LOCUS       NM_172588               5393 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus serine incorporator 5 (Serinc5), mRNA.
ACCESSION   NM_172588
VERSION     NM_172588.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5393)
  AUTHORS   Hata,K., Wakamori,K., Hirakawa-Yamamura,A., Ichiyama-Kobayashi,S.,
            Yamaguchi,M., Okuzaki,D., Takahata,Y., Murakami,T., Uzawa,N.,
            Yamashiro,T. and Nishimura,R.
  TITLE     Serinc5 Regulates Sequential Chondrocyte Differentiation by
            Inhibiting Sox9 Function in Pre-Hypertrophic Chondrocytes
  JOURNAL   J Cell Physiol 240 (1), e31490 (2025)
   PUBMED   39568258
REFERENCE   2  (bases 1 to 5393)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 5393)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5393)
  AUTHORS   Timilsina,U., Umthong,S., Lynch,B., Stablewski,A. and Stavrou,S.
  TITLE     SERINC5 Potently Restricts Retrovirus Infection In Vivo
  JOURNAL   mBio 11 (4), e00588-20 (2020)
   PUBMED   32665269
  REMARK    GeneRIF: SERINC5 Potently Restricts Retrovirus Infection In Vivo.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5393)
  AUTHORS   Li,S., Ahmad,I., Shi,J., Wang,B., Yu,C., Zhang,L. and Zheng,Y.H.
  TITLE     Murine Leukemia Virus Glycosylated Gag Reduces Murine SERINC5
            Protein Expression at Steady-State Levels via the Endosome/Lysosome
            Pathway to Counteract SERINC5 Antiretroviral Activity
  JOURNAL   J Virol 93 (2), e01651-18 (2019)
   PUBMED   30355687
  REMARK    GeneRIF: Study shows that glycoGag interacts with Ser5 in live
            cells and internalizes Ser5 via receptor-mediated endocytosis. Ser5
            is polyubiquitinated and relocalized to endosomes and lysosomes for
            massive destruction. In addition to the previously identified
            tyrosine-based sorting signal, results find two more important
            residues for Ser5 relocalization and downregulation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5393)
  AUTHORS   Hecht,J., Seitz,V., Urban,M., Wagner,F., Robinson,P.N., Stiege,A.,
            Dieterich,C., Kornak,U., Wilkening,U., Brieske,N., Zwingman,C.,
            Kidess,A., Stricker,S. and Mundlos,S.
  TITLE     Detection of novel skeletogenesis target genes by comprehensive
            analysis of a Runx2(-/-) mouse model
  JOURNAL   Gene Expr Patterns 7 (1-2), 102-112 (2007)
   PUBMED   16829211
REFERENCE   7  (bases 1 to 5393)
  AUTHORS   Fukazawa,N., Ayukawa,K., Nishikawa,K., Ohashi,H., Ichihara,N.,
            Hikawa,Y., Abe,T., Kudo,Y., Kiyama,H., Wada,K. and Aoki,S.
  TITLE     Identification and functional characterization of mouse TPO1 as a
            myelin membrane protein
  JOURNAL   Brain Res 1070 (1), 1-14 (2006)
   PUBMED   16405874
  REMARK    GeneRIF: TPO1 may play role in myelin formation via Fyn kinase
            activation in central and peripheral nervous systems.
REFERENCE   8  (bases 1 to 5393)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   9  (bases 1 to 5393)
  AUTHORS   Aoki,S., Su,Q., Li,H., Nishikawa,K., Ayukawa,K., Hara,Y.,
            Namikawa,K., Kiryu-Seo,S., Kiyama,H. and Wada,K.
  TITLE     Identification of an axotomy-induced glycosylated protein, AIGP1,
            possibly involved in cell death triggered by endoplasmic
            reticulum-Golgi stress
  JOURNAL   J Neurosci 22 (24), 10751-10760 (2002)
   PUBMED   12486168
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC062131.1.
            
            On Dec 20, 2003 this sequence version replaced NM_172588.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062131.1, AK136799.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..5393
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 47.75 cM"
     gene            1..5393
                     /gene="Serinc5"
                     /gene_synonym="A130038L21Rik; AIGP3; TPO1"
                     /note="serine incorporator 5"
                     /db_xref="GeneID:218442"
                     /db_xref="MGI:MGI:2444223"
     exon            1..150
                     /gene="Serinc5"
                     /gene_synonym="A130038L21Rik; AIGP3; TPO1"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..1509
                     /gene="Serinc5"
                     /gene_synonym="A130038L21Rik; AIGP3; TPO1"
                     /note="AIGP-3; axotomy-induced glycoprotein 3"
                     /codon_start=1
                     /product="serine incorporator 5"
                     /protein_id="NP_766176.1"
                     /db_xref="CCDS:CCDS36744.1"
                     /db_xref="GeneID:218442"
                     /db_xref="MGI:MGI:2444223"
                     /translation="MSARCCAGQLACCCGSAGCSLCCGCCPKFRQSRTTRFMYLFYFI
                     LVIALCCVMMTPSVMKQVKDHIPFFEEFCKKTQAGGDACENLVGYSAVYRVCFGMACF
                     FALFCLLTLKVNNSKSCRAYIHNGFWFFKLLLLGAMCSGAFFIPDQETFLKVWRYVGA
                     GGSFLFICIQLLLIVQFAHKWNKNWTAGTVRNKLWYASLSLVTLIMYSVAVGGLALMA
                     VFYTQWDDCMDNKILLGVHGGLCVLISLVAISPCVQNRQPHSGLLQSGLISCYVTYLT
                     FSALTSKPEKKVLDEHGKNVTICAPDFGQDLHRDENMVTWLGTLLLIVCISYSCLTST
                     TRSSSDALQSRYGAPELEVARCCFCFGPDGEDTEEQQNVKKGPRVIYDEKKGTVYSYS
                     YFHFVFFLASLYVMMTLTSWFHYENATIKTFFSGWSVFWVKMASCWMCVLLYLQTLVA
                     PLCCPSRQFSV"
     exon            151..318
                     /gene="Serinc5"
                     /gene_synonym="A130038L21Rik; AIGP3; TPO1"
                     /inference="alignment:Splign:2.1.0"
     exon            319..500
                     /gene="Serinc5"
                     /gene_synonym="A130038L21Rik; AIGP3; TPO1"
                     /inference="alignment:Splign:2.1.0"
     exon            501..583
                     /gene="Serinc5"
                     /gene_synonym="A130038L21Rik; AIGP3; TPO1"
                     /inference="alignment:Splign:2.1.0"
     exon            584..677
                     /gene="Serinc5"
                     /gene_synonym="A130038L21Rik; AIGP3; TPO1"
                     /inference="alignment:Splign:2.1.0"
     exon            678..889
                     /gene="Serinc5"
                     /gene_synonym="A130038L21Rik; AIGP3; TPO1"
                     /inference="alignment:Splign:2.1.0"
     exon            890..985
                     /gene="Serinc5"
                     /gene_synonym="A130038L21Rik; AIGP3; TPO1"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1112
                     /gene="Serinc5"
                     /gene_synonym="A130038L21Rik; AIGP3; TPO1"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1179
                     /gene="Serinc5"
                     /gene_synonym="A130038L21Rik; AIGP3; TPO1"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1219
                     /gene="Serinc5"
                     /gene_synonym="A130038L21Rik; AIGP3; TPO1"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1364
                     /gene="Serinc5"
                     /gene_synonym="A130038L21Rik; AIGP3; TPO1"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..5319
                     /gene="Serinc5"
                     /gene_synonym="A130038L21Rik; AIGP3; TPO1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5300..5305
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Serinc5"
                     /gene_synonym="A130038L21Rik; AIGP3; TPO1"
                     /note="hexamer: AATAAA"
     polyA_site      5315
                     /gene="Serinc5"
                     /gene_synonym="A130038L21Rik; AIGP3; TPO1"
     polyA_site      5319
                     /gene="Serinc5"
                     /gene_synonym="A130038L21Rik; AIGP3; TPO1"
                     /note="major polyA site"
ORIGIN      
        1 ctgggctcgg ggataggaag caagacgagc ttcttcagtc gcgcgctcgc ggaccaagcc
       61 gagagggccc gagtgacggg cccagcgggc agcgtccccg aggcgaggtc gtcggccgcg
      121 gtgatgtctg cccggtgctg tgctggccag ttggcctgct gttgcggatc tgctggctgc
      181 tccctctgct gtggctgctg ccctaagttc cgacagtctc ggaccacccg cttcatgtat
      241 ttattctact tcatcctggt catcgccctc tgctgtgtga tgatgacacc ctctgtgatg
      301 aagcaggtga aggaccacat tccctttttt gaagagttct gtaaaaagac tcaagccggt
      361 ggtgacgcct gtgagaacct ggtagggtat tctgcggtgt acagagtctg ctttggaatg
      421 gcttgtttct ttgctctgtt ttgcctgctg accttaaaag tcaacaacag caaaagttgc
      481 cgggcctaca ttcacaacgg cttttggttc tttaaattgc tgctgttagg ggccatgtgc
      541 tcaggagcgt tcttcattcc ggatcaggag acctttctga aagtctggcg ctatgtggga
      601 gctgggggca gcttcctctt catttgtatc cagctcctcc tgattgtgca gtttgcacat
      661 aagtggaaca agaactggac tgcaggcacc gtccgtaata agctgtggta cgcctccctg
      721 tccctggtga cactcatcat gtattccgtt gctgttggag gcttggcttt gatggcagtg
      781 ttttacacac agtgggacga ctgcatggac aacaagattc tcctgggagt gcacggtggc
      841 ctatgcgtgc taatctctct ggtagccatc tcaccctgcg tccagaatcg acagccacac
      901 tctgggctgc tgcagtcagg gctcataagc tgttatgtca cctacctcac cttctcagca
      961 ctgaccagca agcctgaaaa aaaagtcctg gatgaacatg ggaagaatgt taccatatgt
     1021 gcgcctgact ttggtcaaga cctgcataga gatgaaaaca tggtgacttg gctgggcacc
     1081 cttcttctaa ttgtgtgcat ctcatattca tgtttgacat cgacaacaag gtcgagctcg
     1141 gatgctctgc agagtcgata cggagcgcca gagctggaag tggcccggtg ctgtttctgc
     1201 tttggtccag atggagaaga cactgaagag cagcagaacg tcaagaaggg acccagggtg
     1261 atttatgatg agaagaaagg caccgtgtac agctactcct atttccactt cgtcttcttc
     1321 ctggcttccc tctacgtgat gatgactctg accagctggt tccactatga aaatgccacc
     1381 attaagacct tcttctcagg ctggtccgtc ttctgggtca agatggcctc ctgctggatg
     1441 tgtgtgctgc tgtacctgca gaccttggtg gcccctctct gctgtccctc caggcagttc
     1501 tctgtgtgag gatgtccagg tgccctgtgg ctcagcaggc ctgtgcccac tgtggagggc
     1561 tgccctttga acgtgtgcac caggggttta agcagcaact ggtgccctgt gaaaagctga
     1621 catcccctgg ctagcttaag taggtctgac aaagctttca ggaaacaaac aaaatctcct
     1681 gattagcttc tagttgtaaa atccaaaagg aaactaccag ttagatcgac aggaattgaa
     1741 atctttagcc aagctggtag gtgcaattat ctctttatgc cttacccaag aattagctga
     1801 agttttgttg ctgttcttcc tggacgtgtt ttaaccaggc cagagcttgg ggcacagcgt
     1861 ctgtcacagg gatgaaaatg tccttgtatg gcctgtcact ctcatccttg gcataaagaa
     1921 gcaacaacaa aaacacttga gtcctcagcc taaggtgggg cttggcccct gtcactcacc
     1981 tttgcctgcc tcccagagcc ctcacagttc cctgtttatg cagagtacag agggagcccc
     2041 tcctttgact ccaccctcaa ctacttctgc acatccctgc cccagcattt tctgttgagg
     2101 tcatgatgct gggagtcatg gccttcttgt cctctctgcc cttggcagag gtccttcatt
     2161 cttgtctaag gtagtgtttg taataatgtg aaaagcacaa tttcttctca ccttcatggg
     2221 atgctccacc atgttttccc tacccagtac aagacactgc agtaatcctg ctcttattta
     2281 tggcagtgtt catgtgactg taaaacaaga tgcatgttgt tgtctttgcc caagtagtgg
     2341 agggttgcag ttcttacttg tgagtgtcat taacagtaat gctttaaggg tcttaacaaa
     2401 aacgttgctt ctttactgca gcttgccaca cccctctcag tgttaaggtc agcccccctg
     2461 actcaccccc accatgaggc cttcctcact tacagtgtgc ccccaatgct aacagcatgg
     2521 tttccttgaa gtagaggagg gctggggtaa ggttcccaag cagcttccaa cagagctggc
     2581 cacacagatc ggccagacaa gctgtgcaag tgtggaatta ggctgagatg caaaagtcgg
     2641 tggttggagg catctcacaa gactacgatt acatccatac aaattcctag atatgctttt
     2701 ggaaagcagt gctcacaagt gtgcatttta gtgccaatgt tcatagtgag ggagaggatt
     2761 tccccagtgc ctatctgaac aaatcagaca gaattgggac ccacataagc ctgattccca
     2821 caagccaaaa tgtcagaatc ttcatttcta ctcactactg taccctcctg ctaaaaggac
     2881 ccacggaaag aaatagtggt gaattcagtg gagagcttgt ctggtttata gtatttgaga
     2941 tcctgtctta aaaggtacac acataaggac accttgtctg taaactctca gcagttcaaa
     3001 gagaggagaa tcacacaaag catagctgta tactagctct aaacaagtct agttaatcca
     3061 gtaggaatgg gagcctcatc atctggggcc tgtgtaaggc agcagcttcg ttgcagcagc
     3121 ccctgctgtg ctgaagaaag gaggtgctga gagagaggca gagaggaact ctgctggggg
     3181 gagcaggatt gttttgccaa ggtttgtctc tgctgagact ggaagccagg cgtggtgact
     3241 tttgaactgg tcacagccag gctgacgagg ccacacatac ctgggctagc ctttgttggc
     3301 cccttttcct ctatggaaag cagctcaggg aaacccagac agtaccagtg gctgccccgg
     3361 tggcttccct ctgaaccaag ccccattcac tttctagctg cctaagtctt ggttgagtac
     3421 atgccctgcc gttcttcaga agttaggcct cacacaggac gaagagctgg ccaccctctt
     3481 ctttactctc agctaatggt ataaatggat ggtcagaatt gagatgaagg gtttctaaga
     3541 gagatataca taagaattga tcctttaatc tctgctgaag tgagggagtc tctggtttct
     3601 agggcagcta gaccctattt caaaacaaaa agttggcatt tgtgatcagc tgtgagaaac
     3661 tactcaggta gaagcctgtt tgtgagctta ggaatactat tgtttgtgaa actggagaaa
     3721 actggaaagt gtgccattgt tttgagataa caacagcaat gttaccttgc ttttaaagat
     3781 aacaggcctt tgcttcgtgc aatacccaag caacactatc aaaattcatg ctttgaagct
     3841 gcccatctga ccttagccat ggcagccctg gaggcagagt ttagaaatca tgtgttctct
     3901 ccctctagtg ttttatgagt aaaatgttag ttatgccatg gagggattct cctgggagtc
     3961 tcattcacac atgatgcctg cttcaagttt ttgtggtgct ggatagctga tctgggtttc
     4021 ttgggaagtc agcagatgaa ttgttctgca ggggtttggg gaagttttat ggagtgggtg
     4081 gactgtggta tggaaagagt tgtgggggga gacatggagt attgagactt ctggttccga
     4141 atcccatagg gagtggccag tgggagacat agtgccatgt ctccagttcc acggtgactt
     4201 cacgccagtg ttaattgccc ccttcccaaa ttgtcaccct ctgtctttat ccaataatgt
     4261 tctcatgccg tccttggtgc ttcacgttac cctggaaaga gagctccaga gcttgcattt
     4321 aaacttctgg gcatctctgc ttcaatgcct ttctaaccag tggctctttt tcgtgtgcgg
     4381 aaacataaac cagtgcacat cccacatact gccaagaagt gaaagggctt cataaggaag
     4441 atgggcacca gggaggaccc tgggcttcct cctcggacat gagcttgcca cctggtcata
     4501 tgctctgaag gtttcttctg tgactgagac tagtaaacat tttattccct gcagagatga
     4561 gctgtctggc atgggggtga cttcagtaga caggagagcc gacatgatgg ctttagctcg
     4621 ttctcacttg ccgttttcca tcactgaggc attcacagag acagttactt taaaaggctg
     4681 aaacacttgg cttttaccaa agaggtgtat ctgattttgt tttagttggg caagggcaga
     4741 actggaatgc atttgcccaa ttgacttcaa gaagtttaac tacattcatg tgaggaaaat
     4801 gatagaagtc tttaaggtaa ttctttagga tcctgggaaa ttctctcagg taaagaaaga
     4861 ttacagcaga tgagtaatat atgtcttgag agctatttat aaaaattgta agaggatcat
     4921 tttgtttcca tttattaaaa agttaaactt ttttactttg caaagaaaat actacaaaca
     4981 tttttatagt cataactgtt aattttttta aaaagacttt tttttttgga aacaattagc
     5041 tgtagccaaa ttttgtggtt acatttttgc tatagtggag tttgaatgca atctgtgtgg
     5101 taagtctact gtttgtttat aaaggtctct gacatggtta gattttgcta ccttttaaaa
     5161 tagttatttt tccccattag ccacaaagcc aattatggat ttgtatttgt gtttttcaat
     5221 gctaattttt ctatgaagca cctgaaattg actagccttt tcctatgtag aaaactcaaa
     5281 catgttaact ctgtacttta ataaaatgta aacttgaaaa aaaaaaaaaa aaaaaaaaaa
     5341 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa
//
