LOCUS       NM_008458               1690 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus serine (or cysteine) peptidase inhibitor, clade A,
            member 3C (Serpina3c), mRNA.
ACCESSION   NM_008458
VERSION     NM_008458.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1690)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1690)
  AUTHORS   Li,B.Y., Guo,Y.Y., Xiao,G., Guo,L. and Tang,Q.Q.
  TITLE     SERPINA3C ameliorates adipose tissue inflammation through the
            Cathepsin G/Integrin/AKT pathway
  JOURNAL   Mol Metab 61, 101500 (2022)
   PUBMED   35436587
  REMARK    GeneRIF: SERPINA3C ameliorates adipose tissue inflammation through
            the Cathepsin G/Integrin/AKT pathway.
REFERENCE   3  (bases 1 to 1690)
  AUTHORS   Qian,L.L., Ji,J.J., Jiang,Y., Guo,J.Q., Wu,Y., Yang,Z., Ma,G.S. and
            Yao,Y.Y.
  TITLE     Serpina3c deficiency induced necroptosis promotes non-alcoholic
            fatty liver disease through beta-catenin/Foxo1/TLR4 signaling
  JOURNAL   FASEB J 36 (5), e22316 (2022)
   PUBMED   35429042
  REMARK    GeneRIF: Serpina3c deficiency induced necroptosis promotes
            non-alcoholic fatty liver disease through beta-catenin/Foxo1/TLR4
            signaling.
REFERENCE   4  (bases 1 to 1690)
  AUTHORS   Guo,J., Qian,L., Ji,J., Ji,Z., Jiang,Y., Wu,Y., Yang,Z., Ma,G. and
            Yao,Y.
  TITLE     Serpina3c regulates adipose differentiation via the
            Wnt/beta-catenin-PPARgamma pathway
  JOURNAL   Cell Signal 93, 110299 (2022)
   PUBMED   35263629
  REMARK    GeneRIF: Serpina3c regulates adipose differentiation via the
            Wnt/beta-catenin-PPARgamma pathway.
REFERENCE   5  (bases 1 to 1690)
  AUTHORS   Qian,L.L., Ji,J.J., Guo,J.Q., Wu,Y.P., Ma,G.S. and Yao,Y.Y.
  TITLE     Protective role of serpina3c as a novel thrombin inhibitor against
            atherosclerosis in mice
  JOURNAL   Clin Sci (Lond) 135 (3), 447-463 (2021)
   PUBMED   33458764
REFERENCE   6  (bases 1 to 1690)
  AUTHORS   Forsyth,S., Horvath,A. and Coughlin,P.
  TITLE     A review and comparison of the murine alpha1-antitrypsin and
            alpha1-antichymotrypsin multigene clusters with the human clade A
            serpins
  JOURNAL   Genomics 81 (3), 336-345 (2003)
   PUBMED   12659817
  REMARK    Review article
REFERENCE   7  (bases 1 to 1690)
  AUTHORS   Bleck,B., Hohoff,C., Binas,B., Rustow,B., Dixkens,C., Hameister,H.,
            Borchers,T. and Spener,F.
  TITLE     Cloning and chromosomal localisation of the murine epidermal-type
            fatty acid binding protein gene (Fabpe)
  JOURNAL   Gene 215 (1), 123-130 (1998)
   PUBMED   9666100
REFERENCE   8  (bases 1 to 1690)
  AUTHORS   Chen,L.M., Ma,Jx., Liang,Y.M., Chao,L. and Chao,J.
  TITLE     Tissue kallikrein-binding protein reduces blood pressure in
            transgenic mice
  JOURNAL   J Biol Chem 271 (44), 27590-27594 (1996)
   PUBMED   8910346
REFERENCE   9  (bases 1 to 1690)
  AUTHORS   Chai,K.X., Chao,J. and Chao,L.
  TITLE     Molecular cloning and sequence analysis of the mouse
            kallikrein-binding protein gene
  JOURNAL   Biochim Biophys Acta 1129 (1), 127-130 (1991)
   PUBMED   1756173
REFERENCE   10 (bases 1 to 1690)
  AUTHORS   Inglis,J.D. and Hill,R.E.
  TITLE     The murine Spi-2 proteinase inhibitor locus: a multigene family
            with a hypervariable reactive site domain
  JOURNAL   EMBO J 10 (2), 255-261 (1991)
   PUBMED   1991447
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC142112.3.
            
            On Nov 17, 2006 this sequence version replaced NM_008458.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC116724.1, SRR14995045.989749.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-94                AC142112.3         143593-143686
            95-748              AC142112.3         145371-146024
            749-1022            AC142112.3         147819-148092
            1023-1173           AC142112.3         149001-149151
            1174-1690           AC142112.3         150042-150558
FEATURES             Location/Qualifiers
     source          1..1690
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 53.46 cM"
     gene            1..1690
                     /gene="Serpina3c"
                     /gene_synonym="1A1; Kalbp; Klkbp; spi2"
                     /note="serine (or cysteine) peptidase inhibitor, clade A,
                     member 3C"
                     /db_xref="GeneID:16625"
                     /db_xref="MGI:MGI:102848"
     exon            1..94
                     /gene="Serpina3c"
                     /gene_synonym="1A1; Kalbp; Klkbp; spi2"
                     /inference="alignment:Splign:2.1.0"
     exon            95..748
                     /gene="Serpina3c"
                     /gene_synonym="1A1; Kalbp; Klkbp; spi2"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..1365
                     /gene="Serpina3c"
                     /gene_synonym="1A1; Kalbp; Klkbp; spi2"
                     /note="serine (or cysteine) proteinase inhibitor, clade A
                     (alpha-1 antiproteinase, antitrypsin), member 3C; serine
                     (or cysteine) proteinase inhibitor, clade A, member 3C;
                     serine protease inhibitor A3C; KBP; serpin A3C;
                     kallikrein-binding protein"
                     /codon_start=1
                     /product="serine protease inhibitor A3C precursor"
                     /protein_id="NP_032484.1"
                     /db_xref="CCDS:CCDS26148.1"
                     /db_xref="GeneID:16625"
                     /db_xref="MGI:MGI:102848"
                     /translation="MAFIVALGLVITGICPGVLCFPDGTLERDTLFHKDKENGTQLDS
                     LTLASINTDFAFSLYKKLALKNPDTNIVFSPLSISAALAIVSLGAKGNTLEEILEGLN
                     FNLTETPEADIHQGFGHLLQRLSHPGEQVQISTGSALFVEKHLQILAEFQEKARALYQ
                     AEAFTADFQQPLEATKLINDYVSNQTQRKIKGLISDLDTDTLMVLVNYIYFKGKWKMP
                     FNPRDTFESEFYLDVKRSVKVPMMKIKTLTTPYFRDEELSCTVVELKYKGNASALFIL
                     PDQGRMQQVEASLQPETLRKWKNSLRPRKMGELYLPKFSISTDYSLKNILPELGIKEI
                     FSKQADLSGITGTKDLIVSQMVHKAVLDVAETGTEGVAATGVNFRILSRRTSLWFNRT
                     FLMVISHTDVQTTLFIAKITHPKRA"
     exon            749..1022
                     /gene="Serpina3c"
                     /gene_synonym="1A1; Kalbp; Klkbp; spi2"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1173
                     /gene="Serpina3c"
                     /gene_synonym="1A1; Kalbp; Klkbp; spi2"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1690
                     /gene="Serpina3c"
                     /gene_synonym="1A1; Kalbp; Klkbp; spi2"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1582
                     /gene="Serpina3c"
                     /gene_synonym="1A1; Kalbp; Klkbp; spi2"
     regulatory      1658..1663
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Serpina3c"
                     /gene_synonym="1A1; Kalbp; Klkbp; spi2"
                     /note="hexamer: AATACA"
     polyA_site      1678
                     /gene="Serpina3c"
                     /gene_synonym="1A1; Kalbp; Klkbp; spi2"
                     /note="major polyA site"
ORIGIN      
        1 actggggaca acaacatgcc aggcaagcgg caaccctgaa catcaggagt cagttatcac
       61 agaagctgga agctggctgg agtaagctct gcagcctgga gaacagacaa gatggccttc
      121 attgtagctc tggggctcgt gataactggg atctgccctg gtgtcctctg cttcccagat
      181 ggcacattag aaagagacac tttattccat aaagacaaag aaaatgggac acaactcgac
      241 agtctcacat tggcctccat caacactgac tttgccttca gcctctacaa gaagctggct
      301 ttgaagaatc cagatacaaa tattgtcttc tccccactta gcatctcagc tgccttggcc
      361 atcgtgtccc tgggagcaaa gggcaacacc ctggaagaga tactagaagg tctcaacttc
      421 aatctcacag agacccctga agcagacatc caccagggct ttggacatct cctacagagg
      481 ctcagccatc caggggagca ggtacagatc agcacaggca gtgccctgtt tgttgaaaag
      541 cacctgcaga ttctggcaga attccaggag aaggcaaggg ctctgtacca ggctgaggcc
      601 ttcacagcag acttccagca gcctctcgag gccacaaagc tcatcaatga ctatgtgagc
      661 aatcagaccc agaggaagat caagggactc atctcagacc tggatacgga tacactgatg
      721 gtgctggtga attacatcta ctttaaaggc aaatggaaga tgccctttaa tccccgtgac
      781 acatttgagt cagagttcta cttggatgtg aagaggtctg tgaaggtgcc catgatgaaa
      841 attaagaccc tgaccacacc ctacttccgg gatgaggagc tgtcctgcac tgtggtggaa
      901 ctgaagtaca aaggaaatgc cagcgccctg ttcattctcc ctgaccaggg caggatgcag
      961 caggtagaag ccagcttgca accagagacc ctgaggaagt ggaagaactc tctgaggccc
     1021 aggaaaatgg gtgagctcta cctgcccaag ttctccatct ctactgacta cagcctgaag
     1081 aacatccttc cagagctggg cattaaagaa atcttctcca aacaagctga cctatctggg
     1141 atcacaggaa ccaaggacct gatagtgtct cagatggtcc acaaggctgt gctggacgtg
     1201 gctgagacag gcacagaagg agttgctgcc acaggggtca attttcgcat tcttagtaga
     1261 agaaccagtc tgtggttcaa caggacattc ctgatggtca tctctcacac agatgttcag
     1321 actactctct ttatagccaa aatcactcac cctaagagag cctaaaactc tccaagttct
     1381 gaatattctg cccaggactc tgagatggac cctatatgtg gatctctgtt tacatcctgg
     1441 cattcaagct ctgattggct gttgcaaagt tggcttagac agcgacattg actatctccg
     1501 tggctcccac atgcacagaa gactttggac tatctgtgtc aggctctcgg gtgtcttggg
     1561 agcatctgtg catgtttctg aacctggaat ctgcctttat tcttcttccc tggtgactcc
     1621 tctttatgta tctgtatccc aaacctaggc attggcaaat acacagagtt ccagtatagg
     1681 ctctgagcac
//
