LOCUS       NM_001253706            4737 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus septin 6 (Septin6), transcript variant 4, mRNA.
ACCESSION   NM_001253706 NR_033443
VERSION     NM_001253706.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4737)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4737)
  AUTHORS   Hong,Y., Li,X. and Zhu,J.
  TITLE     LSD1-mediated stabilization of SEPT6 protein activates the
            TGF-beta1 pathway and regulates non-small-cell lung cancer
            metastasis
  JOURNAL   Cancer Gene Ther 29 (2), 189-201 (2022)
   PUBMED   33664458
  REMARK    GeneRIF: LSD1-mediated stabilization of SEPT6 protein activates the
            TGF-beta1 pathway and regulates non-small-cell lung cancer
            metastasis.
REFERENCE   3  (bases 1 to 4737)
  AUTHORS   Zhu,Y., Zhuo,J., Li,C., Wang,Q., Liu,X. and Ye,L.
  TITLE     Regulatory network analysis of hypertension and hypotension
            microarray data from mouse model
  JOURNAL   Clin Exp Hypertens 40 (7), 631-636 (2018)
   PUBMED   29400567
  REMARK    GeneRIF: Sept6 and Pigx might participate in the pathogenesis of
            high blood pressure.
REFERENCE   4  (bases 1 to 4737)
  AUTHORS   Valadares,N.F., d' Muniz Pereira,H., Ulian Araujo,A.P. and
            Garratt,R.C.
  TITLE     Septin structure and filament assembly
  JOURNAL   Biophys Rev 9 (5), 481-500 (2017)
   PUBMED   28905266
  REMARK    Review article
REFERENCE   5  (bases 1 to 4737)
  AUTHORS   Neubauer,K. and Zieger,B.
  TITLE     The Mammalian Septin Interactome
  JOURNAL   Front Cell Dev Biol 5, 3 (2017)
   PUBMED   28224124
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4737)
  AUTHORS   Mostowy,S. and Cossart,P.
  TITLE     Septins: the fourth component of the cytoskeleton
  JOURNAL   Nat Rev Mol Cell Biol 13 (3), 183-194 (2012)
   PUBMED   22314400
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4737)
  AUTHORS   Cao,L., Yu,W., Wu,Y. and Yu,L.
  TITLE     The evolution, complex structures and function of septin proteins
  JOURNAL   Cell Mol Life Sci 66 (20), 3309-3323 (2009)
   PUBMED   19597764
  REMARK    Review article
REFERENCE   8  (bases 1 to 4737)
  AUTHORS   Finger,F.P.
  TITLE     One ring to bind them. Septins and actin assembly
  JOURNAL   Dev Cell 3 (6), 761-763 (2002)
   PUBMED   12479801
  REMARK    Review article
REFERENCE   9  (bases 1 to 4737)
  AUTHORS   Aubert,J., Dunstan,H., Chambers,I. and Smith,A.
  TITLE     Functional gene screening in embryonic stem cells implicates Wnt
            antagonism in neural differentiation
  JOURNAL   Nat Biotechnol 20 (12), 1240-1245 (2002)
   PUBMED   12447396
REFERENCE   10 (bases 1 to 4737)
  AUTHORS   Ono,R., Taki,T., Taketani,T., Kawaguchi,H., Taniwaki,M.,
            Okamura,T., Kawa,K., Hanada,R., Kobayashi,M. and Hayashi,Y.
  TITLE     SEPTIN6, a human homologue to mouse Septin6, is fused to MLL in
            infant acute myeloid leukemia with complex chromosomal
            abnormalities involving 11q23 and Xq24
  JOURNAL   Cancer Res 62 (2), 333-337 (2002)
   PUBMED   11809673
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY776992.1, AK172894.1 and CN459422.1.
            
            On Dec 1, 2011 this sequence version replaced NR_033443.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK172894.1, BC010489.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-219               BY776992.1         1-219
            220-4712            AK172894.1         1-4493
            4713-4737           CN459422.1         29-53               c
FEATURES             Location/Qualifiers
     source          1..4737
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 21.32 cM"
     gene            1..4737
                     /gene="Septin6"
                     /gene_synonym="2810035H17Rik; C920001C06Rik; mKIAA0128;
                     Sep6; Sept6"
                     /note="septin 6"
                     /db_xref="GeneID:56526"
                     /db_xref="MGI:MGI:1888939"
     exon            1..317
                     /gene="Septin6"
                     /gene_synonym="2810035H17Rik; C920001C06Rik; mKIAA0128;
                     Sep6; Sept6"
                     /inference="alignment:Splign:2.1.0"
     CDS             288..1571
                     /gene="Septin6"
                     /gene_synonym="2810035H17Rik; C920001C06Rik; mKIAA0128;
                     Sep6; Sept6"
                     /note="isoform 4 is encoded by transcript variant 4"
                     /codon_start=1
                     /product="septin-6 isoform 4"
                     /protein_id="NP_001240635.1"
                     /db_xref="CCDS:CCDS57749.1"
                     /db_xref="GeneID:56526"
                     /db_xref="MGI:MGI:1888939"
                     /translation="MAAADIARQVGEDCRTVPLAGHVGFDSLPDQLVNKSVSQGFCFN
                     ILCVGETGLGKSTLMDTLFNTKFEGEPATHTQPGVQLQSNTYDLQESNVGLKLTIVST
                     VGFGDQINKEDSYKPIVEFIDAQFEAYLQEELKIRRVLHSYHDSRIHVCLYFIAPTGH
                     SLKSLDLVTMKKLDSKVNIIPVIAKSDAISKSELAKFKIKITSELVSNGVQIYQFPTD
                     DESVSEINGTMNAHLPFAVVGSTEEVKIGNKMMRARQYPWGTVQVENEAHCDFVKLRE
                     MLIRVNMEDLREQTHARHYELYRRCKLEEMGFKDTDPDSKPFSLQETYEAKRNEFLGE
                     LQKKEEEMRQMFVQRVKEKEAELKEAEKELHEKFDRLKKLHQEEKKKLEDKKKCLDEE
                     MNAFKQRKAAAELLQSQGSQAGGSQTLKRDKEKKN"
     exon            318..432
                     /gene="Septin6"
                     /gene_synonym="2810035H17Rik; C920001C06Rik; mKIAA0128;
                     Sep6; Sept6"
                     /inference="alignment:Splign:2.1.0"
     exon            433..628
                     /gene="Septin6"
                     /gene_synonym="2810035H17Rik; C920001C06Rik; mKIAA0128;
                     Sep6; Sept6"
                     /inference="alignment:Splign:2.1.0"
     exon            629..815
                     /gene="Septin6"
                     /gene_synonym="2810035H17Rik; C920001C06Rik; mKIAA0128;
                     Sep6; Sept6"
                     /inference="alignment:Splign:2.1.0"
     exon            816..977
                     /gene="Septin6"
                     /gene_synonym="2810035H17Rik; C920001C06Rik; mKIAA0128;
                     Sep6; Sept6"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1074
                     /gene="Septin6"
                     /gene_synonym="2810035H17Rik; C920001C06Rik; mKIAA0128;
                     Sep6; Sept6"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1243
                     /gene="Septin6"
                     /gene_synonym="2810035H17Rik; C920001C06Rik; mKIAA0128;
                     Sep6; Sept6"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1376
                     /gene="Septin6"
                     /gene_synonym="2810035H17Rik; C920001C06Rik; mKIAA0128;
                     Sep6; Sept6"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1567
                     /gene="Septin6"
                     /gene_synonym="2810035H17Rik; C920001C06Rik; mKIAA0128;
                     Sep6; Sept6"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..1612
                     /gene="Septin6"
                     /gene_synonym="2810035H17Rik; C920001C06Rik; mKIAA0128;
                     Sep6; Sept6"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..4715
                     /gene="Septin6"
                     /gene_synonym="2810035H17Rik; C920001C06Rik; mKIAA0128;
                     Sep6; Sept6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2304..2309
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Septin6"
                     /gene_synonym="2810035H17Rik; C920001C06Rik; mKIAA0128;
                     Sep6; Sept6"
                     /note="hexamer: AATAAA"
     polyA_site      2326
                     /gene="Septin6"
                     /gene_synonym="2810035H17Rik; C920001C06Rik; mKIAA0128;
                     Sep6; Sept6"
                     /note="major polyA site"
     regulatory      4694..4699
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Septin6"
                     /gene_synonym="2810035H17Rik; C920001C06Rik; mKIAA0128;
                     Sep6; Sept6"
                     /note="hexamer: ATTAAA"
     polyA_site      4715
                     /gene="Septin6"
                     /gene_synonym="2810035H17Rik; C920001C06Rik; mKIAA0128;
                     Sep6; Sept6"
ORIGIN      
        1 agaggccgag actcgggttg cagagagaac tggaactggg ctcgccctag gggaaggcag
       61 cgcggccaat ccgtcccctc cccacaccta ctctgagggg gtgggtgata gaggagaggt
      121 tggggttgga gcagcggtga gggggcccct ccctggcacc tccctccacc agacttggtc
      181 gcgcccgaag tgtaacactt tctctttgtc ggaggagctc ttctgtttcc tgtgcagcag
      241 ctcccgttgc ggaggcaccc gaagcagccc tggcggacca aggagcgatg gcagcggccg
      301 atatagctcg ccaggtgggc gaagattgtc gaactgtccc cctggctgga catgtggggt
      361 tcgacagctt gcctgaccag ctggtgaata agtcagtcag ccagggcttc tgcttcaaca
      421 tcctgtgcgt gggggagaca ggtttgggca agtccacgct catggatacc ctgtttaaca
      481 ccaagtttga aggggagcca gcgacccaca cacagccagg ggttcagctc cagtccaata
      541 cctacgacct ccaggagagc aacgtggggt tgaaactcac aattgtgagc actgtaggct
      601 ttggggatca gatcaacaag gaggacagct acaagcccat cgtggaattc attgatgctc
      661 agtttgaggc ctacctacaa gaggagctga agatccgaag agtactgcac tcctaccatg
      721 actcccgaat ccatgtctgc ttgtatttca ttgccccgac aggacattcg cttaagtctc
      781 tggacctagt gaccatgaag aagctggata gtaaggtgaa catcattccc gttattgcca
      841 agtcagatgc catttctaag agtgagctgg caaagttcaa gatcaaaatc accagcgaac
      901 ttgtgagcaa tggagtccag atctatcagt tccccacaga cgatgagtcg gtgagcgaga
      961 tcaatggaac catgaatgcc cacctgccgt ttgctgttgt tggcagcaca gaagaagtga
     1021 agataggcaa caagatgatg cgggctcggc agtatccttg ggggactgtg caggttgaaa
     1081 acgaggctca ctgcgacttt gtgaagctgc gggagatgct gattcgggtc aacatggagg
     1141 atctgcggga gcagacccac gcccggcact atgaattgta ccgccgctgt aagctggagg
     1201 agatgggctt caaggacacc gaccctgaca gcaaaccatt cagtttgcag gagacatatg
     1261 aggcaaagag aaatgagttc cttggggagc tccagaagaa agaagaggag atgaggcaga
     1321 tgtttgtcca gagagtcaaa gagaaagaag cggagctcaa ggaggctgaa aaagagctgc
     1381 atgagaaatt tgaccgtctg aagaaactgc accaggaaga gaagaagaag ctggaggata
     1441 agaagaaatg tctggatgag gaaatgaacg ccttcaagca gagaaaggcg gcagctgagc
     1501 tgctccagtc tcagggctct caggctgggg gctcacagac tctgaaaagg gacaaagaga
     1561 agaagaatta actctgctgt ttgctgcatg ctgcatgaca cccagggtcc tgtttgggct
     1621 tcctgtagac gcgccctttc ctgtgcaaca gagctgggct tccctctctt tatttccccc
     1681 cttaacatgc ttagagggca tacaccccat gccttccctt tttcttcctt caaatgttta
     1741 tagaagcctg agagtcaaat gatgatgtct ggttcctgac caagaagcca gcaatctcgt
     1801 ggcttggaga tacattccat acctcagtcc ctctcctagt accctccacc atatgctctc
     1861 tcacatcctc aatccatctc tgccagactc acacatgttt acaggtcact gtttgtcact
     1921 tttgtgtacc agcttcccca ttagaattca accgatactt gttttcttga agaatttcca
     1981 tccaccagtc aggggtcaga actgtcccct tatactcctg catcctagtc actgggattg
     2041 ttctcccact cctctaatgc caagagccat agccccttat aataggttct aaaagaattg
     2101 ccagcgatgc ctgtttcttc tcccatctta gccaagccct ttcttgattt cctttattcg
     2161 gagtcagttt acacaagctg tgttaaaagt cagccacaca tttattcaca ccaagccctt
     2221 cctatacaaa acacaattgc tggaacagat agtgtatatt ccccctctct aattctaggg
     2281 acccccacag atacagaagg gaaaataaac tggaatgtta tcaccagcct agagtcttga
     2341 ttcataggct tctaaaattc tccttggggg tttcagcatg ccattggtca attcttgcca
     2401 tcccaatgaa gtggaatagc aagaataata ataatccaag tagctgatca aagaatccag
     2461 gcgtggggtt gtctagtgtt ctagtctccc tgatgaatgt aatggtaggg tgaacctgca
     2521 tttgcacaag tgacacttga aagagggaag aaaagaggca ttgtcacttg aaaggtcatt
     2581 tactttggtc taaggatttg atatttttaa aaatatggta gttttaagtt ttataatggg
     2641 tcccgcctga ttgtggcttt tggaaaccct ttgaagtaca gagccttcca ccgtcagggc
     2701 caggaggcag agtatggctt ttggcgtttg gctagtgaca gagcaacagc tagaggcgac
     2761 ctggcaatga tctgtggcta atatggcgtc tctctgccct tcctttgcag taacccatgg
     2821 ctgtgtattg aatagtatgg cccgctacag ctggactgga ctccacttag ccttttaagc
     2881 gaaggttctt attttaactg acaacttttt ttaaaaaata tggtgccaga cagctgggcc
     2941 ctccacccct gctctggtac ttcaagcatt ttgtttttgt ttttgttttt gagttctgca
     3001 acttgcttct gcctcccagt cccactggca tggaccctga cttcttttat cttgttataa
     3061 aggtggctgt atgatcacta cctctaaaaa aatgcaataa ataaatttgc aggccttctg
     3121 aactgttaca aaagggcagg ggccattgtc tacaatcata gttaataact tgaacctaag
     3181 actaagccca aagcagaact tgttaaagca agcaagacaa tgtgcgcact ttctcttttc
     3241 ttgttggcaa agagagaagg cggttttgat ctgtactggc caatggccag aggcaaggac
     3301 caggtgacaa agtgaaagcc tgagctagtc cttcagaaaa accaactgga agtggagaat
     3361 tgcaggaaac cctatgccta gaggcgaaac aaaatgaagc cagccacctc gggaacagaa
     3421 agccctaaag caaaatctcc aagtatctca gatacactca gtaatcagga gagccaggct
     3481 actgagtgaa ggctgtctgg gtctcctaga gaaaggcccc ttatttgtac ccatggagtt
     3541 ctgtttgttt ttaaaaaaac aagttcttac tatgtagccc tggctagcct tgaaatcaca
     3601 aaacagacca ggctggcctg aaattcacag agatttgcct gctggtattt tgcactggca
     3661 ttaaaggcaa acaccaccac acccagctgc cttagggggg ttaatccacc ttcccagact
     3721 gcctgccagc ctgaaagtac caccttcctt aaaaagtact tgtattttta aacgaggcct
     3781 ttcatttgca tctgtatata cactccctac ttgagcctgg aggatttcag aatacttcac
     3841 aagtatttga gctacacaac cctctaaaag caagcaaaaa ctgtatataa agtgaggagc
     3901 tttttgatca gcatggctga tataccccac cccatgctat aggaggatag tgacacgtag
     3961 agaaacgaag ggactcatcc aaggtcccag cgctattcct tggcaagcaa aatttccaat
     4021 ttcctgtctc tgggttccta atccttttca ccaagcaacc caagtattta tggttttttc
     4081 tggagacaag atttttttct ttttttttta tgttcagaga aaccagtgtt agatgactct
     4141 tgagggtttt tatgtagaaa aataggatag ggtgggtagg cacaggtgaa gagaaagctc
     4201 caggccagct gccatgatgc tggatgatca gttagctgta agtctgtaag tcaaaacaga
     4261 aaatcagatc ctgtaagtct gaaccaggac caggccagtg tacatttcac tggtgcactg
     4321 tgtaatcagg gaactcaggt agatataaaa agcaatggta cctattaaaa gatgatgcta
     4381 aatttcattg agaagttctc actgtaaatg agacaaactt ttgtctgtct tcacttgaaa
     4441 gtctttaatt agtacaattg ttactatttt tttaaaaaat tactctaagt tccctgttta
     4501 cttctggcaa aacaaaaaac actcattaga gaaatggtct gtgcttttcc agactggaat
     4561 ggaatggctt cctgaaacac acacacacac cccatttctc ttaagccaag aagtctgctt
     4621 tctccacctg gtttggattt tttaaaaatc atttggcatt cacgtttggc tgttaatatg
     4681 tgcttatttt taaattaaag caagatgcaa ttaaaaaaaa aaaaaaaaaa aaaaaaa
//
