttkd tpltltvlhk amlqldegnv lpaatngppv
      361 hlpsesftlk ynrpfiflaf dkytwsslmm sqvmnpa
//
