LOCUS       NM_009245               1424 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus serine (or cysteine) peptidase inhibitor, clade A,
            member 1C (Serpina1c), mRNA.
ACCESSION   NM_009245
VERSION     NM_009245.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1424)
  AUTHORS   Heit,C., Jackson,B.C., McAndrews,M., Wright,M.W., Thompson,D.C.,
            Silverman,G.A., Nebert,D.W. and Vasiliou,V.
  TITLE     Update of the human and mouse SERPIN gene superfamily
  JOURNAL   Hum Genomics 7 (1), 22 (2013)
   PUBMED   24172014
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1424)
  AUTHORS   Wilkinson,T.S., Dhaliwal,K., Hamilton,T.W., Lipka,A.F., Farrell,L.,
            Davidson,D.J., Duffin,R., Morris,A.C., Haslett,C., Govan,J.R.,
            Gregory,C.D., Sallenave,J.M. and Simpson,A.J.
  TITLE     Trappin-2 promotes early clearance of Pseudomonas aeruginosa
            through CD14-dependent macrophage activation and neutrophil
            recruitment
  JOURNAL   Am J Pathol 174 (4), 1338-1346 (2009)
   PUBMED   19264904
  REMARK    GeneRIF: Trappin-2 may therefore play an important role in innate
            recognition and clearance of pathogens during the very earliest
            stages of pulmonary infection.
REFERENCE   3  (bases 1 to 1424)
  AUTHORS   Winkler,I.G., Hendy,J., Coughlin,P., Horvath,A. and Levesque,J.P.
  TITLE     Serine protease inhibitors serpina1 and serpina3 are down-regulated
            in bone marrow during hematopoietic progenitor mobilization
  JOURNAL   J Exp Med 201 (7), 1077-1088 (2005)
   PUBMED   15795238
REFERENCE   4  (bases 1 to 1424)
  AUTHORS   Forsyth,S., Horvath,A. and Coughlin,P.
  TITLE     A review and comparison of the murine alpha1-antitrypsin and
            alpha1-antichymotrypsin multigene clusters with the human clade A
            serpins
  JOURNAL   Genomics 81 (3), 336-345 (2003)
   PUBMED   12659817
  REMARK    Review article
REFERENCE   5  (bases 1 to 1424)
  AUTHORS   Barbour,K.W., Wei,F., Brannan,C., Flotte,T.R., Baumann,H. and
            Berger,F.G.
  TITLE     The murine alpha(1)-proteinase inhibitor gene family: polymorphism,
            chromosomal location, and structure
  JOURNAL   Genomics 80 (5), 515-522 (2002)
   PUBMED   12408969
REFERENCE   6  (bases 1 to 1424)
  AUTHORS   Tardiff,J. and Krauter,K.S.
  TITLE     Divergent expression of alpha1-protease inhibitor genes in mouse
            and human
  JOURNAL   Nucleic Acids Res 26 (16), 3794-3799 (1998)
   PUBMED   9685498
REFERENCE   7  (bases 1 to 1424)
  AUTHORS   Paterson,T. and Moore,S.
  TITLE     The expression and characterization of five recombinant murine
            alpha 1-protease inhibitor proteins
  JOURNAL   Biochem Biophys Res Commun 219 (1), 64-69 (1996)
   PUBMED   8619829
REFERENCE   8  (bases 1 to 1424)
  AUTHORS   de Meeus,A., Alonso,S., Demaille,J. and Bouvagnet,P.
  TITLE     A detailed linkage map of subtelomeric murine chromosome 12 region
            including the situs inversus mutation locus IV
  JOURNAL   Mamm Genome 3 (11), 637-643 (1992)
   PUBMED   1360279
REFERENCE   9  (bases 1 to 1424)
  AUTHORS   Borriello,F. and Krauter,K.S.
  TITLE     Multiple murine alpha 1-protease inhibitor genes show unusual
            evolutionary divergence
  JOURNAL   Proc Natl Acad Sci U S A 88 (21), 9417-9421 (1991)
   PUBMED   1946354
REFERENCE   10 (bases 1 to 1424)
  AUTHORS   Hill,R.E., Shaw,P.H., Boyd,P.A., Baumann,H. and Hastie,N.D.
  TITLE     Plasma protease inhibitors in mouse and man: divergence within the
            reactive centre regions
  JOURNAL   Nature 311 (5982), 175-177 (1984)
   PUBMED   6547997
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC134902.7 and M75720.1.
            
            On Oct 4, 2005 this sequence version replaced NM_009245.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC024108.1, BC031707.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                AC134902.7         169719-169781
            64-908              M75720.1           1-845
            909-995             AC134902.7         177542-177628
            996-1424            M75720.1           933-1361
FEATURES             Location/Qualifiers
     source          1..1424
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 52.98 cM"
     gene            1..1424
                     /gene="Serpina1c"
                     /gene_synonym="Pi3; Pi6; Skalp; Spi1-3; Spi1-6; Wap3"
                     /note="serine (or cysteine) peptidase inhibitor, clade A,
                     member 1C"
                     /db_xref="GeneID:20702"
                     /db_xref="MGI:MGI:891969"
     exon            1..92
                     /gene="Serpina1c"
                     /gene_synonym="Pi3; Pi6; Skalp; Spi1-3; Spi1-6; Wap3"
                     /inference="alignment:Splign:2.1.0"
     exon            93..724
                     /gene="Serpina1c"
                     /gene_synonym="Pi3; Pi6; Skalp; Spi1-3; Spi1-6; Wap3"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..1338
                     /gene="Serpina1c"
                     /gene_synonym="Pi3; Pi6; Skalp; Spi1-3; Spi1-6; Wap3"
                     /note="serine (or cysteine) proteinase inhibitor, clade A,
                     member 1c; alpha-1-antitrypsin 1-3; apha-1 protease
                     inhibitor 3; trappin-2; pre-elafin; alpha-1-antitrypsin
                     1-6; alpha-1 protease inhibitor 3; alpha-1 protease
                     inhibitor 6; serine protease inhibitor A1c; serpin A1c;
                     serine protease inhibitor 1-3; serine protease inhibitor
                     1-6"
                     /codon_start=1
                     /product="alpha-1-antitrypsin 1-3 precursor"
                     /protein_id="NP_033271.1"
                     /db_xref="CCDS:CCDS26141.1"
                     /db_xref="GeneID:20702"
                     /db_xref="MGI:MGI:891969"
                     /translation="MTPSISWGLLLLAGLCCLVPSFLAEDVQETDTSQKDQSPASHEI
                     ATNLGDFAISLYRELVHQSNTSNIFFSPVSIATAFAMLSLGSKGDTHTQILEGLQFNL
                     TQTSEADIHKSFQHLLQTLNRPDSELQLSTGNGLFVNNDLKLVEKFLEEAKNHYQAEV
                     FSVNFAESEEAKKVINDFVEKGTQGKIAEAVKKLDQDTVFALANYILFKGKWKKPFDP
                     ENTEEAEFHVDESTTVKVPMMTLSGMLDVHHCSTLSSWVLLMDYAGNATAVFLLPDDG
                     KMQHLEQTLSKELISKFLLKRPRRLAQIHFPRLSISGEYNLKTLMSPLGITRIFNNGA
                     DLSGITEENAPLKLSQAVHKAVLTMDETGTEAAAATVLLAVPYSMPPIVRFDHPFLFI
                     IFEEHTQSPLFVGKVVDPTHK"
     exon            725..995
                     /gene="Serpina1c"
                     /gene_synonym="Pi3; Pi6; Skalp; Spi1-3; Spi1-6; Wap3"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1146
                     /gene="Serpina1c"
                     /gene_synonym="Pi3; Pi6; Skalp; Spi1-3; Spi1-6; Wap3"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1424
                     /gene="Serpina1c"
                     /gene_synonym="Pi3; Pi6; Skalp; Spi1-3; Spi1-6; Wap3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1382..1387
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Serpina1c"
                     /gene_synonym="Pi3; Pi6; Skalp; Spi1-3; Spi1-6; Wap3"
                     /note="hexamer: ATTAAA"
     polyA_site      1424
                     /gene="Serpina1c"
                     /gene_synonym="Pi3; Pi6; Skalp; Spi1-3; Spi1-6; Wap3"
                     /note="major polyA site"
ORIGIN      
        1 tatccatctt ggctcccact acttaaatac agactaggac agggctctgt ctcctcagcc
       61 tcggtcacca cccagctctg ggacagcaag ctgaaaatga ctccctccat ctcatggggt
      121 ctactgcttc tggcaggcct gtgttgcctg gtccccagct ttctggctga ggatgttcag
      181 gagacagaca cctcccagaa ggatcagtcc ccagcctccc atgagatcgc tacaaacctg
      241 ggagactttg caatcagcct ataccgggag ctggtccatc agtccaacac ttccaacatc
      301 ttcttctccc cagtgagcat tgccacagcc tttgctatgc tctccctagg gagcaagggt
      361 gacactcaca cgcagatcct agagggcctg cagttcaacc tcacacaaac atcggaggct
      421 gacatccaca agtccttcca acacctcctc caaaccctca acagaccaga cagtgagctg
      481 cagctgagca caggcaatgg cctctttgtc aacaatgacc tgaagctggt ggagaagttt
      541 ctggaagagg ccaagaacca ttatcaggca gaagtcttct ctgtcaactt tgcagagtca
      601 gaggaggcca agaaagtgat taatgatttt gtggagaagg gaacccaagg aaagatagct
      661 gaggcggtga aaaaactgga ccaagacaca gttttcgccc tggcaaatta cattctcttt
      721 aaaggcaaat ggaagaagcc attcgatcct gagaacactg aggaagctga gttccacgtg
      781 gacgagtcca ccacggtgaa ggtgcccatg atgaccctct cgggaatgct tgatgtgcac
      841 cattgcagca cgctgtccag ctgggtgctg ctgatggatt atgcaggcaa tgccactgct
      901 gtcttccttc tgcccgatga tgggaagatg cagcatctgg agcaaactct cagcaaggag
      961 ctcatctcca agttcctgct aaagaggccc agaaggttag cccagatcca cttccccaga
     1021 ctgtccatct ctggagaata taacttgaag acactcatga gtccactggg catcacccgg
     1081 atcttcaaca atggggctga cctctccgga atcacagagg agaatgctcc cctgaagctc
     1141 agccaggctg tgcataaggc tgtgctgacc atggatgaga caggaacaga agctgcagca
     1201 gctacagtct tactagccgt tccttattct atgcccccta tcgtgcgctt cgatcaccct
     1261 ttccttttca taatatttga agaacacact cagagccccc tctttgtggg aaaagtggta
     1321 gatcccacac ataaatgacc accctaagat gtcatccttc cttctgaatt gggttccttc
     1381 cattaaacac aggctggcct ggctcgtgcc tgatgctaca gcaa
//
