LOCUS       NM_001113487            3796 bp    mRNA    linear   ROD 15-JUL-2024
DEFINITION  Mus musculus septin 9 (Septin9), transcript variant 2, mRNA.
ACCESSION   NM_001113487
VERSION     NM_001113487.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3796)
  AUTHORS   Guo,Y., Zeng,J., Zhuang,Y., Jiang,C. and Xie,W.
  TITLE     MiR-503-5p alleviates peripheral neuropathy-induced neuropathic
            pain in T2DM mice by regulating SEPT9 to inhibit astrocyte
            activation
  JOURNAL   Sci Rep 14 (1), 14361 (2024)
   PUBMED   38906977
  REMARK    GeneRIF: MiR-503-5p alleviates peripheral neuropathy-induced
            neuropathic pain in T2DM mice by regulating SEPT9 to inhibit
            astrocyte activation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3796)
  AUTHORS   Martens,A.K., Erwig,M., Patzig,J., Fledrich,R., Fuchtbauer,E.M. and
            Werner,H.B.
  TITLE     Targeted inactivation of the Septin2 and Septin9 genes in
            myelinating Schwann cells of mice
  JOURNAL   Cytoskeleton (Hoboken) 80 (7-8), 290-302 (2023)
   PUBMED   36378242
REFERENCE   3  (bases 1 to 3796)
  AUTHORS   Chen,L., Ouyang,Y.C., Gu,L.J., Guo,J.N., Han,Z.M., Wang,Z.B.,
            Hou,Y., Schatten,H. and Sun,Q.Y.
  TITLE     Septin 9 controls CCNB1 stabilization via APC/CCDC20 during meiotic
            metaphase I/anaphase I transition in mouse oocytes
  JOURNAL   Cell Prolif 56 (2), e13359 (2023)
   PUBMED   36354207
  REMARK    GeneRIF: Septin 9 controls CCNB1 stabilization via APC/C[CDC20]
            during meiotic metaphase I/anaphase I transition in mouse oocytes.
REFERENCE   4  (bases 1 to 3796)
  AUTHORS   Keppner,A., Correia,M., Santambrogio,S., Koay,T.W., Maric,D.,
            Osterhof,C., Winter,D.V., Clerc,A., Stumpe,M., Chalmel,F.,
            Dewilde,S., Odermatt,A., Kressler,D., Hankeln,T., Wenger,R.H. and
            Hoogewijs,D.
  TITLE     Androglobin, a chimeric mammalian globin, is required for male
            fertility
  JOURNAL   Elife 11, e72374 (2022)
   PUBMED   35700329
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3796)
  AUTHORS   Moore,K.S., Moore,R., Fulmer,D.B., Guo,L., Gensemer,C.,
            Stairley,R., Glover,J., Beck,T.C., Morningstar,J.E., Biggs,R.,
            Muhkerjee,R., Awgulewitsch,A. and Norris,R.A.
  TITLE     DCHS1, Lix1L, and the Septin Cytoskeleton: Molecular and
            Developmental Etiology of Mitral Valve Prolapse
  JOURNAL   J Cardiovasc Dev Dis 9 (2), 62 (2022)
   PUBMED   35200715
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3796)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   7  (bases 1 to 3796)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 3796)
  AUTHORS   Sorensen,A.B., Warming,S., Fuchtbauer,E.M. and Pedersen,F.S.
  TITLE     Alternative splicing, expression, and gene structure of the
            septin-like putative proto-oncogene Sint1
  JOURNAL   Gene 285 (1-2), 79-89 (2002)
   PUBMED   12039034
REFERENCE   9  (bases 1 to 3796)
  AUTHORS   Sorensen,A.B., Lund,A.H., Ethelberg,S., Copeland,N.G., Jenkins,N.A.
            and Pedersen,F.S.
  TITLE     Sint1, a common integration site in SL3-3-induced T-cell lymphomas,
            harbors a putative proto-oncogene with homology to the septin gene
            family
  JOURNAL   J Virol 74 (5), 2161-2168 (2000)
   PUBMED   10666245
REFERENCE   10 (bases 1 to 3796)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU148654.1, AK122415.2 and AW538697.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK122415.2, SRR7974084.23444.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-206               BU148654.1         1-206
            207-3716            AK122415.2         1-3510
            3717-3796           AW538697.2         1-80                c
FEATURES             Location/Qualifiers
     source          1..3796
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 82.61 cM"
     gene            1..3796
                     /gene="Septin9"
                     /gene_synonym="Msf; MSF1; PNUTL4; Sept9; Sint1"
                     /note="septin 9"
                     /db_xref="GeneID:53860"
                     /db_xref="MGI:MGI:1858222"
     exon            1..350
                     /gene="Septin9"
                     /gene_synonym="Msf; MSF1; PNUTL4; Sept9; Sint1"
                     /inference="alignment:Splign:2.1.0"
     CDS             296..2026
                     /gene="Septin9"
                     /gene_synonym="Msf; MSF1; PNUTL4; Sept9; Sint1"
                     /note="isoform b is encoded by transcript variant 2; SL3-3
                     integration site 1 protein; MLL septin-like fusion"
                     /codon_start=1
                     /product="septin-9 isoform b"
                     /protein_id="NP_001106959.1"
                     /db_xref="CCDS:CCDS48991.1"
                     /db_xref="GeneID:53860"
                     /db_xref="MGI:MGI:1858222"
                     /translation="MSDPAVNAQLDGIISDFEALKRSFEVEEIEPPNSTPPRRVQTPL
                     LRATVASSSQKFQDLGVKNSEPAARLVDSLSQRSPKPSLRRVELAGAKAPEPMSRRTE
                     ISIDISSKQVESTASAAGPSRFGLKRAEVLGHKTPEPVPRRTEITIVKPQESVLRRVE
                     TPASKIPEGSAVPATDAAPKRVEIQVPKPAEAPNCPLPSQTLENSEAPMSQLQSRLEP
                     RPSVAEVPYRNQEDSEVTPSCVGDMADNPRDAMLKQAPASRNEKAPMEFGYVGIDSIL
                     EQMRRKAMKQGFEFNIMVVGQSGLGKSTLINTLFKSKISRKSVQPTSEERIPKTIEIK
                     SITHDIEEKGVRMKLTVIDTPGFGDHINNENCWQPIMKFINDQYEKYLQEEVNINRKK
                     RIPDTRVHCCLYFIPATGHSLRPLDIEFMKRLSKVVNIVPVIAKADTLTLEERVYFKQ
                     RITADLLSNGIDVYPQKEFDEDAEDRLVNEKFREMIPFAVVGSDHEYQVNGKRILGRK
                     TKWGTIEVENTTHCEFAYLRDLLIRTHMQNIKDITSNIHFEAYRVKRLNEGNSAMANG
                     IEKEPEAQEM"
     exon            351..989
                     /gene="Septin9"
                     /gene_synonym="Msf; MSF1; PNUTL4; Sept9; Sint1"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1181
                     /gene="Septin9"
                     /gene_synonym="Msf; MSF1; PNUTL4; Sept9; Sint1"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1310
                     /gene="Septin9"
                     /gene_synonym="Msf; MSF1; PNUTL4; Sept9; Sint1"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1392
                     /gene="Septin9"
                     /gene_synonym="Msf; MSF1; PNUTL4; Sept9; Sint1"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..1530
                     /gene="Septin9"
                     /gene_synonym="Msf; MSF1; PNUTL4; Sept9; Sint1"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1648
                     /gene="Septin9"
                     /gene_synonym="Msf; MSF1; PNUTL4; Sept9; Sint1"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..1744
                     /gene="Septin9"
                     /gene_synonym="Msf; MSF1; PNUTL4; Sept9; Sint1"
                     /inference="alignment:Splign:2.1.0"
     exon            1745..1841
                     /gene="Septin9"
                     /gene_synonym="Msf; MSF1; PNUTL4; Sept9; Sint1"
                     /inference="alignment:Splign:2.1.0"
     exon            1842..1893
                     /gene="Septin9"
                     /gene_synonym="Msf; MSF1; PNUTL4; Sept9; Sint1"
                     /inference="alignment:Splign:2.1.0"
     exon            1894..3796
                     /gene="Septin9"
                     /gene_synonym="Msf; MSF1; PNUTL4; Sept9; Sint1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3764..3769
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Septin9"
                     /gene_synonym="Msf; MSF1; PNUTL4; Sept9; Sint1"
                     /note="hexamer: AATAAA"
     polyA_site      3784
                     /gene="Septin9"
                     /gene_synonym="Msf; MSF1; PNUTL4; Sept9; Sint1"
                     /note="major polyA site"
ORIGIN      
        1 tctgcagtcc ctgtagaagc agctctggtt ccatcccctc caggcccagt tttgacaggc
       61 gggcgcaaca gccagtgccg agtcgcggag gccggctggg gtacgggaac ctgatccagc
      121 cgggaggcgg gggcggggcg ggggcccggg tgcttgggga ggggccggcg cccgccttcc
      181 tcccccattc attcagccga ccgtgggggc cgaggggctc cggcggccag ctctgcaccg
      241 ggagcgggag cgcgcagggc ccggtctccg cgggactccc tgcgcaccag ccaccatgtc
      301 cgaccccgcg gtcaacgcac agctggacgg gatcatttca gactttgaag ccttaaagag
      361 atcgtttgaa gtcgaggaga ttgagccgcc caactccacg ccaccccgga gggtccagac
      421 ccctctgctc cgcgccacgg tggccagctc cagccagaaa ttccaggacc tgggggtgaa
      481 gaactcagag cccgctgccc gccttgtaga ctccctgagc cagcgctccc ccaagccttc
      541 cctgcggagg gtggagctgg cgggagccaa ggcgcctgag cccatgtctc gacgcacaga
      601 gatctccatc gacatctcct ccaagcaggt ggagagcacg gcctccgctg ccgggccctc
      661 acggttcggc cttaagaggg ctgaagtcct gggccacaag accccagagc ctgtccctcg
      721 gaggacggag atcaccattg tcaagcctca ggagtcagtg ctccgcaggg tggagacccc
      781 tgcctccaag attcccgagg gctctgccgt gcctgccaca gatgcagccc ccaagagggt
      841 agagatccag gtgcccaagc cagctgaggc acccaactgt ccgctcccgt cccagaccct
      901 ggagaactcc gaggccccga tgtctcaact gcagagcagg ctggagccca ggccttccgt
      961 ggctgaggtc ccatatcgga accaggaaga ctccgaggtg actcccagct gtgttggcga
     1021 catggctgac aaccctagag atgccatgct caagcaggcc cccgcgtcac ggaacgaaaa
     1081 ggcccccatg gagttcggct atgtggggat cgactccatc ctggagcaga tgcgcaggaa
     1141 ggctatgaaa cagggcttcg agtttaacat catggtggtt gggcagagcg gcctcgggaa
     1201 gtccacttta atcaataccc tcttcaagtc caaaatcagc cggaagtcgg tgcagcccac
     1261 ctcggaggaa cgcatcccca agacgatcga aatcaagtcg atcacccacg atattgaaga
     1321 gaagggggtt cgaatgaagc tgacagtgat tgacacgccg ggcttcggag accacatcaa
     1381 caatgagaac tgctggcagc ccattatgaa gttcatcaat gaccaatatg agaagtacct
     1441 gcaggaggaa gtcaacatca accggaagaa gcgcattccc gacacccgtg tccactgctg
     1501 cctctacttc atcccagcca ccggccactc gctcaggccc ctggacattg aattcatgaa
     1561 gcgcctaagc aaagtggtga acattgtccc agtcatcgcc aaggctgaca cgctgaccct
     1621 ggaggagagg gtctacttca aacagcggat cactgcagac ctgctgtcca acggcattga
     1681 cgtgtacccg cagaaggagt ttgatgagga cgcagaagac cggctggtga acgaaaagtt
     1741 ccgggagatg atcccatttg ctgtggtggg cagcgaccat gagtatcaag tcaatggcaa
     1801 gaggattctg ggaaggaaga ccaagtgggg cactatcgaa gttgagaata ccactcactg
     1861 tgaatttgct tacctgcggg atctccttat caggacgcac atgcaaaaca tcaaagacat
     1921 caccagcaac atccacttcg aagcctaccg agtgaaacgc ctcaacgagg gcaacagcgc
     1981 catggccaac gggatcgaga aggagccgga agcccaggag atgtagatgc gtcccgcccc
     2041 tggaccccac ccccagatct tttcatcatc cctggcccac ccacctaccc tgtcttattt
     2101 tatataatta tctccttgtc acctgcctcc atccatctct tcccacactt tgccaggtaa
     2161 caagagaggg tttacctccc aagtgtgctc ttattggctg cagcagcagg gtgggcgggg
     2221 ctaagcctgg gcttgcctct gtgctctatt tccacccggg ctcagcccct gaggggttag
     2281 aagagctatg tgtccgtccc ccgctctgag ttctaagctg aagcctgtgg gggccaagtc
     2341 ctagggggtg cagaggagcc cgttagacca caagacccca tggccgcagc ctcaagcagg
     2401 ttagagactg ccccaaagga ggatggagct ggccgggtat tcctgaaacc tcacctgccc
     2461 ctccgggggc gtttcttaca gcgccctcag ctgcctgccc ctcaagggaa ctagaggcgt
     2521 cacagccaaa gttgccaatc acttagacaa agtgacaacc gtgcccctcg agcttgtccc
     2581 agagcagaaa gtgccttgat ctacaagagc cagtcacctc ttcccagatg tccctttggg
     2641 tgaaaagcag ggacgtgctg gagagaggga ggtatctttt ctccctcgcc cttgggttct
     2701 ctctcccctg tgctgtagat atcgctacta cactgggctt taattataaa agacgaagcg
     2761 tgaaagatgc tccccgatgt taggaagccc cgcccccaat gtaaggaagg tcaaagcaag
     2821 aagatgagtc gaagccatga gggaggaagc cgtggaaggg aggcataaga gtgtgtggga
     2881 gctctcctgc ccaggtgccg cggaaggcat atccgcgtgg tcctcagttt gggccaagat
     2941 attctggtta cattgatgct ccgctgcctc accctgtccc accccacaca ccccaggctc
     3001 aagccttgat gattcagtga ctgtactggg tgggagccag aaacctgacc attttgttgt
     3061 ctacatgagc ctagactagc cctgtgcccc agaacccatc aaaaataccc ctaaagaggg
     3121 aaagatgagg gggtcagaga tggatagcca ggctcactca tcttctctca gagggaacat
     3181 tagggaccat ccatgcacag ctgaccaaag ccgtgtcctt cctgcctgcc tcccattctc
     3241 atttgcccct gaggagaaag tttggtgagg tgcgttaggt tggacccgct tggggaaggt
     3301 gcctctacag acccagggct agctttctgc agcccagaag tgcagtggga ggggtggggt
     3361 gcagacagat ggagacgaac attgtttcct gctttgggcg tctactccct catccaagca
     3421 tggaagggcc cctcgtcatg ccctgtggcc gaacagttcg cttgccagct tgccaagttc
     3481 ttttgccaaa atcaggactt tgaaggaaat ctccagcacg ctggacccag ggcactccgg
     3541 ccttcaccag cccaagtgac cctggggatt tagcagcaac ccggtcatca ggatgacttt
     3601 gtgcctctgt aaccaggtat tgaaactgtt cgtctcacca ggccggtcca cgtggccctc
     3661 tgctgggggc ttcctggtgg gggggcagaa aagtctctct ctctctctct ctctcttttt
     3721 ttttttttgt ataaataaca aagtgttgaa atgtatttcc tgaaataaat gtttcaaata
     3781 caaacttttt ttctgg
//
