LOCUS       NM_009859               2533 bp    mRNA    linear   ROD 15-OCT-2024
DEFINITION  Mus musculus septin 7 (Septin7), transcript variant 1, mRNA.
ACCESSION   NM_009859
VERSION     NM_009859.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2533)
  AUTHORS   Choi,E.S., Hnath,B., Sha,C.M. and Dokholyan,N.V.
  TITLE     Unveiling the double-edged sword: SOD1 trimers possess
            tissue-selective toxicity and bind septin-7 in motor neuron-like
            cells
  JOURNAL   Structure 32 (10), 1776-1792 (2024)
   PUBMED   39208794
  REMARK    GeneRIF: Unveiling the double-edged sword: SOD1 trimers possess
            tissue-selective toxicity and bind septin-7 in motor neuron-like
            cells.
REFERENCE   2  (bases 1 to 2533)
  AUTHORS   De Gasperi,R., Csernoch,L., Dienes,B., Gonczi,M., Chakrabarty,J.K.,
            Goeta,S., Aslan,A., Toro,C.A., Karasik,D., Brown,L.M., Brotto,M.
            and Cardozo,C.P.
  TITLE     Septin 7 interacts with Numb to preserve sarcomere structural
            organization and muscle contractile function
  JOURNAL   Elife 12, 89424 (2024)
   PUBMED   38695862
  REMARK    GeneRIF: Septin 7 interacts with Numb to preserve sarcomere
            structural organization and muscle contractile function.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2533)
  AUTHORS   Szabo,L., Telek,A., Fodor,J., Dobrosi,N., Docs,K., Hegyi,Z.,
            Gonczi,M., Csernoch,L. and Dienes,B.
  TITLE     Reduced Expression of Septin7 Hinders Skeletal Muscle Regeneration
  JOURNAL   Int J Mol Sci 24 (17), 13536 (2023)
   PUBMED   37686339
  REMARK    GeneRIF: Reduced Expression of Septin7 Hinders Skeletal Muscle
            Regeneration.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2533)
  AUTHORS   Raduly,Z., Szabo,L., Dienes,B., Szentesi,P., Bana,A.V., Hajdu,T.,
            Kokai,E., Hegedus,C., Csernoch,L. and Gonczi,M.
  TITLE     Migration of Myogenic Cells Is Highly Influenced by Cytoskeletal
            Septin7
  JOURNAL   Cells 12 (14), 1825 (2023)
   PUBMED   37508490
  REMARK    GeneRIF: Migration of Myogenic Cells Is Highly Influenced by
            Cytoskeletal Septin7.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2533)
  AUTHORS   Hinson,S.R., Honorat,J.A., Grund,E.M., Clarkson,B.D., Miske,R.,
            Scharf,M., Zivelonghi,C., Al-Lozi,M.T., Bucelli,R.C., Budhram,A.,
            Cho,T., Choi,E., Grell,J., Lopez-Chiriboga,A.S., Levin,M.,
            Merati,M., Montalvo,M., Pittock,S.J., Wilson,M.R., Howe,C.L. and
            McKeon,A.
  TITLE     Septin-5 and -7-IgGs: Neurologic, Serologic, and Pathophysiologic
            Characteristics
  JOURNAL   Ann Neurol 92 (6), 1090-1101 (2022)
   PUBMED   36053822
  REMARK    GeneRIF: Septin-5 and -7-IgGs: Neurologic, Serologic, and
            Pathophysiologic Characteristics.
REFERENCE   6  (bases 1 to 2533)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2533)
  AUTHORS   Peng,X.R., Jia,Z., Zhang,Y., Ware,J. and Trimble,W.S.
  TITLE     The septin CDCrel-1 is dispensable for normal development and
            neurotransmitter release
  JOURNAL   Mol Cell Biol 22 (1), 378-387 (2002)
   PUBMED   11739749
REFERENCE   8  (bases 1 to 2533)
  AUTHORS   Kinoshita,A., Noda,M. and Kinoshita,M.
  TITLE     Differential localization of septins in the mouse brain
  JOURNAL   J Comp Neurol 428 (2), 223-239 (2000)
   PUBMED   11064363
REFERENCE   9  (bases 1 to 2533)
  AUTHORS   Thomas,J.W., Summers,T.J., Lee-Lin,S.Q., Maduro,V.V., Idol,J.R.,
            Mastrian,S.D., Ryan,J.F., Jamison,D.C. and Green,E.D.
  TITLE     Comparative genome mapping in the sequence-based era: early
            experience with human chromosome 7
  JOURNAL   Genome Res 10 (5), 624-633 (2000)
   PUBMED   10810084
  REMARK    Review article
REFERENCE   10 (bases 1 to 2533)
  AUTHORS   Soulier,S. and Vilotte,J.L.
  TITLE     Sequence of murine CDC10 cDNA, gene organization and expression
            analysis
  JOURNAL   Biochim Biophys Acta 1442 (2-3), 339-346 (1998)
   PUBMED   9804986
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT025561.11.
            
            On Apr 19, 2011 this sequence version replaced NM_009859.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK088997.1, AK144127.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-261               CT025561.11        155165-155425
            262-266             CT025561.11        166929-166933
            267-369             CT025561.11        168120-168222
            370-476             CT025561.11        180270-180376
            477-577             CT025561.11        189394-189494
            578-712             CT025561.11        190910-191044
            713-830             CT025561.11        196411-196528
            831-923             CT025561.11        199121-199213
            924-1020            CT025561.11        200538-200634
            1021-1072           CT025561.11        202218-202269
            1073-1198           CT025561.11        204138-204263
            1199-1334           CT025561.11        206443-206578
            1335-1474           CT025561.11        208852-208991
            1475-2533           CT025561.11        210239-211297
FEATURES             Location/Qualifiers
     source          1..2533
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 10.25 cM"
     gene            1..2533
                     /gene="Septin7"
                     /gene_synonym="Cdc10; E430034N22; Sept7"
                     /note="septin 7"
                     /db_xref="GeneID:235072"
                     /db_xref="MGI:MGI:1335094"
     exon            1..261
                     /gene="Septin7"
                     /gene_synonym="Cdc10; E430034N22; Sept7"
                     /inference="alignment:Splign:2.1.0"
     CDS             201..1514
                     /gene="Septin7"
                     /gene_synonym="Cdc10; E430034N22; Sept7"
                     /note="isoform 1 is encoded by transcript variant 1; cell
                     division cycle 10 homolog; CDC10 protein homolog"
                     /codon_start=1
                     /product="septin-7 isoform 1"
                     /protein_id="NP_033989.2"
                     /db_xref="CCDS:CCDS40565.1"
                     /db_xref="GeneID:235072"
                     /db_xref="MGI:MGI:1335094"
                     /translation="MSVSARSAAAEERSVNCGTMVAQPKNLEGYVGFANLPNQVYRKS
                     VKRGFEFTLMVVGESGLGKSTLINSLFLTDLYSPEYPGPSHRIKKTVQVEQSKVLIKE
                     GGVQLLLTIVDTPGFGDAVDNSNCWQPVIDYIDSKFEDYLNAESRVNRRQMPDNRVQC
                     CLYFIAPSGHGLKPLDIEFMKRLHEKVNIIPLIAKADTLTPEECQQFKKQIMKEIQEH
                     KIKIYEFPETDDEEENKLVKKIKDRLPLAVVGSNTIIEVNGKRVRGRQYPWGVAEVEN
                     GEHCDFTILRNMLIRTHMQDLKDVTNNVHYENYRSRKLAAVTYNGVDNNKNKGQLTKS
                     PLAQMEEERREHVAKMKKMEMEMEQVFEMKVKEKVQKLKDSEAELQRRHEQMKKNLEA
                     QHKELEEKRRQFEEEKANWEAQQRILEQQNSSRTLEKNKKKGKIF"
     exon            262..266
                     /gene="Septin7"
                     /gene_synonym="Cdc10; E430034N22; Sept7"
                     /inference="alignment:Splign:2.1.0"
     exon            267..369
                     /gene="Septin7"
                     /gene_synonym="Cdc10; E430034N22; Sept7"
                     /inference="alignment:Splign:2.1.0"
     exon            370..476
                     /gene="Septin7"
                     /gene_synonym="Cdc10; E430034N22; Sept7"
                     /inference="alignment:Splign:2.1.0"
     exon            477..577
                     /gene="Septin7"
                     /gene_synonym="Cdc10; E430034N22; Sept7"
                     /inference="alignment:Splign:2.1.0"
     exon            578..712
                     /gene="Septin7"
                     /gene_synonym="Cdc10; E430034N22; Sept7"
                     /inference="alignment:Splign:2.1.0"
     exon            713..830
                     /gene="Septin7"
                     /gene_synonym="Cdc10; E430034N22; Sept7"
                     /inference="alignment:Splign:2.1.0"
     exon            831..923
                     /gene="Septin7"
                     /gene_synonym="Cdc10; E430034N22; Sept7"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1020
                     /gene="Septin7"
                     /gene_synonym="Cdc10; E430034N22; Sept7"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1072
                     /gene="Septin7"
                     /gene_synonym="Cdc10; E430034N22; Sept7"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1198
                     /gene="Septin7"
                     /gene_synonym="Cdc10; E430034N22; Sept7"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1334
                     /gene="Septin7"
                     /gene_synonym="Cdc10; E430034N22; Sept7"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1474
                     /gene="Septin7"
                     /gene_synonym="Cdc10; E430034N22; Sept7"
                     /inference="alignment:Splign:2.1.0"
     exon            1475..2533
                     /gene="Septin7"
                     /gene_synonym="Cdc10; E430034N22; Sept7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2507..2512
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Septin7"
                     /gene_synonym="Cdc10; E430034N22; Sept7"
                     /note="hexamer: AATAAA"
     polyA_site      2528
                     /gene="Septin7"
                     /gene_synonym="Cdc10; E430034N22; Sept7"
                     /note="major polyA site"
ORIGIN      
        1 gggtaatctc gcgagaacgc atccgcctcg gctcggcccg gaagcctcag ggcgggcgag
       61 agccagtggg gcagtccgcc cgctgccgtg tgcgtaagtg gggcagcgac gccgggcggc
      121 tacgctgcgg aatcggcgta ggtggttttg gagaatccgc cggctgcgcc gcgccggggc
      181 tggtcgcgga gggggagggg atgtcggtca gtgcgagatc cgctgctgcc gaggagagga
      241 gcgtcaactg cggcaccatg gtagctcaac cgaagaacct tgagggctat gtgggctttg
      301 ccaacctccc aaatcaagtg tacagaaaat ccgtgaaaag aggatttgaa ttcactctta
      361 tggtagtagg tgaatctgga ctgggaaagt cgacattaat caactcatta ttcctcacag
      421 atttgtattc tccagagtat ccaggacctt ctcatagaat caaaaagact gtacaggtgg
      481 agcaatccaa agttttaatc aaagaaggtg gtgttcagtt gctgctgaca atagttgata
      541 ctccaggatt tggagatgca gtggataata gtaattgctg gcagcctgtt atcgactaca
      601 ttgatagtaa atttgaagat tacttaaatg cagaatctcg agtgaacaga cgtcagatgc
      661 ctgataacag ggtgcagtgt tgtttatact tcattgctcc ttcaggacat ggacttaaac
      721 cattggacat tgagtttatg aaacgtttgc atgaaaaagt gaatatcatc ccattaattg
      781 ccaaagcaga cacacttaca ccagaggaat gccaacagtt taaaaagcag ataatgaaag
      841 aaattcaaga acataaaatt aaaatatatg aatttccaga aacagatgat gaagaagaga
      901 ataaactggt taagaagata aaggaccgtt tacctcttgc tgtggtaggt agtaatacta
      961 tcattgaagt taatggcaaa agagtcagag gaaggcagta tccttggggt gtggctgaag
     1021 ttgaaaatgg tgaacattgt gatttcacaa ttctaagaaa tatgttgata agaacacata
     1081 tgcaggactt gaaagatgtt accaataacg tacactatga gaactacaga agcagaaagc
     1141 tagcagcagt gacttacaat ggagtggata acaacaagaa caaagggcag cttaccaaga
     1201 gccctctggc acagatggaa gaagaaagaa gggaacatgt agccaaaatg aagaagatgg
     1261 agatggagat ggaacaggtg tttgagatga aggtcaaaga aaaagttcaa aaactgaagg
     1321 actctgaagc agagctccag cggcgccatg agcaaatgaa aaagaattta gaagcacagc
     1381 acaaagaatt agaggaaaaa cgtcgtcagt ttgaagaaga aaaggcaaac tgggaagctc
     1441 aacagcgtat tttagagcaa cagaactctt caagaacctt ggaaaagaac aagaagaaag
     1501 gcaagatctt ttaaactcta ttgaccacca gttatgtatt agttgccaat atgccagctt
     1561 ggacatcagt gtttgttgga tccgtttgac caatttgcac caattttatc cataatgatg
     1621 gatttaacag catgacaaaa attatttttt gttgttctcg aaggagatta agatgccttg
     1681 aattgtctag gatattgtgt acttagaaat taacagctct aagtaccttt ctacattttt
     1741 tttctttttt ttttaaatta aaagatgtct tcagtttaat gcaagaaaac attttactgt
     1801 tgtacaatca tgttctggtg gtttgattgt ttacagaata ttctaaaata aaaggactct
     1861 ggaaggtttt cattgaggat aaattgccat aatatgatgc aaactatgct tctctatgat
     1921 aattataata cagaggttcc attcgatgca gcctatacaa taatgtattt agtctaacac
     1981 agtggaccct attttttgac acttccattg tttaaaagta cacatggaaa aaacatatat
     2041 gcttacagtg cacctagagc tttttataac agcctttttt gtttgtttgt ttgttttgga
     2101 ttctttaaat atataaatat attattctca tttagtgccc ctgtagccag aacctcatta
     2161 ctgcttcatt tttgtaataa catttaattt agatattttc catatattgg ccctgctaaa
     2221 atagaatata gcatctttca tatggtagga accaacgagg aaactttcct ttaactccct
     2281 ttttacactt tatggaaagt agcaggagga gaaatgcatt tgtagatcat ttctaggcaa
     2341 attgtgaagc taacgaccag cctgtttctt cctatactca gtcttgtttt actagaaatg
     2401 ggaatcatgg cctcttgaag agaaaaaagt caccattctg catttagctg tatctatata
     2461 ttgcatacct gtattttttt gtttgtattg taaaaaaaat tcacataata aacaatgttg
     2521 tgatgtaaca gag
//
