LOCUS       NM_030685               2457 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus stress-associated endoplasmic reticulum protein 1
            (Serp1), mRNA.
ACCESSION   NM_030685
VERSION     NM_030685.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2457)
  AUTHORS   Cai,J., Sun,Z., Zhang,L. and Xu,H.
  TITLE     SERP1 reduces inchoate acute hepatic injury through regulation of
            endoplasmic reticulum stress via the GSK3beta/beta-catenin/TCF/LEF
            signaling pathway
  JOURNAL   Mol Med Rep 25 (6) (2022)
   PUBMED   35419615
  REMARK    GeneRIF: SERP1 reduces inchoate acute hepatic injury through
            regulation of endoplasmic reticulum stress via the
            GSK3beta/betacatenin/TCF/LEF signaling pathway.
REFERENCE   2  (bases 1 to 2457)
  AUTHORS   Shang,L., Dong,P., Du,L., Yang,X., Wang,H. and Li,S.
  TITLE     SERP1 prevents hypoxia-reoxygenation-induced H9c2 apoptosis through
            activating JAK2/STAT3 pathway-dependent attenuation of endoplasmic
            reticulum stress
  JOURNAL   Biochem Biophys Res Commun 508 (1), 256-262 (2019)
   PUBMED   30497776
  REMARK    GeneRIF: This study suggests SERP1 as a potential regulator
            invovled in the pathophysiology of myocardial ischemia/reperfusion
            injury(MI/R injury).
REFERENCE   3  (bases 1 to 2457)
  AUTHORS   Xiao,Y., Han,J., Wang,Q., Mao,Y., Wei,M., Jia,W. and Wei,L.
  TITLE     A Novel Interacting Protein SERP1 Regulates the N-Linked
            Glycosylation and Function of GLP-1 Receptor in the Liver
  JOURNAL   J Cell Biochem 118 (11), 3616-3626 (2017)
   PUBMED   28597972
  REMARK    GeneRIF: findings identify a group of proteins that interact with
            GLP-1R and show that one specific interacting protein, SERP1, has
            an important role in facilitating the glycosylation of GLP-1R and
            rescuing its activities after ER stress induced by tunicamycin.
REFERENCE   4  (bases 1 to 2457)
  AUTHORS   Francisco,A.B., Singh,R., Li,S., Vani,A.K., Yang,L., Munroe,R.J.,
            Diaferia,G., Cardano,M., Biunno,I., Qi,L., Schimenti,J.C. and
            Long,Q.
  TITLE     Deficiency of suppressor enhancer Lin12 1 like (SEL1L) in mice
            leads to systemic endoplasmic reticulum stress and embryonic
            lethality
  JOURNAL   J Biol Chem 285 (18), 13694-13703 (2010)
   PUBMED   20197277
REFERENCE   5  (bases 1 to 2457)
  AUTHORS   Favaloro,V., Spasic,M., Schwappach,B. and Dobberstein,B.
  TITLE     Distinct targeting pathways for the membrane insertion of
            tail-anchored (TA) proteins
  JOURNAL   J Cell Sci 121 (11), 1832-1840 (2008)
   PUBMED   18477612
REFERENCE   6  (bases 1 to 2457)
  AUTHORS   Hori,O., Miyazaki,M., Tamatani,T., Ozawa,K., Takano,K., Okabe,M.,
            Ikawa,M., Hartmann,E., Mai,P., Stern,D.M., Kitao,Y. and Ogawa,S.
  TITLE     Deletion of SERP1/RAMP4, a component of the endoplasmic reticulum
            (ER) translocation sites, leads to ER stress
  JOURNAL   Mol Cell Biol 26 (11), 4257-4267 (2006)
   PUBMED   16705175
  REMARK    GeneRIF: SERP1-/- mice, made by targeted gene disruption,
            demonstrated growth retardation, increased mortality, and impaired
            glucose tolerance.
REFERENCE   7  (bases 1 to 2457)
  AUTHORS   Matsuki,T., Nakae,S., Sudo,K., Horai,R. and Iwakura,Y.
  TITLE     Abnormal T cell activation caused by the imbalance of the
            IL-1/IL-1R antagonist system is responsible for the development of
            experimental autoimmune encephalomyelitis
  JOURNAL   Int Immunol 18 (2), 399-407 (2006)
   PUBMED   16415102
REFERENCE   8  (bases 1 to 2457)
  AUTHORS   Klingenspor,M., Xu,P., Cohen,R.D., Welch,C. and Reue,K.
  TITLE     Altered gene expression pattern in the fatty liver dystrophy mouse
            reveals impaired insulin-mediated cytoskeleton dynamics
  JOURNAL   J Biol Chem 274 (33), 23078-23084 (1999)
   PUBMED   10438476
REFERENCE   9  (bases 1 to 2457)
  AUTHORS   Welch,C.L., Xia,Y.R., Shechter,I., Farese,R., Mehrabian,M.,
            Mehdizadeh,S., Warden,C.H. and Lusis,A.J.
  TITLE     Genetic regulation of cholesterol homeostasis: chromosomal
            organization of candidate genes
  JOURNAL   J Lipid Res 37 (7), 1406-1421 (1996)
   PUBMED   8827514
  REMARK    Erratum:[J Lipid Res 1996 Oct;37(10):2269]
REFERENCE   10 (bases 1 to 2457)
  AUTHORS   Warden,C.H., Mehrabian,M., He,K.Y., Yoon,M.Y., Diep,A., Xia,Y.R.,
            Wen,P.Z., Svenson,K.L., Sparkes,R.S. and Lusis,A.J.
  TITLE     Linkage mapping of 40 randomly isolated liver cDNA clones in the
            mouse
  JOURNAL   Genomics 18 (2), 295-307 (1993)
   PUBMED   8288233
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CV676503.1, AK149786.1 and AI114944.1.
            
            On Nov 21, 2008 this sequence version replaced NM_030685.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC002114.1, SRR1660817.58940.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-130               CV676503.1         10-139
            131-1413            AK149786.1         1-1283
            1414-2432           AK149786.1         1285-2303
            2433-2457           AI114944.1         1-25                c
FEATURES             Location/Qualifiers
     source          1..2457
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 28.58 cM"
     gene            1..2457
                     /gene="Serp1"
                     /gene_synonym="D3Ucla1; Ramp4"
                     /note="stress-associated endoplasmic reticulum protein 1"
                     /db_xref="GeneID:28146"
                     /db_xref="MGI:MGI:92638"
     exon            1..475
                     /gene="Serp1"
                     /gene_synonym="D3Ucla1; Ramp4"
                     /inference="alignment:Splign:2.1.0"
     CDS             392..592
                     /gene="Serp1"
                     /gene_synonym="D3Ucla1; Ramp4"
                     /note="ribosome associated membrane protein 4;
                     ribosome-attached membrane protein 4"
                     /codon_start=1
                     /product="stress-associated endoplasmic reticulum protein
                     1"
                     /protein_id="NP_109610.1"
                     /db_xref="CCDS:CCDS38436.1"
                     /db_xref="GeneID:28146"
                     /db_xref="MGI:MGI:92638"
                     /translation="MVAKQRIRMANEKHSKNITQRGNVAKTSRNAPEEKASVGPWLLA
                     LFIFVVCGSAIFQIIQSIRMGM"
     exon            476..551
                     /gene="Serp1"
                     /gene_synonym="D3Ucla1; Ramp4"
                     /inference="alignment:Splign:2.1.0"
     exon            552..2451
                     /gene="Serp1"
                     /gene_synonym="D3Ucla1; Ramp4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      812..817
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Serp1"
                     /gene_synonym="D3Ucla1; Ramp4"
                     /note="hexamer: AATAAA"
     polyA_site      836
                     /gene="Serp1"
                     /gene_synonym="D3Ucla1; Ramp4"
     regulatory      2411..2416
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Serp1"
                     /gene_synonym="D3Ucla1; Ramp4"
                     /note="hexamer: AATAAA"
     polyA_site      2451
                     /gene="Serp1"
                     /gene_synonym="D3Ucla1; Ramp4"
                     /note="major polyA site"
ORIGIN      
        1 ttttccggag cggggaagag cctggctgcg gtggcggccg gcgctcgccc tccctctccg
       61 gagcgggcgg agtccacact tccgcggggc ggggtctgcc cagtgctgac gttggcagcc
      121 gaacccgaac tagttcgagg ttgccggttg cactgtccgg tggttggact cttgcctctc
      181 ggccctgcgg cccgctctcc ccggcacgcc gccccaaagg ctgctcagac cgccgcgatc
      241 ggcggctgcc ggtgttccag cgctccgcgt cccggcccag tggctgtaga cggcgtaggc
      301 accgcgatca gagccgagcc tccctcccgg tggcccggga ccggcgagcg agcgagtccg
      361 agaggttctt ggggcaggtg gcgctgcgaa aatggtcgcc aagcagagga tccgtatggc
      421 caacgagaag cacagcaaga acataactca gcgcggcaac gtcgctaaga cctcgagaaa
      481 tgcccccgaa gaaaaggcgt cggtaggacc ctggttattg gccctcttca tttttgttgt
      541 ctgtggctct gcaattttcc agattattca aagtatcagg atgggcatgt gaagtgactg
      601 accttgagat ctttccattc tcctgtgaat tttaacttga actcattcct gatgttcgat
      661 gccctagtta aaaaccattg agtaaatcgg cctgcctcag aatgactttt catatccgcc
      721 ttcatgtgtc attccaaggt gtcttcaaga gtcattccag gtttgctagt ccatgccaca
      781 gtgccttgca aaagcaccac atgaataaag caataaaatt tgattattaa gttccagtag
      841 tagaccatac ttattcagta cagaatgagt tttatatggt tattaaaaca tgactaatta
      901 gattaaatct gtgtagacag ggtatagatt ttgttaaccc taatgtgtaa atgcaattag
      961 cttaaatttt ggaatcttat ggttttctat agctatgccc tttttactct tgaattggaa
     1021 agcacactcc attataggga catgtaactg tcctataata aggtgctttt aaatggtcac
     1081 ctacacggct tagttttacc acaatcattg tcacctaaaa ctttttaaaa gcttctaggg
     1141 catattgtaa gtaaagatgc ttacagctgc atctgtttct aatgataatg tttctgttac
     1201 acagccttga attttgcatg agtaagtata gtcacctagg gtcccattcg agcctggatt
     1261 gaacattttc taacttaatc aaagtgattg cagttccact aaaagctatc atggtgaaat
     1321 gaaattagag atggtttgct gatgtcatac tgatcagaat tatcaaaggg tttactgtgt
     1381 agatacggag aaagacaaga actaaatgcc ttgtcgaaac atgtggagtc ccgtgtgcca
     1441 tatgatatct tagcatgtta attgcacttt taataccaaa aaggcacatc aactaaagtt
     1501 ttgattgaaa tgcccttagg gttctaggtc tatcgatcta aatgagcatt tggaatgaaa
     1561 tgaatttact gatgaggatc agtctagtct tcctttgtat gacttcgtag gttgtgattg
     1621 atcattttct ttttactaat agtaagggtg agagtaatga ggcaggtttg acattttctg
     1681 gtactattga aaactacaat tagtcctatt tatgcactta gccagaactt ggtgcagaca
     1741 ccaagcaata tctgtttatg aatggagaga agcctgctta tgtttgcttt gttatttgcc
     1801 tcaggagatc tcttttgaaa tacgctgttt tcaaaggaac agaagggaaa cttgcccctg
     1861 ttctgagagc agtgtaaacc tcacagggct ttggatcccc tcggaccccc ttggacacag
     1921 aggagaagga agggaaggag tgggtcggga tgcacaggaa tctttcctgt atcggaccag
     1981 gaaagaaagc tggctgtggg tctgtagggt catgactgtt gtctgcctct tttcaccctg
     2041 taagtgaatc cctgaacttg gttccctctg aagccagtct tggttaacta attctatttt
     2101 actataactt taaaagtgaa agatattctc taaatttata gcaggtgcct tatttccttt
     2161 gaatcaaatc attccatacc agaatttccc ttggtttact atagataatt ggctttaaga
     2221 tattcttgtt tttaaacata caatgtttta attattttgt taaattgctg tagccatcaa
     2281 tcatttcaca tttgtaaaat tacattccct ttgtatcatg taatttacct attcagtgca
     2341 ttttatattc aggttggatt atgcatattt gggtcaatga aagttgtgtc tgtttgattt
     2401 atggtttaaa aataaagttc cctggatatt tgatgctgtt gtaaaagaaa aaaaaaa
//
