LOCUS       NM_010891               3223 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Mus musculus septin 2 (Septin2), transcript variant 2, mRNA.
ACCESSION   NM_010891
VERSION     NM_010891.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3223)
  AUTHORS   Zhang,Y., Zhang,H., Zhao,S., Qi,Z., He,Y., Zhang,X., Wu,W., Yan,K.,
            Hu,L., Sun,S., Tang,X., Zhou,Q., Chen,F., Gu,A., Wang,L., Zhang,Z.,
            Yu,B., Wang,D., Han,Y., Xie,L. and Ji,Y.
  TITLE     S-Nitrosylation of Septin2 Exacerbates Aortic Aneurysm and
            Dissection by Coupling the TIAM1-RAC1 Axis in Macrophages
  JOURNAL   Circulation 149 (24), 1903-1920 (2024)
   PUBMED   38357802
  REMARK    GeneRIF: S-Nitrosylation of Septin2 Exacerbates Aortic Aneurysm and
            Dissection by Coupling the TIAM1-RAC1 Axis in Macrophages.
REFERENCE   2  (bases 1 to 3223)
  AUTHORS   Martens,A.K., Erwig,M., Patzig,J., Fledrich,R., Fuchtbauer,E.M. and
            Werner,H.B.
  TITLE     Targeted inactivation of the Septin2 and Septin9 genes in
            myelinating Schwann cells of mice
  JOURNAL   Cytoskeleton (Hoboken) 80 (7-8), 290-302 (2023)
   PUBMED   36378242
REFERENCE   3  (bases 1 to 3223)
  AUTHORS   Yang,Z., Zhou,L., Si,T., Chen,S., Liu,C., Ng,K.K., Wang,Z.,
            Chen,Z., Qiu,C., Liu,G., Wang,Q., Zhou,X., Zhang,L., Yao,Z., He,S.,
            Yang,M. and Zhou,Z.
  TITLE     Lysyl hydroxylase LH1 promotes confined migration and metastasis of
            cancer cells by stabilizing Septin2 to enhance actin network
  JOURNAL   Mol Cancer 22 (1), 21 (2023)
   PUBMED   36721170
  REMARK    GeneRIF: Lysyl hydroxylase LH1 promotes confined migration and
            metastasis of cancer cells by stabilizing Septin2 to enhance actin
            network.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3223)
  AUTHORS   Fan,M., Liu,Y., Shang,Y., Xue,Y., Liang,J. and Huang,Z.
  TITLE     JADE2 Is Essential for Hippocampal Synaptic Plasticity and
            Cognitive Functions in Mice
  JOURNAL   Biol Psychiatry 92 (10), 800-814 (2022)
   PUBMED   36008159
REFERENCE   5  (bases 1 to 3223)
  AUTHORS   Keppner,A., Correia,M., Santambrogio,S., Koay,T.W., Maric,D.,
            Osterhof,C., Winter,D.V., Clerc,A., Stumpe,M., Chalmel,F.,
            Dewilde,S., Odermatt,A., Kressler,D., Hankeln,T., Wenger,R.H. and
            Hoogewijs,D.
  TITLE     Androglobin, a chimeric mammalian globin, is required for male
            fertility
  JOURNAL   Elife 11, e72374 (2022)
   PUBMED   35700329
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3223)
  AUTHORS   Kinoshita,A., Noda,M. and Kinoshita,M.
  TITLE     Differential localization of septins in the mouse brain
  JOURNAL   J Comp Neurol 428 (2), 223-239 (2000)
   PUBMED   11064363
REFERENCE   7  (bases 1 to 3223)
  AUTHORS   Kinoshita,A., Kinoshita,M., Akiyama,H., Tomimoto,H., Akiguchi,I.,
            Kumar,S., Noda,M. and Kimura,J.
  TITLE     Identification of septins in neurofibrillary tangles in Alzheimer's
            disease
  JOURNAL   Am J Pathol 153 (5), 1551-1560 (1998)
   PUBMED   9811347
REFERENCE   8  (bases 1 to 3223)
  AUTHORS   Kinoshita,M., Kumar,S., Mizoguchi,A., Ide,C., Kinoshita,A.,
            Haraguchi,T., Hiraoka,Y. and Noda,M.
  TITLE     Nedd5, a mammalian septin, is a novel cytoskeletal component
            interacting with actin-based structures
  JOURNAL   Genes Dev 11 (12), 1535-1547 (1997)
   PUBMED   9203580
REFERENCE   9  (bases 1 to 3223)
  AUTHORS   Li,Y. and Olsen,B.R.
  TITLE     Murine models of human genetic skeletal disorders
  JOURNAL   Matrix Biol 16 (2), 49-52 (1997)
   PUBMED   9205941
  REMARK    Review article
REFERENCE   10 (bases 1 to 3223)
  AUTHORS   Kumar,S., Tomooka,Y. and Noda,M.
  TITLE     Identification of a set of genes with developmentally
            down-regulated expression in the mouse brain
  JOURNAL   Biochem Biophys Res Commun 185 (3), 1155-1161 (1992)
   PUBMED   1378265
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ075082.1, D49382.2 and AC108412.8.
            
            On Apr 30, 2009 this sequence version replaced NM_010891.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, and 3 all encode the same isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK171331.1, AK146616.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-333               CJ075082.1         24-356
            334-1368            D49382.2           289-1323
            1369-3223           AC108412.8         152137-153991
FEATURES             Location/Qualifiers
     source          1..3223
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 47.24 cM"
     gene            1..3223
                     /gene="Septin2"
                     /gene_synonym="mKIAA0158; Nedd-5; Nedd5; Sept2"
                     /note="septin 2"
                     /db_xref="GeneID:18000"
                     /db_xref="MGI:MGI:97298"
     exon            1..76
                     /gene="Septin2"
                     /gene_synonym="mKIAA0158; Nedd-5; Nedd5; Sept2"
                     /inference="alignment:Splign:2.1.0"
     exon            77..107
                     /gene="Septin2"
                     /gene_synonym="mKIAA0158; Nedd-5; Nedd5; Sept2"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..1184
                     /gene="Septin2"
                     /gene_synonym="mKIAA0158; Nedd-5; Nedd5; Sept2"
                     /note="isoform a is encoded by transcript variant 2;
                     neural precursor cell expressed, developmentally
                     down-regulated gene 5"
                     /codon_start=1
                     /product="septin-2 isoform a"
                     /protein_id="NP_035021.1"
                     /db_xref="CCDS:CCDS15190.1"
                     /db_xref="GeneID:18000"
                     /db_xref="MGI:MGI:97298"
                     /translation="MSKQQPTQFINPETPGYVGFANLPNQVHRKSVKKGFEFTLMVVG
                     ESGLGKSTLINSLFLTDLYPERIIPGAAEKIERTVQIEASTVEIEERGVKLRLTVVDT
                     PGYGDAINCRDCFKTIISYIDEQFERYLHDESGLNRRHIIDNRVHCCFYFISPFGHGL
                     KPLDVAFMKAIHNKVNIVPVIAKADTLTLKERERLKKRILDEIEEHSIKIYHLPDAES
                     DEDEDFKEQTRLLKASIPFSVVGSNQLIEAKGKKVRGRLYPWGVVEVENPEHNDFLKL
                     RTMLITHMQDLQEVTQDLHYENFRSERLKRGGRKVENEDMNKDQILLEKEAELRRMQE
                     MIARMQAQMQMQMQGGDSDSGALGQHV"
     exon            108..228
                     /gene="Septin2"
                     /gene_synonym="mKIAA0158; Nedd-5; Nedd5; Sept2"
                     /inference="alignment:Splign:2.1.0"
     exon            229..315
                     /gene="Septin2"
                     /gene_synonym="mKIAA0158; Nedd-5; Nedd5; Sept2"
                     /inference="alignment:Splign:2.1.0"
     exon            316..439
                     /gene="Septin2"
                     /gene_synonym="mKIAA0158; Nedd-5; Nedd5; Sept2"
                     /inference="alignment:Splign:2.1.0"
     exon            440..574
                     /gene="Septin2"
                     /gene_synonym="mKIAA0158; Nedd-5; Nedd5; Sept2"
                     /inference="alignment:Splign:2.1.0"
     exon            575..692
                     /gene="Septin2"
                     /gene_synonym="mKIAA0158; Nedd-5; Nedd5; Sept2"
                     /inference="alignment:Splign:2.1.0"
     exon            693..794
                     /gene="Septin2"
                     /gene_synonym="mKIAA0158; Nedd-5; Nedd5; Sept2"
                     /inference="alignment:Splign:2.1.0"
     exon            795..940
                     /gene="Septin2"
                     /gene_synonym="mKIAA0158; Nedd-5; Nedd5; Sept2"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1024
                     /gene="Septin2"
                     /gene_synonym="mKIAA0158; Nedd-5; Nedd5; Sept2"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1082
                     /gene="Septin2"
                     /gene_synonym="mKIAA0158; Nedd-5; Nedd5; Sept2"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1202
                     /gene="Septin2"
                     /gene_synonym="mKIAA0158; Nedd-5; Nedd5; Sept2"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..3223
                     /gene="Septin2"
                     /gene_synonym="mKIAA0158; Nedd-5; Nedd5; Sept2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3196..3201
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Septin2"
                     /gene_synonym="mKIAA0158; Nedd-5; Nedd5; Sept2"
                     /note="hexamer: AATAAA"
     polyA_site      3223
                     /gene="Septin2"
                     /gene_synonym="mKIAA0158; Nedd-5; Nedd5; Sept2"
                     /note="major polyA site"
ORIGIN      
        1 atctgttcgc gcgcgctcta ctgggcgggg caggtccgtg ctctcgcctg acgagcgttc
       61 tccggcgtgt gagcggatag acaggaaaat caagaaagat gtctaagcaa caaccaactc
      121 agtttataaa tccagaaact cctggctatg ttggatttgc aaatcttccc aatcaagttc
      181 accgaaaatc agtgaagaag gggttcgagt tcactctgat ggtggttggt gaatctggtc
      241 taggaaaatc aactctcata aacagcttat tcctgactga tctctaccca gaaagaatta
      301 ttcctggagc tgcagagaaa attgaaagaa ctgtccagat agaggcttcg actgttgaga
      361 ttgaagagcg gggtgtgaag ctgcggctta cagtagtgga cactcccggc tacggggatg
      421 ccatcaactg cagggattgt ttcaagacaa ttatctccta cattgatgag cagtttgaac
      481 gctacctaca tgatgagagt ggactgaaca ggcgtcacat cattgataac agggtacatt
      541 gttgcttcta cttcatttca ccttttggac atggactgaa gcccttagat gttgcattta
      601 tgaaagcgat acacaataag gtgaatattg tgcctgtcat tgcgaaagct gacactctca
      661 ctctgaagga gcgtgagcgg cttaagaaaa ggattttgga tgaaattgaa gagcatagca
      721 ttaaaatcta tcacttacct gatgcagagt cagatgaaga tgaagacttt aaggagcaga
      781 ctagactcct caaggccagt atcccattct ctgtggttgg ctccaaccag ttgattgaag
      841 ccaaaggcaa gaaggttaga ggccgtctct acccatgggg tgttgtagag gtggagaacc
      901 cagaacacaa tgactttctg aagctgagaa cgatgctcat cacccacatg caggacctac
      961 aggaagtgac ccaagacctt cactatgaaa acttccgttc tgagaggctg aagagaggcg
     1021 gcaggaaagt agagaatgag gacatgaata aagaccagat cttgcttgaa aaggaggctg
     1081 agctccgccg catgcaagag atgattgcaa gaatgcaagc gcagatgcag atgcagatgc
     1141 agggtggtga cagtgacagc ggggctctcg ggcagcatgt gtgaggccga gctttcatat
     1201 tggaaacact ttggataaga aagacttcct gataagtgct acagcatcaa ggttcttagc
     1261 cctgtggaag gaagggcacc catccacaat gaagcacctg tgtctgagga tttcagttgg
     1321 ttgttttttg ttttttgttt ggttggggtt tttttttttt tttttttttc ttttttaaca
     1381 tttggtggtt tttgttttta ctcttttttt cttttccttc tttttctgcc ctcaaccccc
     1441 caactccttt ggtatgaagt acttttaaca tttatatttc attgttacac tttaaatttt
     1501 gtaaggaaaa ctctgatatt ttattcctcc tgaaccacta atgttagaat ttatttctaa
     1561 gaatcagtca acatgtatac tcttaatagt gaatttctat gatatagctg gcctgactaa
     1621 tcactgacaa gtactctttg atttctatct agacattttt atgctcagaa tgttcctgtg
     1681 tggtggacat tgatgtacct gtgacagaag tggttgtgca tacttggtgg caaattattt
     1741 gcttactaga attgaagtca cattgttaac tttatatttg tacagaacac ctaaaaccaa
     1801 ttttgctgct gtagttcatt cggcttattc atctgcacaa ttatctgtta accaggtaga
     1861 acagaagaga gttatctaat gagatacatg tttatactta aatagctttt aaaaagcagg
     1921 atttcagggt tgaattttaa gagctctgga ttctagtgcc agatcatttt caaacctctg
     1981 tagagaaagc tcactacaag gactttttat actgtggatg ctgattatgc tatgctgtgg
     2041 agagaaccaa agcagctatg agctccagct tcatattgta acaagactct ttataaggaa
     2101 gagtcagtaa actttttact caactaaaaa ggcaatactt ttttaaagaa accaaaatgt
     2161 ttatatttta tactgcactt taatgtactt tctataacta ggtgcaaaag gtcatagcag
     2221 tggaaatcat agtccttggc tggcatggat ccaaccccag gcttgtgatt gggtggtgct
     2281 cttgaacaaa aggccacttg aagcccagat gcctgccagg ttttcgtcta actcttcccc
     2341 ttttcagtga tccttctatt gaaaggaaaa tagcagtgct gggtttttta tgtgcagact
     2401 gtctcatctg tttccaggca ctgtcatttt cttcagtgtg tgtagtataa atgtcttcac
     2461 accatgaacg aaaggctttt cagatctgtg ccccaagcag gcaagcagag tcctgcctgg
     2521 tttatattct ggcacttccc tcttctaccc tgtcttctaa tgtcaggcag tgaccttaga
     2581 agggaagggg caggtgaagg aggcagtggt gtggagaagc aaagcaggtg ctaactgtgt
     2641 gctttcattt gctgcaggag gaaggacttg attgatgatg aggcagggat ttacgtttaa
     2701 ttcagtccaa aactcagtag tactaataag atgaagctta agcatggttg tttataaatt
     2761 taatgaggaa aaatacattt gctcgctttg cctcttcaca ttgcatcact gtgagtgatc
     2821 agggaagttc attgtgtgaa gttcctatca agaaaagcgt caatgacttt agagtaccca
     2881 tgcagtcctt tgtttggctt attttgacat taagtttgtt ggagaaaaat ttaaaaacaa
     2941 aaaaatgaaa gaattcccaa gtattcggtg tgagtcccat gtttttgagt taaggtgcta
     3001 cttcgggtca gctgacatct aatattggca gtgtggattg tgaggtcttg cagccacaat
     3061 tctaaccccc ttcagtttta ctgcttttgc taacagatac ttgctctttc actaagaagt
     3121 aacttgtact tgtagaaatg tattttgaaa acatttcaca cttcaacttt gtatccattt
     3181 aaattaacct ttttcaataa agcactattg tttagatatt aaa
//
