LOCUS       NM_172953               2162 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus serine (or cysteine) peptidase inhibitor, clade A,
            member 5 (Serpina5), mRNA.
ACCESSION   NM_172953 NM_008785
VERSION     NM_172953.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2162)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2162)
  AUTHORS   Cao,S., Qian,Z., Wu,R., Sun,S., Jing,J., Zhang,G., Chen,W., Ge,Y.,
            Ma,J., Wang,S., Ouyang,L., Xue,T., Wang,D., Zhao,S., Liang,K.,
            Ge,X., Lin,Y., Chen,L. and Yao,B.
  TITLE     SERPINA5 Protein in Cumulus-Oocyte Complexes Increases the
            Fertilisation Ability of Mouse Sperm
  JOURNAL   Reprod Sci 29 (8), 2350-2362 (2022)
   PUBMED   35194761
  REMARK    GeneRIF: SERPINA5 Protein in Cumulus-Oocyte Complexes Increases the
            Fertilisation Ability of Mouse Sperm.
REFERENCE   3  (bases 1 to 2162)
  AUTHORS   Whiley,P.A.F., O'Donnell,L., Moody,S.C., Handelsman,D.J.,
            Young,J.C., Richards,E.A., Almstrup,K., Western,P.S. and
            Loveland,K.L.
  TITLE     Activin A Determines Steroid Levels and Composition in the Fetal
            Testis
  JOURNAL   Endocrinology 161 (7) (2020)
   PUBMED   32274496
REFERENCE   4  (bases 1 to 2162)
  AUTHORS   Rieger,D., Assinger,A., Einfinger,K., Sokolikova,B. and Geiger,M.
  TITLE     Protein C inhibitor (PCI) binds to phosphatidylserine exposing
            cells with implications in the phagocytosis of apoptotic cells and
            activated platelets
  JOURNAL   PLoS One 9 (7), e101794 (2014)
   PUBMED   25000564
  REMARK    GeneRIF: role of PCI not only for the function and/or maturation of
            macrophages, but also as a negative regulator of apoptotic cell and
            activated platelets removal
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2162)
  AUTHORS   Heit,C., Jackson,B.C., McAndrews,M., Wright,M.W., Thompson,D.C.,
            Silverman,G.A., Nebert,D.W. and Vasiliou,V.
  TITLE     Update of the human and mouse SERPIN gene superfamily
  JOURNAL   Hum Genomics 7 (1), 22 (2013)
   PUBMED   24172014
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2162)
  AUTHORS   Odet,F., Guyot,R., Leduque,P. and Le Magueresse-Battistoni,B.
  TITLE     Evidence for similar expression of protein C inhibitor and the
            urokinase-type plasminogen activator system during mouse testis
            development
  JOURNAL   Endocrinology 145 (3), 1481-1489 (2004)
   PUBMED   14645112
REFERENCE   7  (bases 1 to 2162)
  AUTHORS   Uhrin,P., Dewerchin,M., Hilpert,M., Chrenek,P., Schofer,C.,
            Zechmeister-Machhart,M., Kronke,G., Vales,A., Carmeliet,P.,
            Binder,B.R. and Geiger,M.
  TITLE     Disruption of the protein C inhibitor gene results in impaired
            spermatogenesis and male infertility
  JOURNAL   J Clin Invest 106 (12), 1531-1539 (2000)
   PUBMED   11120760
REFERENCE   8  (bases 1 to 2162)
  AUTHORS   Wagenaar,G.T., van Vuuren,A.J., Girma,M., Tiekstra,M.J., Kwast,L.,
            Koster,J.G., Rijneveld,A.W., Elisen,M.G., van der Poll,T. and
            Meijers,J.C.
  TITLE     Characterization of transgenic mice that secrete functional human
            protein C inhibitor into the circulation
  JOURNAL   Thromb Haemost 83 (1), 93-101 (2000)
   PUBMED   10669161
REFERENCE   9  (bases 1 to 2162)
  AUTHORS   Zechmeister-Machhart,M., Hufnagl,P., Uhrin,P., Korschineck,I.,
            Binder,B.R. and Geiger,M.
  TITLE     Molecular cloning and sequence analysis of the mouse protein C
            inhibitor gene
  JOURNAL   Gene 186 (1), 61-66 (1997)
   PUBMED   9047345
REFERENCE   10 (bases 1 to 2162)
  AUTHORS   Zechmeister-Machhart,M., Hufnagl,P., Uhrin,P., Xu,J., Geiger,M. and
            Binder,B.R.
  TITLE     Molecular cloning and tissue distribution of mouse protein C
            inhibitor (PCI)
  JOURNAL   Immunopharmacology 32 (1-3), 96-98 (1996)
   PUBMED   8796278
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK077160.1 and AK087714.1.
            
            On Nov 28, 2009 this sequence version replaced NM_172953.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK077160.1, BC090981.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-770               AK077160.1         2-771
            771-1533            AK087714.1         734-1496
            1534-2162           AK077160.1         1535-2163
FEATURES             Location/Qualifiers
     source          1..2162
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 53.3 cM"
     gene            1..2162
                     /gene="Serpina5"
                     /gene_synonym="4933415L04; PAI-3; Pci"
                     /note="serine (or cysteine) peptidase inhibitor, clade A,
                     member 5"
                     /db_xref="GeneID:268591"
                     /db_xref="MGI:MGI:107817"
     exon            1..147
                     /gene="Serpina5"
                     /gene_synonym="4933415L04; PAI-3; Pci"
                     /inference="alignment:Splign:2.1.0"
     exon            148..773
                     /gene="Serpina5"
                     /gene_synonym="4933415L04; PAI-3; Pci"
                     /inference="alignment:Splign:2.1.0"
     exon            774..1044
                     /gene="Serpina5"
                     /gene_synonym="4933415L04; PAI-3; Pci"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1192
                     /gene="Serpina5"
                     /gene_synonym="4933415L04; PAI-3; Pci"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..2162
                     /gene="Serpina5"
                     /gene_synonym="4933415L04; PAI-3; Pci"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agctcccaat gaagcagagc tggagtgggg tggagacaga gtctctgcgg tcagtgacat
       61 ttgccggctg caattcctct gctctgctct ctgtcctctt gtaagccagg tggactatac
      121 cttgacactc agccaccacg atacagaagc tgtcaccaca atgaggttct tccccattct
      181 gtgcctggtg ctgttcatca gccatggggt ggcttcccgc cgacactccc attccaagaa
      241 gaagaaggct aaagagtcct cggtgggtgc tgtgggacct cccagtagca aagactttgc
      301 tttcagactc tacagggcct tggtttctga atcccctggt cagaatgtct tcttctcccc
      361 cttgagcgtg tctatgagtt tgggcatgct ctccctgggg gctggcttga agacgaagac
      421 ccagatccta gatggcctag gcctcagcct ccagcaaggc caagaagaca agctccacaa
      481 gggcttccaa cagctgctac agagattcag gcagcctagt gatggcctgc agctgagcct
      541 gggcagtgcc ctttttaaag acccagcagt acatatccgg gacgacttcc tgagtgccat
      601 gaagacactg tacatgtcag acactttctc taccaacttt gggaaccctg aaatcgccaa
      661 gaagcagatc aacaactatg tagccaagca gaccaagggc aagattgtag actttatcaa
      721 ggatcttgac agcacccatg tcatgatagt ggtaaattac atcttcttca aagccaagtg
      781 gcagacggcc ttcagtgaga caaacaccca caagatggat ttccatgtga cccccaaaag
      841 gaccacacag gtgcccatga tgaaccgtga agatgggtat tcctactacc tggaccaaaa
      901 catctcctgc acggtggtgg ggatccctta tcaaggcaat gccatcgctc tatttattct
      961 ccccagcgag ggcaagatga agcaggtgga ggatggcctg gatgagagaa cattgaggaa
     1021 ctggcttaag atgttcacca aaagacgctt agatctttac ctccccaagt tctccattga
     1081 ggctacctac aaactggaaa atgtcctccc caagctgggc atccaggacg tcttcaccac
     1141 ccatgctgac ttgtctggca ttactgacca taccaatatc aagttgtctg agatggtgca
     1201 caaatccatg atggaggttg aagagtcagg aaccacagca gctgccatca caggagccat
     1261 cttcacattc agatctgctc ggccgagctc cctgaagata gaattcacca gaccctttct
     1321 gctgaccctt atggaggatt cacatatact tttcgttggc aaggtgaccc ggccctgagg
     1381 agggactcct tctgaaactc atgggcttac acagagggag ccaggcatgt tcttcagccc
     1441 atccatctct tggttgctag tgattttcat agagtagatt gactagtaag gtgttgtaag
     1501 tgataagatc aatatcccta tggctgcttc cttgatcaca gtttcaagat gtgttcttgc
     1561 tctcatcctt catcattgac actgacccta aagaggtcac tagatttctc caaggtccta
     1621 ccatcttata tgtgacatag ttgtgtccag actccaggcc tctcctgctc agtctagctc
     1681 tacaaagttc tgtaaaagac tggtccgcat atataaaggt caccaggaag cacagtcata
     1741 aacctggtcc cccacctatc agcaccaact ctcagttcat cagggttgag aaaggacact
     1801 ggattgagct tctgaaatgc cactggtagc tctgtaacat gggaatggaa atgtccctct
     1861 ctgggcctgt gtttctttgt gtgtccagtg aaggaacaga actagaagcc cattcagcaa
     1921 cctgtgagat tcttacacag gggttggctt ctctatgtta gccaggggtg ctgtaagaac
     1981 tcaggttagt agcatacttg agtaatcagg gtcaaagtgt ctcaccacaa acaaaggtat
     2041 caaatcacaa gcctggctgg ctgaggtggt gtgatagagg tctgtggtaa acagcagaac
     2101 ttagggtgca gactgactta ttgatttcca ccttggcaat ggcaataaag cattttgtaa
     2161 gg
//
