LOCUS       NM_173024               2070 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus serine (or cysteine) peptidase inhibitor, clade A,
            member 3B (Serpina3b), mRNA.
ACCESSION   NM_173024
VERSION     NM_173024.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2070)
  AUTHORS   Heit,C., Jackson,B.C., McAndrews,M., Wright,M.W., Thompson,D.C.,
            Silverman,G.A., Nebert,D.W. and Vasiliou,V.
  TITLE     Update of the human and mouse SERPIN gene superfamily
  JOURNAL   Hum Genomics 7 (1), 22 (2013)
   PUBMED   24172014
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2070)
  AUTHORS   Horvath,A.J., Forsyth,S.L. and Coughlin,P.B.
  TITLE     Expression patterns of murine antichymotrypsin-like genes reflect
            evolutionary divergence at the Serpina3 locus
  JOURNAL   J Mol Evol 59 (4), 488-497 (2004)
   PUBMED   15638460
REFERENCE   3  (bases 1 to 2070)
  AUTHORS   Forsyth,S., Horvath,A. and Coughlin,P.
  TITLE     A review and comparison of the murine alpha1-antitrypsin and
            alpha1-antichymotrypsin multigene clusters with the human clade A
            serpins
  JOURNAL   Genomics 81 (3), 336-345 (2003)
   PUBMED   12659817
  REMARK    Review article
REFERENCE   4  (bases 1 to 2070)
  AUTHORS   Inglis,J.D. and Hill,R.E.
  TITLE     The murine Spi-2 proteinase inhibitor locus: a multigene family
            with a hypervariable reactive site domain
  JOURNAL   EMBO J 10 (2), 255-261 (1991)
   PUBMED   1991447
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC142112.3.
            
            On May 2, 2007 this sequence version replaced NM_173024.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK037160.1, BC145808.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-79                AC142112.3         169391-169469       c
            80-728              AC142112.3         166367-167015       c
            729-1002            AC142112.3         164327-164600       c
            1003-1153           AC142112.3         163243-163393       c
            1154-2070           AC142112.3         157920-158836       c
FEATURES             Location/Qualifiers
     source          1..2070
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 53.4 cM"
     gene            1..2070
                     /gene="Serpina3b"
                     /gene_synonym="6A1; A030003A19Rik"
                     /note="serine (or cysteine) peptidase inhibitor, clade A,
                     member 3B"
                     /db_xref="GeneID:271047"
                     /db_xref="MGI:MGI:2182835"
     exon            1..79
                     /gene="Serpina3b"
                     /gene_synonym="6A1; A030003A19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            80..728
                     /gene="Serpina3b"
                     /gene_synonym="6A1; A030003A19Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..1354
                     /gene="Serpina3b"
                     /gene_synonym="6A1; A030003A19Rik"
                     /note="serine protease inhibitor A3B; antitrypsin; alpha-1
                     antiproteinase; serine (or cysteine) proteinase inhibitor,
                     clade A, member 3B; serpin A3B"
                     /codon_start=1
                     /product="serine protease inhibitor A3B precursor"
                     /protein_id="NP_766612.1"
                     /db_xref="CCDS:CCDS26147.1"
                     /db_xref="GeneID:271047"
                     /db_xref="MGI:MGI:2182835"
                     /translation="MAFIAALGLLMAEICPAVICCSDGTLGMHNAVQKGQDTQKQLDS
                     LTLASINTDFAFSFYKELALKNPHKNIAFSPFGIATALNSLTLGAKGNTLEEILEVLK
                     FNLTETSEADIHQGFKHLLQRLSHPGDQVQIRTGNALFVEKHLQILAEFKEKARALYH
                     TEVFTANFQQPHEAMKLINSYMSNQTQGKIKELVSDMDGNTSMVIVNDLFFKAEWMVP
                     FNSDDTFMGKFIVDRSRHVKVPMMKTKNLRTPYFRDEELKCTVVELNYKGNGKAMFIL
                     PDQGKMQQVEASLQPGTLKKWRKSLRPRKIKELHLPKFSLSQHYNLEDILPELGIREL
                     FSTQADLSGITGVKNITVSEMIHSTELDMTEKGTEGDAITIVGYNFMSAKLKPVFVKF
                     EDQFLYIVLDQGDLWIHVMGKVINPSEK"
     exon            729..1002
                     /gene="Serpina3b"
                     /gene_synonym="6A1; A030003A19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1153
                     /gene="Serpina3b"
                     /gene_synonym="6A1; A030003A19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..2070
                     /gene="Serpina3b"
                     /gene_synonym="6A1; A030003A19Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaaaacattc cagaaaggca gaaaactggc acatcgggat ttacctaaca gatactagca
       61 gctggctttg actctgcaga gaacagagaa gatggccttc attgcagctc tagggctctt
      121 aatggctgag atctgccctg ctgtcatctg ctgctcagat ggcacactag gaatgcacaa
      181 tgcagtccag aaaggccagg acactcaaaa acaactggac agtttaacac tggcttccat
      241 caacactgac tttgccttca gtttctacaa ggagctagct ttgaagaatc cacataaaaa
      301 tattgccttc tctccctttg gcatcgcaac tgctctgaac tccttgactc tgggagcaaa
      361 gggcaacacc ttggaagaga ttctagaagt tcttaaattc aatctgacag aaacatctga
      421 ggcagacatc caccagggct ttaagcacct cctacagagg ctcagccatc caggggacca
      481 ggtacagatc aggacaggca atgccctgtt tgttgaaaag cacctgcaga tcctggcaga
      541 gttcaaggag aaggcaaggg ctctgtacca cactgaggtc ttcacagcca acttccagca
      601 gcctcatgaa gctatgaagc tcatcaatag ctatatgagc aatcagaccc aggggaagat
      661 caaggaactg gtctcagaca tggatggcaa tacatctatg gtgatagtga atgatctctt
      721 ttttaaagcg gaatggatgg tgccttttaa ctctgatgac acgttcatgg gaaaattcat
      781 agtggacagg agtaggcatg tgaaagtgcc aatgatgaaa actaagaacc tgaggacacc
      841 ctacttccgg gatgaagagc tgaaatgcac tgtggtggag ctgaactaca aaggcaatgg
      901 caaggccatg ttcatcctcc ctgaccaggg caagatgcag caggtggaag ccagcttaca
      961 accagggacc ctgaagaagt ggaggaaatc tttgaggccc aggaagataa aagagctcca
     1021 cttacccaag ttctccttat cccaacacta caacctagaa gacatccttc cagagctggg
     1081 tatcagggaa ctcttctcca cacaggctga cctttctggc atcacaggag tgaagaacat
     1141 aacagtctct gagatgatcc acagcactga gctggacatg actgagaaag gcacagaagg
     1201 agatgcaatc acaatagtcg gatacaactt catgtctgca aaacttaaac ctgtgtttgt
     1261 taaatttgag gaccaattcc tgtacattgt tttagatcaa ggtgatttgt ggatccatgt
     1321 aatgggcaag gttatcaacc cctcagaaaa gtagaacttc ccgagttgtg gggcttcttt
     1381 ccaagctaac agattgagtc tttatgcaat tttcagcttc caccctctca taggctgtgg
     1441 catttttgta atcaaacagt gcccttgact aactttacta gtcacatttc acatgagcct
     1501 gtggatggtc tgggtcaagc tcctagtctt cttggcaaca cgagctcacc ttcctgagcc
     1561 tgaactcagc ctttcctctg ctcccctgtt tactcccctt tacctgtgac tatcaaaagc
     1621 ctgggcaggt tggctcactc ctctgatatg ctctgatcat gtctgctttc cacttctgca
     1681 gccttggtgg aactatgaaa gtttacaggc caacccatat ggacaacagg acaaggtaca
     1741 agacaggaac attctgccct gtctatttgt agcatctgaa acacttggtg cccagtttct
     1801 gcctcactct ttccttacta tcgtctgtac cacccactga cccttgcagg gtctcctgac
     1861 tctgtccaca cagttggagt cccctctcct atagctgcat gtggtctgtt gctcacacca
     1921 gctcctctcc ccctaacact cctactcagg gcagagtagt accttttctc tcagttccca
     1981 gatgaccagc ctcacaggac agctggacac ctccacctcc atcacccaaa atgaaaggga
     2041 ggagcaaatg atcaataaac gtatccctgc
//
