LOCUS       NP_033989                437 aa            linear   ROD 15-OCT-2024
DEFINITION  septin-7 isoform 1 [Mus musculus].
ACCESSION   NP_033989
VERSION     NP_033989.2
DBSOURCE    REFSEQ: accession NM_009859.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 437)
  AUTHORS   Choi,E.S., Hnath,B., Sha,C.M. and Dokholyan,N.V.
  TITLE     Unveiling the double-edged sword: SOD1 trimers possess
            tissue-selective toxicity and bind septin-7 in motor neuron-like
            cells
  JOURNAL   Structure 32 (10), 1776-1792 (2024)
   PUBMED   39208794
  REMARK    GeneRIF: Unveiling the double-edged sword: SOD1 trimers possess
            tissue-selective toxicity and bind septin-7 in motor neuron-like
            cells.
REFERENCE   2  (residues 1 to 437)
  AUTHORS   De Gasperi,R., Csernoch,L., Dienes,B., Gonczi,M., Chakrabarty,J.K.,
            Goeta,S., Aslan,A., Toro,C.A., Karasik,D., Brown,L.M., Brotto,M.
            and Cardozo,C.P.
  TITLE     Septin 7 interacts with Numb to preserve sarcomere structural
            organization and muscle contractile function
  JOURNAL   Elife 12, 89424 (2024)
   PUBMED   38695862
  REMARK    GeneRIF: Septin 7 interacts with Numb to preserve sarcomere
            structural organization and muscle contractile function.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 437)
  AUTHORS   Szabo,L., Telek,A., Fodor,J., Dobrosi,N., Docs,K., Hegyi,Z.,
            Gonczi,M., Csernoch,L. and Dienes,B.
  TITLE     Reduced Expression of Septin7 Hinders Skeletal Muscle Regeneration
  JOURNAL   Int J Mol Sci 24 (17), 13536 (2023)
   PUBMED   37686339
  REMARK    GeneRIF: Reduced Expression of Septin7 Hinders Skeletal Muscle
            Regeneration.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 437)
  AUTHORS   Raduly,Z., Szabo,L., Dienes,B., Szentesi,P., Bana,A.V., Hajdu,T.,
            Kokai,E., Hegedus,C., Csernoch,L. and Gonczi,M.
  TITLE     Migration of Myogenic Cells Is Highly Influenced by Cytoskeletal
            Septin7
  JOURNAL   Cells 12 (14), 1825 (2023)
   PUBMED   37508490
  REMARK    GeneRIF: Migration of Myogenic Cells Is Highly Influenced by
            Cytoskeletal Septin7.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 437)
  AUTHORS   Hinson,S.R., Honorat,J.A., Grund,E.M., Clarkson,B.D., Miske,R.,
            Scharf,M., Zivelonghi,C., Al-Lozi,M.T., Bucelli,R.C., Budhram,A.,
            Cho,T., Choi,E., Grell,J., Lopez-Chiriboga,A.S., Levin,M.,
            Merati,M., Montalvo,M., Pittock,S.J., Wilson,M.R., Howe,C.L. and
            McKeon,A.
  TITLE     Septin-5 and -7-IgGs: Neurologic, Serologic, and Pathophysiologic
            Characteristics
  JOURNAL   Ann Neurol 92 (6), 1090-1101 (2022)
   PUBMED   36053822
  REMARK    GeneRIF: Septin-5 and -7-IgGs: Neurologic, Serologic, and
            Pathophysiologic Characteristics.
REFERENCE   6  (residues 1 to 437)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   7  (residues 1 to 437)
  AUTHORS   Peng,X.R., Jia,Z., Zhang,Y., Ware,J. and Trimble,W.S.
  TITLE     The septin CDCrel-1 is dispensable for normal development and
            neurotransmitter release
  JOURNAL   Mol Cell Biol 22 (1), 378-387 (2002)
   PUBMED   11739749
REFERENCE   8  (residues 1 to 437)
  AUTHORS   Kinoshita,A., Noda,M. and Kinoshita,M.
  TITLE     Differential localization of septins in the mouse brain
  JOURNAL   J Comp Neurol 428 (2), 223-239 (2000)
   PUBMED   11064363
REFERENCE   9  (residues 1 to 437)
  AUTHORS   Thomas,J.W., Summers,T.J., Lee-Lin,S.Q., Maduro,V.V., Idol,J.R.,
            Mastrian,S.D., Ryan,J.F., Jamison,D.C. and Green,E.D.
  TITLE     Comparative genome mapping in the sequence-based era: early
            experience with human chromosome 7
  JOURNAL   Genome Res 10 (5), 624-633 (2000)
   PUBMED   10810084
  REMARK    Review article
REFERENCE   10 (residues 1 to 437)
  AUTHORS   Soulier,S. and Vilotte,J.L.
  TITLE     Sequence of murine CDC10 cDNA, gene organization and expression
            analysis
  JOURNAL   Biochim Biophys Acta 1442 (2-3), 339-346 (1998)
   PUBMED   9804986
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT025561.11.
            
            On Jan 31, 2003 this sequence version replaced NP_033989.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK088997.1, AK144127.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..437
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 10.25 cM"
     Protein         1..437
                     /product="septin-7 isoform 1"
                     /note="cell division cycle 10 homolog; CDC10 protein
                     homolog"
                     /calculated_mol_wt=50518
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylserine.
                     /evidence=ECO:0000250|UniProtKB:Q16181; propagated from
                     UniProtKB/Swiss-Prot (O55131.1)"
     Site            30
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0007744|PubMed:18034455; propagated from
                     UniProtKB/Swiss-Prot (O55131.1)"
     Region          47..317
                     /region_name="CDC_Septin"
                     /note="CDC/Septin GTPase family; cd01850"
                     /db_xref="CDD:206649"
     Region          47..317
                     /region_name="Interaction with SEPTIN12.
                     /evidence=ECO:0000250|UniProtKB:Q16181"
                     /note="propagated from UniProtKB/Swiss-Prot (O55131.1)"
     Region          57..64
                     /region_name="G1 motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01056"
                     /note="propagated from UniProtKB/Swiss-Prot (O55131.1)"
     Site            57..64
                     /site_type="other"
                     /note="G1 box"
                     /db_xref="CDD:206649"
     Site            order(59..65,113,116,194..195,197,250..251)
                     /site_type="other"
                     /note="GTP/Mg2+ binding site [chemical binding]"
                     /db_xref="CDD:206649"
     Site            77
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (O55131.1)"
     Site            88..96
                     /site_type="other"
                     /note="Switch I region"
                     /db_xref="CDD:206649"
     Site            90
                     /site_type="other"
                     /note="G2 box"
                     /db_xref="CDD:206649"
     Region          113..116
                     /region_name="G3 motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01056"
                     /note="propagated from UniProtKB/Swiss-Prot (O55131.1)"
     Site            113..116
                     /site_type="other"
                     /note="G3 box"
                     /db_xref="CDD:206649"
     Site            order(115..150,151..160)
                     /site_type="other"
                     /note="Switch II region"
                     /db_xref="CDD:206649"
     Region          194..197
                     /region_name="G4 motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01056"
                     /note="propagated from UniProtKB/Swiss-Prot (O55131.1)"
     Site            194..197
                     /site_type="other"
                     /note="G4 box"
                     /db_xref="CDD:206649"
     Site            228
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (O55131.1)"
     Site            250..252
                     /site_type="other"
                     /note="G5 box"
                     /db_xref="CDD:206649"
     Region          <328..433
                     /region_name="DUF4670"
                     /note="Domain of unknown function (DUF4670); pfam15709"
                     /db_xref="CDD:464815"
     Site            334
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (O55131.1)"
     Site            373
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (O55131.1)"
     Region          378..437
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O55131.1)"
     Site            424
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q16181; propagated from
                     UniProtKB/Swiss-Prot (O55131.1)"
     Site            426
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (O55131.1)"
     CDS             1..437
                     /gene="Septin7"
                     /gene_synonym="Cdc10; E430034N22; Sept7"
                     /coded_by="NM_009859.4:201..1514"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS40565.1"
                     /db_xref="GeneID:235072"
                     /db_xref="MGI:MGI:1335094"
ORIGIN      
        1 msvsarsaaa eersvncgtm vaqpknlegy vgfanlpnqv yrksvkrgfe ftlmvvgesg
       61 lgkstlinsl fltdlyspey pgpshrikkt vqveqskvli keggvqlllt ivdtpgfgda
      121 vdnsncwqpv idyidskfed ylnaesrvnr rqmpdnrvqc clyfiapsgh glkpldiefm
      181 krlhekvnii pliakadtlt peecqqfkkq imkeiqehki kiyefpetdd eeenklvkki
      241 kdrlplavvg sntiievngk rvrgrqypwg vaevengehc dftilrnmli rthmqdlkdv
      301 tnnvhyenyr srklaavtyn gvdnnknkgq ltksplaqme eerrehvakm kkmememeqv
      361 femkvkekvq klkdseaelq rrheqmkknl eaqhkeleek rrqfeeekan weaqqrileq
      421 qnssrtlekn kkkgkif
//
