LOCUS       NM_001168294            2254 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus serine (or cysteine) peptidase inhibitor, clade A,
            member 3F (Serpina3f), transcript variant 1, mRNA.
ACCESSION   NM_001168294
VERSION     NM_001168294.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2254)
  AUTHORS   Kidoya,H., Naito,H., Muramatsu,F., Yamakawa,D., Jia,W., Ikawa,M.,
            Sonobe,T., Tsuchimochi,H., Shirai,M., Adams,R.H., Fukamizu,A. and
            Takakura,N.
  TITLE     APJ Regulates Parallel Alignment of Arteries and Veins in the Skin
  JOURNAL   Dev Cell 33 (3), 247-259 (2015)
   PUBMED   25920569
REFERENCE   2  (bases 1 to 2254)
  AUTHORS   Heit,C., Jackson,B.C., McAndrews,M., Wright,M.W., Thompson,D.C.,
            Silverman,G.A., Nebert,D.W. and Vasiliou,V.
  TITLE     Update of the human and mouse SERPIN gene superfamily
  JOURNAL   Hum Genomics 7 (1), 22 (2013)
   PUBMED   24172014
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2254)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   4  (bases 1 to 2254)
  AUTHORS   Ghesquiere,B., Van Damme,J., Martens,L., Vandekerckhove,J. and
            Gevaert,K.
  TITLE     Proteome-wide characterization of N-glycosylation events by
            diagonal chromatography
  JOURNAL   J Proteome Res 5 (9), 2438-2447 (2006)
   PUBMED   16944957
REFERENCE   5  (bases 1 to 2254)
  AUTHORS   Winkler,I.G., Hendy,J., Coughlin,P., Horvath,A. and Levesque,J.P.
  TITLE     Serine protease inhibitors serpina1 and serpina3 are down-regulated
            in bone marrow during hematopoietic progenitor mobilization
  JOURNAL   J Exp Med 201 (7), 1077-1088 (2005)
   PUBMED   15795238
REFERENCE   6  (bases 1 to 2254)
  AUTHORS   Horvath,A.J., Forsyth,S.L. and Coughlin,P.B.
  TITLE     Expression patterns of murine antichymotrypsin-like genes reflect
            evolutionary divergence at the Serpina3 locus
  JOURNAL   J Mol Evol 59 (4), 488-497 (2004)
   PUBMED   15638460
REFERENCE   7  (bases 1 to 2254)
  AUTHORS   Forsyth,S., Horvath,A. and Coughlin,P.
  TITLE     A review and comparison of the murine alpha1-antitrypsin and
            alpha1-antichymotrypsin multigene clusters with the human clade A
            serpins
  JOURNAL   Genomics 81 (3), 336-345 (2003)
   PUBMED   12659817
  REMARK    Review article
REFERENCE   8  (bases 1 to 2254)
  AUTHORS   Inglis,J.D. and Hill,R.E.
  TITLE     The murine Spi-2 proteinase inhibitor locus: a multigene family
            with a hypervariable reactive site domain
  JOURNAL   EMBO J 10 (2), 255-261 (1991)
   PUBMED   1991447
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK150157.1, BC139132.1, AK138954.1 and AC142112.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. All three variants encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK150157.1, AK149697.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1458              AK150157.1         2-1459
            1459-2037           BC139132.1         1307-1885
            2038-2248           AK138954.1         1998-2208
            2249-2254           AC142112.3         76336-76341         c
FEATURES             Location/Qualifiers
     source          1..2254
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 53.65 cM"
     gene            1..2254
                     /gene="Serpina3f"
                     /gene_synonym="2A1"
                     /note="serine (or cysteine) peptidase inhibitor, clade A,
                     member 3F"
                     /db_xref="GeneID:238393"
                     /db_xref="MGI:MGI:2182838"
     exon            1..77
                     /gene="Serpina3f"
                     /gene_synonym="2A1"
                     /inference="alignment:Splign:2.1.0"
     exon            78..289
                     /gene="Serpina3f"
                     /gene_synonym="2A1"
                     /inference="alignment:Splign:2.1.0"
     exon            290..908
                     /gene="Serpina3f"
                     /gene_synonym="2A1"
                     /inference="alignment:Splign:2.1.0"
     CDS             302..1639
                     /gene="Serpina3f"
                     /gene_synonym="2A1"
                     /note="antitrypsin; alpha-1 antiproteinasin; serpin A3F"
                     /codon_start=1
                     /product="serine protease inhibitor A3F"
                     /protein_id="NP_001161766.1"
                     /db_xref="CCDS:CCDS26149.1"
                     /db_xref="GeneID:238393"
                     /db_xref="MGI:MGI:2182838"
                     /translation="MAGVSPAVFGCPDVTLGRNTAVREVQENITSVDSLTLASSNTDF
                     AFSLYKELVLKNPDENVVFSPFSICTALALLSLGAKSNTLKEILEGLKFNLTETPEPD
                     IHQGFRYLLDLLSQPGNQVQISTGSALFIEKHLQILAEFKEKARALYQAEAFTADFQQ
                     PLEATKLINDYVSNHTQGKIKELISDLDKRTLMVLVNYIYFKGKWEMPFDPDDTCKSE
                     FYLDENRSVKVPMMKINNLTTPYFRDEELSCTVVELKYTGNASAMFILPDQGKMQQVE
                     ASLQPETLRNWKDSLKPRLINELCLPKFSISTDYSLEHILPELGIRELFSTQADLSAI
                     TGTKDLRTSQVVHKAVLDVAETGTEAAAGTGYQNLQCCQGVIYSMKIYFDRPFLMIIS
                     DTNTHIALFMAKVSNPESDENFLNVEYAFPQVLEIMPEYRSVCTCCLPCLTRQ"
     exon            909..1182
                     /gene="Serpina3f"
                     /gene_synonym="2A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1333
                     /gene="Serpina3f"
                     /gene_synonym="2A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..2254
                     /gene="Serpina3f"
                     /gene_synonym="2A1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2232..2237
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Serpina3f"
                     /gene_synonym="2A1"
                     /note="hexamer: AATAAA"
     polyA_site      2254
                     /gene="Serpina3f"
                     /gene_synonym="2A1"
                     /note="major polyA site"
ORIGIN      
        1 agcagaccag gaaggcagca gccctgccca ccaggagcca gctaccacag acactggcct
       61 ttgctccagc tctgcagaag gtttacagca gtcacctgag tccttccaga agacccctct
      121 tggaagagaa gaattagcac taaaatacaa acagcaccag gaccatccac aacagaactg
      181 agctgtcaaa gccattggca agatcttaaa aactaaagaa gagaagggaa gaacaagctc
      241 taggaaaatg agagtggagg aaaagacagc agcttccaaa caatgagcag agaagagagt
      301 aatggctggt gtctcccctg ctgtctttgg ctgcccagat gtcaccctgg gaaggaacac
      361 tgcagtccgt gaagtccaag aaaatatcac atcagtggac agtttaacac tggcctccag
      421 caacactgac tttgccttca gcctctacaa ggagctggtt ttgaagaatc cagatgaaaa
      481 tgttgtcttc tccccattca gcatctgcac tgccttggcc ctgctgtccc tgggagcaaa
      541 gagcaacacc ctgaaggaaa tcctagaagg tctcaagttc aacctcacag agacccctga
      601 accagacatc caccagggct ttaggtactt gctagacctt ctcagtcagc cagggaacca
      661 ggtacagatc agcacaggca gtgccctgtt tattgaaaag cacctgcaga tcctggcaga
      721 gttcaaggag aaagcaaggg ctctgtacca ggctgaggcc ttcacagcag atttccagca
      781 gcctctcgag gccacaaagc tcatcaatga ctatgtgagc aatcacaccc aggggaagat
      841 caaggaactc atttcagacc tggataaaag gacattgatg gtgctggtga attacatcta
      901 ctttaaaggc aaatgggaga tgccctttga tccggatgat acatgtaagt ctgagttcta
      961 cttggatgag aataggtctg tgaaggtgcc catgatgaaa attaataacc tgacgacacc
     1021 ctacttccgg gatgaggagc tgtcctgcac tgtggtggag ctgaagtaca caggaaatgc
     1081 cagtgccatg ttcatcctcc cggaccaggg caagatgcag caggtggaag ccagcttgca
     1141 accagagacc ctgaggaatt ggaaggactc tctgaagccc aggttgataa atgagctctg
     1201 cctgcccaag ttctccatct ccaccgacta cagcctggag cacatccttc ctgagctggg
     1261 catcagggag ctcttctcca cccaggctga cctgtctgca atcacaggaa ccaaggatct
     1321 gagaacttct caggtggtcc acaaggctgt gctggatgtg gctgagacag gcacagaagc
     1381 agctgctggc acaggatatc aaaatctcca atgttgtcaa ggtgtaatct actctatgaa
     1441 aatatatttc gacaggccat tcctgatgat tatctctgac acaaacactc atattgccct
     1501 ctttatggca aaagtttcaa atccagagag tgatgagaac ttcctaaatg tggagtatgc
     1561 ttttccccaa gtgctggaaa ttatgcctga atataggtct gtctgcacat gttgccttcc
     1621 atgtctgact agacagtgac actgaccaat tctgtcacgt cctcatgcag agaaacaagc
     1681 ctatgactgg ttattgtcag actccctgtc ataatggtag cactaaatca agttcctgac
     1741 ctgaaatttt tgttattccc cgtccctgct gtctccactg tatctgcttc aactcaaaag
     1801 actgggaccg tcagtgaggc tctctcctaa cttaggctct gcttatgtct gccttcagct
     1861 tttcagtaat gatgggacta tacaagttta caggccaacc cataaggttt aagaagggaa
     1921 cctgcaactg tggtcctatc tgcagcatct gaaatgtttg gtgcccagtt ctaccttact
     1981 cttgccttcc tctgggcaga gctattctca gtccctgcat agtctcctgg ccccacccag
     2041 atctgataca ggtggagccc tcacccctgc agctgcatgg ggctgtgggt cagggtagtt
     2101 cttctacccc tagcactcct aatcaggaca gagaagtcgc ctaaccctaa gtgtctagtt
     2161 gaccaaccac acaagacaga tggacacctc caccttcatc acacaaattg aaagggcagg
     2221 agctaaggat caataaacat gtaactgcat tgaa
//
