LOCUS       NM_019760               2827 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus serine incorporator 1 (Serinc1), mRNA.
ACCESSION   NM_019760
VERSION     NM_019760.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2827)
  AUTHORS   Yoo,D., Park,J., Lee,C., Song,I., Lee,Y.H., Yun,T., Lee,H.,
            Heguy,A., Han,J.Y., Dasen,J.S., Kim,H. and Baek,M.
  TITLE     Little skate genome provides insights into genetic programs
            essential for limb-based locomotion
  JOURNAL   Elife 11, e78345 (2022)
   PUBMED   36288084
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2827)
  AUTHORS   Chu,E.P., Elso,C.M., Pollock,A.H., Alsayb,M.A., Mackin,L.,
            Thomas,H.E., Kay,T.W., Silveira,P.A., Mansell,A.S., Gaus,K. and
            Brodnicki,T.C.
  TITLE     Disruption of Serinc1, which facilitates serine-derived lipid
            synthesis, fails to alter macrophage function, lymphocyte
            proliferation or autoimmune disease susceptibility
  JOURNAL   Mol Immunol 82, 19-33 (2017)
   PUBMED   28006656
  REMARK    GeneRIF: These results suggest that Serinc1 is dispensable for
            certain immune cell functions and does not contribute to previously
            reported links between lipid composition in immune cells and
            autoimmunity.
REFERENCE   3  (bases 1 to 2827)
  AUTHORS   Elso,C.M., Chu,E.P., Alsayb,M.A., Mackin,L., Ivory,S.T.,
            Ashton,M.P., Broer,S., Silveira,P.A. and Brodnicki,T.C.
  TITLE     Sleeping Beauty Transposon Mutagenesis as a Tool for Gene Discovery
            in the NOD Mouse Model of Type 1 Diabetes
  JOURNAL   G3 (Bethesda) 5 (12), 2903-2911 (2015)
   PUBMED   26438296
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2827)
  AUTHORS   Fossat,N., Tourle,K., Radziewic,T., Barratt,K., Liebhold,D.,
            Studdert,J.B., Power,M., Jones,V., Loebel,D.A. and Tam,P.P.
  TITLE     C to U RNA editing mediated by APOBEC1 requires RNA-binding protein
            RBM47
  JOURNAL   EMBO Rep 15 (8), 903-910 (2014)
   PUBMED   24916387
REFERENCE   5  (bases 1 to 2827)
  AUTHORS   Gohlke,J.M., Armant,O., Parham,F.M., Smith,M.V., Zimmer,C.,
            Castro,D.S., Nguyen,L., Parker,J.S., Gradwohl,G., Portier,C.J. and
            Guillemot,F.
  TITLE     Characterization of the proneural gene regulatory network during
            mouse telencephalon development
  JOURNAL   BMC Biol 6, 15 (2008)
   PUBMED   18377642
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2827)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   7  (bases 1 to 2827)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 2827)
  AUTHORS   Grossman,T.R., Luque,J.M. and Nelson,N.
  TITLE     Identification of a ubiquitous family of membrane proteins and
            their expression in mouse brain
  JOURNAL   J Exp Biol 203 (Pt 3), 447-457 (2000)
   PUBMED   10637174
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153823.5.
            
            On Feb 15, 2022 this sequence version replaced NM_019760.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC017148.1, AK141574.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-121               AC153823.5         177461-177581       c
            122-283             AC153823.5         172769-172930       c
            284-453             AC153823.5         170429-170598       c
            454-533             AC153823.5         169424-169503       c
            534-671             AC153823.5         169065-169202       c
            672-932             AC153823.5         168060-168320       c
            933-1077            AC153823.5         164802-164946       c
            1078-1308           AC153823.5         164467-164697       c
            1309-2827           AC153823.5         160878-162396       c
FEATURES             Location/Qualifiers
     source          1..2827
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 29.19 cM"
     gene            1..2827
                     /gene="Serinc1"
                     /gene_synonym="1500011D18Rik; AIGP-2; mKIAA1253; Tde1l;
                     Tde2; TMS-2; Tms2"
                     /note="serine incorporator 1"
                     /db_xref="GeneID:56442"
                     /db_xref="MGI:MGI:1926228"
     exon            1..121
                     /gene="Serinc1"
                     /gene_synonym="1500011D18Rik; AIGP-2; mKIAA1253; Tde1l;
                     Tde2; TMS-2; Tms2"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..1444
                     /gene="Serinc1"
                     /gene_synonym="1500011D18Rik; AIGP-2; mKIAA1253; Tde1l;
                     Tde2; TMS-2; Tms2"
                     /note="tumor differentially expressed 2; membrane protein
                     TMS-2; axotomy induced glycoprotein 2; axotomy-induced
                     glyco/Golgi protein 2; tumor differentially expressed
                     protein 2; tumor differentially expressed 1, like"
                     /codon_start=1
                     /product="serine incorporator 1"
                     /protein_id="NP_062734.1"
                     /db_xref="CCDS:CCDS23853.1"
                     /db_xref="GeneID:56442"
                     /db_xref="MGI:MGI:1926228"
                     /translation="MGSVLGLCSVASWIPCLCGSAPCLLCRCCPSGNNSTVTRLIYAL
                     FLLVGVCVACVMLIPGMEEQLNKIPGFCENEKGVVPCNILVGYKAVYRLCFGLAMFYL
                     LLSLLMIKVKSSSDPRAAVHNGFWFFKFATAVAIIIGAFFIPEGTFTTVWFYVGMAGA
                     FCFILIQLVLLIDFAHSWNESWVEKMEEGNSRCWYAALLSATALNYLLSLVAVVLFFV
                     YYTHPASCAENKAFISVNMLLCIGASVMSILPKIQESQPRSGLLQSSVITVYTMYLTW
                     SAMTNEPETNCNPSLLSIIGFNTTRPIPKDGQSVQWWHPQGIIGLVLFLLCVFYSSIR
                     TSNNSQVNKLTLTSDESTLIEDGNGRSDGSLDDGDGIHRAVDNERDGVTYSYSFFHFM
                     LFLASLYIMMTLTNWYRYEPSREMKSQWTAVWVKISSSWIGLVLYVWTLVAPLVLTNR
                     DFD"
     exon            122..283
                     /gene="Serinc1"
                     /gene_synonym="1500011D18Rik; AIGP-2; mKIAA1253; Tde1l;
                     Tde2; TMS-2; Tms2"
                     /inference="alignment:Splign:2.1.0"
     exon            284..453
                     /gene="Serinc1"
                     /gene_synonym="1500011D18Rik; AIGP-2; mKIAA1253; Tde1l;
                     Tde2; TMS-2; Tms2"
                     /inference="alignment:Splign:2.1.0"
     exon            454..533
                     /gene="Serinc1"
                     /gene_synonym="1500011D18Rik; AIGP-2; mKIAA1253; Tde1l;
                     Tde2; TMS-2; Tms2"
                     /inference="alignment:Splign:2.1.0"
     exon            534..671
                     /gene="Serinc1"
                     /gene_synonym="1500011D18Rik; AIGP-2; mKIAA1253; Tde1l;
                     Tde2; TMS-2; Tms2"
                     /inference="alignment:Splign:2.1.0"
     exon            672..932
                     /gene="Serinc1"
                     /gene_synonym="1500011D18Rik; AIGP-2; mKIAA1253; Tde1l;
                     Tde2; TMS-2; Tms2"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1077
                     /gene="Serinc1"
                     /gene_synonym="1500011D18Rik; AIGP-2; mKIAA1253; Tde1l;
                     Tde2; TMS-2; Tms2"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1308
                     /gene="Serinc1"
                     /gene_synonym="1500011D18Rik; AIGP-2; mKIAA1253; Tde1l;
                     Tde2; TMS-2; Tms2"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..2827
                     /gene="Serinc1"
                     /gene_synonym="1500011D18Rik; AIGP-2; mKIAA1253; Tde1l;
                     Tde2; TMS-2; Tms2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2807..2812
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Serinc1"
                     /gene_synonym="1500011D18Rik; AIGP-2; mKIAA1253; Tde1l;
                     Tde2; TMS-2; Tms2"
                     /note="hexamer: AATAAA"
     polyA_site      2827
                     /gene="Serinc1"
                     /gene_synonym="1500011D18Rik; AIGP-2; mKIAA1253; Tde1l;
                     Tde2; TMS-2; Tms2"
                     /note="major polyA site"
ORIGIN      
        1 agacagtaaa taagcccaga aaaaggacga aagaagctgt ctccatcttg tcggcacgcg
       61 ccgagctggt gacgcggcgg cgatggggag cgttctgggg ctgtgctccg tggcgagctg
      121 gattccgtgt ttgtgtggca gtgccccgtg tttgctgtgc cgatgctgcc ccagtgggaa
      181 caactccact gtgactagat tgatctacgc acttttcttg ctcgtcggag tatgtgtagc
      241 ttgtgtaatg ttaataccag gaatggaaga acaactgaat aagattcctg ggttctgtga
      301 gaatgagaaa ggtgttgttc cctgtaatat cctggttggc tacaaagctg tgtatcgcct
      361 gtgctttggt ttggccatgt tctatcttct cctctcttta ctaatgatca aggtaaaaag
      421 cagcagtgac cctagagcgg cagtccacaa tggattctgg ttctttaaat ttgctacagc
      481 agttgcaatt atcattggcg cattcttcat cccagaaggc acttttacaa ctgtgtggtt
      541 ttatgtaggc atggcgggcg ccttttgttt catccttata caactagtct tacttattga
      601 ttttgcccat tcttggaatg aatcgtgggt tgaaaaaatg gaagaaggga actcaagatg
      661 ttggtatgca gccctactgt cagctacagc tctgaattac ttgctgtctt tagttgccgt
      721 cgtgctattc tttgtctact acactcaccc agccagctgt gcagagaaca aggcgttcat
      781 cagtgtcaac atgctcctct gcattggcgc ctcagtaatg tccattctgc ccaagatcca
      841 ggaatcacaa ccaaggtctg gcttgttaca gtcgtcagta attacagtct acacaatgta
      901 tttgacatgg tctgctatga ccaatgaacc agaaacaaat tgcaatccaa gtctactgag
      961 catcattggc ttcaatacca caaggcctat tccaaaggac gggcagtctg ttcagtggtg
     1021 gcatcctcaa ggaattatag gacttgttct tttcctgctg tgtgtgtttt attcgagcat
     1081 ccgtacctcc aacaacagtc aggttaataa gctgactcta acaagtgatg agtcaacatt
     1141 gatagaggat gggaatggca gaagtgacgg atcactagat gatggtgatg gcatccaccg
     1201 agctgtagat aacgagaggg atggagtcac gtacagttac tccttctttc acttcatgct
     1261 cttcttggct tcactttaca tcatgatgac cctcaccaat tggtacaggt atgagccttc
     1321 tcgtgagatg aaaagtcagt ggacagcagt ctgggtgaaa atctcttcca gttggattgg
     1381 ccttgtgctg tacgtgtgga cactagtggc accacttgtt cttacaaatc gggattttga
     1441 ctgaatggga tgtctggcat gagtcccact ttggccattg tctatttgac agtaacagta
     1501 ttcccaattt ttgtaaagtt gtatgtgctg ttgtgtaagt gtaacactgt ttttctcttg
     1561 catgaaatag atttactctg ccaattttat ccatgttctt gctaagtcta ttgatgatat
     1621 gaattggaaa gggagaattt tgaatatggt gagaaattgg gaaaaatgga cattgatagg
     1681 catatcatct gctttgtgta catatggtat taaaactgaa aacaaatatt cttgacattt
     1741 gggtttcaaa attgtgttag cacttatttt agaaacatta attaagtgta tggctgcctt
     1801 tgaaatactt gatgtgttgt tgttgcctta cagaggacta caagtataaa gcaaatagct
     1861 gttttaaaat tatgtaaata agtcacaggc tagttatttg aaaactctaa gtcactttaa
     1921 ttttgtcaga atcttctctt actaggtagg cccaggatgt tccatagtta gtggaaaaca
     1981 gtacaggagg tggagggaag ctaagcaata gacaggagcc gtcacaggaa gtcactggca
     2041 atacgggttt aaagcaggta cttagatcac ggttttctct gtaagaaaat atggccgtca
     2101 cccccgccca ccaaaaaaaa atgatttgct ctttgtgaac acacaattat gaatttcatg
     2161 gcgatgttaa caattctgca tttagacaag gttttgcaaa agatattgtg ttagaaaaat
     2221 ttgaaactaa aagcttccca aacaaaatgg gaaaccttac aggacataaa acattaggct
     2281 cgggttaggc actaagataa agtctagtcc agttctcatt ttaaaagtca actagctcta
     2341 aagctagtta gtgacaaagt tggataccaa aaatagccaa cactatgaca taaaaacttt
     2401 gtgttcaaaa tgtacaattc actttataca ttattaatag tagataaatt tgtgtaaaat
     2461 gtatcgctgc tgtccagcat gcttttcttc tttttatcca aacatgaggc caggaggata
     2521 attaacttga ggaatagaca acttacattc actacatatt taatcatgct taaaatgttt
     2581 gtatttactg ccatgcaatt gatatagtaa atcgactaga aaattagtat gccacttaat
     2641 taagataaaa atgcttagtt atttatgtta gtatctagct tttaaagaac tacatgtgtc
     2701 tttaaaagta tttattgtgc aaatgtacta tagcagttca tcttcatgtt ccagccttac
     2761 tctgtgttaa tactgcttca caattctgaa tggctgtgtt ctcttaaata aatgcattca
     2821 aagaaaa
//
