LOCUS       NM_001199940            2193 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus serine (or cysteine) peptidase inhibitor, clade A,
            member 3I (Serpina3i), mRNA.
ACCESSION   NM_001199940 XM_003085578 XM_893705
VERSION     NM_001199940.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2193)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2193)
  AUTHORS   Teufelberger,A.R., Van Nevel,S., Hulpiau,P., Nordengrun,M.,
            Savvides,S.N., De Graeve,S., Akula,S., Holtappels,G., De Ruyck,N.,
            Declercq,W., Vandenabeele,P., Hellman,L., Broker,B.M., Krysko,D.V.,
            Bachert,C. and Krysko,O.
  TITLE     Mouse Strain-Dependent Difference Toward the Staphylococcus aureus
            Allergen Serine Protease-Like Protein D Reveals a Novel Regulator
            of IL-33
  JOURNAL   Front Immunol 11, 582044 (2020)
   PUBMED   33072128
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2193)
  AUTHORS   Heit,C., Jackson,B.C., McAndrews,M., Wright,M.W., Thompson,D.C.,
            Silverman,G.A., Nebert,D.W. and Vasiliou,V.
  TITLE     Update of the human and mouse SERPIN gene superfamily
  JOURNAL   Hum Genomics 7 (1), 22 (2013)
   PUBMED   24172014
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2193)
  AUTHORS   Winkler,I.G., Hendy,J., Coughlin,P., Horvath,A. and Levesque,J.P.
  TITLE     Serine protease inhibitors serpina1 and serpina3 are down-regulated
            in bone marrow during hematopoietic progenitor mobilization
  JOURNAL   J Exp Med 201 (7), 1077-1088 (2005)
   PUBMED   15795238
REFERENCE   5  (bases 1 to 2193)
  AUTHORS   Forsyth,S., Horvath,A. and Coughlin,P.
  TITLE     A review and comparison of the murine alpha1-antitrypsin and
            alpha1-antichymotrypsin multigene clusters with the human clade A
            serpins
  JOURNAL   Genomics 81 (3), 336-345 (2003)
   PUBMED   12659817
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY136799.1, AC142112.3 and CJ239048.1.
            
            On or before Dec 31, 2010 this sequence version replaced
            XM_893705.3, XM_003085578.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The genomic coordinates used for
            the transcript record were based on transcript alignments from
            paralogous genes.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849381,
                              SAMN00849383 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-366               BY136799.1         2-367
            367-846             AC142112.3         31753-32232         c
            847-1120            AC142112.3         30747-31020         c
            1121-1393           CJ239048.1         448-720
            1394-2193           AC142112.3         28100-28899         c
FEATURES             Location/Qualifiers
     source          1..2193
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 53.78 cM"
     gene            1..2193
                     /gene="Serpina3i"
                     /gene_synonym="2B2; EG628900; Gm6930"
                     /note="serine (or cysteine) peptidase inhibitor, clade A,
                     member 3I"
                     /db_xref="GeneID:628900"
                     /db_xref="MGI:MGI:2182841"
     exon            1..93
                     /gene="Serpina3i"
                     /gene_synonym="2B2; EG628900; Gm6930"
                     /inference="alignment:Splign:2.1.0"
     exon            94..227
                     /gene="Serpina3i"
                     /gene_synonym="2B2; EG628900; Gm6930"
                     /inference="alignment:Splign:2.1.0"
     exon            228..846
                     /gene="Serpina3i"
                     /gene_synonym="2B2; EG628900; Gm6930"
                     /inference="alignment:Splign:2.1.0"
     CDS             240..1466
                     /gene="Serpina3i"
                     /gene_synonym="2B2; EG628900; Gm6930"
                     /note="serine (or cysteine) proteinase inhibitor, clade A,
                     member 3I; antitrypsin; alpha-1 antiproteinase"
                     /codon_start=1
                     /product="serine (or cysteine) peptidase inhibitor, clade
                     A, member 3I"
                     /protein_id="NP_001186869.1"
                     /db_xref="CCDS:CCDS49157.1"
                     /db_xref="GeneID:628900"
                     /db_xref="MGI:MGI:2182841"
                     /translation="MAGVSPAVLGCPDVTLERNTAVHEVQENITSGDSLTVASSNTDF
                     AFSLYRKLVLKNPDENVVFSPFSIFTALALLSLGAKSNTLKEILEGLKFNLTETPEPD
                     IHQGFRYLLDLLSQPGDQVQISTGSALFVEKHLQILAEFKEKARALYQAEAFTADFLQ
                     PCQAKKLINDYVSNQTQGKIKELISDLDKSTLMVLVNYIYFKGKWKMPFDPRDTFNSK
                     FYLDEKRSVKVPMMKIEELTTPYFRDDELSCSVVELKYTGNASALFILPDQGKMQQVE
                     TSLHPETLRKWKNSLKPSRISELHLPKFSISNDYSLEHVLPVLGIREVFSMQADLSAI
                     TGTMDLRVSQVVHKAVLDVTETGTEAAAATGVKVNLRCGKIYSMTIYFKRPFLIIISD
                     INTHIALFMAKVTNPK"
     exon            847..1120
                     /gene="Serpina3i"
                     /gene_synonym="2B2; EG628900; Gm6930"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1271
                     /gene="Serpina3i"
                     /gene_synonym="2B2; EG628900; Gm6930"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..2193
                     /gene="Serpina3i"
                     /gene_synonym="2B2; EG628900; Gm6930"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgcagtgga gagaacaaca gaccaggaag gcagcaactc tgaccaccag gagccagcta
       61 tcacagacac tggcagctgg ctcagctctg caggttgccc agagatgtct actcatcgga
      121 ttgctactac acagaaatcc tcaaagcaag aataaaatat gatcccggag ggatagattt
      181 aggctctact cagttttcgt cccatcagaa agcctttttg agctaaggag aagagagtaa
      241 tggctggtgt ctcccctgct gtccttggat gcccagatgt caccttggaa aggaacacgg
      301 cagtccatga agtccaagaa aatatcacat caggggacag tttaacagtg gcctccagca
      361 acactgactt tgccttcagc ctctacagga agctggtttt gaagaatcca gatgaaaatg
      421 ttgtcttctc cccattcagc atcttcactg ccttggccct cctgtccctg ggagcaaaga
      481 gcaacaccct gaaggaaatc ctagaaggtc tcaagttcaa cctcacagag acccctgaac
      541 cagacatcca ccagggcttt aggtacttgc tagaccttct cagtcagcca ggggaccagg
      601 tacagatcag cacaggcagt gccctgtttg ttgaaaagca cctgcagatc ctggcagagt
      661 tcaaggagaa ggcaagggct ctgtaccagg ctgaggcctt cacagcagat ttcctgcagc
      721 cttgccaggc caaaaagctc atcaatgact atgtgagcaa tcagacccag gggaagatca
      781 aggaactcat ctcagacctg gataagagca cgttgatggt gctggtgaat tatatctact
      841 ttaaaggcaa atggaagatg ccctttgacc cccgtgatac atttaattcc aagttttact
      901 tggatgagaa gaggtctgtg aaggtgccaa tgatgaaaat agaggaacta actacaccct
      961 acttccggga tgatgagctg tcctgctctg tggtagagct gaagtacaca ggaaatgcca
     1021 gtgccctgtt cattctccct gaccagggca agatgcagca ggtggaaacc agcttgcatc
     1081 cagagaccct gaggaagtgg aagaactctc tgaaacccag taggataagt gagctccacc
     1141 tgcctaagtt ctccatctcc aatgactaca gccttgagca cgtccttccc gtgctgggca
     1201 tcagggaagt cttctccatg caggctgacc tgtctgcaat tacaggaacc atggatctga
     1261 gagtctctca ggtggtccac aaggctgtgc tggatgtgac tgagacaggc acagaagcag
     1321 ctgctgccac aggagtcaaa gttaatctac gttgtggaaa aatctattct atgacaatat
     1381 atttcaagag gccattcctg ataattatct ctgacataaa tactcacatt gccctcttca
     1441 tggccaaagt tacaaatccc aagtgagacc agaacttctc aaatggggaa agggcccctt
     1501 tccaagagct gggaattgag cctgtatgtc tgtctgcaca ttttggcttc catgctctgc
     1561 ttggctgagg catgcctgac tagacagtga cactgactaa atctgtgact gcctcatgca
     1621 gagaagccta tggctggtca gtgtcagact ccctgtcatc ttggcagctc tagctcaggt
     1681 tcctgacctg aaatttgtgt taatccctgt gcctgctctc tcccctgtat ctgtcaaccc
     1741 aaaagcctgg gcccagcagt gaggctctaa cttaggctct gcttatgtct accttcagcc
     1801 tttcagtcat gatgatacta tgcaagttta caggccaacc cttaaggact aagaagtgaa
     1861 cctgctgccc tgggtctatc tgcagcatct gaaatgtttg gttcccagtt ctgccttact
     1921 cttgccttcc tctgggcaga gctatccaca gcccctgcag agtctcctga ccccatacag
     1981 atctggcaca ggtggagacc tcagccctgc agctgcatgg ggcctgtggg tcagagcagc
     2041 tcctctcccg ctaacactcc tactcaggac agagaagaag ccttacccta agtctctatt
     2101 tgaccaacta caaaggacag gtggacacct ccaccttcat cacacaaatt gaaagggcag
     2161 gagctaagga tcgataaata attaactgca ttg
//
