LOCUS       NM_172702               1892 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus serine incorporator 2 (Serinc2), transcript variant 1,
            mRNA.
ACCESSION   NM_172702
VERSION     NM_172702.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1892)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AA986627.1, BG077215.2, BU511121.1, CB055666.1 and BE956082.1.
            
            On May 23, 2007 this sequence version replaced NM_172702.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031720.1, AK075863.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                AA986627.1         1-45
            46-624              BG077215.2         1-579
            625-806             BU511121.1         561-742
            807-1471            CB055666.1         1-665
            1472-1892           BE956082.1         1-421               c
FEATURES             Location/Qualifiers
     source          1..1892
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 63.43 cM"
     gene            1..1892
                     /gene="Serinc2"
                     /gene_synonym="2310004K20Rik; FKSG84; TDE2; Tde2l"
                     /note="serine incorporator 2"
                     /db_xref="GeneID:230779"
                     /db_xref="MGI:MGI:1919132"
     exon            1..129
                     /gene="Serinc2"
                     /gene_synonym="2310004K20Rik; FKSG84; TDE2; Tde2l"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..1443
                     /gene="Serinc2"
                     /gene_synonym="2310004K20Rik; FKSG84; TDE2; Tde2l"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="serine incorporator 2 isoform 1"
                     /protein_id="NP_766290.2"
                     /db_xref="CCDS:CCDS51310.1"
                     /db_xref="GeneID:230779"
                     /db_xref="MGI:MGI:1919132"
                     /translation="MGACLGACSLLSCASCLCGSAPCILCGCCPSTRNSTVSRLLFTS
                     FLFLGVLVSIIMLSPGVESQLYKLPWVCEDRTQQPLVLQGPLDCGSLLGFRAVYRMCF
                     ATAAFFFFFMLLMICVRSSRDPRAAIQNGFWFFKFLILVGITVGAFYIPDGSFPKIWF
                     YFGVVGSFLFILIQLILFVDFAHSWNQRWLCKAEECDSPAWYAGLFFFTFLFYLLSIA
                     AVALMFVYYTESGACHEGKVFISLNLTFCVCVSIIAVLPKVQDAQPNSGLLQASVITL
                     YTMFVTWSALSNVPDQKCNPHLPTKNGTGQVDLEDYSTVWWDAPSIVGLVIFILCTFF
                     ISLRSSDHRQVNSLMQTEECPAEMVQQQQVAVSDGRAYDNEQDGVTYSYSFFHFCLVL
                     ASLHVMMTLTNWYSPGETRKMISTWTSVWVKICASWAGLFLYLWTLVAPLLLPNRDFS
                     "
     exon            130..291
                     /gene="Serinc2"
                     /gene_synonym="2310004K20Rik; FKSG84; TDE2; Tde2l"
                     /inference="alignment:Splign:2.1.0"
     exon            292..482
                     /gene="Serinc2"
                     /gene_synonym="2310004K20Rik; FKSG84; TDE2; Tde2l"
                     /inference="alignment:Splign:2.1.0"
     exon            483..562
                     /gene="Serinc2"
                     /gene_synonym="2310004K20Rik; FKSG84; TDE2; Tde2l"
                     /inference="alignment:Splign:2.1.0"
     exon            563..700
                     /gene="Serinc2"
                     /gene_synonym="2310004K20Rik; FKSG84; TDE2; Tde2l"
                     /inference="alignment:Splign:2.1.0"
     exon            701..870
                     /gene="Serinc2"
                     /gene_synonym="2310004K20Rik; FKSG84; TDE2; Tde2l"
                     /inference="alignment:Splign:2.1.0"
     exon            871..961
                     /gene="Serinc2"
                     /gene_synonym="2310004K20Rik; FKSG84; TDE2; Tde2l"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1097
                     /gene="Serinc2"
                     /gene_synonym="2310004K20Rik; FKSG84; TDE2; Tde2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1307
                     /gene="Serinc2"
                     /gene_synonym="2310004K20Rik; FKSG84; TDE2; Tde2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1876
                     /gene="Serinc2"
                     /gene_synonym="2310004K20Rik; FKSG84; TDE2; Tde2l"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1857..1862
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Serinc2"
                     /gene_synonym="2310004K20Rik; FKSG84; TDE2; Tde2l"
                     /note="hexamer: AATAAA"
     polyA_site      1876
                     /gene="Serinc2"
                     /gene_synonym="2310004K20Rik; FKSG84; TDE2; Tde2l"
                     /note="major polyA site"
ORIGIN      
        1 tgggtttggg gtggggccag ccaagcgcct ggagtcccac cggatccggg atccgaggcc
       61 ggtgccccga gccccgcgcc cctcaccgcc atgggggcct gtctcggggc ctgctccctg
      121 ctcagctgcg catcctgcct ctgcggctct gcaccctgca tcctatgtgg ctgttgcccc
      181 tcaacccgca actccacggt gagccgcctc ctcttcacca gcttcctctt cttgggggtg
      241 ctggtgtcca tcatcatgct gagcccggga gtggagagtc agctttacaa gctgccctgg
      301 gtgtgtgagg acaggaccca gcaacccctg gtcctgcagg ggcccctgga ctgcggctcc
      361 ctgctgggtt tccgcgctgt ctaccgtatg tgctttgcca cagcagcctt tttcttcttc
      421 ttcatgctgt taatgatctg tgtccgcagt agccgggatc cgcgagcagc catccagaac
      481 gggttttggt tttttaaatt cctgatcctt gtgggtatca ctgtgggcgc cttctacatc
      541 cctgatggct cctttcccaa gatctggttc tactttggcg tcgtgggctc cttcctcttc
      601 atcctcatcc agctgatcct gtttgttgac tttgcccact cctggaatca gcggtggctg
      661 tgtaaggccg aggagtgtga ctctccagcc tggtacgcag gccttttctt cttcaccttc
      721 ctcttctacc tgttgtccat cgctgctgtg gcactgatgt tcgtctacta cacggagtct
      781 ggtgcctgcc atgagggcaa ggtcttcatc agcctcaatc tcaccttctg tgtctgcgtc
      841 tccatcattg ctgtcctgcc caaggtccag gatgctcagc ccaactcggg tctgctgcaa
      901 gcctccgtca taaccttgta tacaatgttt gtcacctggt ctgccctatc caacgtccct
      961 gaccaaaaat gcaaccctca cctgcccact aaaaatggaa caggccaggt ggacctggag
     1021 gactacagca cggtgtggtg ggatgccccg agcattgtgg gcctcgtcat cttcatcctg
     1081 tgcaccttct tcattagcct gcgatcctct gaccaccgtc aggtgaacag cctgatgcag
     1141 acagaggagt gtccggcaga gatggtgcag cagcagcagg tggccgtcag tgatggcaga
     1201 gcctatgaca atgagcagga tggtgtcacc tacagctact ccttcttcca cttctgcctg
     1261 gtgctggcct ccctgcatgt catgatgacg cttaccaact ggtacagccc tggagagacc
     1321 cggaagatga tcagcacttg gacctcagtg tgggtgaaga tctgtgccag ctgggcgggg
     1381 ctgttcctct acctgtggac cctagtggca cccctgctcc tgcccaacag agacttcagc
     1441 tgagaatgcc ctgctgcctg cctacctggt gccttggggc tcaacaaggg tcagcccacc
     1501 cttggccaca gctatctgct ctcttccagg acccgctcaa gtcaggattc tccattctca
     1561 gtgcctccag ggtctgtggg acattatgct ctgacccaag ccctgccttc ctttgcccat
     1621 gatcatgcat acccaccctt gggactgaag ttaacccctg ttctcagggt ctccagaaga
     1681 gggcatgaga gtagagagtg gcccagagct tctcagctga cagggggggg ggggtcaccc
     1741 tatacactaa ggcctgtggg ggtacccacc ctatacacta aggcctgtgc tccaggcctc
     1801 cagagcccac ccccttccta gaccatgtgc cttaatgagt ctctaagact tcactcaata
     1861 aacatgccag tacctgaaaa aaaaaaaaaa aa
//
