LOCUS       NM_001347496            2703 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus septin 8 (Septin8), transcript variant 4, mRNA.
ACCESSION   NM_001347496 XM_011248833
VERSION     NM_001347496.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2703)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2703)
  AUTHORS   Liu,H., Tan,R., Tong,J., Wen,S., Wu,C., Rao,M., Zhu,J., Qi,S. and
            Kong,E.
  TITLE     Palmitoylation is required for Sept8-204 and Sept5 to form
            vesicle-like structure and colocalize with synaptophysin
  JOURNAL   J Cell Biochem 125 (3), e30529 (2024)
   PUBMED   38308620
  REMARK    GeneRIF: Palmitoylation is required for Sept8-204 and Sept5 to form
            vesicle-like structure and colocalize with synaptophysin.
REFERENCE   3  (bases 1 to 2703)
  AUTHORS   Liu,H., Yan,P., Wu,C., Rao,M., Zhu,J., Lv,L., Li,W., Liang,Y.,
            Qi,S., Lu,K. and Kong,E.
  TITLE     Palmitoylated Sept8-204 modulates learning and anxiety by
            regulating filopodia arborization and actin dynamics
  JOURNAL   Sci Signal 16 (814), eadi8645 (2023)
   PUBMED   38051778
  REMARK    GeneRIF: Palmitoylated Sept8-204 modulates learning and anxiety by
            regulating filopodia arborization and actin dynamics.
REFERENCE   4  (bases 1 to 2703)
  AUTHORS   Keppner,A., Correia,M., Santambrogio,S., Koay,T.W., Maric,D.,
            Osterhof,C., Winter,D.V., Clerc,A., Stumpe,M., Chalmel,F.,
            Dewilde,S., Odermatt,A., Kressler,D., Hankeln,T., Wenger,R.H. and
            Hoogewijs,D.
  TITLE     Androglobin, a chimeric mammalian globin, is required for male
            fertility
  JOURNAL   Elife 11, e72374 (2022)
   PUBMED   35700329
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2703)
  AUTHORS   Moore,K.S., Moore,R., Fulmer,D.B., Guo,L., Gensemer,C.,
            Stairley,R., Glover,J., Beck,T.C., Morningstar,J.E., Biggs,R.,
            Muhkerjee,R., Awgulewitsch,A. and Norris,R.A.
  TITLE     DCHS1, Lix1L, and the Septin Cytoskeleton: Molecular and
            Developmental Etiology of Mitral Valve Prolapse
  JOURNAL   J Cardiovasc Dev Dis 9 (2), 62 (2022)
   PUBMED   35200715
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2703)
  AUTHORS   Blaser,S., Jersch,K., Hainmann,I., Zieger,W., Wunderle,D., Busse,A.
            and Zieger,B.
  TITLE     Isolation of new splice isoforms, characterization and expression
            analysis of the human septin SEPT8 (KIAA0202)
  JOURNAL   Gene 312, 313-320 (2003)
   PUBMED   12909369
REFERENCE   7  (bases 1 to 2703)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Hara,Y., Nagase,T.,
            Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: I. The complete nucleotide sequences of 100 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 9 (5), 179-188 (2002)
   PUBMED   12465718
REFERENCE   8  (bases 1 to 2703)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   9  (bases 1 to 2703)
  AUTHORS   Wenderfer,S.E., Slack,J.P., McCluskey,T.S. and Monaco,J.J.
  TITLE     Identification of 40 genes on a 1-Mb contig around the IL-4
            cytokine family gene cluster on mouse chromosome 11
  JOURNAL   Genomics 63 (3), 354-373 (2000)
   PUBMED   10704283
REFERENCE   10 (bases 1 to 2703)
  AUTHORS   Frazer,K.A., Ueda,Y., Zhu,Y., Gifford,V.R., Garofalo,M.R.,
            Mohandas,N., Martin,C.H., Palazzolo,M.J., Cheng,J.F. and Rubin,E.M.
  TITLE     Computational and biological analysis of 680 kb of DNA sequence
            from the human 5q31 cytokine gene cluster region
  JOURNAL   Genome Res 7 (5), 495-512 (1997)
   PUBMED   9149945
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL596095.18.
            
            On Nov 18, 2022 this sequence version replaced NM_001347496.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422603.143387.1,
                                           SRR13422589.367550.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-132               AL596095.18        75900-76031
            133-253             AL596095.18        87988-88108
            254-449             AL596095.18        90425-90620
            450-636             AL596095.18        90941-91127
            637-798             AL596095.18        91940-92101
            799-895             AL596095.18        92644-92740
            896-1064            AL596095.18        93146-93314
            1065-1197           AL596095.18        93479-93611
            1198-1388           AL596095.18        93717-93907
            1389-2703           AL596095.18        104283-105597
FEATURES             Location/Qualifiers
     source          1..2703
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 31.96 cM"
     gene            1..2703
                     /gene="Septin8"
                     /gene_synonym="Sepl; Sept8"
                     /note="septin 8"
                     /db_xref="GeneID:20362"
                     /db_xref="MGI:MGI:894310"
     exon            1..132
                     /gene="Septin8"
                     /gene_synonym="Sepl; Sept8"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..1557
                     /gene="Septin8"
                     /gene_synonym="Sepl; Sept8"
                     /note="isoform 4 is encoded by transcript variant 4"
                     /codon_start=1
                     /product="septin-8 isoform 4"
                     /protein_id="NP_001334425.1"
                     /db_xref="CCDS:CCDS83805.1"
                     /db_xref="GeneID:20362"
                     /db_xref="MGI:MGI:894310"
                     /translation="MAATDLERVSNAEPEPRSLSLGGHVGFDSLPDQLVSKSVTQGFS
                     FNILCVGETGIGKSTLMNTLFNTTFETEEASHHEECVRLRPQTYDLQESNVHLKLTIV
                     DAVGFGDQINKDDSYRPIVDYIDAQFENYLQEELKIRRSLFDYHDTRIHVCLYFITPT
                     GHSLKSLDLVTMKKLDSKVNIIPIIAKADTISKSELHKFKIKIMGELVSNGVQIYQFP
                     TDDEAVAEINAVMNAHLPFAVVGSTEEVKVGNKLVRARQYPWGVVQVENENHCDFVKL
                     REMLIRVNMEDLREQTHSRHYELYRRCKLEEMGFQDSDGDSQPFSLQETYEAKRKEFL
                     SELQRKEEEMRQMFVNKVKETELELKEKERELHEKFEHLKRIHQEEKRKVEEKRRELE
                     EETNAFNCRKAAMEALQSQALHATSQQPLRKDKDKKNRSDIAAAQQSGMSLSNSKVMM
                     TKANVEPLNCSSWWPAIQCCSCLVRDATWREGFL"
     exon            133..253
                     /gene="Septin8"
                     /gene_synonym="Sepl; Sept8"
                     /inference="alignment:Splign:2.1.0"
     exon            254..449
                     /gene="Septin8"
                     /gene_synonym="Sepl; Sept8"
                     /inference="alignment:Splign:2.1.0"
     exon            450..636
                     /gene="Septin8"
                     /gene_synonym="Sepl; Sept8"
                     /inference="alignment:Splign:2.1.0"
     exon            637..798
                     /gene="Septin8"
                     /gene_synonym="Sepl; Sept8"
                     /inference="alignment:Splign:2.1.0"
     exon            799..895
                     /gene="Septin8"
                     /gene_synonym="Sepl; Sept8"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1064
                     /gene="Septin8"
                     /gene_synonym="Sepl; Sept8"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1197
                     /gene="Septin8"
                     /gene_synonym="Sepl; Sept8"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1388
                     /gene="Septin8"
                     /gene_synonym="Sepl; Sept8"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..2703
                     /gene="Septin8"
                     /gene_synonym="Sepl; Sept8"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2667
                     /gene="Septin8"
                     /gene_synonym="Sepl; Sept8"
                     /note="major polyA site"
     regulatory      2670..2675
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Septin8"
                     /gene_synonym="Sepl; Sept8"
                     /note="hexamer: AATAAA"
     polyA_site      2691
                     /gene="Septin8"
                     /gene_synonym="Sepl; Sept8"
ORIGIN      
        1 attcagccgc agccgcccgg gcggagcgcg tcccgcagcc ggctcatccc cgccgcggcc
       61 ccggcgttcc ccgcaacccg cccgcccggt gcgcagctcg ccatggcggc caccgacttg
      121 gaacgcgtct cgaacgcaga gcctgagccc cggagcctgt ccctgggcgg ccatgttggg
      181 tttgacagcc tccctgacca gctggtcagc aagtcagtca ctcagggctt cagcttcaac
      241 atactctgtg tgggcgaaac tgggattggc aagtccacgc taatgaacac actcttcaac
      301 acgacctttg agactgaaga agccagtcac catgaagagt gtgtgcgcct gcggcctcag
      361 acctatgacc tccaagagag taacgttcat ctcaagctga ccatcgtgga tgctgtgggc
      421 tttggcgatc agatcaataa ggatgacagt tacaggccca tagttgacta catcgacgcg
      481 cagtttgaaa actatctgca ggaggagttg aagatccgcc gttccctctt tgactatcac
      541 gacacgagga tccatgtttg cctctacttc atcacgccca ccgggcactc cctgaagtcc
      601 ctggatctgg tgaccatgaa gaaactagat agcaaggtga atataatccc catcattgcc
      661 aaggctgaca ccatctccaa gagcgagctc cacaagttca aaatcaagat catgggtgag
      721 ctggtcagca acggagtcca gatctaccag tttcccaccg atgacgaggc tgtcgccgag
      781 attaatgcag tcatgaacgc acacctgcct tttgccgtgg tgggcagcac agaggaggtg
      841 aaggtgggga ataagctggt tcgagcacga cagtaccctt ggggtgtggt gcaggtggag
      901 aatgagaatc actgtgactt cgtgaagctg cgggagatgc tgatccgggt gaacatggag
      961 gacctgcgcg agcagaccca cagccggcac tacgagctct accgccgctg caagttggag
     1021 gagatgggct tccaggacag tgacggtgac agccagccct tcagcctcca agagacatat
     1081 gaggcaaaga ggaaggagtt cctaagcgag ctgcagagga aggaggaaga gatgcgacag
     1141 atgtttgtca acaaagtcaa ggagacagag cttgagctga aggagaagga acgggagctc
     1201 catgagaagt ttgagcacct gaagcgaatc caccaggagg agaagcgcaa ggtagaggag
     1261 aagcgcaggg agctggaaga ggagaccaac gccttcaact gccggaaggc ggccatggag
     1321 gccctgcagt cacaggcctt gcatgccact tcacagcagc ctctgaggaa agacaaggac
     1381 aagaagaaca gatcagatat agccgcagca cagcagtcgg gcatgagcct ctccaactct
     1441 aaggtgatga tgactaaagc aaatgtggag cccttgaact gcagcagctg gtggcctgcc
     1501 atccagtgct gcagctgcct ggtcagggac gcgacgtgga gggaaggatt cctctgaggc
     1561 cacagttcca ccacacgggg ccagctccgg accatcaggg cgtggaactg gagaccatgg
     1621 ttttttaatg ttaggaccga ggcccctccc ccctagtttt cacatatcaa caaccaaaag
     1681 tgcaaacggt ttccgatttt catcagggaa gcatctggtg tggtccaacc cctttcattc
     1741 ccagacagtc tgatttgtga catggaactc tgaggctaga gtgtagagac agccacgttt
     1801 ggattctgag aaattcaaga atctgctatt aaagggagtg gggaagttac ctgtaaccgc
     1861 ttgacctgag aagaaaccag gaactttgtc aacagcacca gttttccata acgaaactgc
     1921 ccttagtaat ttaaccttca tgctttataa cagaccaaaa cgccatgaca tttcctcatt
     1981 tgcataattt tgccttacta acaagcacat cctgaaagat ggccccccca tccccccaac
     2041 taaaaccaac atgaaccgat acctgatatt ttttaagtgc cagatcagtg cggtctaacg
     2101 cctcagtaag gattgtgtgt aggtgaataa agacagctaa gtgaatgtgt gtaaagtgta
     2161 gtaaaggcag acagatattt atatacaata ttcatagaat ggaaagttaa atatttttgc
     2221 agtgtgtatc taagagagaa acagaccata atagtgccgt ttaaatgtct ttgtcaagtg
     2281 atctctgtgt cctttagacg tgagagtctg gtggtggaat ggcgtggggt ataaagataa
     2341 catttttttt ccactcttcc gtatgttgtg agcctttatg ggtcacctcg ccgtggtgca
     2401 tgtgcaagga cgtgttgcac gcctgtgcct tgcctgttct gtgttgtaaa cagctgttcc
     2461 aaaggcacag acgagtctca gggagactct ataaactcat gctcattata atcaagaaac
     2521 ccagcgacat tcccgcgtgg aggtcctaat ggagtctgtc cagaatagcc taccccatcc
     2581 tcagcagctc atttggggta cagctagagc cacaacgctt tatgacgtct tttacacgtg
     2641 gaattgactg taaaaaaaat aaataaataa ataaaggagg ccaaagcctg acatcatgtt
     2701 aca
//
