LOCUS       NM_001368775            3140 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus septin 4 (Septin4), transcript variant 6, mRNA.
ACCESSION   NM_001368775 XM_006532494
VERSION     NM_001368775.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3140)
  AUTHORS   Li,Y., Xu,L., Hao,C., Yang,S., Wang,J. and Chen,J.
  TITLE     ARTS is essential for di-2-ethylhexyl phthalate (DEHP)-induced
            apoptosis of mouse Leydig cells
  JOURNAL   Ecotoxicol Environ Saf 270, 115882 (2024)
   PUBMED   38171099
  REMARK    GeneRIF: ARTS is essential for di-2-ethylhexyl phthalate
            (DEHP)-induced apoptosis of mouse Leydig cells.
REFERENCE   2  (bases 1 to 3140)
  AUTHORS   Zhang,Y., Zhang,N., Zou,Y., Song,C., Cao,K., Wu,B., You,S., Lu,S.,
            Wang,D., Xu,J., Huang,X., Zhang,P., Fan,Z., Liu,J., Cheng,Z.,
            Zhang,Z., Kong,C., Cao,L. and Sun,Y.
  TITLE     Deacetylation of Septin4 by SIRT2 (Silent Mating Type Information
            Regulation 2 Homolog-2) Mitigates Damaging of Hypertensive
            Nephropathy
  JOURNAL   Circ Res 132 (5), 601-624 (2023)
   PUBMED   36786216
  REMARK    GeneRIF: Deacetylation of Septin4 by SIRT2 (Silent Mating Type
            Information Regulation 2 Homolog-2) Mitigates Damaging of
            Hypertensive Nephropathy.
REFERENCE   3  (bases 1 to 3140)
  AUTHORS   Wang,H.Y., Shen,Y.R., Tsai,Y.C., Wu,S.R., Wang,C.Y. and Kuo,P.L.
  TITLE     Proper phosphorylation of septin 12 regulates septin 4 and soluble
            adenylyl cyclase expression to induce sperm capacitation
  JOURNAL   J Cell Physiol 238 (3), 597-609 (2023)
   PUBMED   36715674
  REMARK    GeneRIF: Proper phosphorylation of septin 12 regulates septin 4 and
            soluble adenylyl cyclase expression to induce sperm capacitation.
REFERENCE   4  (bases 1 to 3140)
  AUTHORS   Chen,L., Ouyang,Y.C., Li,J., Qiao,J.Y., Gu,L.J., Wang,Z.B., Hou,Y.,
            Schatten,H. and Sun,Q.Y.
  TITLE     Septin 4 controls CCNB1 stabilization via APC/CCDC20 during meiotic
            G2/M transition in mouse oocytes
  JOURNAL   J Cell Physiol 237 (1), 730-742 (2022)
   PUBMED   34189751
  REMARK    GeneRIF: Septin 4 controls CCNB1 stabilization via APC/C(CDC20)
            during meiotic G2/M transition in mouse oocytes.
REFERENCE   5  (bases 1 to 3140)
  AUTHORS   Maimon,N., Zamir,Z.Z., Kalkar,P., Zeytuni-Timor,O., Schif-Zuck,S.,
            Larisch,S. and Ariel,A.
  TITLE     The pro-apoptotic ARTS protein induces neutrophil apoptosis,
            efferocytosis, and macrophage reprogramming to promote resolution
            of inflammation
  JOURNAL   Apoptosis 25 (7-8), 558-573 (2020)
   PUBMED   32564202
  REMARK    GeneRIF: The pro-apoptotic ARTS protein induces neutrophil
            apoptosis, efferocytosis, and macrophage reprogramming to promote
            resolution of inflammation.
REFERENCE   6  (bases 1 to 3140)
  AUTHORS   Peng,X.R., Jia,Z., Zhang,Y., Ware,J. and Trimble,W.S.
  TITLE     The septin CDCrel-1 is dispensable for normal development and
            neurotransmitter release
  JOURNAL   Mol Cell Biol 22 (1), 378-387 (2002)
   PUBMED   11739749
REFERENCE   7  (bases 1 to 3140)
  AUTHORS   Hwang,S.Y., Oh,B., Knowles,B.B., Solter,D. and Lee,J.S.
  TITLE     Expression of genes involved in mammalian meiosis during the
            transition from egg to embryo
  JOURNAL   Mol Reprod Dev 59 (2), 144-158 (2001)
   PUBMED   11389549
REFERENCE   8  (bases 1 to 3140)
  AUTHORS   Jiang,C.H., Tsien,J.Z., Schultz,P.G. and Hu,Y.
  TITLE     The effects of aging on gene expression in the hypothalamus and
            cortex of mice
  JOURNAL   Proc Natl Acad Sci U S A 98 (4), 1930-1934 (2001)
   PUBMED   11172053
REFERENCE   9  (bases 1 to 3140)
  AUTHORS   Kinoshita,A., Noda,M. and Kinoshita,M.
  TITLE     Differential localization of septins in the mouse brain
  JOURNAL   J Comp Neurol 428 (2), 223-239 (2000)
   PUBMED   11064363
REFERENCE   10 (bases 1 to 3140)
  AUTHORS   Paavola,P., Horelli-Kuitunen,N., Palotie,A. and Peltonen,L.
  TITLE     Characterization of a novel gene, PNUTL2, on human chromosome
            17q22-q23 and its exclusion as the Meckel syndrome gene
  JOURNAL   Genomics 55 (1), 122-125 (1999)
   PUBMED   9889007
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL596086.9.
            
            On Nov 18, 2022 this sequence version replaced NM_001368775.1.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849384
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1599              AL596086.9         45020-46618
            1600-1644           AL596086.9         47245-47289
            1645-1652           AL596086.9         48630-48637
            1653-1949           AL596086.9         61649-61945
            1950-2043           AL596086.9         62252-62345
            2044-2130           AL596086.9         62730-62816
            2131-2254           AL596086.9         63449-63572
            2255-2389           AL596086.9         67049-67183
            2390-2507           AL596086.9         67299-67416
            2508-2609           AL596086.9         67506-67607
            2610-2706           AL596086.9         67799-67895
            2707-2869           AL596086.9         67987-68149
            2870-2916           AL596086.9         68340-68386
            2917-3140           AL596086.9         68647-68870
FEATURES             Location/Qualifiers
     source          1..3140
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 52.14 cM"
     gene            1..3140
                     /gene="Septin4"
                     /gene_synonym="ARTS; Bh5; Gm11492; hCDCREL-2; Pnutl2;
                     Sept4"
                     /note="septin 4"
                     /db_xref="GeneID:18952"
                     /db_xref="MGI:MGI:1270156"
     exon            1..1599
                     /gene="Septin4"
                     /gene_synonym="ARTS; Bh5; Gm11492; hCDCREL-2; Pnutl2;
                     Sept4"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..2888
                     /gene="Septin4"
                     /gene_synonym="ARTS; Bh5; Gm11492; hCDCREL-2; Pnutl2;
                     Sept4"
                     /note="isoform 6 is encoded by transcript variant 6;
                     M-Septin; peanut-like 2 homolog; septin H5; brain protein
                     H5; peanut-like protein 2; cell division control-related
                     protein 2b; CE5B3 beta; bradeion beta"
                     /codon_start=1
                     /product="septin-4 isoform 6"
                     /protein_id="NP_001355704.1"
                     /db_xref="GeneID:18952"
                     /db_xref="MGI:MGI:1270156"
                     /translation="MASTQKATVYQVYKTNKNGSKVAVSSHRGAEVTTSTPQRGHGYY
                     SSSQRATAAVSLSPPPLPSQRRAEATSTTHHSTSDYLHPVSPQPGPGLSAVSTSRGTE
                     TRTRIEVPCHHSPHHSPHHSPHHSPHRKNQSIQTMSSHLAGVHRNVSPVREESTRRTE
                     TRPGREVAHHSSTTSDAKCRHLYFTGEKEEDPPSKVQNPQGVKVPRRISAYPKDEAIQ
                     TEPTRRTTAEVRSSRNISVQEHGIRMANNPQIVIRKVPPQEPEVGHSSIYSEPKTSQK
                     STKLSSGLKLSVLRDLDGAPRAAPPRPERSVCIGTKPSPKILISEAENTMRSPTRERE
                     VTRKVTISPGKQSTQPPHRVTCRTVSEGSYKSPLYPELSTKPSTHVPSAFELTPRPLP
                     PRSLPRYGPDCSWWALLNPKVETPPNHSSFDLEPKSPPPLDPLESFYEMDSTPFCEDL
                     LFQRDKASLPPSPKDSLYRVPLTEVQKTPKYTSKQPTQGFNAFFLDVSEEMYNRILWW
                     LKDEEIKHFLEDSSDDAELSKFVKDFPGSEPYHSAESKTRVARPQILEPRPQSPDLCD
                     DDVEFRGSLWPQPSDSQQYFSAPAPLSPSSRPRSPWGKLDPYDSSEDDKEYVGFATLP
                     NQVHRKSVKKGFDFTLMVAGESGLGKSTLVNSLFLTDLYRDRKLLGAEERIMQTVEIT
                     KHAVDIEEKGVRLRLTIVDTPGFGDAVNNTECWKPVAEYIDQQFEQYFRDESGLNRKN
                     IQDNRVHCCLYFISPFGHGLRPLDVEFMKALHQRVNIVPILAKADTLTPPEVDRKKCK
                     IREEIEHFGIKIYQFPDCDSDEDEDFKLQDQALKESIPFAVIGSNTVVEARGRRVRGR
                     LYPWGIVEVENPGHCDFVKLRTMLVRTHMQDLKDVTRETHYENYRAQCIQSMTRLVVK
                     ERNRKDRSRN"
     exon            1600..1644
                     /gene="Septin4"
                     /gene_synonym="ARTS; Bh5; Gm11492; hCDCREL-2; Pnutl2;
                     Sept4"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..1652
                     /gene="Septin4"
                     /gene_synonym="ARTS; Bh5; Gm11492; hCDCREL-2; Pnutl2;
                     Sept4"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1949
                     /gene="Septin4"
                     /gene_synonym="ARTS; Bh5; Gm11492; hCDCREL-2; Pnutl2;
                     Sept4"
                     /inference="alignment:Splign:2.1.0"
     exon            1950..2043
                     /gene="Septin4"
                     /gene_synonym="ARTS; Bh5; Gm11492; hCDCREL-2; Pnutl2;
                     Sept4"
                     /inference="alignment:Splign:2.1.0"
     exon            2044..2130
                     /gene="Septin4"
                     /gene_synonym="ARTS; Bh5; Gm11492; hCDCREL-2; Pnutl2;
                     Sept4"
                     /inference="alignment:Splign:2.1.0"
     exon            2131..2254
                     /gene="Septin4"
                     /gene_synonym="ARTS; Bh5; Gm11492; hCDCREL-2; Pnutl2;
                     Sept4"
                     /inference="alignment:Splign:2.1.0"
     exon            2255..2389
                     /gene="Septin4"
                     /gene_synonym="ARTS; Bh5; Gm11492; hCDCREL-2; Pnutl2;
                     Sept4"
                     /inference="alignment:Splign:2.1.0"
     exon            2390..2507
                     /gene="Septin4"
                     /gene_synonym="ARTS; Bh5; Gm11492; hCDCREL-2; Pnutl2;
                     Sept4"
                     /inference="alignment:Splign:2.1.0"
     exon            2508..2609
                     /gene="Septin4"
                     /gene_synonym="ARTS; Bh5; Gm11492; hCDCREL-2; Pnutl2;
                     Sept4"
                     /inference="alignment:Splign:2.1.0"
     exon            2610..2706
                     /gene="Septin4"
                     /gene_synonym="ARTS; Bh5; Gm11492; hCDCREL-2; Pnutl2;
                     Sept4"
                     /inference="alignment:Splign:2.1.0"
     exon            2707..2869
                     /gene="Septin4"
                     /gene_synonym="ARTS; Bh5; Gm11492; hCDCREL-2; Pnutl2;
                     Sept4"
                     /inference="alignment:Splign:2.1.0"
     exon            2870..2916
                     /gene="Septin4"
                     /gene_synonym="ARTS; Bh5; Gm11492; hCDCREL-2; Pnutl2;
                     Sept4"
                     /inference="alignment:Splign:2.1.0"
     exon            2917..3140
                     /gene="Septin4"
                     /gene_synonym="ARTS; Bh5; Gm11492; hCDCREL-2; Pnutl2;
                     Sept4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3119..3124
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Septin4"
                     /gene_synonym="ARTS; Bh5; Gm11492; hCDCREL-2; Pnutl2;
                     Sept4"
                     /note="hexamer: AATAAA"
     polyA_site      3140
                     /gene="Septin4"
                     /gene_synonym="ARTS; Bh5; Gm11492; hCDCREL-2; Pnutl2;
                     Sept4"
                     /note="major polyA site"
ORIGIN      
        1 actcttagaa cagctgccac ttccaagggg gacagagaac agcagctctg aaaacaatga
       61 gggtaaacac tcatgcttaa ccgggatcct gaaaacaagc ccgctgacaa aacatggcat
      121 ctacccagaa ggccacagtc tatcaggtgt acaagacaaa taaaaatggg tccaaggtag
      181 cagtttcttc gcacagaggg gcagaggtta ctacctccac tcctcagcgg ggacatgggt
      241 attattcctc aagccagcga gctactgctg ctgtctcctt gagtcctcct cctcttccat
      301 cccagagaag agccgaagct acatccacca ctcaccattc aacatcagac tacctacacc
      361 ctgtgtcccc acagccaggg cctggcctct ctgcagtctc cacttcacgg ggaactgaga
      421 cccgaacaag aatagaggtg ccctgccatc actctcctca tcactctcca catcactctc
      481 ctcatcactc tcctcatcga aagaaccagt caattcagac aatgtcctcc cacctcgcag
      541 gagtgcatcg gaatgtcagt ccagtcaggg aagagtcaac acgaagaact gagaccaggc
      601 cagggcgtga ggttgcccac cattcctcca cgacctctga tgcaaaatgc cgtcacttgt
      661 attttactgg agaaaaagag gaggacccac cctccaaggt ccagaacccc cagggggtta
      721 aagtaccccg taggatttca gcatacccga aggatgaagc tatacaaaca gagcccaccc
      781 gaaggactac tgctgaggtc agatcttcaa gaaatatctc cgtccaagag catggcattc
      841 gcatggctaa taaccctcag atagtcatta gaaaggtccc tccccaggaa ccagaagttg
      901 gtcacagctc aatatattca gaacctaaga cctcgcaaaa gagcacgaaa ttgtcatcag
      961 gcctcaaact ttctgtcctt agagatttag atggggcacc ccgagctgct ccacctcgac
     1021 cagagcgttc tgtctgtatt gggaccaagc cctccccaaa gattttaata tccgaagcag
     1081 agaacactat gagatcccca acccgagaac gtgaggtcac acgcaaggtg accatttccc
     1141 caggaaaaca gtcaacgcag ccacctcatc gtgtgacatg tcgaacagtg tctgaaggat
     1201 cctataagtc tcccctgtat ccagagcttt caacaaagcc ctccacccat gtcccctcag
     1261 catttgagtt gactcctcgg cctttgcccc ctcggtcctt acctaggtat ggacctgatt
     1321 gctcatggtg ggccttactg aatcctaaag ttgaaacgcc cccaaaccat tcatcatttg
     1381 atcttgaacc taagtcgcct cctcccctag accctttaga gtccttttat gaaatggact
     1441 caaccccttt ctgtgaggac ctgctgttcc agagagacaa agcaagccta ccaccatccc
     1501 cgaaggattc tttataccga gtaccattga cagaagtgca aaagaccccg aagtacacca
     1561 gcaaacaacc cactcaaggg ttcaatgctt tcttcctgga tgtttccgag gaaatgtaca
     1621 accggatcct ctggtggctg aaagacgagg agatcaagca cttcctggag gacagcagtg
     1681 atgatgctga gctgagcaag ttcgtgaagg atttcccagg aagcgaaccc taccactcag
     1741 cggagtccaa gacaagggtg gccaggcccc agatcttgga gccaaggccc cagagcccag
     1801 acctctgtga tgatgacgtg gagtttagag gctccttgtg gccccagccc tctgacagtc
     1861 agcagtactt cagtgcccca gcccctctca gcccttcctc caggccccgc agtccatggg
     1921 gcaagcttga tccttatgat tcctctgagg atgacaagga gtatgtgggc tttgcaaccc
     1981 tccccaatca agtccacagg aagtctgtga agaaaggctt tgactttaca ctcatggtgg
     2041 caggagaatc tggtctgggt aaatccactc ttgtcaacag cctcttcctc actgacttgt
     2101 accgggatcg gaaactgctg ggcgccgaag agcggatcat gcaaaccgtg gagattacta
     2161 agcacgcagt ggatatagaa gagaagggag tgaggctgcg gctcaccatt gtggacactc
     2221 caggatttgg ggatgcagtc aacaacacag agtgctggaa gcctgtggcc gaatacatcg
     2281 accagcagtt tgagcagtac ttccgagacg agagtggcct gaaccgcaag aacatccagg
     2341 acaaccgggt gcactgctgc ctgtacttca tctccccgtt tggccacggg ctccggccat
     2401 tggatgttga attcatgaag gccctgcatc agcgggtcaa cattgtgcct atcttggcta
     2461 aggcggacac actgacgcct cctgaagtgg accgaaagaa atgcaaaatc cgggaggaga
     2521 tcgagcactt tggaatcaag atctatcagt tcccagactg tgattccgat gaggacgagg
     2581 acttcaaatt acaggaccaa gccctaaagg aaagcatccc atttgcggtg attggcagca
     2641 acactgtggt agaagccagg gggcggagag ttcgaggccg cctctaccct tggggcatcg
     2701 tggaagtgga aaacccaggt cactgcgact ttgtcaagtt gaggacgatg ctggtgcgta
     2761 cccacatgca ggacctaaag gatgtgaccc gagagacaca ctacgagaac tacagggcac
     2821 agtgtatcca gagcatgacc cggctagtag tgaaggaacg gaatcgcaag gacagatcca
     2881 gaaactgaga agctaatccg ggagaaagac gaagagctgc ggcggatgca ggagatgtta
     2941 cacaaaatcc aaagacagat gaaggagact cactaactgg cttttggacc tgaatattta
     3001 aatctcttct tcctgcctat gccagcctct attccctgca tcagctctgc tcaggacccc
     3061 ccgcagctcc taccagttcg ccttatatcc ctgctgactt ctcaagagac tcagaggaaa
     3121 taaactaacc tatatgtggc
//
