LOCUS       NM_001167705            1864 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus serine (or cysteine) peptidase inhibitor, clade A,
            member 3A (Serpina3a), transcript variant 1, mRNA.
ACCESSION   NM_001167705 XM_282560 XM_910062
VERSION     NM_001167705.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1864)
  AUTHORS   Zhao,T., Xiao,T., Cao,D., Xia,W., Gao,L., Cheng,L., Zang,M., Li,X.
            and Xu,E.Y.
  TITLE     Sertoli cell PUMILIO proteins modulate mouse testis size through
            translational control of cell cycle regulators
  JOURNAL   Biol Reprod 107 (1), 135-147 (2022)
   PUBMED   35678316
REFERENCE   2  (bases 1 to 1864)
  AUTHORS   Whiley,P.A.F., O'Donnell,L., Moody,S.C., Handelsman,D.J.,
            Young,J.C., Richards,E.A., Almstrup,K., Western,P.S. and
            Loveland,K.L.
  TITLE     Activin A Determines Steroid Levels and Composition in the Fetal
            Testis
  JOURNAL   Endocrinology 161 (7) (2020)
   PUBMED   32274496
REFERENCE   3  (bases 1 to 1864)
  AUTHORS   Heit,C., Jackson,B.C., McAndrews,M., Wright,M.W., Thompson,D.C.,
            Silverman,G.A., Nebert,D.W. and Vasiliou,V.
  TITLE     Update of the human and mouse SERPIN gene superfamily
  JOURNAL   Hum Genomics 7 (1), 22 (2013)
   PUBMED   24172014
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1864)
  AUTHORS   Horvath,A.J., Forsyth,S.L. and Coughlin,P.B.
  TITLE     Expression patterns of murine antichymotrypsin-like genes reflect
            evolutionary divergence at the Serpina3 locus
  JOURNAL   J Mol Evol 59 (4), 488-497 (2004)
   PUBMED   15638460
REFERENCE   5  (bases 1 to 1864)
  AUTHORS   Forsyth,S., Horvath,A. and Coughlin,P.
  TITLE     A review and comparison of the murine alpha1-antitrypsin and
            alpha1-antichymotrypsin multigene clusters with the human clade A
            serpins
  JOURNAL   Genomics 81 (3), 336-345 (2003)
   PUBMED   12659817
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC142112.3.
            
            On or before Nov 17, 2009 this sequence version replaced
            XM_910062.2, XM_282560.6.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC063325.1, SRR5189685.159993.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: downstream AUG is associated
                                                with N-terminal localization
                                                signal
            RefSeq Select criteria           :: based on conservation, longest
                                                protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-200               AC142112.3         184542-184741       c
            201-860             AC142112.3         180853-181512       c
            861-1134            AC142112.3         178771-179044       c
            1135-1285           AC142112.3         177680-177830       c
            1286-1864           AC142112.3         175569-176147       c
FEATURES             Location/Qualifiers
     source          1..1864
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 53.34 cM"
     gene            1..1864
                     /gene="Serpina3a"
                     /note="serine (or cysteine) peptidase inhibitor, clade A,
                     member 3A"
                     /db_xref="GeneID:74069"
                     /db_xref="MGI:MGI:1921319"
     exon            1..200
                     /gene="Serpina3a"
                     /inference="alignment:Splign:2.1.0"
     exon            201..860
                     /gene="Serpina3a"
                     /inference="alignment:Splign:2.1.0"
     CDS             218..1486
                     /gene="Serpina3a"
                     /note="isoform 1 is encoded by transcript variant 1;
                     serine (or cysteine) proteinase inhibitor, clade A
                     (alpha-1 antiproteinase, antitrypsin), member 3A; serine
                     protease inhibitor A3A; serpin A3A"
                     /codon_start=1
                     /product="serine protease inhibitor A3A isoform 1"
                     /protein_id="NP_001161177.1"
                     /db_xref="CCDS:CCDS49156.1"
                     /db_xref="GeneID:74069"
                     /db_xref="MGI:MGI:1921319"
                     /translation="MAFIAALGLLMAGICPAITYWATADGQLGRHTEVQKDRDHEIQL
                     DSVTLASINTDFAFSLYKKLALKNPHKNIVFSPLSISAALALMSLGAKDNTLEEILEG
                     LKFNLTETPEADIHQNFGHLLQMLIQPENQVQINAGNALFIDKHLQILTEFKEKARAL
                     YKAEAFTADFQLPREATKLINDYVRKQTQGKIKELVSDLHRNTSMALVNFLNFQGFWN
                     VTFDPEDTFLGNFTLDRKRTVNVPMMKTEELTTNYFRDEEMQSTVMELNYIGNASFLF
                     ILPDQGRIQHVEDSLQPQSLRKWRKSLRPRMLDELSLPKFSLSQDYNLNDILPELGIK
                     EVFSTQADLSGITGAKNIRVSQMIHQAALDVTETHTEADVITIARYNFQSAKIKAKIV
                     KVDREFLYLILDPMFKSISVMGKVINPLTN"
     exon            861..1134
                     /gene="Serpina3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1285
                     /gene="Serpina3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1864
                     /gene="Serpina3a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagacctcga taagtaccct tcctggtctc ctatttctct ttcttttact cccatttcct
       61 tccaggttcg cggtccccct cgcacgcacg aataactgaa tcctgcggga cgggatagac
      121 cagaagcatg aggacagtct ggctatttca gatgtttcct tttttgctgg gtcccaatat
      181 cagacaggag ctacttgaag cctggagaac agagatgatg gccttcattg cagctctggg
      241 gctcctgatg gcgggaatct gtcctgctat cacctactgg gcaactgcag atgggcaact
      301 gggaaggcac actgaagtcc agaaagacag agaccatgaa atacaactgg acagtgtcac
      361 actggcttcc atcaacactg actttgcctt cagcctctac aagaagcttg ctttgaagaa
      421 tccacataaa aatattgtct tctccccact tagcatctca gctgccttgg ccctcatgtc
      481 cctgggagca aaggacaaca ccctggaaga gattctagaa ggtctcaagt tcaatctcac
      541 agagacccca gaagcagaca tccaccagaa ctttgggcac ctcctacaaa tgctcattca
      601 gccagagaac caggttcaga tcaatgctgg caacgccctg tttattgata agcacctgca
      661 gatcttgaca gagttcaagg agaaggcaag ggctctgtac aaggctgagg ccttcacagc
      721 agacttccag ttgcctcgtg aggccacaaa gctcatcaat gactatgtga ggaaacagac
      781 ccaggggaag atcaaggaac tggtctcaga cctgcatagg aacacatcca tggcactagt
      841 gaatttcctc aactttcaag gcttttggaa cgtgactttt gaccctgaag acacgttcct
      901 gggaaatttc acattggata ggaagaggac cgtgaatgtg cccatgatga aaaccgagga
      961 gctaaccaca aactacttcc gggacgagga gatgcaaagt actgtgatgg agctgaatta
     1021 cataggcaat gccagcttcc tgtttatcct ccctgaccag ggcaggatac agcacgtgga
     1081 agatagcttg caaccccagt ctctgaggaa atggaggaaa tctttgaggc ccaggatgct
     1141 agatgaactc tccctgccca agttctcctt atcacaagac tacaacctaa atgacatcct
     1201 tccagagctg ggtatcaagg aagtcttctc cacacaggct gacctgtctg ggatcactgg
     1261 agccaaaaat ataagagtct ctcagatgat ccaccaggct gcgctggatg ttaccgagac
     1321 acacacagaa gcagatgtca tcacaatagc ccgatataac ttccaatctg caaaaattaa
     1381 ggctaaaatt gttaaggtgg acagggaatt cttgtacctt attttagacc caatgtttaa
     1441 gagtattagc gttatgggta aggttatcaa ccctttaaca aactagatct tctcaagtgg
     1501 tggggcttct ttccaagttt gatttgcttt ttggcttcta tcctctgatt ggctaggata
     1561 tgcttgtaat tgttcactga agttgattaa ctttagtggt cacacataca caagggactg
     1621 tggatggtct gtgtcaggca tcagtcctgt tggcatcact agcacatatt cctgggcctg
     1681 aaatctgtct ctcttccact tcccagatga acttctccat ctgcatcacc caaaatgaat
     1741 aggtaggagc aaacagtaga taaacctata cctgcacaga aagtgtccag gcagtgttca
     1801 ctcagctcct gttggcagga ggtggcctct agtgacaaga gggacattaa acaatgccaa
     1861 ttgc
//
