LOCUS       NM_013789               1460 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus secretion regulating guanine nucleotide exchange
            factor (Sergef), mRNA.
ACCESSION   NM_013789
VERSION     NM_013789.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1460)
  AUTHORS   Takenaka,N., Nihata,Y. and Satoh,T.
  TITLE     Rac1 Activation Caused by Membrane Translocation of a Guanine
            Nucleotide Exchange Factor in Akt2-Mediated Insulin Signaling in
            Mouse Skeletal Muscle
  JOURNAL   PLoS One 11 (5), e0155292 (2016)
   PUBMED   27163697
  REMARK    GeneRIF: Rac1 activation is caused by membrane translocation of a
            guanine nucleotide exchange factor FLJ00068 in Akt2-mediated
            insulin signaling in mouse skeletal muscle.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1460)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   3  (bases 1 to 1460)
  AUTHORS   Uhlmann,J., Wiemann,S. and Ponstingl,H.
  TITLE     DelGEF, an RCC1-related protein encoded by a gene on chromosome
            11p14 critical for two forms of hereditary deafness
  JOURNAL   FEBS Lett 460 (1), 153-160 (1999)
   PUBMED   10571079
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY228093.1, AK145819.1 and AC090652.32.
            
            On Jun 9, 2010 this sequence version replaced NM_013789.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC049603.1, AJ243952.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                BY228093.1         2-14
            14-1377             AK145819.1         3-1366
            1378-1378           AC090652.32        34763-34763         c
            1379-1444           AK145819.1         1368-1433
            1445-1460           AC090652.32        34681-34696         c
FEATURES             Location/Qualifiers
     source          1..1460
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 30.2 cM"
     gene            1..1460
                     /gene="Sergef"
                     /gene_synonym="DelGEF; Gef; Gnef; Gnefr"
                     /note="secretion regulating guanine nucleotide exchange
                     factor"
                     /db_xref="GeneID:27414"
                     /db_xref="MGI:MGI:1351630"
     exon            1..95
                     /gene="Sergef"
                     /gene_synonym="DelGEF; Gef; Gnef; Gnefr"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..1430
                     /gene="Sergef"
                     /gene_synonym="DelGEF; Gef; Gnef; Gnefr"
                     /note="guanine nucleotide exchange factor (RCC1 related);
                     guanine nucleotide exchange factor-related protein;
                     deafness locus-associated putative guanine nucleotide
                     exchange factor"
                     /codon_start=1
                     /product="secretion-regulating guanine nucleotide exchange
                     factor"
                     /protein_id="NP_038817.1"
                     /db_xref="CCDS:CCDS21279.1"
                     /db_xref="GeneID:27414"
                     /db_xref="MGI:MGI:1351630"
                     /translation="MARESCASETVSAAAVLFAWGANSYGQLGLGHKEDVFLPQQLSD
                     FCQAGCIKSVTGGGGHSAVVTDGGDLFVCGLNKDGQLGLGHTEEVLRFTICKPLRGCP
                     IRQVACGWDFTIMLTEKGQVLSCGSNAFGQLGVPHGPRKCVVPQAIECLREKVVCVAA
                     GLRHALATTATGSVFQWGTGLASSGRRLCPGQNLPLFLTAKEPSRVTGLENSTAVCAV
                     AGSDHSASLTDTGELYVWGRNKHGQLASRAVFLPLPQRIEAHYFQDEKVTAVWSGWTH
                     LVAKTETGKVFTWGRADYGQLGRRLEPPEAQKPVEQDSSLAFQGPQNSVPSPLHCLTG
                     ATEISCGSEHNLAVIRDKCCSWGWNEHGMCGDGTESNVWTPTPVQALPPSPSRLLLVG
                     CGAGHSLAVCQLPAHPVPCQDLKVTCPLPDDTENTESQGAVDRDRLEGETISDLNPDR
                     TRNGGGGCESETVQ"
     exon            96..231
                     /gene="Sergef"
                     /gene_synonym="DelGEF; Gef; Gnef; Gnefr"
                     /inference="alignment:Splign:2.1.0"
     exon            232..387
                     /gene="Sergef"
                     /gene_synonym="DelGEF; Gef; Gnef; Gnefr"
                     /inference="alignment:Splign:2.1.0"
     exon            388..482
                     /gene="Sergef"
                     /gene_synonym="DelGEF; Gef; Gnef; Gnefr"
                     /inference="alignment:Splign:2.1.0"
     exon            483..543
                     /gene="Sergef"
                     /gene_synonym="DelGEF; Gef; Gnef; Gnefr"
                     /inference="alignment:Splign:2.1.0"
     exon            544..657
                     /gene="Sergef"
                     /gene_synonym="DelGEF; Gef; Gnef; Gnefr"
                     /inference="alignment:Splign:2.1.0"
     exon            658..720
                     /gene="Sergef"
                     /gene_synonym="DelGEF; Gef; Gnef; Gnefr"
                     /inference="alignment:Splign:2.1.0"
     exon            721..879
                     /gene="Sergef"
                     /gene_synonym="DelGEF; Gef; Gnef; Gnefr"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1046
                     /gene="Sergef"
                     /gene_synonym="DelGEF; Gef; Gnef; Gnefr"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1083
                     /gene="Sergef"
                     /gene_synonym="DelGEF; Gef; Gnef; Gnefr"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1460
                     /gene="Sergef"
                     /gene_synonym="DelGEF; Gef; Gnef; Gnefr"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1426..1431
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sergef"
                     /gene_synonym="DelGEF; Gef; Gnef; Gnefr"
                     /note="hexamer: AATAAA"
     polyA_site      1448
                     /gene="Sergef"
                     /gene_synonym="DelGEF; Gef; Gnef; Gnefr"
                     /note="major polyA site"
ORIGIN      
        1 gtcagccctc ccggaagcgc cggctgagcg tgtgcatggc gcgggagtcc tgcgcctccg
       61 agactgtctc tgccgctgct gtgctcttcg cctggggtgc aaacagctat gggcaacttg
      121 gccttggcca taaggaagat gtgtttctgc cccagcaact gagtgacttc tgtcaagctg
      181 ggtgtatcaa gagtgtcaca ggaggaggag ggcattctgc agttgtcaca gatggaggag
      241 atctttttgt ttgtggcctg aataaagatg ggcagttggg gcttggtcac acagaggaag
      301 ttctgcgttt taccatctgc aagcctctcc gtggttgtcc catccgacag gtggcctgtg
      361 gctgggactt caccatcatg cttacagaaa aaggtcaagt tctgtcctgt ggatccaatg
      421 cctttggcca gttaggtgtg cctcacggcc ctcgcaaatg cgtggtcccc caggccattg
      481 agtgcctgag agagaaggtt gtttgtgtcg ctgctggact gaggcatgcc ttagccacta
      541 cagcgactgg cagtgtgttc cagtggggga ctggcttggc atcttctggt cgacgcctgt
      601 gccctgggca gaatctccca ctgtttttga cagcaaagga acccagcaga gtgacaggcc
      661 tggagaattc tacagcagtg tgtgctgttg caggatctga ccactcggcc tcattaacag
      721 atacaggaga gctgtacgtc tggggccgta acaagcatgg gcagctggcc tcccgcgctg
      781 tgttccttcc tctgccccag agaatagaag cacattactt tcaggatgaa aaggtcactg
      841 ctgtctggag tggctggaca cacctggttg ctaagacaga aactggcaag gtgtttacct
      901 ggggtcgagc agactatggt cagctaggga ggaggttgga gcctcctgaa gctcagaaac
      961 ctgtagagca agactcatcg ctcgccttcc aggggccaca gaacagtgtg ccttcacctc
     1021 tgcattgcct gacaggagca acagagattt cttgtggctc ggagcacaac ttggcagtaa
     1081 ttagggacaa gtgctgctcc tggggttgga acgaacacgg catgtgtggg gatggcactg
     1141 agtccaatgt ctggactcca actccagtgc aggctctgcc accatcacca tcaagactcc
     1201 tcctcgtggg ctgtggggct ggccactcct tggccgtatg tcagctgcca gcacaccctg
     1261 tgccatgcca ggatctcaag gtcacctgcc ctctcccaga tgacacagag aacactgaat
     1321 ctcagggtgc cgtggacaga gacagactgg aaggagagac gatcagtgac ctcaacccag
     1381 acaggacgag aaatgggggt ggggggtgtg agagcgagac cgttcaataa agtggcttta
     1441 taccaacaga agattccctg
//
