LOCUS       NP_001106959             576 aa            linear   ROD 27-APR-2025
DEFINITION  septin-9 isoform b [Mus musculus].
ACCESSION   NP_001106959
VERSION     NP_001106959.1
DBSOURCE    REFSEQ: accession NM_001113487.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 576)
  AUTHORS   Guo,Y., Zeng,J., Zhuang,Y., Jiang,C. and Xie,W.
  TITLE     MiR-503-5p alleviates peripheral neuropathy-induced neuropathic
            pain in T2DM mice by regulating SEPT9 to inhibit astrocyte
            activation
  JOURNAL   Sci Rep 14 (1), 14361 (2024)
   PUBMED   38906977
  REMARK    GeneRIF: MiR-503-5p alleviates peripheral neuropathy-induced
            neuropathic pain in T2DM mice by regulating SEPT9 to inhibit
            astrocyte activation.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 576)
  AUTHORS   Martens,A.K., Erwig,M., Patzig,J., Fledrich,R., Fuchtbauer,E.M. and
            Werner,H.B.
  TITLE     Targeted inactivation of the Septin2 and Septin9 genes in
            myelinating Schwann cells of mice
  JOURNAL   Cytoskeleton (Hoboken) 80 (7-8), 290-302 (2023)
   PUBMED   36378242
REFERENCE   3  (residues 1 to 576)
  AUTHORS   Chen,L., Ouyang,Y.C., Gu,L.J., Guo,J.N., Han,Z.M., Wang,Z.B.,
            Hou,Y., Schatten,H. and Sun,Q.Y.
  TITLE     Septin 9 controls CCNB1 stabilization via APC/CCDC20 during meiotic
            metaphase I/anaphase I transition in mouse oocytes
  JOURNAL   Cell Prolif 56 (2), e13359 (2023)
   PUBMED   36354207
  REMARK    GeneRIF: Septin 9 controls CCNB1 stabilization via APC/C[CDC20]
            during meiotic metaphase I/anaphase I transition in mouse oocytes.
REFERENCE   4  (residues 1 to 576)
  AUTHORS   Keppner,A., Correia,M., Santambrogio,S., Koay,T.W., Maric,D.,
            Osterhof,C., Winter,D.V., Clerc,A., Stumpe,M., Chalmel,F.,
            Dewilde,S., Odermatt,A., Kressler,D., Hankeln,T., Wenger,R.H. and
            Hoogewijs,D.
  TITLE     Androglobin, a chimeric mammalian globin, is required for male
            fertility
  JOURNAL   Elife 11, e72374 (2022)
   PUBMED   35700329
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 576)
  AUTHORS   Moore,K.S., Moore,R., Fulmer,D.B., Guo,L., Gensemer,C.,
            Stairley,R., Glover,J., Beck,T.C., Morningstar,J.E., Biggs,R.,
            Muhkerjee,R., Awgulewitsch,A. and Norris,R.A.
  TITLE     DCHS1, Lix1L, and the Septin Cytoskeleton: Molecular and
            Developmental Etiology of Mitral Valve Prolapse
  JOURNAL   J Cardiovasc Dev Dis 9 (2), 62 (2022)
   PUBMED   35200715
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 576)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   7  (residues 1 to 576)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (residues 1 to 576)
  AUTHORS   Sorensen,A.B., Warming,S., Fuchtbauer,E.M. and Pedersen,F.S.
  TITLE     Alternative splicing, expression, and gene structure of the
            septin-like putative proto-oncogene Sint1
  JOURNAL   Gene 285 (1-2), 79-89 (2002)
   PUBMED   12039034
REFERENCE   9  (residues 1 to 576)
  AUTHORS   Sorensen,A.B., Lund,A.H., Ethelberg,S., Copeland,N.G., Jenkins,N.A.
            and Pedersen,F.S.
  TITLE     Sint1, a common integration site in SL3-3-induced T-cell lymphomas,
            harbors a putative proto-oncogene with homology to the septin gene
            family
  JOURNAL   J Virol 74 (5), 2161-2168 (2000)
   PUBMED   10666245
REFERENCE   10 (residues 1 to 576)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU148654.1, AK122415.2 and AW538697.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK122415.2, SRR7974084.23444.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..576
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 82.61 cM"
     Protein         1..576
                     /product="septin-9 isoform b"
                     /note="SL3-3 integration site 1 protein; MLL septin-like
                     fusion"
                     /calculated_mol_wt=64644
     Region          <31..225
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          286..560
                     /region_name="CDC_Septin"
                     /note="CDC/Septin GTPase family; cd01850"
                     /db_xref="CDD:206649"
     Site            296..303
                     /site_type="other"
                     /note="G1 box"
                     /db_xref="CDD:206649"
     Site            order(298..304,353,356,435..436,438,492..493)
                     /site_type="other"
                     /note="GTP/Mg2+ binding site [chemical binding]"
                     /db_xref="CDD:206649"
     Site            328..336
                     /site_type="other"
                     /note="Switch I region"
                     /db_xref="CDD:206649"
     Site            330
                     /site_type="other"
                     /note="G2 box"
                     /db_xref="CDD:206649"
     Site            353..356
                     /site_type="other"
                     /note="G3 box"
                     /db_xref="CDD:206649"
     Site            355..401
                     /site_type="other"
                     /note="Switch II region"
                     /db_xref="CDD:206649"
     Site            435..438
                     /site_type="other"
                     /note="G4 box"
                     /db_xref="CDD:206649"
     Site            492..494
                     /site_type="other"
                     /note="G5 box"
                     /db_xref="CDD:206649"
     CDS             1..576
                     /gene="Septin9"
                     /gene_synonym="Msf; MSF1; PNUTL4; Sept9; Sint1"
                     /coded_by="NM_001113487.1:296..2026"
                     /note="isoform b is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS48991.1"
                     /db_xref="GeneID:53860"
                     /db_xref="MGI:MGI:1858222"
ORIGIN      
        1 msdpavnaql dgiisdfeal krsfeveeie ppnstpprrv qtpllratva sssqkfqdlg
       61 vknsepaarl vdslsqrspk pslrrvelag akapepmsrr teisidissk qvestasaag
      121 psrfglkrae vlghktpepv prrteitivk pqesvlrrve tpaskipegs avpatdaapk
      181 rveiqvpkpa eapncplpsq tlenseapms qlqsrleprp svaevpyrnq edsevtpscv
      241 gdmadnprda mlkqapasrn ekapmefgyv gidsileqmr rkamkqgfef nimvvgqsgl
      301 gkstlintlf kskisrksvq ptseeripkt ieiksithdi eekgvrmklt vidtpgfgdh
      361 innencwqpi mkfindqyek ylqeevninr kkripdtrvh cclyfipatg hslrpldief
      421 mkrlskvvni vpviakadtl tleervyfkq ritadllsng idvypqkefd edaedrlvne
      481 kfremipfav vgsdheyqvn gkrilgrktk wgtieventt hcefaylrdl lirthmqnik
      541 ditsnihfea yrvkrlnegn samangieke peaqem
//
