LOCUS       NP_001334425             484 aa            linear   ROD 01-MAY-2025
DEFINITION  septin-8 isoform 4 [Mus musculus].
ACCESSION   NP_001334425 XP_011247135
VERSION     NP_001334425.1
DBSOURCE    REFSEQ: accession NM_001347496.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 484)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 484)
  AUTHORS   Liu,H., Tan,R., Tong,J., Wen,S., Wu,C., Rao,M., Zhu,J., Qi,S. and
            Kong,E.
  TITLE     Palmitoylation is required for Sept8-204 and Sept5 to form
            vesicle-like structure and colocalize with synaptophysin
  JOURNAL   J Cell Biochem 125 (3), e30529 (2024)
   PUBMED   38308620
  REMARK    GeneRIF: Palmitoylation is required for Sept8-204 and Sept5 to form
            vesicle-like structure and colocalize with synaptophysin.
REFERENCE   3  (residues 1 to 484)
  AUTHORS   Liu,H., Yan,P., Wu,C., Rao,M., Zhu,J., Lv,L., Li,W., Liang,Y.,
            Qi,S., Lu,K. and Kong,E.
  TITLE     Palmitoylated Sept8-204 modulates learning and anxiety by
            regulating filopodia arborization and actin dynamics
  JOURNAL   Sci Signal 16 (814), eadi8645 (2023)
   PUBMED   38051778
  REMARK    GeneRIF: Palmitoylated Sept8-204 modulates learning and anxiety by
            regulating filopodia arborization and actin dynamics.
REFERENCE   4  (residues 1 to 484)
  AUTHORS   Keppner,A., Correia,M., Santambrogio,S., Koay,T.W., Maric,D.,
            Osterhof,C., Winter,D.V., Clerc,A., Stumpe,M., Chalmel,F.,
            Dewilde,S., Odermatt,A., Kressler,D., Hankeln,T., Wenger,R.H. and
            Hoogewijs,D.
  TITLE     Androglobin, a chimeric mammalian globin, is required for male
            fertility
  JOURNAL   Elife 11, e72374 (2022)
   PUBMED   35700329
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 484)
  AUTHORS   Moore,K.S., Moore,R., Fulmer,D.B., Guo,L., Gensemer,C.,
            Stairley,R., Glover,J., Beck,T.C., Morningstar,J.E., Biggs,R.,
            Muhkerjee,R., Awgulewitsch,A. and Norris,R.A.
  TITLE     DCHS1, Lix1L, and the Septin Cytoskeleton: Molecular and
            Developmental Etiology of Mitral Valve Prolapse
  JOURNAL   J Cardiovasc Dev Dis 9 (2), 62 (2022)
   PUBMED   35200715
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 484)
  AUTHORS   Blaser,S., Jersch,K., Hainmann,I., Zieger,W., Wunderle,D., Busse,A.
            and Zieger,B.
  TITLE     Isolation of new splice isoforms, characterization and expression
            analysis of the human septin SEPT8 (KIAA0202)
  JOURNAL   Gene 312, 313-320 (2003)
   PUBMED   12909369
REFERENCE   7  (residues 1 to 484)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Hara,Y., Nagase,T.,
            Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: I. The complete nucleotide sequences of 100 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 9 (5), 179-188 (2002)
   PUBMED   12465718
REFERENCE   8  (residues 1 to 484)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   9  (residues 1 to 484)
  AUTHORS   Wenderfer,S.E., Slack,J.P., McCluskey,T.S. and Monaco,J.J.
  TITLE     Identification of 40 genes on a 1-Mb contig around the IL-4
            cytokine family gene cluster on mouse chromosome 11
  JOURNAL   Genomics 63 (3), 354-373 (2000)
   PUBMED   10704283
REFERENCE   10 (residues 1 to 484)
  AUTHORS   Frazer,K.A., Ueda,Y., Zhu,Y., Gifford,V.R., Garofalo,M.R.,
            Mohandas,N., Martin,C.H., Palazzolo,M.J., Cheng,J.F. and Rubin,E.M.
  TITLE     Computational and biological analysis of 680 kb of DNA sequence
            from the human 5q31 cytokine gene cluster region
  JOURNAL   Genome Res 7 (5), 495-512 (1997)
   PUBMED   9149945
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL596095.18.
            
            On Nov 30, 2016 this sequence version replaced XP_011247135.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422603.143387.1,
                                           SRR13422589.367550.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..484
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 31.96 cM"
     Protein         1..484
                     /product="septin-8 isoform 4"
                     /calculated_mol_wt=55743
     Region          1..23
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8CHH9.4)"
     mat_peptide     2..429
                     /product="Septin-8. /id=PRO_0000173534"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8CHH9.4)"
                     /calculated_mol_wt=49681
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine.
                     /evidence=ECO:0007744|PubMed:17242355; propagated from
                     UniProtKB/Swiss-Prot (Q8CHH9.4)"
     Site            10
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:16452087,
                     ECO:0007744|PubMed:17242355; propagated from
                     UniProtKB/Swiss-Prot (Q8CHH9.4)"
     Region          41..309
                     /region_name="CDC_Septin"
                     /note="CDC/Septin GTPase family; cd01850"
                     /db_xref="CDD:206649"
     Region          51..58
                     /region_name="G1 motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01056"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8CHH9.4)"
     Site            51..58
                     /site_type="other"
                     /note="G1 box"
                     /db_xref="CDD:206649"
     Site            order(53..59,103,106,186..187,189,241..242)
                     /site_type="other"
                     /note="GTP/Mg2+ binding site [chemical binding]"
                     /db_xref="CDD:206649"
     Site            78..86
                     /site_type="other"
                     /note="Switch I region"
                     /db_xref="CDD:206649"
     Site            80
                     /site_type="other"
                     /note="G2 box"
                     /db_xref="CDD:206649"
     Region          103..106
                     /region_name="G3 motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01056"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8CHH9.4)"
     Site            103..106
                     /site_type="other"
                     /note="G3 box"
                     /db_xref="CDD:206649"
     Site            order(105..143,145..152)
                     /site_type="other"
                     /note="Switch II region"
                     /db_xref="CDD:206649"
     Region          186..189
                     /region_name="G4 motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01056"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8CHH9.4)"
     Site            186..189
                     /site_type="other"
                     /note="G4 box"
                     /db_xref="CDD:206649"
     Site            241..243
                     /site_type="other"
                     /note="G5 box"
                     /db_xref="CDD:206649"
     Region          409..429
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8CHH9.4)"
     CDS             1..484
                     /gene="Septin8"
                     /gene_synonym="Sepl; Sept8"
                     /coded_by="NM_001347496.2:103..1557"
                     /note="isoform 4 is encoded by transcript variant 4"
                     /db_xref="CCDS:CCDS83805.1"
                     /db_xref="GeneID:20362"
                     /db_xref="MGI:MGI:894310"
ORIGIN      
        1 maatdlervs naepeprsls lgghvgfdsl pdqlvsksvt qgfsfnilcv getgigkstl
       61 mntlfnttfe teeashheec vrlrpqtydl qesnvhlklt ivdavgfgdq inkddsyrpi
      121 vdyidaqfen ylqeelkirr slfdyhdtri hvclyfitpt ghslksldlv tmkkldskvn
      181 iipiiakadt iskselhkfk ikimgelvsn gvqiyqfptd deavaeinav mnahlpfavv
      241 gsteevkvgn klvrarqypw gvvqvenenh cdfvklreml irvnmedlre qthsrhyely
      301 rrckleemgf qdsdgdsqpf slqetyeakr keflselqrk eeemrqmfvn kvketelelk
      361 ekerelhekf ehlkrihqee krkveekrre leeetnafnc rkaamealqs qalhatsqqp
      421 lrkdkdkknr sdiaaaqqsg mslsnskvmm tkanveplnc sswwpaiqcc sclvrdatwr
      481 egfl
//
