LOCUS       NM_144834               1587 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus serine (or cysteine) peptidase inhibitor, clade A
            (alpha-1 antiproteinase, antitrypsin), member 10 (Serpina10),
            transcript variant 1, mRNA.
ACCESSION   NM_144834
VERSION     NM_144834.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1587)
  AUTHORS   Butschkau,A., Nagel,P., Grambow,E., Zechner,D., Broze,G.J. Jr. and
            Vollmar,B.
  TITLE     Contribution of protein Z and protein Z-dependent protease
            inhibitor in generalized Shwartzman reaction
  JOURNAL   Crit Care Med 41 (12), e447-e456 (2013)
   PUBMED   23963134
REFERENCE   2  (bases 1 to 1587)
  AUTHORS   Heit,C., Jackson,B.C., McAndrews,M., Wright,M.W., Thompson,D.C.,
            Silverman,G.A., Nebert,D.W. and Vasiliou,V.
  TITLE     Update of the human and mouse SERPIN gene superfamily
  JOURNAL   Hum Genomics 7 (1), 22 (2013)
   PUBMED   24172014
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1587)
  AUTHORS   Yang,L. and Rezaie,A.R.
  TITLE     Residues of the 39-loop restrict the plasma inhibitor specificity
            of factor IXa
  JOURNAL   J Biol Chem 288 (18), 12692-12698 (2013)
   PUBMED   23530052
  REMARK    GeneRIF: structural features within residues of the 39-loop
            contribute to the resistance of FIXa to inhibition by plasma
            inhibitors ZPI and TFPI.
REFERENCE   4  (bases 1 to 1587)
  AUTHORS   Girard,T.J., Lasky,N.M., Tuley,E.A. and Broze,G.J. Jr.
  TITLE     Protein Z, protein Z-dependent protease inhibitor (serpinA10), and
            the acute-phase response
  JOURNAL   J Thromb Haemost 11 (2), 375-378 (2013)
   PUBMED   23205927
  REMARK    GeneRIF: Letter: ZPI is a typical acute phase reactant.
REFERENCE   5  (bases 1 to 1587)
  AUTHORS   Huang,X., Yan,Y., Tu,Y., Gatti,J., Broze,G.J. Jr., Zhou,A. and
            Olson,S.T.
  TITLE     Structural basis for catalytic activation of protein Z-dependent
            protease inhibitor (ZPI) by protein Z
  JOURNAL   Blood 120 (8), 1726-1733 (2012)
   PUBMED   22786881
REFERENCE   6  (bases 1 to 1587)
  AUTHORS   Zhang,J., Tu,Y., Lu,L., Lasky,N. and Broze,G.J. Jr.
  TITLE     Protein Z-dependent protease inhibitor deficiency produces a more
            severe murine phenotype than protein Z deficiency
  JOURNAL   Blood 111 (10), 4973-4978 (2008)
   PUBMED   18344422
  REMARK    GeneRIF: PZ and ZPI deficiency would be associated with a modest
            thrombotic risk with ZPI deficiency producing a more severe
            phenotype.
REFERENCE   7  (bases 1 to 1587)
  AUTHORS   Forsyth,S., Horvath,A. and Coughlin,P.
  TITLE     A review and comparison of the murine alpha1-antitrypsin and
            alpha1-antichymotrypsin multigene clusters with the human clade A
            serpins
  JOURNAL   Genomics 81 (3), 336-345 (2003)
   PUBMED   12659817
  REMARK    Review article
REFERENCE   8  (bases 1 to 1587)
  AUTHORS   Zhang,J. and Broze,G.J. Jr.
  TITLE     Mouse protein Z-dependent protease inhibitor cDNA
  JOURNAL   Thromb Haemost 85 (5), 861-865 (2001)
   PUBMED   11372680
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC125360.4, AK050552.1 and
            AI591819.1.
            
            On Oct 20, 2022 this sequence version replaced NM_144834.4.
            
            Summary: The protein encoded by this gene is a member of the large
            serpin family of proteins, and is also known as serpin PZ-dependent
            protease inhibitor (ZPI or PZI). This protein is thought to play an
            important role in the regulation of coagulation. It directly
            inhibits factor XIa, and also inhibits factor Xa in the presence of
            calcium, phospholipids, and protein Z (PZ). Deficiencies in this
            gene lead to an increase in thrombosis. Alternative splicing
            results in multiple transcript variants that encode multiple
            protein isoforms. [provided by RefSeq, Aug 2014].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY324633.1, BC025821.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AC125360.4         131570-131574       c
            6-497               AK050552.1         2-493
            498-577             AC125360.4         128612-128691       c
            578-1218            AK050552.1         577-1217
            1219-1587           AI591819.1         1-369
FEATURES             Location/Qualifiers
     source          1..1587
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 52.97 cM"
     gene            1..1587
                     /gene="Serpina10"
                     /gene_synonym="PZI; ZPI"
                     /note="serine (or cysteine) peptidase inhibitor, clade A
                     (alpha-1 antiproteinase, antitrypsin), member 10"
                     /db_xref="GeneID:217847"
                     /db_xref="MGI:MGI:2667725"
     exon            1..39
                     /gene="Serpina10"
                     /gene_synonym="PZI; ZPI"
                     /inference="alignment:Splign:2.1.0"
     exon            40..808
                     /gene="Serpina10"
                     /gene_synonym="PZI; ZPI"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..1425
                     /gene="Serpina10"
                     /gene_synonym="PZI; ZPI"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; serine (or cysteine) proteinase inhibitor,
                     clade A (alpha-1 antiproteinase, antitrypsin), member 10;
                     protein Z-dependent protease inhibitor; PZ-dependent
                     protease inhibitor"
                     /codon_start=1
                     /product="protein Z-dependent protease inhibitor isoform 1
                     precursor"
                     /protein_id="NP_659083.2"
                     /db_xref="CCDS:CCDS26134.1"
                     /db_xref="GeneID:217847"
                     /db_xref="MGI:MGI:2667725"
                     /translation="MRVASSLFLPVLLTEVWLVTSFNLSSHSPEASVHLESQDYENQT
                     WEEYTRTDPREEEEEEEEKEEGKDEEYWLRASQQLSNETSSFGFNLLRKISMRHDGNV
                     IFSPFGLSVAMVNLMLGTKGETKVQIENGLNLQALSQAGPLILPALFKKVKETFSSNR
                     DLGLSQGSFAFIHKDFDIKETYFNLSKKYFDIEYVSINFQNSSQARGLINHCIVKETE
                     GKIPKLFDEINPETKLILVDYVLFKGKWLTPFDPSFTEADTFHLDKYRAIKVPMMYRE
                     GNFTSTFDKKFRCHILKLPYQGNATMLVVLMEKTGDYLALEDYLTVDLVETWLQNMKT
                     RKMEVFFPKFKLNQRYEMHELLKQMGIRRLFSTSADLSELSAMARNLQVSRVLQQSVL
                     EVDERGTEAVSGTLSEIIAYSMPPAIKVNRPFHFIIYEEMSRMLLFLGRVVNPTVL"
     exon            809..1082
                     /gene="Serpina10"
                     /gene_synonym="PZI; ZPI"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1233
                     /gene="Serpina10"
                     /gene_synonym="PZI; ZPI"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1587
                     /gene="Serpina10"
                     /gene_synonym="PZI; ZPI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1566..1571
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Serpina10"
                     /gene_synonym="PZI; ZPI"
                     /note="hexamer: ACTAAA"
     polyA_site      1587
                     /gene="Serpina10"
                     /gene_synonym="PZI; ZPI"
                     /note="major polyA site"
ORIGIN      
        1 gctctgaatg atcttctcgg caccagaggt ccaggactgg atgaagggaa gtggcccctg
       61 gcctccacag ctgaccacat gagggtggct tctagcctct ttcttcctgt cctcctgaca
      121 gaggtgtggc tggtgactag tttcaatctc agctcccatt caccagaggc ttccgttcac
      181 ctggagtctc aggattatga gaatcaaacc tgggaagagt acacacggac tgatcccagg
      241 gaggaggagg aggaggagga ggaaaaggag gaaggcaagg atgaggaata ttggctgagg
      301 gccagtcagc agctctccaa tgagacttca agctttgggt tcaacctgct tcgaaagatc
      361 tccatgaggc acgacggcaa tgtgatcttc tcaccttttg gcctgtctgt ggccatggtg
      421 aatttgatgc tggggaccaa gggagagacc aaagtccaga tagaaaatgg actcaaccta
      481 caggccctga gccaagcagg acccctgatc cttccagccc tcttcaagaa ggtcaaagag
      541 accttctcca gcaaccggga cctgggcctc agccagggta gctttgcctt catccacaag
      601 gactttgata tcaaagagac ctatttcaat ctctccaaga agtattttga tatagagtat
      661 gtgtctataa attttcaaaa ttcctcacaa gccagagggc tcataaacca ctgcattgtc
      721 aaagagactg aggggaaaat ccccaagctt tttgatgaga ttaatcctga aacaaagtta
      781 attctggtgg actacgtctt gttcaaaggg aagtggctga ctccatttga ccccagcttc
      841 actgaggccg acactttcca cctggacaag tacagggcaa ttaaggtgcc catgatgtac
      901 cgggaaggga actttacctc cacctttgac aagaagttcc gctgtcacat cctcaaactg
      961 ccctaccaag gaaatgccac catgctagtg gtcctcatgg agaagacagg tgattacttg
     1021 gccctggagg actacttgac cgtggatctc gtggagacat ggctgcagaa tatgaaaacc
     1081 aggaaaatgg aggtcttctt tcccaagttc aagctgaacc agaggtatga gatgcacgag
     1141 ctgctcaaac agatgggaat caggaggctc ttctccacct cagctgacct cagcgaactc
     1201 tcagccatgg caagaaacct tcaggtgtcc agggttttac aacagtcggt gcttgaggtg
     1261 gatgaaaggg gaacagaagc agtgtcaggg acgctgtcag agattatcgc ttactccatg
     1321 cctcctgcca tcaaagtgaa ccggcctttt cacttcatca tctatgagga gatgtccagg
     1381 atgctcctat ttctgggcag ggtggtaaac cccacagtcc tgtgactcgg gtgtatgtaa
     1441 gacctcgttc accacggttg ctgagccaga ggtgtctgaa acacaagatg ctggtggtag
     1501 gtgggaaagg atgtgttctc tgtacccagc ctgctcgctg tggctgttcc ctgattaaca
     1561 ctgaaactaa aacaactcat actttaa
//
