LOCUS       NM_026687               3158 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus serine (or cysteine) peptidase inhibitor, clade A,
            member 1F (Serpina1f), transcript variant 1, mRNA.
ACCESSION   NM_026687 XM_127079
VERSION     NM_026687.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3158)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3158)
  AUTHORS   Heit,C., Jackson,B.C., McAndrews,M., Wright,M.W., Thompson,D.C.,
            Silverman,G.A., Nebert,D.W. and Vasiliou,V.
  TITLE     Update of the human and mouse SERPIN gene superfamily
  JOURNAL   Hum Genomics 7 (1), 22 (2013)
   PUBMED   24172014
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3158)
  AUTHORS   Yamazaki,K., Adachi,T., Sato,K., Yanagisawa,Y., Fukata,H., Seki,N.,
            Mori,C. and Komiyama,M.
  TITLE     Identification and characterization of novel and unknown mouse
            epididymis-specific genes by complementary DNA microarray
            technology
  JOURNAL   Biol Reprod 75 (3), 462-468 (2006)
   PUBMED   16707773
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC098741.2, AK002574.1 and AK165409.1.
            
            On Sep 28, 2009 this sequence version replaced NM_026687.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB233454.1, SRR5189685.83244.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-140               AC098741.2         164366-164505
            141-163             AK002574.1         29-51
            164-862             AK165409.1         2-700
            863-985             AK002574.1         751-873
            986-986             AC098741.2         168002-168002
            987-1027            AK002574.1         875-915
            1028-1075           AK165409.1         701-748
            1076-1076           AK002574.1         964-964
            1077-3158           AK165409.1         750-2831
FEATURES             Location/Qualifiers
     source          1..3158
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 52.98 cM"
     gene            1..3158
                     /gene="Serpina1f"
                     /gene_synonym="0610012A11Rik; epserin; Serpina2"
                     /note="serine (or cysteine) peptidase inhibitor, clade A,
                     member 1F"
                     /db_xref="GeneID:68348"
                     /db_xref="MGI:MGI:1915598"
     exon            1..140
                     /gene="Serpina1f"
                     /gene_synonym="0610012A11Rik; epserin; Serpina2"
                     /inference="alignment:Splign:2.1.0"
     exon            141..233
                     /gene="Serpina1f"
                     /gene_synonym="0610012A11Rik; epserin; Serpina2"
                     /inference="alignment:Splign:2.1.0"
     exon            234..862
                     /gene="Serpina1f"
                     /gene_synonym="0610012A11Rik; epserin; Serpina2"
                     /inference="alignment:Splign:2.1.0"
     CDS             235..1470
                     /gene="Serpina1f"
                     /gene_synonym="0610012A11Rik; epserin; Serpina2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; serine protease inhibitor 1-6; alpha-1 protease
                     inhibitor 6; alpha-1-antiproteinase; alpha-1-antitrypsin
                     1-6; epsin; epididymal serine protease inhibitor; serine
                     protease inhibitor A1f; serpin A1f"
                     /codon_start=1
                     /product="alpha-1-antitrypsin 1-6 isoform 1 precursor"
                     /protein_id="NP_080963.2"
                     /db_xref="CCDS:CCDS26137.1"
                     /db_xref="GeneID:68348"
                     /db_xref="MGI:MGI:1915598"
                     /translation="MTTPFSSHGLLLLVGLCCLLLITKTKHEKLYEDPSIDPFQCRKV
                     ALTICNVSITLFKKMAQLSGNGNILFSPIRVIAAISMLSLGSNGNLSKHILETLRFNK
                     TGLPEAEIHKCFWYLLHSIHQTEEPSSLQTGSSVFIHQDLTSVDKFVKGVKDLYHSDM
                     ISINFTDSSQAKTQINNYVMEKSQKEIVNIVKNLESDTFLAVVNYIIWNAKLDSNFGC
                     RSVKVKDYHLGYGMTIKVPMIHNMAMHYLFRVEDLSSTVLMLTLLTGNFATYFIIPDP
                     GKMQKVEQSLTYPHFRRMRRQLLTRLVDLEIPELSLSETHDLESMMSLLGITYVFNSG
                     TNSSDMNDTLQKSFKVVSKAVLTIDEKGSKPSTNSCFKKLGSTDMGRMQLNRPFLIFI
                     QDHTNDVPLFLGRVVNPQN"
     exon            863..1136
                     /gene="Serpina1f"
                     /gene_synonym="0610012A11Rik; epserin; Serpina2"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1281
                     /gene="Serpina1f"
                     /gene_synonym="0610012A11Rik; epserin; Serpina2"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..3158
                     /gene="Serpina1f"
                     /gene_synonym="0610012A11Rik; epserin; Serpina2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1524..1529
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Serpina1f"
                     /gene_synonym="0610012A11Rik; epserin; Serpina2"
                     /note="hexamer: ATTAAA"
     polyA_site      1569
                     /gene="Serpina1f"
                     /gene_synonym="0610012A11Rik; epserin; Serpina2"
                     /note="major polyA site"
ORIGIN      
        1 aaatgtcatc atcacacaca gggacggagc gtgccccacg ctctgctatg cctataagtc
       61 cccagggtga cagctacagg ggaagtcact gctgcatgat cagcccacaa gcttctcact
      121 gcctccacgg acgctactca gctcctgctc tgattctgac ctcacagtac tccggctggt
      181 cctagaggct gaagcttggc aaacctacaa acttccccca agatcatttc caggatgaca
      241 acaccctttt cctcccatgg actcctcctg ctagtgggct tgtgctgtct gcttctcata
      301 accaagacta aacatgaaaa actctatgaa gacccaagca ttgatccctt ccagtgccgg
      361 aaggtggctc ttaccatctg caatgtctcc atcaccttgt tcaaaaagat ggcccaactg
      421 tcaggaaatg gaaatatttt attctccccg attagagtca ttgctgccat ttcaatgctg
      481 tccctgggat ccaatggcaa cttaagcaaa cacatcctgg agactctaag gttcaacaaa
      541 acaggcttgc ctgaagcgga gatccacaag tgtttctggt atctgctcca ttccatccac
      601 cagactgaag agccatcatc actacaaact ggtagcagcg tgttcatcca ccaggacctg
      661 acatcagtag acaaatttgt gaaaggagtc aaggacctat accattctga catgatctcc
      721 atcaacttta cagacagcag tcaggccaag acacagatca acaattacgt gatggagaaa
      781 agccagaagg aaatagtgaa cattgtcaag aacctggaga gtgatacatt cctggctgtg
      841 gtgaactaca ttatctggaa tgccaaactt gacagcaact ttggctgccg gtccgtcaaa
      901 gtgaaggact accacttagg atacggcatg acaatcaagg taccgatgat ccataacatg
      961 gccatgcatt acttgttccg agtcgaggat ctgtctagca cggtgctgat gcttactctg
     1021 ctcacaggca acttcgcaac ctacttcatc atacccgatc cagggaagat gcagaaggtg
     1081 gaacagagcc taacctaccc acacttccgc cggatgagac gacaattatt gacaaggttg
     1141 gttgatttag agataccaga actctcattg tctgagaccc atgacttgga gtcaatgatg
     1201 agtctactag gaatcaccta tgttttcaac agtggcacca atagctctga catgaatgac
     1261 acacttcaga agtccttcaa ggtggtaagt aaggctgtgc tgaccatcga tgaaaagggg
     1321 tcaaagccta gtacaaactc atgctttaaa aagctcggat cgactgatat gggccggatg
     1381 cagctcaaca gacctttcct catcttcatc caggatcaca caaatgatgt ccccctcttt
     1441 ttaggcagag tggtaaatcc ccagaactaa gtgctctcag gaatcagcct ctctcctgaa
     1501 agccatgtcc ccttctgggt aacattaaac atggggccgt ttcacccatg cctgagtgca
     1561 aacagcaaat ccctctcctt gtggtgtctg tgtcttcctc tgtcccctga ggtatgtggg
     1621 gtctccaggt cacagtgcat cacactgtct cctgcatctg tgttgaggag gtccccatga
     1681 tgtcccagct ccagcactga aggcagaggg ccatgtcccc ttctggttgt actgtgtcat
     1741 ctcactgggt ctggcctctc catctcacca caattttcct gagaatggct agaggaaata
     1801 gttggtagaa ctcttcctcc acaggactgg agcaggaccc cagcctgttg ctgtcattcg
     1861 ttccctgcta gaagggactc acaaatcctc caatgatcag agaggtctct gggtgattcc
     1921 cctcgggctt ctcctgccaa tcaggccact agacacaaag ccactttgtc ctggctgacc
     1981 gtgaagccat gctgtatgag tggctctgaa aagccataag gataggtacc tacatgagaa
     2041 ggacaccttt cctttcgcta gggtccccct gagatcttcc tgaagtcata tacaactgca
     2101 cctaccccat ctccaggccc tcaacatagt attccaggga taaatataaa tccagtgcct
     2161 catagtagat ctcaggattc atcattgtca tcggggccag gcagtctacc ccatcctcct
     2221 caacccttgt tatgcccaga tcttgggaac cccagaagaa ctctaggaat tgctagtcca
     2281 atgtaatata actgaagagc ctttattcga gtcatacaag gatcaaaaac ctttcccact
     2341 gcacaggtta ggaacgggat gctcgctgtt ccagttcaga ggcttggagt ttttatacgt
     2401 gcatatgcat aagcagggat ccttgggtta catgacaggg gaggtgacaa gaggaagtca
     2461 ttctttcaaa cctgatgtcg tttgttcaga cagtgcagaa ttgtgcgact gggagggggc
     2521 tcttctgacc tgggaagtaa ctttatggtg ctatcaggaa ctagtgtgtt tttacaaact
     2581 ggccagggct gtctggggac acttaattgc ccttctctca tggcccaagg gtggggcact
     2641 tatcttttca aggatgtttg atccttattt ctctcaagga caggagccat ctgcaccaga
     2701 gaaatgttat caaggagagt gccagccttg gtgacacaga ggctgggata tgttgccttt
     2761 gtctgtaccc aaagccacca tctgctgctc ccctggtggt gggagaggga ggggagtgtt
     2821 gaaagggtca ttagggagaa gagagaacta ccaggagaag gggaattgca atattgtgga
     2881 gccaggctgg gccctctctg tttgcccttt ctgaaaggct ggaggcatct atgctgggag
     2941 aagggggagg ggattggagt ggtgggagag tgcagaggca ggtttcctgc atctcttcac
     3001 cctcagcctt gctaactgcc tgcagcagac agaatcccct tcccaggaaa tgcacctact
     3061 gctcagaaca cttgtgtact gtgggagtgc tgcctgcttc atctgcagat cataccccac
     3121 cccaacccta actccctgaa taaatgtgga cagaaagc
//
