LOCUS       NM_213614               2155 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus septin 5 (Septin5), mRNA.
ACCESSION   NM_213614 XM_359275
VERSION     NM_213614.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2155)
  AUTHORS   Eom,T.Y., Schmitt,J.E., Li,Y., Davenport,C.M., Steinberg,J.,
            Bonnan,A., Alam,S., Ryu,Y.S., Paul,L., Hansen,B.S., Khairy,K.,
            Pelletier,S., Pruett-Miller,S.M., Roalf,D.R., Gur,R.E.,
            Emanuel,B.S., McDonald-McGinn,D.M., Smith,J.N., Li,C.,
            Christie,J.M., Northcott,P.A. and Zakharenko,S.S.
  TITLE     Tbx1 haploinsufficiency leads to local skull deformity,
            paraflocculus and flocculus dysplasia, and motor-learning deficit
            in 22q11.2 deletion syndrome
  JOURNAL   Nat Commun 15 (1), 10510 (2024)
   PUBMED   39638997
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2155)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2155)
  AUTHORS   Liu,H., Tan,R., Tong,J., Wen,S., Wu,C., Rao,M., Zhu,J., Qi,S. and
            Kong,E.
  TITLE     Palmitoylation is required for Sept8-204 and Sept5 to form
            vesicle-like structure and colocalize with synaptophysin
  JOURNAL   J Cell Biochem 125 (3), e30529 (2024)
   PUBMED   38308620
  REMARK    GeneRIF: Palmitoylation is required for Sept8-204 and Sept5 to form
            vesicle-like structure and colocalize with synaptophysin.
REFERENCE   4  (bases 1 to 2155)
  AUTHORS   Hinson,S.R., Honorat,J.A., Grund,E.M., Clarkson,B.D., Miske,R.,
            Scharf,M., Zivelonghi,C., Al-Lozi,M.T., Bucelli,R.C., Budhram,A.,
            Cho,T., Choi,E., Grell,J., Lopez-Chiriboga,A.S., Levin,M.,
            Merati,M., Montalvo,M., Pittock,S.J., Wilson,M.R., Howe,C.L. and
            McKeon,A.
  TITLE     Septin-5 and -7-IgGs: Neurologic, Serologic, and Pathophysiologic
            Characteristics
  JOURNAL   Ann Neurol 92 (6), 1090-1101 (2022)
   PUBMED   36053822
  REMARK    GeneRIF: Septin-5 and -7-IgGs: Neurologic, Serologic, and
            Pathophysiologic Characteristics.
REFERENCE   5  (bases 1 to 2155)
  AUTHORS   Chang,M., He,Y., Liu,C., Lin,R., Huang,X., Liang,D., Zhang,J. and
            Lu,Y.
  TITLE     Downregulation of SEPTIN5 inhibits prostate cancer progression by
            increasing CD8+ T cell infiltration
  JOURNAL   Int J Biol Sci 18 (16), 6035-6051 (2022)
   PUBMED   36439885
  REMARK    GeneRIF: Downregulation of SEPTIN5 inhibits prostate cancer
            progression by increasing CD8[+] T cell infiltration.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2155)
  AUTHORS   Lund,J., Chen,F., Hua,A., Roe,B., Budarf,M., Emanuel,B.S. and
            Reeves,R.H.
  TITLE     Comparative sequence analysis of 634 kb of the mouse chromosome 16
            region of conserved synteny with the human velocardiofacial
            syndrome region on chromosome 22q11.2
  JOURNAL   Genomics 63 (3), 374-383 (2000)
   PUBMED   10704284
REFERENCE   7  (bases 1 to 2155)
  AUTHORS   Lund,J., Roe,B., Chen,F., Budarf,M., Galili,N., Riblet,R.,
            Miller,R.D., Emanuel,B.S. and Reeves,R.H.
  TITLE     Sequence-ready physical map of the mouse chromosome 16 region with
            conserved synteny to the human velocardiofacial syndrome region on
            22q11.2
  JOURNAL   Mamm Genome 10 (5), 438-443 (1999)
   PUBMED   10337614
REFERENCE   8  (bases 1 to 2155)
  AUTHORS   Sutherland,H.F., Kim,U.J. and Scambler,P.J.
  TITLE     Cloning and comparative mapping of the DiGeorge syndrome critical
            region in the mouse
  JOURNAL   Genomics 52 (1), 37-43 (1998)
   PUBMED   9740669
REFERENCE   9  (bases 1 to 2155)
  AUTHORS   Botta,A., Lindsay,E.A., Jurecic,V. and Baldini,A.
  TITLE     Comparative mapping of the DiGeorge syndrome region in mouse shows
            inconsistent gene order and differential degree of gene
            conservation
  JOURNAL   Mamm Genome 8 (12), 890-895 (1997)
   PUBMED   9383280
  REMARK    Erratum:[Mamm Genome 1998 Apr;9(4):344]
REFERENCE   10 (bases 1 to 2155)
  AUTHORS   McKie,J.M., Sutherland,H.F., Harvey,E., Kim,U.J. and Scambler,P.J.
  TITLE     A human gene similar to Drosophila melanogaster peanut maps to the
            DiGeorge syndrome region of 22q11
  JOURNAL   Hum Genet 101 (1), 6-12 (1997)
   PUBMED   9385360
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CA945297.1 and BC059848.1.
            
            On Oct 19, 2007 this sequence version replaced NM_213614.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK134700.1, BC141073.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-122               CA945297.1         17-138
            123-2155            BC059848.1         1-2033
FEATURES             Location/Qualifiers
     source          1..2155
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 11.53 cM"
     gene            1..2155
                     /gene="Septin5"
                     /gene_synonym="Cdcrel-1; Cdcrel1; Pnutl1; Sept5"
                     /note="septin 5"
                     /db_xref="GeneID:18951"
                     /db_xref="MGI:MGI:1195461"
     exon            1..131
                     /gene="Septin5"
                     /gene_synonym="Cdcrel-1; Cdcrel1; Pnutl1; Sept5"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..1198
                     /gene="Septin5"
                     /gene_synonym="Cdcrel-1; Cdcrel1; Pnutl1; Sept5"
                     /EC_number="3.1.5.1"
                     /note="peanut-like protein 1; cell division
                     control-related protein 1; peanut-like 1 homolog"
                     /codon_start=1
                     /product="septin-5"
                     /protein_id="NP_998779.2"
                     /db_xref="CCDS:CCDS57021.1"
                     /db_xref="GeneID:18951"
                     /db_xref="MGI:MGI:1195461"
                     /translation="MSTGLRYKSKLATPEDKQDIDKQYVGFATLPNQVHRKSVKKGFD
                     FTLMVAGESGLGKSTLVHSLFLTDLYKDRKLLSAEERINQTVEILKHTVDIEEKGVKL
                     KLTIVDTPGFGDAVNNSECWKPITDYVDQQFEQYFRDESGLNRKNIQDNRVHCCLYFI
                     SPFGHGLRPVDVGFMKALHEKVNIVPLIAKADCLVPSEIRKLKDRIREEIDKFGIHVY
                     QFPECDSDEDEDFKQQDRELKESAPFAVIGSNTVVEAKGQRVRGRLYPWGIVEVENQA
                     HCDFVKLRNMLIRTHMHDLKDVTCDVHYENYRAHCIQQMTSKLTQDSRMESPIPILPL
                     PTPDAETEKLIRMKDEELRRMQEMLQKMKQQMQDQ"
     exon            132..142
                     /gene="Septin5"
                     /gene_synonym="Cdcrel-1; Cdcrel1; Pnutl1; Sept5"
                     /inference="alignment:Splign:2.1.0"
     exon            143..239
                     /gene="Septin5"
                     /gene_synonym="Cdcrel-1; Cdcrel1; Pnutl1; Sept5"
                     /inference="alignment:Splign:2.1.0"
     exon            240..326
                     /gene="Septin5"
                     /gene_synonym="Cdcrel-1; Cdcrel1; Pnutl1; Sept5"
                     /inference="alignment:Splign:2.1.0"
     exon            327..450
                     /gene="Septin5"
                     /gene_synonym="Cdcrel-1; Cdcrel1; Pnutl1; Sept5"
                     /inference="alignment:Splign:2.1.0"
     exon            451..585
                     /gene="Septin5"
                     /gene_synonym="Cdcrel-1; Cdcrel1; Pnutl1; Sept5"
                     /inference="alignment:Splign:2.1.0"
     exon            586..703
                     /gene="Septin5"
                     /gene_synonym="Cdcrel-1; Cdcrel1; Pnutl1; Sept5"
                     /inference="alignment:Splign:2.1.0"
     exon            704..805
                     /gene="Septin5"
                     /gene_synonym="Cdcrel-1; Cdcrel1; Pnutl1; Sept5"
                     /inference="alignment:Splign:2.1.0"
     exon            806..902
                     /gene="Septin5"
                     /gene_synonym="Cdcrel-1; Cdcrel1; Pnutl1; Sept5"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1038
                     /gene="Septin5"
                     /gene_synonym="Cdcrel-1; Cdcrel1; Pnutl1; Sept5"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1141
                     /gene="Septin5"
                     /gene_synonym="Cdcrel-1; Cdcrel1; Pnutl1; Sept5"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..2127
                     /gene="Septin5"
                     /gene_synonym="Cdcrel-1; Cdcrel1; Pnutl1; Sept5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2109..2114
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Septin5"
                     /gene_synonym="Cdcrel-1; Cdcrel1; Pnutl1; Sept5"
                     /note="hexamer: AACAAA"
     polyA_site      2127
                     /gene="Septin5"
                     /gene_synonym="Cdcrel-1; Cdcrel1; Pnutl1; Sept5"
                     /note="major polyA site"
ORIGIN      
        1 tcacccctca gccggcctcg gcctccaccg ctggtcgccg cgccccgccc gcgcgcccgc
       61 cgccacacgt cccccgccgg cggccaccat gagcacagga ctgcggtaca aaagcaagct
      121 ggcgacccca gaggacaaac aggacatcga caagcagtac gttggcttcg ccacactgcc
      181 caaccaggtg caccgcaagt ccgtcaagaa aggtttcgac ttcacgctca tggtggccgg
      241 tgagtccggc ctggggaagt ccacccttgt ccatagcctc tttctgaccg acctgtataa
      301 ggaccggaaa ctgctgagtg ctgaggaacg catcaaccag acggtagaga tcctgaaaca
      361 caccgtcgac attgaggaga agggggtcaa gttaaagctc accattgtgg acacgcccgg
      421 ctttggggac gcggtgaaca actctgaatg ttggaagccc atcactgact atgtggacca
      481 gcagtttgag cagtatttcc gtgatgagag tggcctgaac cgcaagaaca tccaggacaa
      541 ccgggtacac tgctgcctgt acttcatctc cccgttcgga cacggactga ggccagtgga
      601 tgtaggcttc atgaaggcac tgcatgagaa ggtgaacatc gtcccactca tcgccaaagc
      661 tgactgcctg gtgcccagtg agatccggaa gctgaaggac agaatacgtg aggagatcga
      721 caagtttggg atccacgtgt accagtttcc agaatgtgat tcggatgaag atgaagactt
      781 caagcaacag gaccgggaac tgaaggaaag tgcacccttc gccgttattg gcagcaacac
      841 tgtggtggag gccaaggggc agcgggtccg ggggcgactg tacccctggg ggatcgtcga
      901 agtggagaat caggcgcact gcgactttgt gaagctccgc aacatgctca tccgcactca
      961 catgcacgac ctcaaagatg tgacgtgcga cgtgcactat gagaactacc gtgcccactg
     1021 catccagcag atgaccagca aactcaccca ggacagccgc atggagagcc ccattcctat
     1081 cctcccacta cccacaccgg atgcggagac cgagaagctc atcaggatga aggatgaaga
     1141 gctaaggcgc atgcaggaga tgttgcagaa gatgaagcag caaatgcaag accagtgaca
     1201 cccgccccag ccccacgtcg tcgacaagga tagacggccg gtttccgggc tggcccctcc
     1261 tacccctgga tcccagactg tcctggattc caccctgggt tcatctggat ctcagaaggc
     1321 ctggacctca ccctaatcca aagtggcttt gaccagactg ttcagacctg gagccacaga
     1381 gccacagccc ccagatgacc ctaatttatt ctcggcgtcc acccttcccg gtcatttgta
     1441 tctgcttccg agtgctctga atcacagccc ctccccaacc tcctgccccc gccccacccc
     1501 gcacctcccc gcctatcata agggaacaag atgtgcacaa cctccaagat ctcccttcct
     1561 agaagatcac tgccccccag cgggccaata aaccagggta gaggagggac gtggatgcag
     1621 gatcttgggc ctattaccca agctagtgct gcagagtgga gttgggaggc ccccctctgc
     1681 cgattccagt gggctacgaa gcatttgcta atggcctact gagcgcggaa gtaggccggt
     1741 tcctccctta ctccctaatc atgctctgtt caggatcgga ggcggcgggg tttggaggct
     1801 aaggccttta ggaagacccc agatctagag gcttctggga ggaaggcggg gccgcgatgc
     1861 tctagaccgc tcgcgcccct tcctgagtct acctgaagga ctccaagggc ggtagagacg
     1921 gggtgtccct atgcctagac tactttcgtc cacccatagg tcaaggtctt ttcttcccag
     1981 caactctgtt gcacaaggat tccagccctt ggcctcctcc atatctccac ccgcatgatt
     2041 cctccccaca caccccatgc tccgttttgt tcagttgtga atgccgcgtc ctgtcctggt
     2101 gacaggagaa caaagttggt gaacgtcaaa aaaaaaaaaa aaaaaaaaaa aaaaa
//
