LOCUS       NM_009247               1374 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus serine (or cysteine) peptidase inhibitor, clade A,
            member 1E (Serpina1e), mRNA.
ACCESSION   NM_009247
VERSION     NM_009247.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1374)
  AUTHORS   Theis,A., Singer,R.A., Garofalo,D., Paul,A., Narayana,A. and
            Sussel,L.
  TITLE     Groucho co-repressor proteins regulate beta cell development and
            proliferation by repressing Foxa1 in the developing mouse pancreas
  JOURNAL   Development 148 (6) (2021)
   PUBMED   33658226
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1374)
  AUTHORS   Heit,C., Jackson,B.C., McAndrews,M., Wright,M.W., Thompson,D.C.,
            Silverman,G.A., Nebert,D.W. and Vasiliou,V.
  TITLE     Update of the human and mouse SERPIN gene superfamily
  JOURNAL   Hum Genomics 7 (1), 22 (2013)
   PUBMED   24172014
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1374)
  AUTHORS   Sohrab,S., Petrusca,D.N., Lockett,A.D., Schweitzer,K.S., Rush,N.I.,
            Gu,Y., Kamocki,K., Garrison,J. and Petrache,I.
  TITLE     Mechanism of alpha-1 antitrypsin endocytosis by lung endothelium
  JOURNAL   FASEB J 23 (9), 3149-3158 (2009)
   PUBMED   19423638
  REMARK    GeneRIF: clathrin-mediated endocytosis regulates A1AT intracellular
            function in the lung endothelium and may be an important
            determinant of the serpin's protection against developing cigarette
            smoke-induced emphysema
REFERENCE   4  (bases 1 to 1374)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   5  (bases 1 to 1374)
  AUTHORS   Ghesquiere,B., Van Damme,J., Martens,L., Vandekerckhove,J. and
            Gevaert,K.
  TITLE     Proteome-wide characterization of N-glycosylation events by
            diagonal chromatography
  JOURNAL   J Proteome Res 5 (9), 2438-2447 (2006)
   PUBMED   16944957
REFERENCE   6  (bases 1 to 1374)
  AUTHORS   Forsyth,S., Horvath,A. and Coughlin,P.
  TITLE     A review and comparison of the murine alpha1-antitrypsin and
            alpha1-antichymotrypsin multigene clusters with the human clade A
            serpins
  JOURNAL   Genomics 81 (3), 336-345 (2003)
   PUBMED   12659817
  REMARK    Review article
REFERENCE   7  (bases 1 to 1374)
  AUTHORS   Barbour,K.W., Wei,F., Brannan,C., Flotte,T.R., Baumann,H. and
            Berger,F.G.
  TITLE     The murine alpha(1)-proteinase inhibitor gene family: polymorphism,
            chromosomal location, and structure
  JOURNAL   Genomics 80 (5), 515-522 (2002)
   PUBMED   12408969
REFERENCE   8  (bases 1 to 1374)
  AUTHORS   Tardiff,J. and Krauter,K.S.
  TITLE     Divergent expression of alpha1-protease inhibitor genes in mouse
            and human
  JOURNAL   Nucleic Acids Res 26 (16), 3794-3799 (1998)
   PUBMED   9685498
REFERENCE   9  (bases 1 to 1374)
  AUTHORS   Paterson,T. and Moore,S.
  TITLE     The expression and characterization of five recombinant murine
            alpha 1-protease inhibitor proteins
  JOURNAL   Biochem Biophys Res Commun 219 (1), 64-69 (1996)
   PUBMED   8619829
REFERENCE   10 (bases 1 to 1374)
  AUTHORS   Borriello,F. and Krauter,K.S.
  TITLE     Multiple murine alpha 1-protease inhibitor genes show unusual
            evolutionary divergence
  JOURNAL   Proc Natl Acad Sci U S A 88 (21), 9417-9421 (1991)
   PUBMED   1946354
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC061176.1.
            
            On Oct 4, 2005 this sequence version replaced NM_009247.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061176.1, AK004999.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1374              BC061176.1         12-1385
FEATURES             Location/Qualifiers
     source          1..1374
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 52.98 cM"
     gene            1..1374
                     /gene="Serpina1e"
                     /gene_synonym="Dom5; PI5; Spi1-5"
                     /note="serine (or cysteine) peptidase inhibitor, clade A,
                     member 1E"
                     /db_xref="GeneID:20704"
                     /db_xref="MGI:MGI:891967"
     exon            1..41
                     /gene="Serpina1e"
                     /gene_synonym="Dom5; PI5; Spi1-5"
                     /inference="alignment:Splign:2.1.0"
     exon            42..673
                     /gene="Serpina1e"
                     /gene_synonym="Dom5; PI5; Spi1-5"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..1287
                     /gene="Serpina1e"
                     /gene_synonym="Dom5; PI5; Spi1-5"
                     /note="serine (or cysteine) proteinase inhibitor, clade A,
                     member 1e; alpha-1 protease inhibitor 5;
                     alpha-1-antitrypsin 1-5; serine protease inhibitor A1e;
                     serpin A1e; serine protease inhibitor 1-5"
                     /codon_start=1
                     /product="alpha-1-antitrypsin 1-5 precursor"
                     /protein_id="NP_033273.1"
                     /db_xref="CCDS:CCDS26142.1"
                     /db_xref="GeneID:20704"
                     /db_xref="MGI:MGI:891967"
                     /translation="MTPSISWCLLLLAGLCCLVPSFLAEDVQETDTSQKDQSPASHEI
                     ATNLGDFAISLYRELVHQSNTSNIFFSPVSIATAFAMLSLGSKGDTHTQILEGLQFNL
                     TQTSEADIHNSFQHLLQTLNRPDSELQLSTGNGLFVNNDLKLVEKFLEEAKNHYQAEV
                     FSVNFAESEEAKKVINDFVEKGTQGKIVEAVKKLEQDTVFVLANYILFKGKWKKPFDP
                     ENTKQAEFHVDESTTVKVPMMTLSGMLDVHHCSTLSSWVLLMDYAGNATAVFLLPDDG
                     KMQHLEQTLNKELISKFLLNRRRRLAQIHIPRLSISGNYNLETLMSPLGITRIFNSGA
                     DLSGITEENAPLKLSQAVHKAVLTIDETGTEAAAATVLQGGFLSMPPILHFNRPFLFI
                     IFEEHSQSPLFVGKVVDPTHK"
     exon            674..944
                     /gene="Serpina1e"
                     /gene_synonym="Dom5; PI5; Spi1-5"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1095
                     /gene="Serpina1e"
                     /gene_synonym="Dom5; PI5; Spi1-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1374
                     /gene="Serpina1e"
                     /gene_synonym="Dom5; PI5; Spi1-5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1332..1337
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Serpina1e"
                     /gene_synonym="Dom5; PI5; Spi1-5"
                     /note="hexamer: ATTAAA"
     polyA_site      1374
                     /gene="Serpina1e"
                     /gene_synonym="Dom5; PI5; Spi1-5"
                     /note="major polyA site"
ORIGIN      
        1 tcctcagcct cggtcaccac ccagctctga gacagcaagc tgaaaatgac tccctccatc
       61 tcatggtgtc tactgcttct ggcaggcctg tgttgcctgg tccccagctt tctggctgag
      121 gatgttcagg agacagacac ctcccagaag gatcagtccc cagcctccca tgagattgct
      181 acaaacctgg gagactttgc catcagtcta taccgggagc tggtccatca gtccaacact
      241 tccaacatct tcttctcccc agtgagcatt gccacagcct ttgctatgct ctccctaggg
      301 agcaagggtg acactcacac gcagatccta gagggcctgc agttcaacct cacacaaaca
      361 tcggaggctg acatccacaa ttccttccaa cacctcctcc aaaccctcaa cagaccagac
      421 agtgagctgc agctgagcac aggcaatggc ctctttgtca acaatgacct gaagctggtg
      481 gagaagtttc tggaagaggc caagaaccat tatcaggcag aagtcttctc tgtcaacttt
      541 gcagagtcag aggaggccaa gaaagtgatt aatgattttg tggagaaggg aacccaagga
      601 aagatagttg aggctgtgaa aaaactagaa caagacacag ttttcgtcct ggcaaattac
      661 attctcttta aaggcaaatg gaagaagcca ttcgatcctg agaacactaa gcaagctgag
      721 ttccacgtgg acgagtccac cacggtgaag gtgcccatga tgaccctctc gggcatgctt
      781 gacgtgcacc attgcagcac gctctccagc tgggtgctgc tgatggatta cgcgggcaac
      841 gccactgctg tcttcctcct gcccgatgat gggaagatgc agcatctgga gcaaactctc
      901 aacaaggagc tcatctctaa gttcctgcta aacaggcgca gaaggttagc ccagatccat
      961 atccccagac tgtccatctc tggaaactat aacttggaga cactcatgag tccactgggc
     1021 atcacccgga tcttcaacag tggggctgac ctctccggaa tcacagagga gaatgctccc
     1081 ctgaagctca gccaggctgt gcataaggcc gtgctgacca tcgatgagac aggaacagaa
     1141 gctgcagcag ctacagtctt acaaggcggt tttttgtcta tgccccctat cttgcacttc
     1201 aaccgccctt tccttttcat aatatttgaa gaacactctc agagccccct ctttgtggga
     1261 aaagtggtag atcccacaca taaatgacca ccctaagaag tcatccttcc ttctgaattg
     1321 ggttcctttc cattaaacac gggctggcct ggctcatgcc tgatgctaca gaaa
//
