LOCUS       NM_019942               3550 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus septin 6 (Septin6), transcript variant 2, mRNA.
ACCESSION   NM_019942
VERSION     NM_019942.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3550)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3550)
  AUTHORS   Hong,Y., Li,X. and Zhu,J.
  TITLE     LSD1-mediated stabilization of SEPT6 protein activates the
            TGF-beta1 pathway and regulates non-small-cell lung cancer
            metastasis
  JOURNAL   Cancer Gene Ther 29 (2), 189-201 (2022)
   PUBMED   33664458
  REMARK    GeneRIF: LSD1-mediated stabilization of SEPT6 protein activates the
            TGF-beta1 pathway and regulates non-small-cell lung cancer
            metastasis.
REFERENCE   3  (bases 1 to 3550)
  AUTHORS   Zhu,Y., Zhuo,J., Li,C., Wang,Q., Liu,X. and Ye,L.
  TITLE     Regulatory network analysis of hypertension and hypotension
            microarray data from mouse model
  JOURNAL   Clin Exp Hypertens 40 (7), 631-636 (2018)
   PUBMED   29400567
  REMARK    GeneRIF: Sept6 and Pigx might participate in the pathogenesis of
            high blood pressure.
REFERENCE   4  (bases 1 to 3550)
  AUTHORS   Valadares,N.F., d' Muniz Pereira,H., Ulian Araujo,A.P. and
            Garratt,R.C.
  TITLE     Septin structure and filament assembly
  JOURNAL   Biophys Rev 9 (5), 481-500 (2017)
   PUBMED   28905266
  REMARK    Review article
REFERENCE   5  (bases 1 to 3550)
  AUTHORS   Neubauer,K. and Zieger,B.
  TITLE     The Mammalian Septin Interactome
  JOURNAL   Front Cell Dev Biol 5, 3 (2017)
   PUBMED   28224124
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3550)
  AUTHORS   Mostowy,S. and Cossart,P.
  TITLE     Septins: the fourth component of the cytoskeleton
  JOURNAL   Nat Rev Mol Cell Biol 13 (3), 183-194 (2012)
   PUBMED   22314400
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3550)
  AUTHORS   Cao,L., Yu,W., Wu,Y. and Yu,L.
  TITLE     The evolution, complex structures and function of septin proteins
  JOURNAL   Cell Mol Life Sci 66 (20), 3309-3323 (2009)
   PUBMED   19597764
  REMARK    Review article
REFERENCE   8  (bases 1 to 3550)
  AUTHORS   Finger,F.P.
  TITLE     One ring to bind them. Septins and actin assembly
  JOURNAL   Dev Cell 3 (6), 761-763 (2002)
   PUBMED   12479801
  REMARK    Review article
REFERENCE   9  (bases 1 to 3550)
  AUTHORS   Aubert,J., Dunstan,H., Chambers,I. and Smith,A.
  TITLE     Functional gene screening in embryonic stem cells implicates Wnt
            antagonism in neural differentiation
  JOURNAL   Nat Biotechnol 20 (12), 1240-1245 (2002)
   PUBMED   12447396
REFERENCE   10 (bases 1 to 3550)
  AUTHORS   Ono,R., Taki,T., Taketani,T., Kawaguchi,H., Taniwaki,M.,
            Okamura,T., Kawa,K., Hanada,R., Kobayashi,M. and Hayashi,Y.
  TITLE     SEPTIN6, a human homologue to mouse Septin6, is fused to MLL in
            infant acute myeloid leukemia with complex chromosomal
            abnormalities involving 11q23 and Xq24
  JOURNAL   Cancer Res 62 (2), 333-337 (2002)
   PUBMED   11809673
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY776992.1, AK160884.1, AK048455.1 and BM245544.2.
            
            On Apr 3, 2010 this sequence version replaced NM_019942.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660811.76616.1,
                                           SRR1660817.166272.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139, SAMN01164141
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-207               BY776992.1         1-207
            208-796             AK160884.1         2-590
            797-3496            AK048455.1         619-3318
            3497-3550           BM245544.2         1-54                c
FEATURES             Location/Qualifiers
     source          1..3550
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 21.32 cM"
     gene            1..3550
                     /gene="Septin6"
                     /gene_synonym="2810035H17Rik; C920001C06Rik; mKIAA0128;
                     Sep6; Sept6"
                     /note="septin 6"
                     /db_xref="GeneID:56526"
                     /db_xref="MGI:MGI:1888939"
     exon            1..317
                     /gene="Septin6"
                     /gene_synonym="2810035H17Rik; C920001C06Rik; mKIAA0128;
                     Sep6; Sept6"
                     /inference="alignment:Splign:2.1.0"
     CDS             288..1577
                     /gene="Septin6"
                     /gene_synonym="2810035H17Rik; C920001C06Rik; mKIAA0128;
                     Sep6; Sept6"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="septin-6 isoform 2"
                     /protein_id="NP_064326.2"
                     /db_xref="CCDS:CCDS30066.1"
                     /db_xref="GeneID:56526"
                     /db_xref="MGI:MGI:1888939"
                     /translation="MAAADIARQVGEDCRTVPLAGHVGFDSLPDQLVNKSVSQGFCFN
                     ILCVGETGLGKSTLMDTLFNTKFEGEPATHTQPGVQLQSNTYDLQESNVGLKLTIVST
                     VGFGDQINKEDSYKPIVEFIDAQFEAYLQEELKIRRVLHSYHDSRIHVCLYFIAPTGH
                     SLKSLDLVTMKKLDSKVNIIPVIAKSDAISKSELAKFKIKITSELVSNGVQIYQFPTD
                     DESVSEINGTMNAHLPFAVVGSTEEVKIGNKMMRARQYPWGTVQVENEAHCDFVKLRE
                     MLIRVNMEDLREQTHARHYELYRRCKLEEMGFKDTDPDSKPFSLQETYEAKRNEFLGE
                     LQKKEEEMRQMFVQRVKEKEAELKEAEKELHEKFDRLKKLHQEEKKKLEDKKKCLDEE
                     MNAFKQRKAAAELLQSQGSQAGGSQTLKRDKEKKNFF"
     exon            318..432
                     /gene="Septin6"
                     /gene_synonym="2810035H17Rik; C920001C06Rik; mKIAA0128;
                     Sep6; Sept6"
                     /inference="alignment:Splign:2.1.0"
     exon            433..628
                     /gene="Septin6"
                     /gene_synonym="2810035H17Rik; C920001C06Rik; mKIAA0128;
                     Sep6; Sept6"
                     /inference="alignment:Splign:2.1.0"
     exon            629..815
                     /gene="Septin6"
                     /gene_synonym="2810035H17Rik; C920001C06Rik; mKIAA0128;
                     Sep6; Sept6"
                     /inference="alignment:Splign:2.1.0"
     exon            816..977
                     /gene="Septin6"
                     /gene_synonym="2810035H17Rik; C920001C06Rik; mKIAA0128;
                     Sep6; Sept6"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1074
                     /gene="Septin6"
                     /gene_synonym="2810035H17Rik; C920001C06Rik; mKIAA0128;
                     Sep6; Sept6"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1243
                     /gene="Septin6"
                     /gene_synonym="2810035H17Rik; C920001C06Rik; mKIAA0128;
                     Sep6; Sept6"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1376
                     /gene="Septin6"
                     /gene_synonym="2810035H17Rik; C920001C06Rik; mKIAA0128;
                     Sep6; Sept6"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1567
                     /gene="Septin6"
                     /gene_synonym="2810035H17Rik; C920001C06Rik; mKIAA0128;
                     Sep6; Sept6"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..3550
                     /gene="Septin6"
                     /gene_synonym="2810035H17Rik; C920001C06Rik; mKIAA0128;
                     Sep6; Sept6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2556..2561
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Septin6"
                     /gene_synonym="2810035H17Rik; C920001C06Rik; mKIAA0128;
                     Sep6; Sept6"
                     /note="hexamer: AATAAA"
     polyA_site      2581
                     /gene="Septin6"
                     /gene_synonym="2810035H17Rik; C920001C06Rik; mKIAA0128;
                     Sep6; Sept6"
                     /note="major polyA site"
ORIGIN      
        1 agaggccgag actcgggttg cagagagaac tggaactggg ctcgccctag gggaaggcag
       61 cgcggccaat ccgtcccctc cccacaccta ctctgagggg gtgggtgata gaggagaggt
      121 tggggttgga gcagcggtga gggggcccct ccctggcacc tccctccacc agacttggtc
      181 gcgcccgaag tgtaacactt tctctttgtc ggaggagctc ttctgtttcc tgtgcagcag
      241 ctcccgttgc ggaggcaccc gaagcagccc tggcggacca aggagcgatg gcagcggccg
      301 atatagctcg ccaggtgggc gaagattgtc gaactgtccc cctggctgga catgtggggt
      361 tcgacagctt gcctgaccag ctggtgaata agtcagtcag ccagggcttc tgcttcaaca
      421 tcctgtgcgt gggggagaca ggtttgggca agtccacgct catggatacc ctgtttaaca
      481 ccaagtttga aggggagcca gcgacccaca cacagccagg ggttcagctc cagtccaata
      541 cctacgacct ccaggagagc aacgtggggt tgaaactcac aattgtgagc actgtaggct
      601 ttggggatca gatcaacaag gaggacagct acaagcccat cgtggaattc attgatgctc
      661 agtttgaggc ctacctacaa gaggagctga agatccgaag agtactgcac tcctaccatg
      721 actcccgaat ccatgtctgc ttgtatttca ttgccccgac aggacattcg cttaagtctc
      781 tggacctagt gaccatgaag aagctggata gtaaggtgaa catcattccc gttattgcca
      841 agtcagatgc catttctaag agtgagctgg caaagttcaa gatcaaaatc accagcgaac
      901 ttgtgagcaa tggagtccag atctatcagt tccccacaga cgatgagtcg gtgagcgaga
      961 tcaatggaac catgaatgcc cacctgccgt ttgctgttgt tggcagcaca gaagaagtga
     1021 agataggcaa caagatgatg cgggctcggc agtatccttg ggggactgtg caggttgaaa
     1081 acgaggctca ctgcgacttt gtgaagctgc gggagatgct gattcgggtc aacatggagg
     1141 atctgcggga gcagacccac gcccggcact atgaattgta ccgccgctgt aagctggagg
     1201 agatgggctt caaggacacc gaccctgaca gcaaaccatt cagtttgcag gagacatatg
     1261 aggcaaagag aaatgagttc cttggggagc tccagaagaa agaagaggag atgaggcaga
     1321 tgtttgtcca gagagtcaaa gagaaagaag cggagctcaa ggaggctgaa aaagagctgc
     1381 atgagaaatt tgaccgtctg aagaaactgc accaggaaga gaagaagaag ctggaggata
     1441 agaagaaatg tctggatgag gaaatgaacg ccttcaagca gagaaaggcg gcagctgagc
     1501 tgctccagtc tcagggctct caggctgggg gctcacagac tctgaaaagg gacaaagaga
     1561 agaagaactt tttttaacct tgtcttcagc agctgtacta agtctaaagg agaagactgc
     1621 cattatagaa gagttagtta gggctccata ctgtctcaag caagaaacca accaatcccc
     1681 ctcccctgca actgcgcaca tatacaccac actcaacaag tgtacatgtg tccctgtgtc
     1741 caggcaagaa gctctcttct gacttacatg gtgtttcaca tggaattgtc ttgtcccaaa
     1801 ctcacaaggc aggaaaagaa tcatcagagc tggaaatgga ccaaatgtaa cctcagagag
     1861 acaacaacag gaccactcac ccaggtgttg ttaagtgact gtggcagacc tcagctgtgg
     1921 tgtggaagtg ctgttcacca ggttttgagt gttacgttgt ttttcttaaa acgattctct
     1981 ggttcagtgg gttgactgtc ttcagacact attaagctga ttttgaatat ggaagagaaa
     2041 gttgagtggc atttgcacct tcagcattca cagactttct gcagacccca gcaaggtggg
     2101 gagaaatgga acaattacca ttcagctgga gaaagacatg agggcggggg gaacttaagc
     2161 ttagttgaga acaaagtttc tccacacaaa cttccaaggg gctttgcagg tttcgcaaga
     2221 ggtttctatt caacttggta tcttgaagga gagctttgat ggcggtacat ctgccttgaa
     2281 atcattggct ttccttactc tctgaatacc atgtgaatgt gctcattcct atctgtccac
     2341 accacagaca ccaacattct gctgtctcgt ctcttgagag agcctctttg catgttttcc
     2401 agaatctccg tttgtttttc ctttcttctc tgtggttctt tttgctcaaa ggtgtgatca
     2461 gtcactgctc ctccggggct tccattctcc agaagataca tcccggaacc agcactgttt
     2521 agctcattat ctttctaatg tccatgtcaa ttttcaataa aattcaaaga aatgctcagt
     2581 ggctccatga tctgctccca tcagttggtg gcatgggtca cggcaatttg ctttaggaat
     2641 gggtggccac ctcccaagtg gataaattgg gaggctcaga gagctgccag gagcctacta
     2701 agtcttcctc agtggactgg catgtccctt ccccgtgcct ttcttcctcc tgtccctgac
     2761 attcccatgg gactgggtgg tattagcagg aagtcctcag ctttcccttt aactagcact
     2821 ggttgaacta gtgttcgaca gtagaaggag ggtaaagaca gaaaatggca ttccacagaa
     2881 caaaaacaaa aacagctctt atttactcct gtgctgtgaa cattttccca atttcactag
     2941 ttgaaaggca ttctgtagat accaagcctt gggtcactca gggatgcctc caatcctccc
     3001 gggcattgca ataggtaaaa gggagagtgg tcagttttca gaaatctgct tgtgagtgaa
     3061 ttggggcttg cttccctcag cttcatttgc ctgaagacca aatgatgaag aaaggaaacc
     3121 tagaagcctc tgcttggata ccagagcaaa taaaattgac caacctctac gcagctcaca
     3181 cactaggggg cagcagagtg agactatact tacgacgttg gtgaacactg atactgagaa
     3241 ggtgttggaa aacacaggat ccataatctg ttggaatagc gggaaagttg tgttgtgtta
     3301 agaaaaccac aggcggcctg gtaatacagt aagtcgccta ccgccaagcc caactatttg
     3361 agttcgatcc ccaggaccca catgggggaa cgcgagaact gattccttgc aagttgctct
     3421 ctgacctccc aacacgtgct ccagcacttc acccctacac gcacttcatc tcaagccccc
     3481 agcccccaca cacaccaaaa aataaataaa taaataaata aataaaaaga aagaaaagaa
     3541 aaaagaaaag
//
