LOCUS       NM_026535               3690 bp    mRNA    linear   ROD 12-AUG-2024
DEFINITION  Mus musculus serine (or cysteine) peptidase inhibitor, clade A
            (alpha-1 antiproteinase, antitrypsin), member 12 (Serpina12), mRNA.
ACCESSION   NM_026535
VERSION     NM_026535.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3690)
  AUTHORS   Tindall,C.A., Mohlis,K., Rapohn,I., Dommel,S., Riedl,V.,
            Schneekonig,M., Hofling,C., Rossner,S., Stichel,J.,
            Beck-Sickinger,A.G., Weiner,J. and Heiker,J.T.
  TITLE     LRP1 is the cell-surface endocytosis receptor for vaspin in
            adipocytes
  JOURNAL   FEBS J 291 (10), 2134-2154 (2024)
   PUBMED   37921063
  REMARK    GeneRIF: LRP1 is the cell-surface endocytosis receptor for vaspin
            in adipocytes.
REFERENCE   2  (bases 1 to 3690)
  AUTHORS   Yu,H., Zhou,L., Loong,J.H.C., Lam,K.H., Wong,T.L., Ng,K.Y.,
            Tong,M., Ma,V.W.S., Wang,Y., Zhang,X., Lee,T.K., Yun,J.P., Yu,J.
            and Ma,S.
  TITLE     SERPINA12 promotes the tumorigenic capacity of HCC stem cells
            through hyperactivation of AKT/beta-catenin signaling
  JOURNAL   Hepatology 78 (6), 1711-1726 (2023)
   PUBMED   36630996
  REMARK    GeneRIF: SERPINA12 promotes the tumorigenic capacity of HCC stem
            cells through hyperactivation of AKT/beta-catenin signaling.
REFERENCE   3  (bases 1 to 3690)
  AUTHORS   Nakatsuka,A., Yamaguchi,S., Eguchi,J., Kakuta,S., Iwakura,Y.,
            Sugiyama,H. and Wada,J.
  TITLE     A Vaspin-HSPA1L complex protects proximal tubular cells from
            organelle stress in diabetic kidney disease
  JOURNAL   Commun Biol 4 (1), 373 (2021)
   PUBMED   33742129
  REMARK    GeneRIF: A Vaspin-HSPA1L complex protects proximal tubular cells
            from organelle stress in diabetic kidney disease.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3690)
  AUTHORS   Zhang,G.Z., Zhang,K., Yang,S.Q., Zhang,Z., Chen,S., Hou,B.J. and
            Yuan,J.Y.
  TITLE     VASPIN reduces inflammation and endoplasmic reticulum stress of
            renal tubular epithelial cells by inhibiting HMGB1 and relieves
            renal ischemia-reperfusion injury
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (17), 8968-8977 (2020)
   PUBMED   32964986
  REMARK    GeneRIF: VASPIN reduces inflammation and endoplasmic reticulum
            stress of renal tubular epithelial cells by inhibiting HMGB1 and
            relieves renal ischemia-reperfusion injury.
REFERENCE   5  (bases 1 to 3690)
  AUTHORS   Aibara,D., Matsuo,K., Yamano,S. and Matsusue,K.
  TITLE     Vaspin is a novel target gene of hepatic CCAAT-enhancer-binding
            protein
  JOURNAL   Gene 721, 144113 (2019)
   PUBMED   31505214
  REMARK    GeneRIF: These results suggest that C/EBPalpha positively regulates
            hepatic vaspin expression through two functional CEBPREs. Thus,
            vaspin is a novel C/EBPalpha target gene in the liver.
REFERENCE   6  (bases 1 to 3690)
  AUTHORS   Nakatsuka,A., Wada,J., Iseda,I., Teshigawara,S., Higashio,K.,
            Murakami,K., Kanzaki,M., Inoue,K., Terami,T., Katayama,A., Hida,K.,
            Eguchi,J., Horiguchi,C.S., Ogawa,D., Matsuki,Y., Hiramatsu,R.,
            Yagita,H., Kakuta,S., Iwakura,Y. and Makino,H.
  TITLE     Vaspin is an adipokine ameliorating ER stress in obesity as a
            ligand for cell-surface GRP78/MTJ-1 complex
  JOURNAL   Diabetes 61 (11), 2823-2832 (2012)
   PUBMED   22837305
  REMARK    GeneRIF: Data suggest that vaspin is ligand for cell-surface GRP78
            (glucose-regulated protein 78kD)/MTJ-1 (DnaJ-like protein 1)
            complex; subsequent signal transduction benefits endoplasmic
            reticulum stress-induced metabolic dysfunctions as seen in obesity.
REFERENCE   7  (bases 1 to 3690)
  AUTHORS   Wada,J.
  TITLE     [Vaspin and insulin resistance]
  JOURNAL   Rinsho Byori 56 (8), 705-711 (2008)
   PUBMED   18800627
  REMARK    GeneRIF: may be the compensatory molecule in the pathogenesis of
            metabolic syndrome. (review)
            Review article
REFERENCE   8  (bases 1 to 3690)
  AUTHORS   Patel,S., Xi,Z.F., Seo,E.Y., McGaughey,D. and Segre,J.A.
  TITLE     Klf4 and corticosteroids activate an overlapping set of
            transcriptional targets to accelerate in utero epidermal barrier
            acquisition
  JOURNAL   Proc Natl Acad Sci U S A 103 (49), 18668-18673 (2006)
   PUBMED   17130451
REFERENCE   9  (bases 1 to 3690)
  AUTHORS   Hida,K., Wada,J., Eguchi,J., Zhang,H., Baba,M., Seida,A.,
            Hashimoto,I., Okada,T., Yasuhara,A., Nakatsuka,A., Shikata,K.,
            Hourai,S., Futami,J., Watanabe,E., Matsuki,Y., Hiramatsu,R.,
            Akagi,S., Makino,H. and Kanwar,Y.S.
  TITLE     Visceral adipose tissue-derived serine protease inhibitor: a unique
            insulin-sensitizing adipocytokine in obesity
  JOURNAL   Proc Natl Acad Sci U S A 102 (30), 10610-10615 (2005)
   PUBMED   16030142
REFERENCE   10 (bases 1 to 3690)
  AUTHORS   Forsyth,S., Horvath,A. and Coughlin,P.
  TITLE     A review and comparison of the murine alpha1-antitrypsin and
            alpha1-antichymotrypsin multigene clusters with the human clade A
            serpins
  JOURNAL   Genomics 81 (3), 336-345 (2003)
   PUBMED   12659817
  REMARK    Review article
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC134902.7.
            
            On Nov 17, 2006 this sequence version replaced NM_026535.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK014589.1, AY326419.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-181               AC134902.7         30226-30406
            182-832             AC134902.7         36281-36931
            833-1103            AC134902.7         38848-39118
            1104-1251           AC134902.7         42097-42244
            1252-3690           AC134902.7         43462-45900
FEATURES             Location/Qualifiers
     source          1..3690
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 53.05 cM"
     gene            1..3690
                     /gene="Serpina12"
                     /gene_synonym="4632419J12Rik"
                     /note="serine (or cysteine) peptidase inhibitor, clade A
                     (alpha-1 antiproteinase, antitrypsin), member 12"
                     /db_xref="GeneID:68054"
                     /db_xref="MGI:MGI:1915304"
     exon            1..181
                     /gene="Serpina12"
                     /gene_synonym="4632419J12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            182..832
                     /gene="Serpina12"
                     /gene_synonym="4632419J12Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             199..1440
                     /gene="Serpina12"
                     /gene_synonym="4632419J12Rik"
                     /note="serine (or cysteine) proteinase inhibitor, clade A
                     (alpha-1 antiproteinase, antitrypsin), member 12; serpin
                     A12; visceral adipose-specific SERPIN; vaspin; visceral
                     adipose tissue-derived serine protease inhibitor"
                     /codon_start=1
                     /product="serpin A12 precursor"
                     /protein_id="NP_080811.1"
                     /db_xref="CCDS:CCDS26145.1"
                     /db_xref="GeneID:68054"
                     /db_xref="MGI:MGI:1915304"
                     /translation="MTRMLDLGLFLAGLLTVKGLLQDRDAPDMYDSPVRVQEWRGKKD
                     ARQLARHNMEFGFKLLQRLASNSPQGNIFLSPLSISTAFSMLSLGAQNSTLEEIREGF
                     NFKEMSNWDVHAAFHYLLHKLNQETEDTKMNLGNALFMDQKLRPQQRFLNLAKNVYDA
                     DMVLTNFQDLENTQKDINRYISQKTHSRIKNMVKSIDPGTVMILTNYIYFRGRWQYEF
                     DPKQTKEEEFFIEKGKTVKVPMMFQRGLYDMAYDSQLSCTILEIPYRGNITATFVLPD
                     NGKLKLLEQGLQADIFAKWKSLLSKRVVDVWVPKLRISSTYNMKKVLSRLGISKIFEE
                     NGDLTRISSHRSLKVGEAVHKAELKMDEKGMEGAAGSGAQTLPMETPRHMKLDRPFLM
                     MIYENFMPSMVFLARIYDPSG"
     exon            833..1103
                     /gene="Serpina12"
                     /gene_synonym="4632419J12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1251
                     /gene="Serpina12"
                     /gene_synonym="4632419J12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..3690
                     /gene="Serpina12"
                     /gene_synonym="4632419J12Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1439..1444
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Serpina12"
                     /gene_synonym="4632419J12Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1473
                     /gene="Serpina12"
                     /gene_synonym="4632419J12Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggtgggagat gaggaggatc cttcagggga agtggtgtgg ccacggctcc tggaagccca
       61 ttgactgact ccagcagctt caattggcca cactctgcct cttcaggagg ccctggaggt
      121 ataaataata aaacaaacca ggcaggcccg tttggccctg tggatggcgc ctggacccac
      181 tgataatccc caaggacaat gactcgcatg ctggacctgg gcctgtttct ggcaggcctc
      241 ctcactgtga aaggtctcct gcaggacaga gatgctccag atatgtatga ttctccagtc
      301 agggtccaag agtggagggg caagaaggat gcccggcagc ttgctcgaca caacatggaa
      361 tttggcttca agctactgca gaggctggcc agcaatagcc ctcagggaaa catcttccta
      421 tccccactga gcatctccac tgccttctcc atgctgtctc tcggggccca gaactccaca
      481 ctggaggaaa tccgggaggg cttcaacttc aaagagatgt caaactggga cgtccatgcg
      541 gctttccact accttctcca caagctcaac caggagacgg aggacacaaa gatgaactta
      601 ggcaatgctt tatttatgga tcagaagctg aggccccaac agaggttcct gaacctggct
      661 aagaatgtgt atgatgcgga catggtgctc actaacttcc aggacttaga aaacactcag
      721 aaggatatca acagatacat cagtcagaaa acccacagca gaatcaaaaa catggtaaaa
      781 agcatagacc caggcaccgt gatgattctc acaaattata tttactttcg aggcaggtgg
      841 cagtatgaat tcgacccaaa acagaccaag gaggaggagt tcttcataga gaaaggcaag
      901 accgtgaagg tacccatgat gttccaaagg ggcttgtacg acatggccta tgacagccag
      961 ctctcctgca ccatcttgga aatcccctac cggggaaaca tcacagccac atttgtcctt
     1021 cctgacaatg gcaagctgaa gctgctggag caggggttgc aggcagacat ctttgccaag
     1081 tggaaaagcc ttctctcaaa aagagtggtg gatgtgtggg tgcccaagct ccgcatctcg
     1141 tctacttaca acatgaagaa ggttctgtcc cgcctgggca tcagcaaaat ctttgaggag
     1201 aatggtgacc tcacccggat ctcatctcat cgaagcctga aggtgggaga ggctgtgcac
     1261 aaggctgaac tgaagatgga tgagaaaggc atggaagggg ctgcaggctc tggagcccag
     1321 acattgccca tggagacccc acgacatatg aagctagaca gacccttcct catgatgatc
     1381 tatgagaatt tcatgccttc catggtcttc ttggcaagga tttatgaccc tagtgggtaa
     1441 taaaggagca ttccctgttg gcttcagacc ccacccattt ccaagggttg cacctccaaa
     1501 acctctccaa acaatgccac ccaccaggga ccaagtgtta tggagtccca acacggccca
     1561 gcagcccagc ttcctctagg gactttgtgc tctgtaccca tttatagcct ctcccaagcc
     1621 atcagcactc ctggaccaaa tgccaacctt tactcccact atgcccacat ctccttcatc
     1681 cctgaaggca gggagtgtct gtgatgtgat aaactccacc tcccctgacc catctgctag
     1741 agtcaggtag atgctcagag ggaaatggga gccacagaca gtgaaccgag cctgggtaga
     1801 agaagacatt gctaggaaag ccacgggtct cattttggaa cctctctgcc tccctttctg
     1861 acgtgaggat tgccctgctc cttgatgagg cgttgaggaa atcggtgcca attccttgca
     1921 gaattcgttt tccattgtga gttccaggct gagaactctg gcatgcgtgt tacatggctc
     1981 acctcccaga gtgtccaggt agggttggtg ctagcccagc tagacctccg ggaacacggt
     2041 ggaagtgacc cagcattaga agaaggctgc cttggggtga agctggagat cgctgccaga
     2101 tttgttcatt tctttcggtc acaggaggaa gattctaagg ttcctcgggc ctctggtcaa
     2161 agacgggttc tactattgaa cctttggaaa atgggggtct ctacctgtct cagaaaactg
     2221 accctgtggt gtcaacttac tgccactagg gggcaccaag ggccagacca atggtgtggg
     2281 tctggagcgc agagggatgc ctttatccct ctggctgtga atagcctgtg caggccttgt
     2341 tgggggaggg acactcagac gggcttggta cctttaaagc agcaattgtc acttcttgcc
     2401 tagcagttct cagaacaccg tgaccttcgt gctttgttca ctaaagctca ataggcaacc
     2461 agaatgagca agccttgtgg aggaaatgaa gcttagagag gcgactcggc ttcctgtggc
     2521 gttagagtaa gcttagcata gcagtactgg agtttgtggt aggaagctct ctcgttgcta
     2581 tacatctctg ctccagccaa tgagaggcca gcaatcacct ctttccgcca tccgacccct
     2641 atgggatgag gatcctcgga ggccaggcct gtggagaggt ctgggaacga ccgggtgagc
     2701 agaaagtttc agagtcagct gcttacctgg gtggaagtag gagttgggga gaaaccagtg
     2761 gatcagaggc tgagctcccc ttgagcaatt tactacatca cagtttataa gtcgtggtgc
     2821 tgctcatgag gcacggccac gttagccact gatccgctga gtggcccagc tggagccaga
     2881 gccaatgcat gtaccgaggg aatagtgatg gatgcctccg gggaccaggt agactagaag
     2941 cattccgtga gattctacct taagaccctg gttaccgtct tctgtcacct cctccagtct
     3001 gagatggcca gcgtcttcct acggatatca actctaaata tctagccccc cttccctccc
     3061 ccacagtccc gtgggaatgc cctccttctc ctgatgagtc cctactcgcc ctccgttctt
     3121 acctcttcac aggcttccat cctcttcctc ggtatcactc aagcagcctt tcttccagga
     3181 aatggcccac ttccaagctc attagtgtct gtgtgtctgt cccctctcct tccacttgag
     3241 ctgaagtcag tcagagcaca ccatgggcta cagttaagct catgtctaca gtctccacta
     3301 accatagaaa cggctccctg aggtacagga aagcacatgg caggacagtc agatcctatt
     3361 tcaggacccc agaaaggaaa ccaacacaat tataacccct gattccaatt atagggctca
     3421 gtcagatagt gtttgcccag tatgtgtgaa gccatgggta taaaaatacc gtcttaaaaa
     3481 tgaaggaaaa aaaaaaggaa gaagttaaaa gtacaatatt ttcccaggat agttaacaag
     3541 agacaaaata caaacctgtc ttccaaacag aaattggaca taagccctaa cttttaaaaa
     3601 tgactgttgc ttagcataaa tatttcccaa tatggttcct gaccttcaca accacatgtt
     3661 caatactcac aataaaaatc acatatctgc
//
