LOCUS       NM_009243               1724 bp    mRNA    linear   ROD 04-OCT-2024
DEFINITION  Mus musculus serine (or cysteine) peptidase inhibitor, clade A,
            member 1A (Serpina1a), transcript variant 1, mRNA.
ACCESSION   NM_009243 XM_619026
VERSION     NM_009243.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1724)
  AUTHORS   Poole,B., Oshins,R., Huo,Z., Aranyos,A., West,J., Duarte,S.,
            Clark,V.C., Beduschi,T., Zarrinpar,A., Brantly,M. and Khodayari,N.
  TITLE     Sirtuin3 promotes the degradation of hepatic Z alpha-1 antitrypsin
            through lipophagy
  JOURNAL   Hepatol Commun 8 (2), e0370 (2024)
   PUBMED   38285890
  REMARK    GeneRIF: Sirtuin3 promotes the degradation of hepatic Z alpha-1
            antitrypsin through lipophagy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1724)
  AUTHORS   Bristow,C.L.
  TITLE     Lipoproteins in Negative Feedback with Alpha-1 Antitrypsin
  JOURNAL   Methods Mol Biol 2750, 167-174 (2024)
   PUBMED   38108976
  REMARK    GeneRIF: Lipoproteins in Negative Feedback with Alpha-1
            Antitrypsin.
REFERENCE   3  (bases 1 to 1724)
  AUTHORS   Pastore,N., Annunziata,F., Colonna,R., Maffia,V., Giuliano,T.,
            Custode,B.M., Lombardi,B., Polishchuk,E., Cacace,V., De Stefano,L.,
            Nusco,E., Sorrentino,N.C., Piccolo,P. and Brunetti-Pierri,N.
  TITLE     Increased expression or activation of TRPML1 reduces hepatic
            storage of toxic Z alpha-1 antitrypsin
  JOURNAL   Mol Ther 31 (9), 2651-2661 (2023)
   PUBMED   37394797
  REMARK    GeneRIF: Increased expression or activation of TRPML1 reduces
            hepatic storage of toxic Z alpha-1 antitrypsin.
REFERENCE   4  (bases 1 to 1724)
  AUTHORS   Meghadri,S.H., Martinez-Delgado,B., Ostermann,L., Gomez-Mariano,G.,
            Perez-Luz,S., Tumpara,S., Wrenger,S., DeLuca,D.S., Maus,U.A.,
            Welte,T. and Janciauskiene,S.
  TITLE     Loss of Serpina1 in Mice Leads to Altered Gene Expression in
            Inflammatory and Metabolic Pathways
  JOURNAL   Int J Mol Sci 23 (18), 10425 (2022)
   PUBMED   36142337
  REMARK    GeneRIF: Loss of Serpina1 in Mice Leads to Altered Gene Expression
            in Inflammatory and Metabolic Pathways.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1724)
  AUTHORS   Campbell,R.A., Campbell,H.D., Bircher,J.S., de Araujo,C.V.,
            Denorme,F., Crandell,J.L., Rustad,J.L., Monts,J., Cody,M.J.,
            Kosaka,Y. and Yost,C.C.
  TITLE     Placental HTRA1 cleaves alpha1-antitrypsin to generate a
            NET-inhibitory peptide
  JOURNAL   Blood 138 (11), 977-988 (2021)
   PUBMED   34192300
  REMARK    GeneRIF: Placental HTRA1 cleaves alpha1-antitrypsin to generate a
            NET-inhibitory peptide.
REFERENCE   6  (bases 1 to 1724)
  AUTHORS   Tardiff,J. and Krauter,K.S.
  TITLE     Divergent expression of alpha1-protease inhibitor genes in mouse
            and human
  JOURNAL   Nucleic Acids Res 26 (16), 3794-3799 (1998)
   PUBMED   9685498
REFERENCE   7  (bases 1 to 1724)
  AUTHORS   Paterson,T. and Moore,S.
  TITLE     The expression and characterization of five recombinant murine
            alpha 1-protease inhibitor proteins
  JOURNAL   Biochem Biophys Res Commun 219 (1), 64-69 (1996)
   PUBMED   8619829
REFERENCE   8  (bases 1 to 1724)
  AUTHORS   Borriello,F. and Krauter,K.S.
  TITLE     Multiple murine alpha 1-protease inhibitor genes show unusual
            evolutionary divergence
  JOURNAL   Proc Natl Acad Sci U S A 88 (21), 9417-9421 (1991)
   PUBMED   1946354
REFERENCE   9  (bases 1 to 1724)
  AUTHORS   Krauter,K.S., Citron,B.A., Hsu,M.T., Powell,D. and Darnell,J.E. Jr.
  TITLE     Isolation and characterization of the alpha 1-antitrypsin gene of
            mice
  JOURNAL   DNA 5 (1), 29-36 (1986)
   PUBMED   3007061
REFERENCE   10 (bases 1 to 1724)
  AUTHORS   Bonhomme,F., Catalan,J., Britton-Davidian,J., Chapman,V.M.,
            Moriwaki,K., Nevo,E. and Thaler,L.
  TITLE     Biochemical diversity and evolution in the genus Mus
  JOURNAL   Biochem Genet 22 (3-4), 275-303 (1984)
   PUBMED   6375655
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC134902.7, AK146619.1, W82055.1 and CJ238440.1.
            
            On Nov 19, 2011 this sequence version replaced NM_009243.3.
            
            Transcript Variant: This variant (1) is the predominant transcript
            and encodes the shorter isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057984.1, AK146619.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                AC134902.7         211050-211117
            69-1428             AK146619.1         2-1361
            1429-1560           W82055.1           358-489
            1561-1724           CJ238440.1         316-479
FEATURES             Location/Qualifiers
     source          1..1724
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 52.98 cM"
     gene            1..1724
                     /gene="Serpina1a"
                     /gene_synonym="Aat-2; Aat2; Dom1; PI1; Spi1-1; Spi1-3"
                     /note="serine (or cysteine) peptidase inhibitor, clade A,
                     member 1A"
                     /db_xref="GeneID:20700"
                     /db_xref="MGI:MGI:891971"
     exon            1..98
                     /gene="Serpina1a"
                     /gene_synonym="Aat-2; Aat2; Dom1; PI1; Spi1-1; Spi1-3"
                     /inference="alignment:Splign:2.1.0"
     exon            99..730
                     /gene="Serpina1a"
                     /gene_synonym="Aat-2; Aat2; Dom1; PI1; Spi1-1; Spi1-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..1344
                     /gene="Serpina1a"
                     /gene_synonym="Aat-2; Aat2; Dom1; PI1; Spi1-1; Spi1-3"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; serine (or cysteine) proteinase inhibitor,
                     clade A, member 1a; alpha-1-antitrypsin 1-1; alpha-1
                     protease inhibitor 1; alpha-1-antiproteinase; AAT; serine
                     protease inhibitor A1a; serpin A1a; alpha-1-antitrypsin 2;
                     serine protease inhibitor 1-1"
                     /codon_start=1
                     /product="alpha-1-antitrypsin 1-1 isoform 1 precursor"
                     /protein_id="NP_033269.1"
                     /db_xref="CCDS:CCDS26140.1"
                     /db_xref="GeneID:20700"
                     /db_xref="MGI:MGI:891971"
                     /translation="MTPSISWGLLLLAGLCCLVPSFLAEDVQETDTSQKDQSPASHEI
                     ATNLGDFAISLYRELVHQSNTSNIFFSPVSIATAFAMLSLGSKGDTHTQILEGLQFNL
                     TQTSEADIHKSFQHLLQTLNRPDSELQLSTGNGLFVNNDLKLVEKFLEEAKNHYQAEV
                     FSVNFAESEEAKKVINDFVEKGTQGKIAEAVKKLDQDTVFALANYILFKGKWKKPFDP
                     ENTEEAEFHVDESTTVKVPMMTLSGMLHVHHCSTLSSWVLLMDYAGNATAVFLLPDDG
                     KMQHLEQTLSKELISKFLLNRRRRLAQIHFPRLSISGEYNLKTLMSPLGITRIFNNGA
                     DLSGITEENAPLKLSQAVHKAVLTIDETGTEAAAVTVLQMVPMSMPPILRFDHPFLFI
                     IFEEHTQSPIFLGKVVDPTHK"
     exon            731..1001
                     /gene="Serpina1a"
                     /gene_synonym="Aat-2; Aat2; Dom1; PI1; Spi1-1; Spi1-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1152
                     /gene="Serpina1a"
                     /gene_synonym="Aat-2; Aat2; Dom1; PI1; Spi1-1; Spi1-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1724
                     /gene="Serpina1a"
                     /gene_synonym="Aat-2; Aat2; Dom1; PI1; Spi1-1; Spi1-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1388..1393
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Serpina1a"
                     /gene_synonym="Aat-2; Aat2; Dom1; PI1; Spi1-1; Spi1-3"
                     /note="hexamer: ATTAAA"
     polyA_site      1430
                     /gene="Serpina1a"
                     /gene_synonym="Aat-2; Aat2; Dom1; PI1; Spi1-1; Spi1-3"
                     /note="major polyA site"
     regulatory      1667..1672
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Serpina1a"
                     /gene_synonym="Aat-2; Aat2; Dom1; PI1; Spi1-1; Spi1-3"
                     /note="hexamer: AATAAA"
     regulatory      1689..1694
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Serpina1a"
                     /gene_synonym="Aat-2; Aat2; Dom1; PI1; Spi1-1; Spi1-3"
                     /note="hexamer: AATAAA"
     polyA_site      1690
                     /gene="Serpina1a"
                     /gene_synonym="Aat-2; Aat2; Dom1; PI1; Spi1-1; Spi1-3"
     polyA_site      1711
                     /gene="Serpina1a"
                     /gene_synonym="Aat-2; Aat2; Dom1; PI1; Spi1-1; Spi1-3"
ORIGIN      
        1 cccccatatc ccccttggct cccattgctt aaatacagac taggacaggg ctctgtctcc
       61 tcagcctcgg tcaccaccca gctctgggac agcaagctga aaatgactcc ctccatctca
      121 tggggtctac tgcttctggc aggcctgtgt tgcctggtcc ccagctttct ggctgaggat
      181 gttcaggaga cagacacctc ccagaaggat cagtccccag cctcccatga gatcgctaca
      241 aacctgggag actttgcaat cagcctatac cgggagctgg tccatcagtc caacacttcc
      301 aacatcttct tctccccagt gagcattgcc acagcctttg ctatgctctc cctagggagc
      361 aagggtgaca ctcacacgca gatcctagag ggcctgcagt tcaacctcac acaaacatcg
      421 gaggctgaca tccacaagtc cttccaacac ctcctccaaa ccctcaacag accagacagt
      481 gagctgcagc tgagcacagg caatggcctc tttgtcaaca atgacctgaa gctggtggag
      541 aagtttctgg aagaggccaa gaaccattat caggcagaag tcttctctgt caactttgca
      601 gagtcagagg aggccaagaa agtgattaat gattttgtgg agaagggaac ccaaggaaag
      661 atagctgagg cggtgaaaaa actggaccaa gacacagttt tcgccctggc aaattacatt
      721 ctctttaaag gcaaatggaa gaagccattc gatcctgaga acactgagga agctgagttc
      781 cacgtggacg agtccaccac ggtgaaggtg cccatgatga ccctctcggg catgcttcat
      841 gtgcaccatt gcagcacgct gtccagctgg gtgctgctga tggattatgc aggcaatgcc
      901 actgctgtct tccttctgcc cgatgatggg aagatgcagc atctggagca aactctcagc
      961 aaggagctca tctctaagtt cctgctaaac aggcgcagaa ggttagccca gatccacttc
     1021 cccagactgt ccatctctgg agaatataac ttgaagacac tcatgagtcc actgggcatc
     1081 acccggatct tcaacaatgg ggctgacctc tccggaatca cagaggaaaa tgctcccctg
     1141 aagctcagcc aggctgtgca taaggctgtg ctgaccatcg atgagacagg aacagaagct
     1201 gcagcagtta cagtcttaca aatggttcct atgtctatgc cccctatcct gcgcttcgac
     1261 caccctttcc ttttcataat atttgaagaa cacactcaga gccccatctt tttgggaaaa
     1321 gtggtagatc ccacacataa atgaccaccc taaaatgtca tccttccttc tgaattgggt
     1381 tccttccatt aaacacaggc tggcctggct cgtgcctgat gctacagcaa gtccttgact
     1441 ctgtgggttg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg
     1501 tgtgtgtgtg tgtctgtgtg tgtgtgtgtc tttatgccct gagtttgttg tggacttgag
     1561 atcatagtat gtcttgatat ctcctccagc catgcaaata ggttgtgggt agaggactgt
     1621 ggctgagacc acagactctg gtccaagaac catctgctct aaaaaaaata aatctgtcat
     1681 ctctggaaaa taaagaggac atgctcaatg actcagggtc cagc
//
