LOCUS       NM_001111017            5630 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus serine active site containing 1 (Serac1), transcript
            variant 3, mRNA.
ACCESSION   NM_001111017
VERSION     NM_001111017.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5630)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5630)
  AUTHORS   Fang,H., Xie,A., Du,M., Li,X., Yang,K., Fu,Y., Yuan,X., Fan,R.,
            Yu,W., Zhou,Z., Sang,T., Nie,K., Li,J., Zhao,Q., Chen,Z., Yang,Y.,
            Hong,C. and Lyu,J.
  TITLE     SERAC1 is a component of the mitochondrial serine transporter
            complex required for the maintenance of mitochondrial DNA
  JOURNAL   Sci Transl Med 14 (634), eabl6992 (2022)
   PUBMED   35235340
REFERENCE   3  (bases 1 to 5630)
  AUTHORS   Manabe,R., Tsutsui,K., Yamada,T., Kimura,M., Nakano,I., Shimono,C.,
            Sanzen,N., Furutani,Y., Fukuda,T., Oguri,Y., Shimamoto,K.,
            Kiyozumi,D., Sato,Y., Sado,Y., Senoo,H., Yamashina,S., Fukuda,S.,
            Kawai,J., Sugiura,N., Kimata,K., Hayashizaki,Y. and Sekiguchi,K.
  TITLE     Transcriptome-based systematic identification of extracellular
            matrix proteins
  JOURNAL   Proc Natl Acad Sci U S A 105 (35), 12849-12854 (2008)
   PUBMED   18757743
REFERENCE   4  (bases 1 to 5630)
  AUTHORS   Schimenti,J.C., Reynolds,J.L. and Planchart,A.
  TITLE     Mutations in Serac1 or Synj2 cause proximal t haplotype-mediated
            male mouse sterility but not transmission ratio distortion
  JOURNAL   Proc Natl Acad Sci U S A 102 (9), 3342-3347 (2005)
   PUBMED   15722415
  REMARK    GeneRIF: role in proximal t-haplotype mediated mouse sterility
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY197974.1, BC119594.1 and AC154650.2.
            
            Transcript Variant: This variant (3) represents the longest
            transcript and encodes the longestz isoform (3).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.32068.1, AK155571.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-202               BY197974.1         1-202
            203-2135            BC119594.1         192-2124
            2136-5630           AC154650.2         113220-116714
FEATURES             Location/Qualifiers
     source          1..5630
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 3.67 cM"
     gene            1..5630
                     /gene="Serac1"
                     /gene_synonym="4930511N22Rik; D17Ertd141e"
                     /note="serine active site containing 1"
                     /db_xref="GeneID:321007"
                     /db_xref="MGI:MGI:2447813"
     exon            1..121
                     /gene="Serac1"
                     /gene_synonym="4930511N22Rik; D17Ertd141e"
                     /inference="alignment:Splign:2.1.0"
     exon            122..213
                     /gene="Serac1"
                     /gene_synonym="4930511N22Rik; D17Ertd141e"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..2087
                     /gene="Serac1"
                     /gene_synonym="4930511N22Rik; D17Ertd141e"
                     /note="isoform 3 is encoded by transcript variant 3;
                     protein SERAC1; serine active site-containing protein 1"
                     /codon_start=1
                     /product="protein SERAC1 isoform 3"
                     /protein_id="NP_001104487.1"
                     /db_xref="CCDS:CCDS49933.1"
                     /db_xref="GeneID:321007"
                     /db_xref="MGI:MGI:2447813"
                     /translation="MSLAAYCVICCRRIGSFAPRSKSRTPWRNIRNIIRFTGSLIVGG
                     SLFITYEVLALKKSLMLDTQVVEREKMKSYIYVHKAPVDRLDNRGIVWQARKELHRAV
                     RKLLAAAAKVLRSPFADSFSTVDIEDHDCAVWLLLRKSREDDLAARLQAVREMSEAHH
                     WHDYQYRIIAQACDPRTLIGLARSKESDLRFFLPPPPLPSLKEDSSTEEELRHLLASL
                     PQTELDECLQYFTSLALSESSQSLAAQKGGLWCFGGNGLPYAESFGKVPSATVEMFCL
                     EAIVKHSEIPSHCDHIEAGGGLQLLQRLYQLHKDCPKVQRNVMRIIGNMALNEHLHPA
                     IVHSGWVSLMAEALKSSHIMEASHAARTLANLDRETVGEKYQDGVYVLHPQCRTSQPI
                     KADVLFIHGLMGAAFKTWRQHDSQRALTESAVVDEDRYTTCWPKTWLAKDCPSLRIIS
                     VEYDTSLSDWRARCPMERKSIAFRSNELLSKLRAAGVGDRPMIWISHSMGGLLVKKML
                     LEASKKPELNALINNTRGIIFYSVPHHGSRLAEYSVNIRYLLFPSLEVKELSKDSPAL
                     KTLQDDFLEFAKDKNFQVLNFVETQPTFIGSMIKLHVVPVESADLGIGDLIPVDVNHL
                     NICKPKTKDAFLYQRTLQFICETLARDLEN"
     exon            214..250
                     /gene="Serac1"
                     /gene_synonym="4930511N22Rik; D17Ertd141e"
                     /inference="alignment:Splign:2.1.0"
     exon            251..387
                     /gene="Serac1"
                     /gene_synonym="4930511N22Rik; D17Ertd141e"
                     /inference="alignment:Splign:2.1.0"
     exon            388..477
                     /gene="Serac1"
                     /gene_synonym="4930511N22Rik; D17Ertd141e"
                     /inference="alignment:Splign:2.1.0"
     exon            478..609
                     /gene="Serac1"
                     /gene_synonym="4930511N22Rik; D17Ertd141e"
                     /inference="alignment:Splign:2.1.0"
     exon            610..731
                     /gene="Serac1"
                     /gene_synonym="4930511N22Rik; D17Ertd141e"
                     /inference="alignment:Splign:2.1.0"
     exon            732..860
                     /gene="Serac1"
                     /gene_synonym="4930511N22Rik; D17Ertd141e"
                     /inference="alignment:Splign:2.1.0"
     exon            861..974
                     /gene="Serac1"
                     /gene_synonym="4930511N22Rik; D17Ertd141e"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1137
                     /gene="Serac1"
                     /gene_synonym="4930511N22Rik; D17Ertd141e"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1288
                     /gene="Serac1"
                     /gene_synonym="4930511N22Rik; D17Ertd141e"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1430
                     /gene="Serac1"
                     /gene_synonym="4930511N22Rik; D17Ertd141e"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..1525
                     /gene="Serac1"
                     /gene_synonym="4930511N22Rik; D17Ertd141e"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..1623
                     /gene="Serac1"
                     /gene_synonym="4930511N22Rik; D17Ertd141e"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..1806
                     /gene="Serac1"
                     /gene_synonym="4930511N22Rik; D17Ertd141e"
                     /inference="alignment:Splign:2.1.0"
     exon            1807..1950
                     /gene="Serac1"
                     /gene_synonym="4930511N22Rik; D17Ertd141e"
                     /inference="alignment:Splign:2.1.0"
     exon            1951..5630
                     /gene="Serac1"
                     /gene_synonym="4930511N22Rik; D17Ertd141e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5611..5616
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Serac1"
                     /gene_synonym="4930511N22Rik; D17Ertd141e"
                     /note="hexamer: ATTAAA"
     polyA_site      5630
                     /gene="Serac1"
                     /gene_synonym="4930511N22Rik; D17Ertd141e"
                     /note="major polyA site"
ORIGIN      
        1 ggtcacgtgc tcactgccgc tgggttaggg cgcaggttac tagtggtggc ggagggtgag
       61 ctctgtagcc ggcggagtcc accgcgagcc gtccgggctg ccagagtcat tgcgccggca
      121 ggatgtccct ggctgcctac tgtgtcatct gttgcaggag gataggatcc tttgctcccc
      181 gatcaaaaag tcgcacgccc tggagaaata tccgaaatat aataagattt actggatccc
      241 tcattgtagg gggttctcta tttattacat atgaagtgct ggccctgaaa aagtctttaa
      301 tgttggacac tcaggtggtg gaacgagaaa aaatgaagtc ttacatctat gtgcacaaag
      361 ctcctgtaga caggttagac aaccgtggga ttgtttggca ggcaagaaaa gaacttcaca
      421 gagcagtaag aaaactgttg gcggcagcag ccaaggtact gcggagccca tttgctgact
      481 ctttcagcac agttgacata gaagatcatg actgtgcagt gtggctgctc ctgaggaaga
      541 gccgggagga cgatctagct gcacggctgc aggccgtgcg tgaaatgtca gaggctcacc
      601 actggcatga ctaccagtac aggataattg ctcaagcctg tgacccgagg acccttattg
      661 gtttggcacg aagcaaagaa agtgatcttc ggttttttct cccaccccct cctttgcctt
      721 ctttaaaaga agactcctcc actgaagagg aactcaggca tctgctggcc tctctgcctc
      781 agacagagct tgatgagtgt ctccagtact ttacatcctt ggctcttagt gaaagcagcc
      841 agagcctggc tgcacagaag ggaggactgt ggtgttttgg aggaaacgga ctgccttacg
      901 cagaaagctt tggaaaggtt ccctcagcca cagtggaaat gttctgttta gaagccatag
      961 taaagcattc ggagataccc tcacactgtg accacattga agcaggcggt ggcttgcaac
     1021 tcctgcagag gctctaccag cttcacaagg actgccccaa agtacagaga aacgtcatga
     1081 ggatcatcgg aaacatggct ttgaacgagc atcttcaccc tgctatagtc cactcaggat
     1141 gggtatctct catggcagaa gccttgaagt ccagccacat tatggaggct tcccacgctg
     1201 ccagaaccct ggctaacctg gaccgagaaa ctgtgggtga gaaataccag gacggagtgt
     1261 acgtgctgca tccccagtgt cggacaagtc agcccattaa agccgatgtc ctttttattc
     1321 atggcctaat gggagcagca tttaaaacct ggcggcagca cgacagccag cgggctctga
     1381 ctgaaagtgc tgtggtggat gaagacaggt acactacatg ctggcccaag acatggctag
     1441 caaaggactg cccctcactt cgcatcatat ctgtggagta cgacacgagt ctcagcgact
     1501 ggagggcaag gtgccctatg gagagaaagt cgattgcatt cagaagcaac gaacttctca
     1561 gcaagctcag ggctgctggt gttggggata ggccaatgat ttggatctca cacagcatgg
     1621 gaggtcttct tgtgaagaag atgctgttgg aagcctctaa gaagcccgaa ctgaatgctc
     1681 ttataaacaa taccagagga attatttttt acagtgtccc tcaccatggg tcacgtttgg
     1741 ctgaatactc cgttaatatt cgatatcttc tctttccctc actggaagtc aaagaactca
     1801 gcaaagactc tcctgcactg aagacgctac aggacgactt tctggagttc gcgaaagaca
     1861 aaaacttcca ggtgctgaac tttgtagaaa cacaaccgac atttatcggc agcatgatta
     1921 aactgcatgt agtgcccgtg gagtcagcag atttaggcat tggggatcta attcctgtgg
     1981 acgtcaacca cttgaacatt tgcaagccga agacaaagga tgcgtttttg taccaacgta
     2041 ctctacagtt catctgcgaa actttagcca gagatcttga aaactgagag atacgttctt
     2101 ccattttttt gtgtgaatat agtgcgagaa acgtggcatt ctccatctgt tgttaaggtc
     2161 tccgcagtcc tgtgcactca ctgcgtgtgg ggtgcaggca gcagagcgca gctcttcacg
     2221 caagcactgg gagatgcccg agtacacctg gaggccacag aggaaggctt acattgagaa
     2281 actccttgtg ctgggccttg gggtagggag cagagctgct gtggccagag ggcccgacca
     2341 cctgagactg tcccagctca cccaagagtc ctgacaggca agctagcaca ccatgagaat
     2401 gaaacttggg gagatcaagc tagaacttac agaggctgtg gttgatctgg gtaccatgtg
     2461 ccatgatgtt ttactgccag cttttaatgt caatatgcca ggtgcacagt tgacactttt
     2521 acaggggctc ctgtgcctgc ttgtatgtgc gggccaggct ctgcttctgg gtttctcaca
     2581 gtgctgagaa cgattgggtt tttttttaag tattccttct aagatatttt aattagctat
     2641 tgaatagtat gctccagata aggtaaggat caggttatga cacacctatt tgaagcagtc
     2701 aggtatgctg accactcagt attaagcctc tccaattttc tggctatgta aagtacagct
     2761 tcccttcatg cccccttaga gggagggtgg gaacgtgtgc tgatgatcgt tgttgagttt
     2821 tagtaatagc attattaaca tgaaagtcag tgtgtgtgtg tgcgtgtgtg tgtgtgtgtg
     2881 tgtgtgtgtg tgtgtgcgcg cgcgcgtgtg cgcgcacgtg catgtgtgtg gtgctaggga
     2941 tcaaactgga aaccttgtgc atgctatgtc ctcagcccca aatttataca acttttagta
     3001 cattcaaagt tactatcacc actgtccaat ttcagtggat tgtgtcatcc ccaaagcagc
     3061 tctctcacca gcaggcagtc ccctcctccg accccaaccc caggaaacac tattgctttc
     3121 cctctctgcg agattgccta gtgaacattc ataaagtcgg tagcgtcacc gtggtgctct
     3181 tagcacaatg gttctttctt gcatcactct ttctgcctct ctctgcttcc tccctgcctt
     3241 gcagtgagca gttttgccca ttctcccatg atgccctgtc tcgccatggg accggtgatg
     3301 actgactgaa accttgggca gcagacatct tttctccttg acctctgctg cccaggtgtt
     3361 tgtcatcgag gtgaacatgc tttaaaactg cgatctgaaa agagctgtct agtgtattgc
     3421 taaattagtg ttagtgtttc tctgacaaga cagtcggcat ttctgctctg tctatatgat
     3481 ggaaaggcca ctctccattt atcacaaagg cttggtgagg cgtagatgat aacgtacacc
     3541 aaggtggata atagagcaag atggaacaaa tccaacactg gcggaatcat cctgaacaaa
     3601 gacatcattg aaaccaatga gcacaagata actgcaaaac agcagcgcct taaagacggc
     3661 acagacacac ggtagctgca gaaggacccc tcaaaggcaa ggaaccctcc tacctcacct
     3721 acctcaccta agctgccctt gagactagtg tgggcataat gaacagatgt ggtcaggggc
     3781 aggaactcaa gcgttggcga agcctgacat ttgctctgcc tgagttcatg taaattagaa
     3841 tgtgatggaa cggcctggaa cataatctgg tattttatca taaatgcaca tagatttctg
     3901 aataatgctg atgataattt atgggtacat ttggaggatc tacaaacaat ccacaactaa
     3961 aaatattttg gtgaagagag gcccttacgt tcctgtcaca gggtcagaga cagcaaggat
     4021 gaagttgctg ggaatttgag ttgggaggtg catgggagca aggatcaagg tctttcttgg
     4081 gcagagaaac agctctgata ctgcaacata gacgttatac cgtgcaggga gcgaagctga
     4141 atgtggagcc agggccatca gaggtgatgg tgtcagcatg gggtcattag ttgtagacat
     4201 cctagggcag ggcatctcgg gagctccctg tgggaacagg taagtgttcg ggaaccctta
     4261 actttaattt cccgctgaca ctactcttac tcagtatacc gctgagccca tcccctgcca
     4321 ccttggtata aagatcccac agtctgctga ttcctctctt ggccaggtct gaacaacaca
     4381 gagagaaatc ttactggttt accattttga aattaccagt atattcttaa tcctgagaga
     4441 cacaatatga gtaactatgt tctgtgaata agcttagaat aaacgtgtcc catctgtttc
     4501 catgaaaaaa tgtatataaa gcatcctcag agcccatcta ttccacagag tgttgtaagg
     4561 gccttgcccg agtctcactg tgtgtgtggt gtcagcgatc atgatagcgg ctctcacaca
     4621 attctctatt cacatataat tgctgtgtgt gtgtttgtgt gtgcgtgtgt gcatgtagct
     4681 cagcgggcaa cagtcaggag ttagttcttc caccatgtga gtcttggggc tcaaactcag
     4741 gtcttcaggc ctgacagcaa gcacctctga tgctcagcca ccccttgggc cttaagccat
     4801 aattgataat ctatcttatt ctcttgcttt tcaaccaatt gttgagtccc aattgttgag
     4861 agattgagag agagaaccaa aacagcatgc agtaagaact atctattgca tttgatatcg
     4921 aggaaggctg gccaaaagaa tccgaggagc cccttcagat ctgaaaagac tcaattttaa
     4981 aagaacgaaa acatctaacg catccaacat gagaacaaat taccaatcaa gatacactgc
     5041 aggctttgac tggtcactga tctctgggta taagtttccc tttccgacaa aacgaccatt
     5101 tgaaagccag cgctttaaca atgtgtaatt agcttacaca tgtcgtcagg gagatttttt
     5161 ttaagtatct caaactagca actttaaacc tttgtatttc agtcacctta acaaatatct
     5221 ttagctctgg gaaatgagtc tatattaccg tcagcgagac tgaacttgtc agcattgccc
     5281 ctgaaatact gtgctaaaaa cgtgcagtca tcgtaactaa ggcagaccaa aagccaaaac
     5341 agactggaca caaaatggaa tctttgggtg gtggttgctc actgctgaag tcattcaacc
     5401 aacagatgct agcttaaaac gccctacagt taaacattgg tttaaaaata aggctattcc
     5461 aactgttgtc ctgttcccca cccccacttg acacccttac actgtcttga aactgggtct
     5521 tactatgtag ctctggctgt ctggaacaat gtaggccagg ttggccttga actcacagag
     5581 aaccccctgc ctctgactcc tgagtaatgg attaaagatg tatgctacca
//
