LOCUS       NM_009244               1434 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus serine (or cysteine) preptidase inhibitor, clade A,
            member 1B (Serpina1b), mRNA.
ACCESSION   NM_009244 XM_001005362
VERSION     NM_009244.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1434)
  AUTHORS   Heit,C., Jackson,B.C., McAndrews,M., Wright,M.W., Thompson,D.C.,
            Silverman,G.A., Nebert,D.W. and Vasiliou,V.
  TITLE     Update of the human and mouse SERPIN gene superfamily
  JOURNAL   Hum Genomics 7 (1), 22 (2013)
   PUBMED   24172014
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1434)
  AUTHORS   McNab,G.L., Dafforn,T.R., Wood,A., Sapey,E. and Stockley,R.A.
  TITLE     A novel model and molecular therapy for Z alpha-1 antitrypsin
            deficiency
  JOURNAL   Mamm Genome 23 (3-4), 241-249 (2012)
   PUBMED   22076419
REFERENCE   3  (bases 1 to 1434)
  AUTHORS   Alam,S., Li,Z., Janciauskiene,S. and Mahadeva,R.
  TITLE     Oxidation of Z alpha1-antitrypsin by cigarette smoke induces
            polymerization: a novel mechanism of early-onset emphysema
  JOURNAL   Am J Respir Cell Mol Biol 45 (2), 261-269 (2011)
   PUBMED   20971880
  REMARK    GeneRIF: Loss of alpha 1-Antitrypsin is associated with emphysema.
REFERENCE   4  (bases 1 to 1434)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   5  (bases 1 to 1434)
  AUTHORS   Sevilla,L.M., Nachat,R., Groot,K.R., Klement,J.F., Uitto,J.,
            Djian,P., Maatta,A. and Watt,F.M.
  TITLE     Mice deficient in involucrin, envoplakin, and periplakin have a
            defective epidermal barrier
  JOURNAL   J Cell Biol 179 (7), 1599-1612 (2007)
   PUBMED   18166659
REFERENCE   6  (bases 1 to 1434)
  AUTHORS   Jiang,Y., Yu,V.C., Buchholz,F., O'Connell,S., Rhodes,S.J.,
            Candeloro,C., Xia,Y.R., Lusis,A.J. and Rosenfeld,M.G.
  TITLE     A novel family of Cys-Cys, His-Cys zinc finger transcription
            factors expressed in developing nervous system and pituitary gland
  JOURNAL   J Biol Chem 271 (18), 10723-10730 (1996)
   PUBMED   8631881
REFERENCE   7  (bases 1 to 1434)
  AUTHORS   Paterson,T. and Moore,S.
  TITLE     The expression and characterization of five recombinant murine
            alpha 1-protease inhibitor proteins
  JOURNAL   Biochem Biophys Res Commun 219 (1), 64-69 (1996)
   PUBMED   8619829
REFERENCE   8  (bases 1 to 1434)
  AUTHORS   Warden,C.H., Mehrabian,M., He,K.Y., Yoon,M.Y., Diep,A., Xia,Y.R.,
            Wen,P.Z., Svenson,K.L., Sparkes,R.S. and Lusis,A.J.
  TITLE     Linkage mapping of 40 randomly isolated liver cDNA clones in the
            mouse
  JOURNAL   Genomics 18 (2), 295-307 (1993)
   PUBMED   8288233
REFERENCE   9  (bases 1 to 1434)
  AUTHORS   Borriello,F. and Krauter,K.S.
  TITLE     Multiple murine alpha 1-protease inhibitor genes show unusual
            evolutionary divergence
  JOURNAL   Proc Natl Acad Sci U S A 88 (21), 9417-9421 (1991)
   PUBMED   1946354
REFERENCE   10 (bases 1 to 1434)
  AUTHORS   Sifers,R.N., Ledley,F.D., Reed-Fourquet,L., Ledbetter,D.H.,
            Ledbetter,S.A. and Woo,S.L.
  TITLE     Complete cDNA sequence and chromosomal localization of mouse alpha
            1-antitrypsin
  JOURNAL   Genomics 6 (1), 100-104 (1990)
   PUBMED   2303252
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY111394.1, BY136397.1, M75716.1 and AI046447.1.
            
            On or before May 4, 2006 this sequence version replaced
            XM_001005362.1, NM_009244.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC022109.1, SRR5189679.160820.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                BY111394.1         1-55
            56-130              BY136397.1         1-75
            131-1107            M75716.1           1-977
            1108-1434           AI046447.1         1-327               c
FEATURES             Location/Qualifiers
     source          1..1434
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 52.98 cM"
     gene            1..1434
                     /gene="Serpina1b"
                     /gene_synonym="D12Ucla2; Dom2; PI2; Spi1-2"
                     /note="serine (or cysteine) preptidase inhibitor, clade A,
                     member 1B"
                     /db_xref="GeneID:20701"
                     /db_xref="MGI:MGI:891970"
     exon            1..93
                     /gene="Serpina1b"
                     /gene_synonym="D12Ucla2; Dom2; PI2; Spi1-2"
                     /inference="alignment:Splign:2.1.0"
     exon            94..725
                     /gene="Serpina1b"
                     /gene_synonym="D12Ucla2; Dom2; PI2; Spi1-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..1339
                     /gene="Serpina1b"
                     /gene_synonym="D12Ucla2; Dom2; PI2; Spi1-2"
                     /note="serine (or cysteine) proteinase inhibitor, clade A,
                     member 1b; alpha-1-antitrypsin 1-2; alpha-1 protease
                     inhibitor 2; alpha-1-antiproteinase; AAT; serine protease
                     inhibitor A1b; serpin A1b; serine protease inhibitor 1-2"
                     /codon_start=1
                     /product="alpha-1-antitrypsin 1-2 precursor"
                     /protein_id="NP_033270.3"
                     /db_xref="CCDS:CCDS26138.1"
                     /db_xref="GeneID:20701"
                     /db_xref="MGI:MGI:891970"
                     /translation="MTPSISWGLLLLAGLCCMVPSFLAEDVQETDTSQKDQSPASHEI
                     ATNLGDFAISLYRELVHQSNTSNIFFSPVSIATAFAMLSLGSKGDTHTQILEGLQFNL
                     TQTSEADIHKSFQHLLQTLNRPDSELQLSTGNGLFVNNDLKLVEKFLEEAKNHYQAEV
                     FSVNFAESEEAKKVINDFVEKGTQGKIVEAVKELDQDTVFALANYILFKGKWKKPFDP
                     ENTEEAEFHVDKSTTVKVPMMMLSGMLDVHHCSILSSWVLLMDYAGNASAVFLLPEDG
                     KMQHLEQTLNKELISKILLNRRRRLVQIHIPRLSISGDYNLKTLMSPLGITRIFNNGA
                     DLSGITEENAPLKLSKAVHKAVLTIDETGTEAAAATVFEAVPMSMPPILRFDHPFLFI
                     IFEEHTQSPIFVGKVVDPTHK"
     exon            726..996
                     /gene="Serpina1b"
                     /gene_synonym="D12Ucla2; Dom2; PI2; Spi1-2"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1147
                     /gene="Serpina1b"
                     /gene_synonym="D12Ucla2; Dom2; PI2; Spi1-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1425
                     /gene="Serpina1b"
                     /gene_synonym="D12Ucla2; Dom2; PI2; Spi1-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1383..1388
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Serpina1b"
                     /gene_synonym="D12Ucla2; Dom2; PI2; Spi1-2"
                     /note="hexamer: ATTAAA"
     polyA_site      1425
                     /gene="Serpina1b"
                     /gene_synonym="D12Ucla2; Dom2; PI2; Spi1-2"
                     /note="major polyA site"
ORIGIN      
        1 atatccccct tggctcccac tgcttaaata cagactagga cagggctctg tctcctcagc
       61 ctcggtcacc acccagctct gggacagcaa gctgaaaatg actccctcca tctcatgggg
      121 tctactgctt ctggcaggcc tgtgttgcat ggttcccagc tttctggctg aggatgttca
      181 ggagacagac acctcccaga aggatcagtc cccagcctcc catgagatcg ctacaaacct
      241 gggagacttt gccatcagcc tataccggga gctggtccat cagtccaaca cttccaacat
      301 cttcttctcc ccagtgagca ttgccacagc ctttgctatg ctctccctag ggagcaaggg
      361 tgacactcac acgcagatcc tagagggcct gcagttcaac ctcacacaaa catcggaggc
      421 tgacatccac aagtccttcc aacacctcct ccaaaccctc aacagaccag acagtgagct
      481 gcagctgagc acaggcaatg gcctctttgt caacaatgac ctgaagctgg tggagaagtt
      541 tctggaagag gccaagaacc attatcaggc agaagtcttc tctgtcaact ttgcagagtc
      601 agaggaggcc aagaaagtga ttaatgattt tgtggagaag ggaacccaag gaaagatagt
      661 tgaggcagtg aaagaactgg accaagacac agttttcgcc ctggcgaatt acattctttt
      721 taaaggcaaa tggaagaagc cattcgatcc tgagaacact gaggaagctg agttccacgt
      781 ggacaagtcc accacggtga aggtgcccat gatgatgctc tcgggcatgc ttgatgtgca
      841 ccattgcagc atactgtcca gctgggtgct gctgatggat tacgcgggca acgccagtgc
      901 tgtcttcctc ctgcccgaag atgggaagat gcagcatctg gagcaaactc tcaacaagga
      961 gctcatctct aagatcctgc taaacaggcg cagaaggtta gtccagatcc atatccccag
     1021 actgtccatc tctggagact ataacttgaa gacactcatg agtccactgg gcatcacccg
     1081 gatcttcaac aatggggctg acctctctgg aatcacagag gagaatgctc ccctgaagct
     1141 cagcaaggct gtgcataagg ctgtgctgac catcgatgag acaggaacag aagctgcagc
     1201 agctacagtc tttgaagccg ttcctatgtc tatgccccct atcctgcgct tcgaccaccc
     1261 tttccttttt ataatatttg aagaacacac tcagagcccc atctttgtgg gaaaagtggt
     1321 agatcccaca cataaatgac caccctacga tgtcatcctt ccttctgaat tgggttcctt
     1381 ccattaaaca caggctggcc tggctcgtgc ctgatgctac agcaaaaaaa aaaa
//
