LOCUS       NM_001373945            1309 bp    mRNA    linear   ROD 07-AUG-2023
DEFINITION  Mus musculus septin 12 (Septin12), transcript variant 3, mRNA.
ACCESSION   NM_001373945 XM_006522578
VERSION     NM_001373945.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1309)
  AUTHORS   Wang HY, Shen YR, Tsai YC, Wu SR, Wang CY and Kuo PL.
  TITLE     Proper phosphorylation of septin 12 regulates septin 4 and soluble
            adenylyl cyclase expression to induce sperm capacitation
  JOURNAL   J Cell Physiol 238 (3), 597-609 (2023)
   PUBMED   36715674
  REMARK    GeneRIF: Proper phosphorylation of septin 12 regulates septin 4 and
            soluble adenylyl cyclase expression to induce sperm capacitation.
REFERENCE   2  (bases 1 to 1309)
  AUTHORS   Chen H, Li P, Du X, Zhao Y, Wang L, Tian Y, Song X, Shuai L, Bai X
            and Chen L.
  TITLE     Homozygous Loss of Septin12, but not its Haploinsufficiency, Leads
            to Male Infertility and Fertilization Failure
  JOURNAL   Front Cell Dev Biol 10, 850052 (2022)
   PUBMED   35547809
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1309)
  AUTHORS   Scovell JM, Bournat JC, Szafran AT, Solis M, Moore J, Rivera A,
            Chen CH, Zhang J, Wilken N, Seth A and Jorgez CJ.
  TITLE     PRSS50 is a testis protease responsible for proper sperm tail
            formation and function
  JOURNAL   Development 148 (8) (2021)
   PUBMED   33913480
REFERENCE   4  (bases 1 to 1309)
  AUTHORS   Shen YR, Wang HY, Tsai YC, Kuo YC, Wu SR, Wang CY and Kuo PL.
  TITLE     The SEPT12 complex is required for the establishment of a
            functional sperm head-tail junction
  JOURNAL   Mol Hum Reprod 26 (6), 402-412 (2020)
   PUBMED   32392324
REFERENCE   5  (bases 1 to 1309)
  AUTHORS   Fragoza R, Das J, Wierbowski SD, Liang J, Tran TN, Liang S, Beltran
            JF, Rivera-Erick CA, Ye K, Wang TY, Yao L, Mort M, Stenson PD,
            Cooper DN, Wei X, Keinan A, Schimenti JC, Clark AG and Yu H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1309)
  AUTHORS   Lai TH, Wu YY, Wang YY, Chen MF, Wang P, Chen TM, Wu YN, Chiang HS,
            Kuo PL and Lin YH.
  TITLE     SEPT12-NDC1 Complexes Are Required for Mammalian Spermiogenesis
  JOURNAL   Int J Mol Sci 17 (11), 1911 (2016)
   PUBMED   27854341
  REMARK    GeneRIF: In mice sperm with mutated SEPT12, NDC1 dispersed around
            the manchette region of the sperm head and annulus, compared with
            concentrating at the sperm neck of wild-type sperm.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1309)
  AUTHORS   Kuo YC, Shen YR, Chen HI, Lin YH, Wang YY, Chen YR, Wang CY and Kuo
            PL.
  TITLE     SEPT12 orchestrates the formation of mammalian sperm annulus by
            organizing core octameric complexes with other SEPT proteins
  JOURNAL   J Cell Sci 128 (5), 923-934 (2015)
   PUBMED   25588830
  REMARK    GeneRIF: results demonstrate the molecular architecture of SEPT12
            filaments at the sperm annulus, their mechanical support of sperm
            motility, and their correlation with male infertility.
REFERENCE   8  (bases 1 to 1309)
  AUTHORS   Yoshida A, Yamamoto N, Kinoshita M, Hiroi N, Hiramoto T, Kang G,
            Trimble WS, Tanigaki K, Nakagawa T and Ito J.
  TITLE     Localization of septin proteins in the mouse cochlea
  JOURNAL   Hear Res 289 (1-2), 40-51 (2012)
   PUBMED   22575789
REFERENCE   9  (bases 1 to 1309)
  AUTHORS   Lin YH, Chou CK, Hung YC, Yu IS, Pan HA, Lin SW and Kuo PL.
  TITLE     SEPT12 deficiency causes sperm nucleus damage and developmental
            arrest of preimplantation embryos
  JOURNAL   Fertil Steril 95 (1), 363-365 (2011)
   PUBMED   20801438
  REMARK    GeneRIF: Oocytes fertilized with spermatozoa obtained from Septin
            12+/- chimeric mice failed to develop beyond the morula stage after
            IVF and intracytoplasmic sperm injection because of significant DNA
            defects in the spermatozoa
REFERENCE   10 (bases 1 to 1309)
  AUTHORS   Lin YH, Lin YM, Wang YY, Yu IS, Lin YW, Wang YH, Wu CM, Pan HA,
            Chao SC, Yen PH, Lin SW and Kuo PL.
  TITLE     The expression level of septin12 is critical for spermiogenesis
  JOURNAL   Am J Pathol 174 (5), 1857-1868 (2009)
   PUBMED   19359518
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163723.3.
            
            On Sep 5, 2019 this sequence version replaced XM_006522578.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189685.29571.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-71                AC163723.3         47554-47624         c
            72-259              AC163723.3         46255-46442         c
            260-385             AC163723.3         43705-43830         c
            386-467             AC163723.3         43546-43627         c
            468-605             AC163723.3         41975-42112         c
            606-723             AC163723.3         41722-41839         c
            724-819             AC163723.3         41538-41633         c
            820-916             AC163723.3         38290-38386         c
            917-968             AC163723.3         37558-37609         c
            969-1309            AC163723.3         37129-37469         c
FEATURES             Location/Qualifiers
     source          1..1309
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 2.49 cM"
     gene            1..1309
                     /gene="Septin12"
                     /gene_synonym="1700028G04Rik; 4933413B09Rik; Sept12"
                     /note="septin 12"
                     /db_xref="GeneID:71089"
                     /db_xref="MGI:MGI:1918339"
     exon            1..71
                     /gene="Septin12"
                     /gene_synonym="1700028G04Rik; 4933413B09Rik; Sept12"
                     /inference="alignment:Splign:2.1.0"
     exon            72..259
                     /gene="Septin12"
                     /gene_synonym="1700028G04Rik; 4933413B09Rik; Sept12"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..1173
                     /gene="Septin12"
                     /gene_synonym="1700028G04Rik; 4933413B09Rik; Sept12"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /codon_start=1
                     /product="septin-12 isoform 3"
                     /protein_id="NP_001360874.1"
                     /db_xref="CCDS:CCDS88872.1"
                     /db_xref="GeneID:71089"
                     /db_xref="MGI:MGI:1918339"
                     /translation="MDERRSPSPCSSRPSSPRTPPNEMFGPVGIEAVLDQLRIKAMKT
                     GFEFNIMVVGQSGLGKSTMVNTLFKSKVWQSTEPNLDVPMPQTLELHSVTHVIEEKGL
                     KLKLTVTDTPGFGDQINNDKCWDPILSYINQQYEQYLQEELLITRQRHIPDTRVHCCV
                     YFVPPTGHCLRPLDIEFLRRLCRTVNVVPVIARADSLTIEERDAFRSRIQQNLKTHCI
                     DVYPQKCFDEDVNDRLLNSKIREQIPFAVVGADREHIVNGRCVLGRKTKWGIIEVENM
                     AHCEFLLLRDLLIRSHLQDLKDITHNVHYENYRVLRLNESHVLPRGPGWVNLAPVSPG
                     QLMAPGPGKVRKRANKDTKDEEC"
     exon            260..385
                     /gene="Septin12"
                     /gene_synonym="1700028G04Rik; 4933413B09Rik; Sept12"
                     /inference="alignment:Splign:2.1.0"
     exon            386..467
                     /gene="Septin12"
                     /gene_synonym="1700028G04Rik; 4933413B09Rik; Sept12"
                     /inference="alignment:Splign:2.1.0"
     exon            468..605
                     /gene="Septin12"
                     /gene_synonym="1700028G04Rik; 4933413B09Rik; Sept12"
                     /inference="alignment:Splign:2.1.0"
     exon            606..723
                     /gene="Septin12"
                     /gene_synonym="1700028G04Rik; 4933413B09Rik; Sept12"
                     /inference="alignment:Splign:2.1.0"
     exon            724..819
                     /gene="Septin12"
                     /gene_synonym="1700028G04Rik; 4933413B09Rik; Sept12"
                     /inference="alignment:Splign:2.1.0"
     exon            820..916
                     /gene="Septin12"
                     /gene_synonym="1700028G04Rik; 4933413B09Rik; Sept12"
                     /inference="alignment:Splign:2.1.0"
     exon            917..968
                     /gene="Septin12"
                     /gene_synonym="1700028G04Rik; 4933413B09Rik; Sept12"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1309
                     /gene="Septin12"
                     /gene_synonym="1700028G04Rik; 4933413B09Rik; Sept12"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccagccctc tcctccccct cagcgcagcc tgccagctac tcccagctcc cccaagggac
       61 tcatccacca ggagcaggca ccactgcacc cttggcccca tggatgagag gcggtcgccc
      121 tccccctgct cctcaaggcc ctccagcccc aggaccccac ccaatgagat gtttggtcct
      181 gtgggcattg aggctgtgct agaccagctg aggatcaagg ctatgaagac tgggtttgag
      241 ttcaatatca tggtagtagg gcagagtggg ctaggcaagt ccaccatggt gaacacactg
      301 ttcaagtcca aagtatggca gtcaactgaa cccaacctgg atgtacccat gccacaaaca
      361 ttggagctgc actctgtgac ccatgtcatc gaggagaagg gattgaagct gaagctgaca
      421 gtgacagaca cacctggctt tggagaccag atcaacaatg acaagtgctg ggaccctatc
      481 ctgagctaca tcaaccaaca gtatgagcag tatctacaag aggagctcct gattacccgc
      541 cagcgccaca tccccgacac ccgtgtgcac tgctgtgtgt actttgtgcc acccactggc
      601 cactgcctac ggcccctaga cattgagttc ctgaggcggc tgtgccggac tgtgaatgtg
      661 gtgccggtga tcgcccgggc tgacagcctg accattgaag aacgagatgc cttcaggagc
      721 aggatccagc aaaacctgaa aactcactgc atcgatgtgt acccacagaa gtgtttcgac
      781 gaggatgtca atgacagact tctcaacagt aagattcggg agcagatccc ttttgctgtg
      841 gtcggggctg accgagagca catagtgaat gggagatgtg tcctgggccg gaagaccaaa
      901 tggggcatca tcgaagtgga aaacatggcg cactgtgagt ttcttctcct gagagatctg
      961 ctcatccgct cccatctcca ggacctgaag gacatcaccc acaatgtaca ctacgagaac
     1021 taccgggtac tcagactcaa tgagagccac gtgctgcccc gggggccagg ctgggtgaac
     1081 ctggctccag tctcccctgg acagctgatg gcccctggac cgggaaaggt ccgaaagcga
     1141 gcaaacaagg ataccaagga cgaagagtgc tgaggggccg tggcccaaac ctgctaggct
     1201 ccttccctcc tcagcagcca gcgcccaaca caccctagag catctatgtg aacctggact
     1261 tgctttgtac aaaaagctgt gctttgacaa ctaaagggtt tgtaaacga
//
