LOCUS       NM_001009818            5183 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus septin 11 (Septin11), transcript variant 3, mRNA.
ACCESSION   NM_001009818
VERSION     NM_001009818.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5183)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5183)
  AUTHORS   Keppner,A., Correia,M., Santambrogio,S., Koay,T.W., Maric,D.,
            Osterhof,C., Winter,D.V., Clerc,A., Stumpe,M., Chalmel,F.,
            Dewilde,S., Odermatt,A., Kressler,D., Hankeln,T., Wenger,R.H. and
            Hoogewijs,D.
  TITLE     Androglobin, a chimeric mammalian globin, is required for male
            fertility
  JOURNAL   Elife 11, e72374 (2022)
   PUBMED   35700329
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5183)
  AUTHORS   Moore,K.S., Moore,R., Fulmer,D.B., Guo,L., Gensemer,C.,
            Stairley,R., Glover,J., Beck,T.C., Morningstar,J.E., Biggs,R.,
            Muhkerjee,R., Awgulewitsch,A. and Norris,R.A.
  TITLE     DCHS1, Lix1L, and the Septin Cytoskeleton: Molecular and
            Developmental Etiology of Mitral Valve Prolapse
  JOURNAL   J Cardiovasc Dev Dis 9 (2), 62 (2022)
   PUBMED   35200715
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5183)
  AUTHORS   Noda,M., Ito,H. and Nagata,K.I.
  TITLE     Physiological significance of WDR45, a responsible gene for
            beta-propeller protein associated neurodegeneration (BPAN), in
            brain development
  JOURNAL   Sci Rep 11 (1), 22568 (2021)
   PUBMED   34799629
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5183)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5183)
  AUTHORS   Roseler,S., Sandrock,K., Bartsch,I., Busse,A., Omran,H., Loges,N.T.
            and Zieger,B.
  TITLE     Lethal phenotype of mice carrying a Sept11 null mutation
  JOURNAL   Biol Chem 392 (8-9), 779-781 (2011)
   PUBMED   21824005
  REMARK    GeneRIF: SEPT11 is involved in vesicle trafficking and may play a
            role in synaptic connectivity. Interestingly, mice that harbor a
            homozygous Sept11 null mutation, die in utero.
REFERENCE   7  (bases 1 to 5183)
  AUTHORS   Shinoda,T., Ito,H., Sudo,K., Iwamoto,I., Morishita,R. and Nagata,K.
  TITLE     Septin 14 is involved in cortical neuronal migration via
            interaction with Septin 4
  JOURNAL   Mol Biol Cell 21 (8), 1324-1334 (2010)
   PUBMED   20181826
REFERENCE   8  (bases 1 to 5183)
  AUTHORS   Tsang,C.W., Fedchyshyn,M., Harrison,J., Xie,H., Xue,J.,
            Robinson,P.J., Wang,L.Y. and Trimble,W.S.
  TITLE     Superfluous role of mammalian septins 3 and 5 in neuronal
            development and synaptic transmission
  JOURNAL   Mol Cell Biol 28 (23), 7012-7029 (2008)
   PUBMED   18809578
REFERENCE   9  (bases 1 to 5183)
  AUTHORS   Ajioka,I., Maeda,T. and Nakajima,K.
  TITLE     Identification of ventricular-side-enriched molecules regulated in
            a stage-dependent manner during cerebral cortical development
  JOURNAL   Eur J Neurosci 23 (2), 296-308 (2006)
   PUBMED   16420439
REFERENCE   10 (bases 1 to 5183)
  AUTHORS   Powles,N., Babbs,C., Ficker,M., Schimmang,T. and Maconochie,M.
  TITLE     Identification and analysis of genes from the mouse otic vesicle
            and their association with developmental subprocesses through in
            situ hybridization
  JOURNAL   Dev Biol 268 (1), 24-38 (2004)
   PUBMED   15031102
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC134827.4, BC064466.1 and CO042161.1.
            
            On Jul 17, 2015 this sequence version replaced NM_001009818.1.
            
            Transcript Variant: This variant (3) differs in the 3' UTR and
            coding sequence compared to variant 4. The resulting isoform (3)
            has a shorter and distinct C-terminus compared to isoform 4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC064466.1, AK166517.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849378, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                AC134827.4         181692-181732       c
            42-5049             BC064466.1         1-5008
            5050-5183           CO042161.1         1-134               c
FEATURES             Location/Qualifiers
     source          1..5183
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 47.29 cM"
     gene            1..5183
                     /gene="Septin11"
                     /gene_synonym="6230410I01Rik; D5Ertd606e; Sept11"
                     /note="septin 11"
                     /db_xref="GeneID:52398"
                     /db_xref="MGI:MGI:1277214"
     exon            1..182
                     /gene="Septin11"
                     /gene_synonym="6230410I01Rik; D5Ertd606e; Sept11"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..1445
                     /gene="Septin11"
                     /gene_synonym="6230410I01Rik; D5Ertd606e; Sept11"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /codon_start=1
                     /product="septin-11 isoform 3"
                     /protein_id="NP_001009818.1"
                     /db_xref="CCDS:CCDS51549.1"
                     /db_xref="GeneID:52398"
                     /db_xref="MGI:MGI:1277214"
                     /translation="MAVAVGRPSNEELRNLSLSGHVGFDSLPDQLVNKSTSQGFCFNI
                     LCVGETGIGKSTLMDTLFNTKFESDPATHNEPGVRLKARSYELQESNVRLKLTIVDTV
                     GFGDQINKDDSYKPIVEYIDAQFEAYLQEELKIKRSLFNYHDTRIHACLYFIAPTGHS
                     LKSLDLVTMKKLDSKVNIIPIIAKADTIAKNELHKFKSKIMSELVSNGVQIYQFPTDE
                     ETVAEINATMSVHLPFAVVGSTEEVKIGNKMAKARQYPWGVVQVENENHCDFVKLREM
                     LIRVNMEDLREQTHTRHYELYRRCKLEEMGFKDTDPDSKPFSLQETYEAKRNEFLGEL
                     QKKEEEMRQMFVMRVKEKEAELKEAEKELHEKFDLLKRTHQEEKKKVEDKKKELEEEV
                     SNFQKKKAAAQLLQSQAQQSGAQQTKKDKDKKNASFA"
     exon            183..297
                     /gene="Septin11"
                     /gene_synonym="6230410I01Rik; D5Ertd606e; Sept11"
                     /inference="alignment:Splign:2.1.0"
     exon            298..493
                     /gene="Septin11"
                     /gene_synonym="6230410I01Rik; D5Ertd606e; Sept11"
                     /inference="alignment:Splign:2.1.0"
     exon            494..680
                     /gene="Septin11"
                     /gene_synonym="6230410I01Rik; D5Ertd606e; Sept11"
                     /inference="alignment:Splign:2.1.0"
     exon            681..842
                     /gene="Septin11"
                     /gene_synonym="6230410I01Rik; D5Ertd606e; Sept11"
                     /inference="alignment:Splign:2.1.0"
     exon            843..939
                     /gene="Septin11"
                     /gene_synonym="6230410I01Rik; D5Ertd606e; Sept11"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1108
                     /gene="Septin11"
                     /gene_synonym="6230410I01Rik; D5Ertd606e; Sept11"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1241
                     /gene="Septin11"
                     /gene_synonym="6230410I01Rik; D5Ertd606e; Sept11"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1429
                     /gene="Septin11"
                     /gene_synonym="6230410I01Rik; D5Ertd606e; Sept11"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..5166
                     /gene="Septin11"
                     /gene_synonym="6230410I01Rik; D5Ertd606e; Sept11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5028..5033
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Septin11"
                     /gene_synonym="6230410I01Rik; D5Ertd606e; Sept11"
                     /note="hexamer: AATATA"
     polyA_site      5049
                     /gene="Septin11"
                     /gene_synonym="6230410I01Rik; D5Ertd606e; Sept11"
                     /note="major polyA site"
     regulatory      5131..5136
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Septin11"
                     /gene_synonym="6230410I01Rik; D5Ertd606e; Sept11"
                     /note="hexamer: AAGAAA"
     polyA_site      5147
                     /gene="Septin11"
                     /gene_synonym="6230410I01Rik; D5Ertd606e; Sept11"
ORIGIN      
        1 ggcggggcgg cgcgggcgag cagatgcggc tggaggcgcg cgggagccgg gcgcgagcag
       61 ggcgcagccg cgagggaggc gcgggggagg ccagcgggag ccggagcacc agcagcagcc
      121 agtgtcggta aagagcagcc agagccacag tcgcgatggc cgtggcggtg gggagaccga
      181 gtaatgaaga gctgcgaaac ttatcacttt ctggccatgt tggatttgac agtctgcccg
      241 accagctggt caacaaatcc acttctcaag gattctgttt caacatcctg tgcgtgggtg
      301 agacaggtat tggcaaatcc acattgatgg acactttatt caacaccaaa tttgaaagtg
      361 acccagctac tcacaacgag ccaggcgtcc ggttaaaagc cagaagctat gaactccagg
      421 aaagcaacgt acggctgaag ctaacaatcg ttgacacagt gggatttgga gaccagatta
      481 ataaagatga cagctataag cctatagtgg aatacattga cgcccagttt gaggcctact
      541 tgcaagaaga attgaaaatt aaacgttctc tcttcaacta tcatgacaca aggattcacg
      601 cctgccttta ctttatcgcc cccacgggac attcactgaa gtccctggac ctggtcacca
      661 tgaagaagct ggacagcaag gtgaacatca tcccgatcat cgcgaaagcc gacaccatcg
      721 ccaaaaacga attgcacaaa ttcaagagta agatcatgag tgaactagtt agcaacggag
      781 tccagatata tcagttcccc acagatgagg aaacagtggc agagattaac gcaacgatga
      841 gtgtccatct cccattcgca gtggtcggca gtactgaaga ggtcaagatt ggcaacaaga
      901 tggcgaaggc caggcagtac ccttggggtg tggtgcaggt tgagaacgaa aaccactgtg
      961 attttgtgaa gctgcgggag atgctgatcc gagtgaacat ggaggacctg cgagagcaga
     1021 cgcacactcg ccactacgag ttgtatcggc gctgcaagct tgaggagatg ggcttcaagg
     1081 acacggaccc cgacagcaag cccttcagtc ttcaggagac ctacgaagca aagaggaacg
     1141 agttcctggg ggagctacag aagaaagagg aggagatgag acagatgttc gtcatgaggg
     1201 tgaaggagaa agaggcggag ctcaaggagg cagaaaaaga gcttcatgag aagttcgacc
     1261 tcctgaagcg gactcaccaa gaggagaaga agaaggtgga agataagaag aaggagcttg
     1321 aggaggaggt gagcaacttc cagaaaaaga aggcggcggc tcagctcttg caatcccagg
     1381 cccagcagtc tggggcccag caaaccaaga aggacaagga taagaaaaat gcaagcttcg
     1441 cataaggcct ggcaagccaa ggacgccccc ccgcattcac ctgctttggc agtagtagcg
     1501 tacctctgtc atctgtgtcc tgtttgattc gttgtttcag cctttccccc aaatatcagt
     1561 aacttagctc attttactga atgttgtcag gtggtggaaa accatagcac aagtggatgg
     1621 catcagcaag cgcgcgcgtg gctggacttt gtttctcgaa agtcgatttg ccttgtatgc
     1681 ctgttccaag tggcggcagg aagcatgtct gtcccttgta tgtcgctttg gaccgaggaa
     1741 agtggggtaa aataactacc tgtacgtctg gcggggaaac tcaccgcctc agcagctcag
     1801 ctaaaaccct gagtagccat gacaacttgc attttcttag ttgtgcatcc cgtgcttgca
     1861 cacctccaga attacctgtc tcttcttcac acttgccaca agccagcggt gggctggaaa
     1921 gtaggcagaa acttgagtga gcatccgaga tagcttttcc cctcctatgg ctttttcatt
     1981 taatcgtttg tttatttggc ttgagcctat gatctggtta gactgtctta gggatggagt
     2041 ctgcatctga atgcctacct tcagagccag gccacagcta cagactggca cgagaaacat
     2101 gattacgttc acccccacca gggcgtcccg gacactctca cgggtccaga tctcaaagaa
     2161 cacctcattt ggtactgctt ggctaaagaa tctttggtta aggaggctgg attcccactt
     2221 ccctccagcc tctctgcaca cacacctgca tttgctttaa gcaggctgag gggggacttg
     2281 gaggctgact ctaggatgtg gctacttcta gtaagttttc atgactcacc atgagaaaac
     2341 ttgctctata cattgtacta ccggtagcac aagtctgaaa ggacgtcctc agttgaaggt
     2401 ggcaggggag tgaatggaca gtgcagccgc tactcaaagc agagatagag gcctgatagc
     2461 cagcctctgg tccacttcct tgctgacagt gtaactcagt tgcctctaag gagttgtcct
     2521 ccctgtcccc tcactgtgac cagttccatc tgctatgact cttgggtcct tcagttacct
     2581 cacctcaccc catgaggatt aactcagaag ccaggacatg ttgcctgctg tgtaagaact
     2641 gagaggggtg catcatttgt cctgtcatct tttccctgac gctcctgtca cctgcttggc
     2701 cacccccttc taaccagatc ttggctcttc cctctcattt ctcatgaacc caggcctccg
     2761 cctctgcatt ttcctctcac gtcaccagtt acacgtgaat gggacaatgc aggctgcatt
     2821 cccctctgtc acacacactt aaaaaaacat tgtccagcca gcccctatct gaccccagcc
     2881 aagttttgtg ttatctttta cctccccatc gtaagaagaa agcagtggcc tttcataaac
     2941 taaattaggc ttcgttagac aaataaggac attggcttca ctggggtgta gaccaggctg
     3001 gagagcagcc acagccatct tcactggtga aggggatagc tccaacacag acatcggctt
     3061 tgcttccatt tttctagcta gctgtggagc agcagggact aatggcatgc tgactaaccg
     3121 acgctgcgtt tgcttcttca ccgggcacca cgtaagagct tgagcactgg tgtcctctgc
     3181 ttgttccggc cactgcttgt gtgagcttta ttttgtgtgt gtgtatgtgc cttggaatag
     3241 aaaacacccc tttgcattca atttctctca tccctaaaag cttttaaaga catgctcaga
     3301 aacaaacaaa caaacaaaca aaaaacccaa acaattgact tttttgatgc caaaattatt
     3361 gaattttttt tgcattaagt ttttgttctc agtaaaataa atcctctgga gagtcaggga
     3421 ataagaagtc aagagaatcc taaagaagct taaaaaagag aaaagcattg cttctgcaac
     3481 tttttcctcc cactgctccc gagcctctgg tagctggtta ttgctgctct ttctttccgt
     3541 atctatacct ttcttcacag tagtccctgg ctctgcacgg aataaacgat actctcaaat
     3601 ctaactggac gtgctttcgc ctttgcatgt aagtacagga gtaagaactc ggatctttct
     3661 gtttcagatt agggaaaaca aatggggcag atgaggtctt cttttagaag gtgtcctgga
     3721 tagtctgagt aatctttttt tttttctttt tctttttttt tttcttttta aagctaaata
     3781 ctggccacat ttctatttta cccgacagtt tatgcttcct cttgatgtca gaggaagttg
     3841 gggattgggt actgaatgtt gtgtaccact gttgtgtatg gcctcctgga ggtcatgtag
     3901 agggcctttg attgtgacag tggcaaaaag ctggggaaag attcccactg tccacgggac
     3961 aaaaatcctg aaaatgatgt ctctgccatg ctgcctttct gcttgctccc tgacattccg
     4021 gatctcaggc tagtggcttc tcctttatgc tcagtgcaca atggccactt ctttttagtt
     4081 tttggttgga cagctttggc ctctctgcac ggtgagcatc ttctgctcct tcaggactgt
     4141 ggtcccctgt aattgtcatc tgtgctgtgg gaggacgact gagtacttgg tcagcaagta
     4201 ctcgggtagc agttgagaac tgttttctca gcttgggctc tgtatgaatc gatccagaag
     4261 ggtctctctc agccagggga gctcctccac ctgaggttag gtgtgggttt cttgctttcg
     4321 tcctccttta ctttgcaact caccagcaac agctcttgct tcctctccat cccgtgcacc
     4381 ttgaatgggt ggacttgact ctctcacttt cctcacacac ccctaagtgt tccacagagt
     4441 tggttgttca ggcgtcccct acccacatcg tactgtctct gtgtggtcct cccagaactg
     4501 tccatctgaa tcccccagct ttgccattca taagtgtctg gagttgtcag gttccaaaag
     4561 tcttagttct attgacagga catttattat ggagtcatta agtgaatcat gacctacaga
     4621 gtctagtttg tatgtaggta tgaagggaat tttaaaaaat aaattgaaaa ttaagctgtg
     4681 aacagcatta gaactttgtc tatttcttga ttttaaaata tgctgataat gccttaaact
     4741 gtagttgtag aattgtcatt ttttgctgtt tgaagataac caatgttttc taaactgttg
     4801 tgtaaccttt cagtgttaat gcagattgtc atgtatgtaa gctgcatgtt agacacttgt
     4861 cttttttttt tataaactaa aataactgta ttgacgtgaa gcctattgtt cctacaagta
     4921 tgaaagtgct gactcagcaa cctgccgagt aacttggtgt ctgttatcgt agtgtggtgc
     4981 caggtgacct atgcatatat cactagtgcc aagacttaaa gtggggaaat atatttttac
     5041 ccaaccgttg ttctgtgtgc ccgtttgtga gttctttcca gtccctgcct gatatgccta
     5101 tgtacacaca tgtgcttgtt atgtcacata aagaaatggg gatggcggct gtgtcctgct
     5161 cttttaaaaa aaaaaaaaaa aaa
//
