LOCUS       NM_011458               1652 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus serine (or cysteine) peptidase inhibitor, clade A,
            member 3K (Serpina3k), mRNA.
ACCESSION   NM_011458 XM_127127
VERSION     NM_011458.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1652)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1652)
  AUTHORS   Gonzalez-Soria,I., Soto-Valadez,A.D., Martinez-Rojas,M.A.,
            Ortega-Trejo,J.A., Perez-Villalva,R., Gamba,G., Sanchez-Navarro,A.
            and Bobadilla,N.A.
  TITLE     SerpinA3K Deficiency Reduces Oxidative Stress in Acute Kidney
            Injury
  JOURNAL   Int J Mol Sci 24 (9), 7815 (2023)
   PUBMED   37175519
  REMARK    GeneRIF: SerpinA3K Deficiency Reduces Oxidative Stress in Acute
            Kidney Injury.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1652)
  AUTHORS   Naba,A., Clauser,K.R., Mani,D.R., Carr,S.A. and Hynes,R.O.
  TITLE     Quantitative proteomic profiling of the extracellular matrix of
            pancreatic islets during the angiogenic switch and insulinoma
            progression
  JOURNAL   Sci Rep 7, 40495 (2017)
   PUBMED   28071719
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1652)
  AUTHORS   Cheng,S., Liang,X., Wang,Y., Jiang,Z., Liu,Y., Hou,W., Li,S.,
            Zhang,J. and Wang,Z.
  TITLE     The circadian Clock gene regulates acrosin activity of sperm
            through serine protease inhibitor A3K
  JOURNAL   Exp Biol Med (Maywood) 241 (2), 205-215 (2016)
   PUBMED   26264441
  REMARK    GeneRIF: SERPINA3K is involved in the Clock gene-mediated male
            fertility by regulating acrosin activity and provide the first
            evidence that SERPINA3K could be regulated by Clock gene via
            retinoic acid-related orphan receptor response elements.
REFERENCE   5  (bases 1 to 1652)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   6  (bases 1 to 1652)
  AUTHORS   Ohkubo,K., Ogata,S., Misumi,Y., Takami,N., Sinohara,H. and
            Ikehara,Y.
  TITLE     Cloning, structure and expression of cDNA for mouse contrapsin and
            a related protein
  JOURNAL   Biochem J 276 (Pt 2) (Pt 2), 337-342 (1991)
   PUBMED   2049065
REFERENCE   7  (bases 1 to 1652)
  AUTHORS   Inglis,J.D. and Hill,R.E.
  TITLE     The murine Spi-2 proteinase inhibitor locus: a multigene family
            with a hypervariable reactive site domain
  JOURNAL   EMBO J 10 (2), 255-261 (1991)
   PUBMED   1991447
REFERENCE   8  (bases 1 to 1652)
  AUTHORS   Suzuki,Y., Yamamoto,K. and Sinohara,H.
  TITLE     Molecular cloning and sequence analysis of full-length cDNA coding
            for mouse contrapsin
  JOURNAL   J Biochem 108 (3), 344-346 (1990)
   PUBMED   2277027
  REMARK    Review article
REFERENCE   9  (bases 1 to 1652)
  AUTHORS   Hill,R.E., Shaw,P.H., Barth,R.K. and Hastie,N.D.
  TITLE     A genetic locus closely linked to a protease inhibitor gene complex
            controls the level of multiple RNA transcripts
  JOURNAL   Mol Cell Biol 5 (8), 2114-2122 (1985)
   PUBMED   2427931
REFERENCE   10 (bases 1 to 1652)
  AUTHORS   Wilcox,F.H.
  TITLE     Genetic variation in plasma prealbumin of the house mouse
  JOURNAL   J Hered 66 (1), 19-22 (1975)
   PUBMED   1141682
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK149436.1.
            
            On Jun 10, 2007 this sequence version replaced NM_011458.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK149436.1, X56786.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1652              AK149436.1         2-1653
FEATURES             Location/Qualifiers
     source          1..1652
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 53.99 cM"
     gene            1..1652
                     /gene="Serpina3k"
                     /gene_synonym="1300001I07Rik; contrapsin; D12Rp54; MMCM2;
                     MMSpi2; RP54; Spi-2; Spi2"
                     /note="serine (or cysteine) peptidase inhibitor, clade A,
                     member 3K"
                     /db_xref="GeneID:20714"
                     /db_xref="MGI:MGI:98377"
     exon            1..60
                     /gene="Serpina3k"
                     /gene_synonym="1300001I07Rik; contrapsin; D12Rp54; MMCM2;
                     MMSpi2; RP54; Spi-2; Spi2"
                     /inference="alignment:Splign:2.1.0"
     exon            61..717
                     /gene="Serpina3k"
                     /gene_synonym="1300001I07Rik; contrapsin; D12Rp54; MMCM2;
                     MMSpi2; RP54; Spi-2; Spi2"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..1334
                     /gene="Serpina3k"
                     /gene_synonym="1300001I07Rik; contrapsin; D12Rp54; MMCM2;
                     MMSpi2; RP54; Spi-2; Spi2"
                     /note="serine (or cysteine) proteinase inhibitor, clade A
                     (alpha-1 antiproteinase, antitrypsin), member 3K; serine
                     (or cysteine) proteinase inhibitor, clade A, member 3K;
                     serine protease inhibitor A3K; serpin A3K; serine protease
                     inhibitor 2"
                     /codon_start=1
                     /product="serine protease inhibitor A3K precursor"
                     /protein_id="NP_035588.2"
                     /db_xref="CCDS:CCDS36537.1"
                     /db_xref="GeneID:20714"
                     /db_xref="MGI:MGI:98377"
                     /translation="MAFIVAMGMILMAGICPAVLCFPDGTKEMDIVFHEHQDNGTQDD
                     SLTLASVNTDFAFSLYKKLALKNQDKNIVFSPLSISAALALVSLGAKGKTMEEILEGL
                     KFNLTETPEADIHQGFGNLLQSLSQPEDQDQINIGNAMFIEKDLQILAEFHEKTRALY
                     QTEAFTADFQQPTEAKNLINDYVSNQTQGMIKKLISELDDGTLMVLVNYIYFKGKWKI
                     SFDPQDTFESEFYLDEKRSVKVPMMKMKLLTARHFRDEELSCSVLELKYTGNASALLI
                     LPDQGRMQQVEASLQPETLRKWRKTLFSSQIEELNLPKFSIASDYRLEEDVLPEMGIK
                     EVFTEQADLSGITEAKKLSVSQVVHKAVLDVAETGTEAAAATGVIGGIRKAVLPAVCF
                     NRPFLIVIYHTSAQSILFMAKVNNPK"
     exon            718..991
                     /gene="Serpina3k"
                     /gene_synonym="1300001I07Rik; contrapsin; D12Rp54; MMCM2;
                     MMSpi2; RP54; Spi-2; Spi2"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1145
                     /gene="Serpina3k"
                     /gene_synonym="1300001I07Rik; contrapsin; D12Rp54; MMCM2;
                     MMSpi2; RP54; Spi-2; Spi2"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1652
                     /gene="Serpina3k"
                     /gene_synonym="1300001I07Rik; contrapsin; D12Rp54; MMCM2;
                     MMSpi2; RP54; Spi-2; Spi2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gatgccaggc aagccaacaa ccctgaacat caggagtcag ctatcacaga ggctctgcag
       61 cctgaagaac agagaagatg gccttcattg tagctatggg gatgatttta atggctggaa
      121 tctgtcctgc tgtcctatgc ttcccagatg gcacaaagga aatggacatt gtattccatg
      181 aacaccaaga caatgggaca caagatgaca gtctcacatt ggcctccgtc aacactgact
      241 ttgccttcag tctgtacaag aagctggctt tgaagaatca agataaaaat attgtcttct
      301 ccccacttag catctcagct gccttggccc tcgtgtccct gggagcaaag ggcaagacca
      361 tggaagagat tttagaaggc ctcaagttca atctcacaga gacccctgaa gcagacatcc
      421 accagggctt tggcaacctc ctacagagtc tcagccagcc agaagaccag gatcagataa
      481 acataggcaa tgccatgttt attgaaaagg acctgcagat cctggcagaa ttccatgaga
      541 agacaagggc tctgtaccag actgaggcct tcacagcaga cttccagcag cctactgagg
      601 ccaaaaacct catcaatgac tatgtgagca atcagaccca ggggatgatc aagaaactga
      661 tctcagaact ggatgatggg acattgatgg tgctggtgaa ttacatctac tttaaaggca
      721 aatggaagat atcctttgac ccccaggaca catttgagtc tgagttctac ttggatgaga
      781 agagatctgt gaaggttccc atgatgaaaa tgaagttact gactgcacgc cacttccgtg
      841 atgaggagct atcgtgctct gtgttggagc tgaagtacac aggaaatgcc agtgccctgc
      901 tcatcctccc tgaccaaggc aggatgcagc aggtggaagc cagcttacaa ccagagaccc
      961 tgaggaaatg gaggaaaact ttgttttcca gccaaataga ggagctaaac ctgcccaagt
     1021 tctccatcgc tagtgactac aggctggaag aggatgtcct tccagaaatg gggattaagg
     1081 aagtcttcac agaacaagct gacctatctg ggatcacaga agccaagaaa ctgagtgtgt
     1141 ctcaggtggt ccacaaggct gtgctggatg tggctgagac aggcacagaa gcagctgctg
     1201 ccacaggggt tattggtggc attcgtaagg ccgtattacc agctgtgtgt ttcaacaggc
     1261 cattcctgat tgttatctat cacacaagtg ctcagagtat cctctttatg gccaaagtca
     1321 ataaccccaa gtagacctaa agctcaccaa gttctcatga ttctgtccag ggctctggga
     1381 cagagtctgc atatggatct ctatatacat cctgtcattc aagctctgat tggctgttcc
     1441 aaagttggct tagacagcta cattgactat ctctgtgatc ccacatgcac ataagacttt
     1501 ggactctcag tgtcgggctc ttgggcctct tgggagcatc tgtgcatatt tctgaacctg
     1561 gaatctgcct ttattcttct tccctggtga ctcctcttta tgtgtctgta ccccaaacct
     1621 aggcattggc aaatacacag agttccaata cc
//
